Published in EMBO J on August 03, 2006
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci U S A (2008) 5.18
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature (2012) 4.26
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem (2010) 3.84
Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol (2013) 3.73
Dual roles of Nrf2 in cancer. Pharmacol Res (2008) 3.41
The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev (2013) 3.40
Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal (2010) 3.19
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res (2008) 3.12
Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog (2009) 2.94
The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet (2013) 2.89
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell (2009) 2.84
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol (2007) 2.38
Structural assembly of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2010) 2.17
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin Cancer Res (2010) 2.14
Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal (2011) 1.82
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene (2010) 1.77
Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents. Med Res Rev (2012) 1.72
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res (2008) 1.64
Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. J Biol Chem (2011) 1.59
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc Natl Acad Sci U S A (2013) 1.56
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem J (2013) 1.49
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains. Proc Natl Acad Sci U S A (2010) 1.48
Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension. J Biol Chem (2009) 1.47
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. J Biol Chem (2013) 1.46
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacol Rev (2012) 1.45
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. EMBO J (2013) 1.43
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. EMBO J (2010) 1.36
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol (2012) 1.30
The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway. Cell Rep (2014) 1.29
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Mol Cell Biol (2012) 1.28
Cysteine-based regulation of the CUL3 adaptor protein Keap1. Toxicol Appl Pharmacol (2009) 1.17
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Cancer Res (2013) 1.12
Prospective type 1 and type 2 disulfides of Keap1 protein. Chem Res Toxicol (2008) 1.09
Comparison of Secondary Structure Formation Using 10 Different Force Fields in Microsecond Molecular Dynamics Simulations. J Chem Theory Comput (2012) 1.07
Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter. Free Radic Biol Med (2011) 1.05
The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response. J Biol Chem (2010) 1.03
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Cancer Res (2013) 1.01
Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. PLoS One (2010) 0.99
The Nrf2-inducible antioxidant defense in astrocytes can be both up- and down-regulated by activated microglia:Involvement of p38 MAPK. Glia (2011) 0.95
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J Biol Chem (2012) 0.95
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proc Natl Acad Sci U S A (2014) 0.95
A novel strategy to activate cytoprotective genes in the injured brain. Biochem Biophys Res Commun (2011) 0.94
Structural analysis of the complex of Keap1 with a prothymosin alpha peptide. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.94
Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction. ACS Med Chem Lett (2012) 0.94
Cross-cancer profiling of molecular alterations within the human autophagy interaction network. Autophagy (2015) 0.94
Small molecules, big targets: drug discovery faces the protein-protein interaction challenge. Nat Rev Drug Discov (2016) 0.93
Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2. Oxid Med Cell Longev (2013) 0.93
Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage. Redox Biol (2014) 0.92
Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2012) 0.92
Comprehensive analysis of loops at protein-protein interfaces for macrocycle design. Nat Chem Biol (2014) 0.91
Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem Biol Drug Des (2011) 0.91
Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J Biomol Screen (2011) 0.91
Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation. Biochem J (2014) 0.90
Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease. Free Radic Biol Med (2013) 0.89
Structural basis of Keap1 interactions with Nrf2. Free Radic Biol Med (2015) 0.88
Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents. Acta Pharm Sin B (2015) 0.86
Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle. Gastroenterology (2011) 0.86
Atypical protein phosphatases: emerging players in cellular signaling. Int J Mol Sci (2013) 0.86
Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response. PLoS One (2011) 0.85
Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder. J Acquir Immune Defic Syndr (2014) 0.85
Protein-structure-guided discovery of functional mutations across 19 cancer types. Nat Genet (2016) 0.84
