Published in Nat Rev Genet on September 01, 2006
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How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
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The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev (2007) 2.57
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Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov (2013) 2.16
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell (2009) 2.15
BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol (2009) 2.04
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature (2010) 2.01
An Arabidopsis jmjC domain protein protects transcribed genes from DNA methylation at CHG sites. EMBO J (2009) 2.00
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Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol (2011) 1.81
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Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol (2008) 1.65
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Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Cell Res (2010) 1.64
Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat Prod Rep (2009) 1.63
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Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis. Proc Natl Acad Sci U S A (2008) 1.58
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs. Cell Stem Cell (2012) 1.58
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. Oncogene (2009) 1.58
Genetic and epigenetic mechanisms of gene regulation during lens development. Prog Retin Eye Res (2007) 1.56
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes. Genes Dev (2015) 1.56
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci U S A (2008) 1.55
Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J (2009) 1.54
Vitamin C: update on physiology and pharmacology. Br J Pharmacol (2009) 1.53
Oct4 targets regulatory nodes to modulate stem cell function. PLoS One (2007) 1.52
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One (2011) 1.48
Dynamic protein methylation in chromatin biology. Cell Mol Life Sci (2009) 1.48
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer. Genes Cancer (2011) 1.47
The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3. Mol Cell Biol (2008) 1.47
A role for SUMO modification in transcriptional repression and activation. Biochem Soc Trans (2007) 1.46
Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J Biol Chem (2010) 1.46
Structural insights into histone lysine demethylation. Curr Opin Struct Biol (2010) 1.44
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nat Chem Biol (2012) 1.41
Refined annotation and assembly of the Tetrahymena thermophila genome sequence through EST analysis, comparative genomic hybridization, and targeted gap closure. BMC Genomics (2008) 1.40
Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Nat Commun (2010) 1.40
The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin. EMBO J (2007) 1.40
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Mol Cell (2008) 1.38
An epigenetic perspective on the free radical theory of development. Free Radic Biol Med (2007) 1.35
Chromatin remodeling in cardiovascular development and physiology. Circ Res (2011) 1.34
DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns. EMBO J (2012) 1.33
Characterization of Drosophila melanogaster JmjC+N histone demethylases. Nucleic Acids Res (2008) 1.32
The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol (2010) 1.32
KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc Natl Acad Sci U S A (2010) 1.31
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem (2010) 1.31
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem (2011) 1.31
SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. Mol Cell Biol (2011) 1.30
Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. PLoS One (2008) 1.29
Breathing-in epigenetic change with vitamin C. EMBO Rep (2013) 1.29
Drosophila SETDB1 is required for chromosome 4 silencing. PLoS Genet (2007) 1.29
Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. J Proteome Res (2010) 1.29
Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid. J Biol Chem (2010) 1.26
KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev (2010) 1.26
Rice jmjC domain-containing gene JMJ706 encodes H3K9 demethylase required for floral organ development. Proc Natl Acad Sci U S A (2008) 1.25
PHF8 targets histone methylation and RNA polymerase II to activate transcription. Mol Cell Biol (2010) 1.25
Inactive yet indispensable: the tale of Jarid2. Trends Cell Biol (2010) 1.24
Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome. EMBO J (2010) 1.23
The establishment of gene silencing at single-cell resolution. Nat Genet (2009) 1.22
Histone lysine methyltransferases and demethylases in Plasmodium falciparum. Int J Parasitol (2008) 1.22
ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis. PLoS One (2007) 1.20
Genetic and molecular control of osterix in skeletal formation. J Cell Biochem (2013) 1.19
The JARID2-PRC2 duality. Genes Dev (2010) 1.18
Mina, an Il4 repressor, controls T helper type 2 bias. Nat Immunol (2009) 1.18
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation. EMBO J (2010) 1.17
Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin. Oncotarget (2013) 1.16
Epigenetic regulatory mechanisms in vertebrate eye development and disease. Heredity (Edinb) (2010) 1.16
JMJ14, a JmjC domain protein, is required for RNA silencing and cell-to-cell movement of an RNA silencing signal in Arabidopsis. Genes Dev (2010) 1.15
Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol (2007) 1.15
Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation. EMBO Rep (2010) 1.14
AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function. Cell Res (2010) 1.14
Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium. Metallomics (2012) 1.12
Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe. Genetics (2007) 1.12
Interactions between epigenetics and metabolism in cancers. Front Oncol (2012) 1.11
Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast. J Biol Chem (2009) 1.11
Chatting histone modifications in mammals. Brief Funct Genomics (2010) 1.10
Lysine methylation of promoter-bound transcription factors and relevance to cancer. Cell Res (2010) 1.10
Metabolic defects provide a spark for the epigenetic switch in cancer. Free Radic Biol Med (2009) 1.10
Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase. Nucleic Acids Res (2010) 1.10
