Published in N Engl J Med on August 22, 2006
Physical and Behavioral Traits of Overweight and Obese Adults | NCT00428987
The Weigh Forward, Financial Incentives for Maintenance of Weight Loss | NCT02538783
Financial Incentives for Maintenance of Weight Loss | NCT01900392
Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA (2013) 18.86
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34
Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA (2007) 7.26
Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med (2011) 6.89
Body-mass index and mortality among adults with incident type 2 diabetes. N Engl J Med (2014) 6.51
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The impact of obesity on US mortality levels: the importance of age and cohort factors in population estimates. Am J Public Health (2013) 4.37
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International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries. Circulation (2007) 3.01
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Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect (2007) 2.62
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General and abdominal obesity and risk of death among black women. N Engl J Med (2011) 2.27
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Concurrent and separate effects of body mass index and waist-to-hip ratio on 24-year mortality in the Population Study of Women in Gothenburg: evidence of age-dependency. Eur J Epidemiol (2006) 1.78
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Oxalate nephropathy complicating Roux-en-Y Gastric Bypass: an underrecognized cause of irreversible renal failure. Clin J Am Soc Nephrol (2008) 1.72
Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology (2009) 1.71
Mortality attributable to obesity among middle-aged adults in the United States. Demography (2009) 1.66
Adherence to a healthy lifestyle and all-cause mortality in CKD. Clin J Am Soc Nephrol (2013) 1.64
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Demographic and behavioral factors associated with daily sugar-sweetened soda consumption in New York City adults. J Urban Health (2008) 1.52
The association of weight with the detection of airflow obstruction and inhaled treatment among patients with a clinical diagnosis of COPD. Chest (2014) 1.51
Comparing 3 dietary pattern methods--cluster analysis, factor analysis, and index analysis--With colorectal cancer risk: The NIH-AARP Diet and Health Study. Am J Epidemiol (2009) 1.50
Asian Americans have greater prevalence of metabolic syndrome despite lower body mass index. Int J Obes (Lond) (2010) 1.50
Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia (2008) 1.47
Commentary: effect of obesity on mortality: comment on article by Banack and Kaufman. Epidemiology (2014) 1.45
The immune system as a sensor of the metabolic state. Immunity (2013) 1.45
Overweight and mortality among baby boomers--now we're getting personal. N Engl J Med (2006) 1.44
Relation between BMI and diabetes mellitus and its complications among US older adults. South Med J (2015) 1.44
The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study. BMJ (2009) 1.43
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Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes. Diabetes Care (2009) 1.41
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Body mass index and mortality: results of a cohort of 184,697 adults in Austria. Eur J Epidemiol (2009) 1.40
Dramatic reversal of derangements in muscle metabolism and left ventricular function after bariatric surgery. Am J Med (2008) 1.39
Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab (2017) 1.39
The impact on National Death Index ascertainment of limiting submissions to Social Security Administration Death Master File matches in epidemiologic studies of mortality. Am J Epidemiol (2009) 1.36
Joint associations of adiposity and physical activity with mortality: the National Institutes of Health-AARP Diet and Health Study. Am J Epidemiol (2009) 1.35
The obesity paradox in chronic disease: facts and numbers. J Cachexia Sarcopenia Muscle (2012) 1.35
Contribution of obesity to international differences in life expectancy. Am J Public Health (2011) 1.34
Estimating health-adjusted life expectancy conditional on risk factors: results for smoking and obesity. Popul Health Metr (2006) 1.34
Obesity and endometrial cancer survival: a systematic review. Int J Obes (Lond) (2012) 1.32
Role of microRNAs in diabetes and its cardiovascular complications. Cardiovasc Res (2011) 1.30
Association of body mass index with outcomes in patients with CKD. J Am Soc Nephrol (2014) 1.30
Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men. Am J Epidemiol (2010) 1.29
Obesity and mortality risk among younger dialysis patients. Clin J Am Soc Nephrol (2012) 1.29
A systematic exploration of differences in contextual factors related to implementing the MOVE! weight management program in VA: a mixed methods study. BMC Health Serv Res (2011) 1.28
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Obesity and mortality in men with locally advanced prostate cancer: analysis of RTOG 85-31. Cancer (2007) 1.28
Obesity and all-cause mortality among black adults and white adults. Am J Epidemiol (2012) 1.26
Effects of physical activity, body mass index, waist-to-hip ratio and waist circumference on total mortality risk in the Swedish National March Cohort. Eur J Epidemiol (2010) 1.26
Past body mass index and risk of mortality among women. Int J Obes (Lond) (2008) 1.25
Smoking and risk of amyotrophic lateral sclerosis: a pooled analysis of 5 prospective cohorts. Arch Neurol (2011) 1.23
Body mass index and adverse cardiovascular outcomes in heart failure patients with preserved ejection fraction: results from the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial. Circ Heart Fail (2011) 1.22
Abdominal obesity is associated with microalbuminuria and an elevated cardiovascular risk profile in patients with hypertension. Vasc Health Risk Manag (2009) 1.22
Determinants of left ventricular mass in obesity; a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson (2009) 1.22
The effect of exercise on visceral adipose tissue in overweight adults: a systematic review and meta-analysis. PLoS One (2013) 1.22
The influence of hip circumference on the relationship between abdominal obesity and mortality. Int J Epidemiol (2012) 1.21