TLR signaling prevents hyperoxia-induced lung injury by protecting the alveolar epithelium from oxidant-mediated death. J Immunol (2012) 0.83
Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. J Biol Chem (2012) 0.82
New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases. Biochem Soc Trans (2014) 0.82
Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention. Free Radic Biol Med (2007) 0.82
Determinants, discriminants, conserved residues--a heuristic approach to detection of functional divergence in protein families. PLoS One (2011) 0.82
CUL3 and protein kinases: insights from PLK1/KLHL22 interaction. Cell Cycle (2013) 0.81
Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.80
The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic test. Acta Neuropathol Commun (2014) 0.80
Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study. Protein Sci (2016) 0.80
Mechanism of cullin3 E3 ubiquitin ligase dimerization. PLoS One (2012) 0.79
Induction of heme oxygenase I (HMOX1) by HPP-4382: a novel modulator of Bach1 activity. PLoS One (2014) 0.78
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway. Bioorg Med Chem Lett (2015) 0.78
Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. Eur J Med Chem (2015) 0.78
Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction. Protein Sci (2013) 0.78
Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase. Genetics (2015) 0.76
Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation. FEBS Open Bio (2015) 0.76
Binding of disordered proteins to a protein hub. Sci Rep (2013) 0.76
Growth, digestive and absorptive capacity and antioxidant status in intestine and hepatopancreas of sub-adult grass carp Ctenopharyngodonidella fed graded levels of dietary threonine. J Anim Sci Biotechnol (2015) 0.75
RNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical Stress. PLoS One (2016) 0.75
Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Mol Cancer (2016) 0.75
Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses. J Mol Biol (2016) 0.75
Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display. Protein Eng Des Sel (2015) 0.75
Co- and Post-Treatment with Lysine Protects Primary Fish Enterocytes against Cu-Induced Oxidative Damage. PLoS One (2016) 0.75
Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection. Nat Commun (2016) 0.75
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants. Arch Biochem Biophys (2016) 0.75
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination. Cell Rep (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Oxidants, oxidative stress and the biology of ageing. Nature (2000) 23.21
Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallogr D Biol Crystallogr (2001) 21.01
SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model. Acta Crystallogr D Biol Crystallogr (1999) 19.57
The finer things in X-ray diffraction data collection. Acta Crystallogr D Biol Crystallogr (1999) 19.10
Efficient anisotropic refinement of macromolecular structures using FFT. Acta Crystallogr D Biol Crystallogr (1999) 15.91
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev (1999) 13.43
Main-chain bond lengths and bond angles in protein structures. J Mol Biol (1993) 9.80
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol (2004) 8.94
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A (2002) 8.01
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell (1995) 7.66
Pathways of oxidative damage. Annu Rev Microbiol (2003) 7.08
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol (2004) 6.93
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol (2003) 6.91
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A (1994) 6.72
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet (2003) 6.69
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell (2006) 6.09
Positioning hydrogen atoms by optimizing hydrogen-bond networks in protein structures. Proteins (1996) 5.83
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell (2003) 5.72
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A (2004) 5.54
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol (2004) 5.47
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell (2003) 5.31
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol (2005) 4.53
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol (2006) 3.97
Sequence and structural analysis of BTB domain proteins. Genome Biol (2005) 3.88
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science (2002) 3.86
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature (2002) 3.78
Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Proc Natl Acad Sci U S A (1993) 3.39
The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. Nat Genet (2000) 3.35
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene (2002) 3.33
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol (2006) 3.27
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm. J Biol Chem (2002) 3.19
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A (2005) 2.92
The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat Res (2001) 2.52
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem (2005) 2.45
Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells (2002) 2.43
Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation. J Biol Chem (2005) 2.37
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Chem Res Toxicol (2005) 2.22
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Oncogene (2001) 2.21
Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J Biol Chem (2003) 2.20
Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life (2001) 2.05
Crystal structure of the Kelch domain of human Keap1. J Biol Chem (2004) 2.04
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells (2001) 1.95
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron. J Biol Chem (2004) 1.81
Giant axonal neuropathy (GAN): case report and two novel mutations in the gigaxonin gene. Neurology (2002) 1.77
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch Biochem Biophys (2005) 1.71
Nrf2 as a target for cancer chemoprevention. Mutat Res (2005) 1.61
Glucose and reactive oxygen species. Curr Opin Clin Nutr Metab Care (2002) 1.54
Antioxidant and cytoprotective responses to redox stress. Biochem Soc Symp (2004) 1.29
Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif. J Biol Chem (2005) 1.27
CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol (2006) 1.27
Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway. Curr Biol (2005) 1.18
Oxidative stress in cardiovascular disease: myth or fact? Arch Biochem Biophys (2003) 1.14
Strategies to reduce oxidative stress in cardiovascular disease. Clin Sci (Lond) (2004) 1.11
Identification of seven novel mutations in the GAN gene. Hum Mutat (2003) 1.07
Clinical and molecular findings in patients with giant axonal neuropathy (GAN). Neurology (2004) 1.06
Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets. J Alzheimers Dis (2004) 1.03
Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients. Aging Cell (2004) 1.00
Genetic alterations of the NRP/B gene are associated with human brain tumors. Oncogene (2004) 0.99
Therapeutic potential in Alzheimer disease. Curr Med Chem (2002) 0.81
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol (2004) 6.93
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol (2003) 6.91
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol (2003) 4.77
Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci (2006) 3.35
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem (2005) 2.45
Crystal structure of the Kelch domain of human Keap1. J Biol Chem (2004) 2.04
PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. J Biol Chem (2006) 1.78
Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. Brain (2010) 1.76
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res (2008) 1.64
Crystal structure of PMM/PGM: an enzyme in the biosynthetic pathway of P. aeruginosa virulence factors. Structure (2002) 1.49
Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Stem Cells Dev (2008) 1.35
Evolutionary trace analysis of the alpha-D-phosphohexomutase superfamily. Protein Sci (2004) 1.32
Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa. Structure (2004) 1.32
CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol (2006) 1.27
Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One (2009) 1.24
Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA. J Mol Biol (2008) 1.22
The reaction of phosphohexomutase from Pseudomonas aeruginosa: structural insights into a simple processive enzyme. J Biol Chem (2006) 1.19
Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum. Proc Natl Acad Sci U S A (2010) 1.16
Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells. Neurochem Int (2005) 1.14
Crystal structure of GDP-mannose dehydrogenase: a key enzyme of alginate biosynthesis in P. aeruginosa. Biochemistry (2003) 1.11
Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival. Cardiovasc Res (2007) 1.11
Effects of interventions on oxidative stress and inflammation of cardiovascular diseases. World J Cardiol (2011) 1.11
Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. PLoS One (2008) 1.10
Characterization of recombinant Francisella tularensis acid phosphatase A. Protein Expr Purif (2005) 1.10
Modulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3). Plant Cell (2011) 1.09
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochem J (2009) 1.09
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett (2013) 1.03
Characterization of the nuclear import and export functions of Ikappa B(epsilon). J Biol Chem (2002) 1.00
Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1. Acta Crystallogr D Biol Crystallogr (2005) 0.99
Roles of active site residues in Pseudomonas aeruginosa phosphomannomutase/phosphoglucomutase. Biochemistry (2003) 0.96
The three-dimensional structural basis of type II hyperprolinemia. J Mol Biol (2012) 0.96
Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochim Biophys Acta (2009) 0.95
Backbone flexibility, conformational change, and catalysis in a phosphohexomutase from Pseudomonas aeruginosa. Biochemistry (2008) 0.94
Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem Biol Drug Des (2011) 0.91
Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J Biomol Screen (2011) 0.91
Complexes of the enzyme phosphomannomutase/phosphoglucomutase with a slow substrate and an inhibitor. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.90
