CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine.

PubWeight™: 1.67‹?› | Rank: Top 3%

🔗 View Article (PMC 1994908)

Published in Gastroenterology on August 16, 2006

Authors

Andromeda M Nauli1, Fatiha Nassir, Shuqin Zheng, Qing Yang, Chun-Min Lo, Sarah B Vonlehmden, Dana Lee, Ronald J Jandacek, Nada A Abumrad, Patrick Tso

Author Affiliations

1: Department of Pathology and Laboratory Medicine, Genome Research Institute, University of Cincinnati College of Medicine, 2120 Galbraith Road, Cincinnati, OH 45237, USA.

Articles citing this

Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature (2010) 3.40

Intestinal lipid absorption. Am J Physiol Endocrinol Metab (2009) 2.41

Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet (2008) 1.98

Role of the gut in lipid homeostasis. Physiol Rev (2012) 1.73

Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab (2009) 1.70

CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem (2008) 1.41

Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. Hum Mol Genet (2010) 1.40

Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem (2011) 1.30

A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER. J Lipid Res (2010) 1.12

Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice. J Lipid Res (2008) 1.03

CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB J (2012) 0.99

Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling. J Lipid Res (2012) 0.98

Gut triglyceride production. Biochim Biophys Acta (2011) 0.97

Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption. J Lipid Res (2009) 0.94

Gut fat sensing in the negative feedback control of energy balance--recent advances. Physiol Behav (2011) 0.94

Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. PLoS One (2012) 0.93

High-fat diet enhances villus growth during the adaptation response to massive proximal small bowel resection. J Gastrointest Surg (2013) 0.91

Anaphylactic reactions to oligosaccharides in red meat: a syndrome in evolution. Clin Mol Allergy (2012) 0.89

CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice. J Lipid Res (2013) 0.89

Role of lipase-generated free fatty acids in converting mesenteric lymph from a noncytotoxic to a cytotoxic fluid. Am J Physiol Gastrointest Liver Physiol (2012) 0.88

CD36 inhibitors reduce postprandial hypertriglyceridemia and protect against diabetic dyslipidemia and atherosclerosis. PLoS One (2012) 0.87

Intestinal caveolin-1 is important for dietary fatty acid absorption. Biochim Biophys Acta (2013) 0.86

Circulating sCD36 is associated with unhealthy fat distribution and elevated circulating triglycerides in morbidly obese individuals. Nutr Diabetes (2014) 0.86

Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection. J Nutr (2010) 0.84

Is apolipoprotein A-IV rate limiting in the intestinal transport and absorption of triglyceride? Am J Physiol Gastrointest Liver Physiol (2013) 0.83

Disruption of retinoblastoma protein expression in the intestinal epithelium impairs lipid absorption. Am J Physiol Gastrointest Liver Physiol (2014) 0.83

Link between intestinal CD36 ligand binding and satiety induced by a high protein diet in mice. PLoS One (2012) 0.82

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. Cell Metab (2016) 0.82

Methods for studying rodent intestinal lipoprotein production and metabolism. Curr Protoc Mouse Biol (2012) 0.81

Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice. Mol Pharmacol (2013) 0.81

Deregulated Lipid Sensing by Intestinal CD36 in Diet-Induced Hyperinsulinemic Obese Mouse Model. PLoS One (2016) 0.80

Intestinal lipid absorption, GLP-2, and CD36: still more mysteries to moving fat. Gastroenterology (2009) 0.79

Chylomicrons produced by Caco-2 cells contained ApoB-48 with diameter of 80-200 nm. Physiol Rep (2014) 0.79

A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport. Pharm Res (2013) 0.79

Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia. Mol Endocrinol (2015) 0.78

Dietary Lipids Inform the Gut and Brain about Meal Arrival via CD36-Mediated Signal Transduction. J Nutr (2015) 0.78

Host mechanisms involved in cattle Escherichia coli O157 shedding: a fundamental understanding for reducing foodborne pathogen in food animal production. Sci Rep (2017) 0.78

CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice. Cell Mol Gastroenterol Hepatol (2017) 0.78

Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. Cell Rep (2016) 0.77

ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph. Lipids (2015) 0.77

Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice. Am J Physiol Gastrointest Liver Physiol (2015) 0.77

Milk phospholipid and plant sterol-dependent modulation of plasma lipids in healthy volunteers. Eur J Nutr (2012) 0.77

Novel functions of PXR in cardiometabolic disease. Biochim Biophys Acta (2016) 0.77

Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane. Nutr Metab (Lond) (2016) 0.76

Protein mediators of sterol transport across intestinal brush border membrane. Subcell Biochem (2010) 0.76

Differing rates of cholesterol absorption among inbred mouse strains yield differing levels of HDL-cholesterol. J Lipid Res (2013) 0.76

Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance. Mol Cell Biol (2016) 0.76

Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats. Am J Physiol Gastrointest Liver Physiol (2015) 0.75