The weight of traumatic stress: a prospective study of posttraumatic stress disorder symptoms and weight status in women. JAMA Psychiatry (2014) 1.21
Association of primary care characteristics with variations in mortality rates in England: an observational study. PLoS One (2012) 1.19
Re: "obesity and US mortality risk over the adult life course". Am J Epidemiol (2013) 1.18
Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Int J Epidemiol (2010) 1.18
The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists. Gastroenterol Hepatol (N Y) (2010) 1.17
Obesity, race, and risk for death or functional decline among Medicare beneficiaries: a cohort study. Ann Intern Med (2011) 1.17
The combined relations of adiposity and smoking on mortality. Am J Clin Nutr (2008) 1.17
Gender differences in healthy ranges for serum alanine aminotransferase levels in adolescence. PLoS One (2011) 1.17
Increased body mass index is associated with improved survival in United States veterans with diffuse large B-cell lymphoma. J Clin Oncol (2012) 1.17
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
Structure of dietary measurement error: results of the OPEN biomarker study. Am J Epidemiol (2003) 8.25
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screening mammography. Ann Intern Med (2003) 7.73
Using intake biomarkers to evaluate the extent of dietary misreporting in a large sample of adults: the OPEN study. Am J Epidemiol (2003) 7.68
The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci (2006) 7.38
Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. JAMA Intern Med (2013) 7.30
Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability. JAMA (2006) 6.93
Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study. J Am Geriatr Soc (2005) 6.54
Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci (2005) 6.42
Meat intake and mortality: a prospective study of over half a million people. Arch Intern Med (2009) 6.42
Detection of ductal carcinoma in situ in women undergoing screening mammography. J Natl Cancer Inst (2002) 6.28
Statistical methods for estimating usual intake of nutrients and foods: a review of the theory. J Am Diet Assoc (2006) 6.26
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci (2006) 6.08
Colonoscopic screening of average-risk women for colorectal neoplasia. N Engl J Med (2005) 5.88
Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med (2004) 5.67
A new statistical method for estimating the usual intake of episodically consumed foods with application to their distribution. J Am Diet Assoc (2006) 5.61
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline. JAMA (2011) 5.21
Prospective breast cancer risk prediction model for women undergoing screening mammography. J Natl Cancer Inst (2006) 5.17
Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults. Am J Clin Nutr (2008) 5.01
Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Exercise type and intensity in relation to coronary heart disease in men. JAMA (2002) 4.69
Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation (2003) 4.67
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc (2002) 4.55
Comparison of screening mammography in the United States and the United kingdom. JAMA (2003) 4.53
Performance benchmarks for screening mammography. Radiology (2006) 4.41
A comparison of a food frequency questionnaire with a 24-hour recall for use in an epidemiological cohort study: results from the biomarker-based Observing Protein and Energy Nutrition (OPEN) study. Int J Epidemiol (2003) 4.39
Menopausal hormone replacement therapy and risk of ovarian cancer. JAMA (2002) 4.39
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Daily activity energy expenditure and mortality among older adults. JAMA (2006) 4.36
Association between smoking and risk of bladder cancer among men and women. JAMA (2011) 4.31
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Hearing loss and cognitive decline in older adults. JAMA Intern Med (2013) 4.25
Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care (2003) 4.23
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med (2005) 4.11
Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc (2003) 4.02
Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci (2002) 4.00
Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst (2010) 3.98
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst (2006) 3.96
Amount of time spent in sedentary behaviors and cause-specific mortality in US adults. Am J Clin Nutr (2012) 3.95
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
Performance of a food-frequency questionnaire in the US NIH-AARP (National Institutes of Health-American Association of Retired Persons) Diet and Health Study. Public Health Nutr (2007) 3.88
Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci Transl Med (2010) 3.81
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med (2011) 3.77
Cancer risk prediction models: a workshop on development, evaluation, and application. J Natl Cancer Inst (2005) 3.75
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA (2009) 3.62
Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci (2007) 3.61
Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet (2009) 3.60
Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study. Arch Intern Med (2007) 3.58
Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J Clin Oncol (2009) 3.58
Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med (2005) 3.56
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Annual Report to the Nation on the status of cancer, 1975-2008, featuring cancers associated with excess weight and lack of sufficient physical activity. Cancer (2012) 3.55
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med (2003) 3.54
Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care (2008) 3.54
Limited literacy and mortality in the elderly: the health, aging, and body composition study. J Gen Intern Med (2006) 3.51
Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst (2007) 3.51
Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr (2009) 3.44
Methods for pooling results of epidemiologic studies: the Pooling Project of Prospective Studies of Diet and Cancer. Am J Epidemiol (2006) 3.41
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. Am J Clin Nutr (2005) 3.40
Performance benchmarks for diagnostic mammography. Radiology (2005) 3.40