Domain motion and interdomain hot spots in a multidomain enzyme. Protein Sci (2010) 0.89
Coordinate regulation of basal and cyclic 5'-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein. Mol Endocrinol (2005) 0.89
Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy. Curr Top Med Chem (2007) 0.89
Solution NMR of a 463-residue phosphohexomutase: domain 4 mobility, substates, and phosphoryl transfer defect. Biochemistry (2012) 0.89
A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family. PLoS One (2012) 0.88
Direct identification of the site of binding on the chaperone SecB for the amino terminus of the translocon motor SecA. Protein Sci (2010) 0.88
ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol Cell Endocrinol (2007) 0.87
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Exp Cell Res (2009) 0.87
Promotion of enzyme flexibility by dephosphorylation and coupling to the catalytic mechanism of a phosphohexomutase. J Biol Chem (2014) 0.86
Gold nanoparticle-mediated detection of circulating cancer cells. Clin Lab Med (2012) 0.86
Characterization of a unique class C acid phosphatase from Clostridium perfringens. Appl Environ Microbiol (2009) 0.86
Interallelic complementation at the ubiquitous urease coding locus of soybean. Plant Physiol (2003) 0.85
Structural studies of yeast Δ(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): active site flexibility and oligomeric state. Biochemistry (2014) 0.85
Synthesis of radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the bcl-2 proto-oncogene. Bioconjug Chem (2003) 0.84
Energetics of OCP1-OCP2 complex formation. Biophys Chem (2008) 0.84
Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates. J Nucl Med (2008) 0.84
Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: preparation, characterization, and in vitro mRNA binding. Bioconjug Chem (2002) 0.84
Crystal structure of Bacillus anthracis phosphoglucosamine mutase, an enzyme in the peptidoglycan biosynthetic pathway. J Bacteriol (2011) 0.83
Breaking the covalent connection: Chain connectivity and the catalytic reaction of PMM/PGM. Protein Sci (2010) 0.83
Identification of an essential active-site residue in the α-D-phosphohexomutase enzyme superfamily. FEBS J (2013) 0.82
Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development. Adv Drug Deliv Rev (2003) 0.81
Crystal structure and immunogenicity of the class C acid phosphatase from Pasteurella multocida. Arch Biochem Biophys (2011) 0.81
Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogens. Proteins (2011) 0.81
Structure of an anti-DNA fab complexed with a non-DNA ligand provides insights into cross-reactivity and molecular mimicry. Proteins (2004) 0.81
Toward an understanding of cochlear homeostasis: the impact of location and the role of OCP1 and OCP2. Acta Otolaryngol (2003) 0.81
Crystal structure of rat alpha-parvalbumin at 1.05 Angstrom resolution. Protein Sci (2004) 0.80
Quaternary structure, conformational variability and global motions of phosphoglucosamine mutase. FEBS J (2011) 0.80
Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Acta Crystallogr D Biol Crystallogr (2004) 0.80
Conservation of functionally important global motions in an enzyme superfamily across varying quaternary structures. J Mol Biol (2012) 0.80
Crystal structure of a high-affinity variant of rat alpha-parvalbumin. Biochemistry (2004) 0.80
Impact of proline residues on parvalbumin stability. Biochemistry (2003) 0.79
Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl (2010) 0.79
CRM1-mediated nuclear export is present during porcine embryogenesis, but is not required for early cleavage. Biol Reprod (2002) 0.78
Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2. PLoS One (2012) 0.77
Crystallization and initial crystallographic analysis of phosphoglucosamine mutase from Bacillus anthracis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.77
Chemical shift assignments of domain 4 from the phosphohexomutase from Pseudomonas aeruginosa suggest that freeing perturbs its coevolved domain interface. Biomol NMR Assign (2013) 0.77
Conformational stabilities of guinea pig OCP1 and OCP2. Biophys Chem (2009) 0.77
Evidence for a Ca(2+)-specific conformational change in avian thymic hormone, a high-affinity beta-parvalbumin. Biochemistry (2009) 0.76
Structure of avian thymic hormone, a high-affinity avian beta-parvalbumin, in the Ca2+-free and Ca2+-bound states. J Mol Biol (2010) 0.75
Impact of DNA hairpin folding energetics on antibody-ssDNA association. J Mol Biol (2007) 0.75
Importance of the C-terminus of ALDH7A1 for Oligomerization and Catalytic Activity. Biochemistry (2017) 0.75
Disparate impact of the S33V mutation on conformational stability in rat β-parvalbumin (oncomodulin) and chicken parvalbumin 3. J Phys Chem B (2010) 0.75
Characterization of avian thymic hormone and chicken parvalbumin 3 target cells. Int Immunopharmacol (2013) 0.75
Structural Investigation of a Dimeric Variant of Pyruvate Kinase M2. Biochemistry (2017) 0.75
Crystal structure of the D94S/G98E variant of rat alpha-parvalbumin. An explanation for the reduced divalent ion affinity. Biochemistry (2005) 0.75