The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains. PLoS Genet (2009) 1.10
Expanding role of the jumonji C domain as an RNA hydroxylase. J Biol Chem (2010) 1.10
Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol (2012) 1.10
Galaxy: a platform for interactive large-scale genome analysis. Genome Res (2005) 35.75
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet (2005) 29.45
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37
The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol (2005) 12.70
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Role of histone H3 lysine 27 methylation in X inactivation. Science (2003) 9.85
Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48
Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35
Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res (2007) 8.41
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev (2004) 7.89
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell (2004) 6.90
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Hydrogen-bonded ferroelectrics based on metal-organic coordination. J Am Chem Soc (2009) 6.69
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature (2011) 6.48
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell (2005) 6.29
Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol (2007) 6.13
A framework for collaborative analysis of ENCODE data: making large-scale analyses biologist-friendly. Genome Res (2007) 5.97
hDOT1L links histone methylation to leukemogenesis. Cell (2005) 5.83
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev (2003) 5.77
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell (2006) 5.54
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol (2002) 5.53
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature (2006) 5.51
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep (2006) 5.19
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16
Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol (2004) 5.12
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature (2003) 5.04
Supramolecular bola-like ferroelectric: 4-methoxyanilinium tetrafluoroborate-18-crown-6. J Am Chem Soc (2011) 4.73
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell (2009) 4.71
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49
Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol (2008) 4.45
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev (2011) 4.45
Dialysis facility ownership and epoetin dosing in patients receiving hemodialysis. JAMA (2007) 4.40
The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature (2005) 4.39
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Subtypes of breast cancer show preferential site of relapse. Cancer Res (2008) 4.38
Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization. Adv Mater (2011) 4.30
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30
Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19
Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science (2011) 4.12
Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol (2002) 4.12
Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res (2006) 4.11
Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood (2005) 4.10
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev (2002) 4.07
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet (2011) 4.04
Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A (2007) 3.92
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. J Neurosci (2005) 3.92
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol (2008) 3.80
The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell (2007) 3.79
Hierarchical recruitment of polycomb group silencing complexes. Mol Cell (2004) 3.73
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell (2007) 3.68
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
TET enzymes, TDG and the dynamics of DNA demethylation. Nature (2013) 3.49
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell (2006) 3.39
Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet (2004) 3.33
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev (2007) 3.31
A role for the elongator complex in zygotic paternal genome demethylation. Nature (2010) 3.27
Genes associated with breast cancer metastatic to bone. J Clin Oncol (2006) 3.21
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J Biol Chem (2002) 3.14
Osteopontin expression correlates with melanoma invasion. J Invest Dermatol (2005) 3.13
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell (2013) 3.09
Sibling recurrence and the genetic epidemiology of autism. Am J Psychiatry (2010) 3.07
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol (2006) 3.01
Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. Am J Med Genet B Neuropsychiatr Genet (2009) 2.98
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene (2002) 2.97
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell (2003) 2.97
A multiferroic perdeutero metal-organic framework. Angew Chem Int Ed Engl (2011) 2.88
Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Cell (2003) 2.86
The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J (2011) 2.74
Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet (2012) 2.70
The diverse functions of Dot1 and H3K79 methylation. Genes Dev (2011) 2.66
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood (2007) 2.65
CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity (2008) 2.49
Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer. J Clin Oncol (2006) 2.48
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res (2011) 2.36
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation (2010) 2.35
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet (2008) 2.35
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature (2009) 2.35
Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun (2013) 2.27
Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis. Oncogene (2009) 2.27
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med (2009) 2.23
Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. J Biol Chem (2003) 2.22
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature (2007) 2.21
Mechanisms of epigenetic inheritance. Curr Opin Cell Biol (2007) 2.20
A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat Protoc (2010) 2.20
Tumor-specific shared antigenic peptides recognized by human T cells. Immunol Rev (2002) 2.18
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell (2013) 2.17