Micellar lipid composition affects micelle interaction with class B scavenger receptor extracellular loops. J Lipid Res (2015) 0.75

Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K. J Atheroscler Thromb (2017) 0.75

Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36. J Lipid Res (2016) 0.75

Cd36 knockout mice are protected against lithogenic diet induced gallstones. J Lipid Res (2017) 0.75

Articles cited by this

A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem (1957) 173.99

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science (2004) 6.19

CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem (1993) 5.81

Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol Chem (1993) 3.51

Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis. J Biol Chem (1977) 3.19

Patterns of antigenic expression on human monocytes as defined by monoclonal antibodies. Cell Immunol (1983) 2.59

The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids. J Biol Chem (1995) 2.58

Monoclonal anti-human monocyte antibodies OKM1 and OKM5 possess distinctive tissue distributions including differential reactivity with vascular endothelium. J Immunol (1984) 2.35

CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest (2005) 2.04

A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology (2004) 2.02

Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. J Lipid Res (1998) 1.97

Expression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transport. Proc Natl Acad Sci U S A (1996) 1.57

FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell (2004) 1.51

Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. J Biol Chem (1996) 1.45

CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance. J Lipid Res (2005) 1.35

Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP). Eur J Biochem (1996) 1.35

Increased apolipoprotein A-IV in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation. Am J Physiol (1992) 1.28

Techniques for the collection of lymph from the liver, small intestine, or thoracic duct of the rat. J Lab Clin Med (1948) 1.27

Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem (2003) 1.26

Localization of the lipid receptors CD36 and CLA-1/SR-BI in the human gastrointestinal tract: towards the identification of receptors mediating the intestinal absorption of dietary lipids. J Histochem Cytochem (2001) 1.20

Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes. Am J Physiol Endocrinol Metab (2001) 1.18

Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes. J Clin Invest (1985) 1.16

PAS IV, an integral membrane protein of mammary epithelial cells, is related to platelet and endothelial cell CD36 (GP IV). Biochemistry (1990) 1.10

Intestinal lipid absorption is not affected in CD36 deficient mice. Mol Cell Biochem (2002) 1.07

Fat feeding increases size, but not number, of chylomicrons produced by small intestine. Am J Physiol (1990) 1.06

Evidence for separate pathways of chylomicron and very low-density lipoprotein assembly and transport by rat small intestine. Am J Physiol (1984) 1.05

The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36. Mol Cell Biochem (2002) 1.04

Role of scavenger receptors SR-BI and CD36 in selective sterol uptake in the small intestine. Biochemistry (2001) 1.02

A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors. Blood (1986) 1.01

Evidence that Lp[a] contains one molecule of apo[a] and one molecule of apoB: evaluation of amino acid analysis data. J Lipid Res (1996) 1.01

Portal transport of absorbed lipids in rats. Am J Physiol (1991) 0.96

Enterocyte fatty acid uptake and intestinal fatty acid-binding protein. Biochem Soc Trans (2004) 0.88

Intestinal alkaline phosphatase release is not associated with chylomicron formation. Am J Physiol Gastrointest Liver Physiol (2002) 0.87

Articles by these authors

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A (2009) 5.64

Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array. BMC Genomics (2006) 5.59

Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2003) 4.07

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature (2012) 3.35

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem (2006) 3.35

A controlled high-fat diet induces an obese syndrome in rats. J Nutr (2003) 2.80

Preperitoneal single-port transvesical enucleation of the prostate (STEP) for large-volume BPH: one-year follow-up of Qmax, IPSS, and QoL. Urology (2012) 2.78

China's facility-based birth strategy and neonatal mortality: a population-based epidemiological study. Lancet (2011) 2.64

GOAT links dietary lipids with the endocrine control of energy balance. Nat Med (2009) 2.42

Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet (2011) 2.32

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest (2002) 2.30

Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood (2002) 2.28

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci U S A (2010) 2.27

Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab (2004) 2.21

Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions. Methods Cell Biol (2002) 2.20

Iterative voting for inference of structural saliency and characterization of subcellular events. IEEE Trans Image Process (2007) 2.17

High-resolution quantitative phase-contrast microscopy by digital holography. Opt Express (2005) 2.06

CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest (2005) 2.04

A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology (2004) 2.02

CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem (2007) 2.02

Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet (2008) 1.98

Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet (2011) 1.95

DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem (2002) 1.90

Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways. J Lipid Res (2008) 1.80

Evidence against the presence of an anandamide transporter. Proc Natl Acad Sci U S A (2003) 1.76

Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab (2009) 1.70

Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry (2006) 1.67

Apolipoprotein A-IV inhibits experimental colitis. J Clin Invest (2004) 1.66

Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. Am J Clin Nutr (2010) 1.66

Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion. Gastroenterology (2011) 1.64

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes (2008) 1.61

The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects. J Lipid Res (2011) 1.60

Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 1.57

Wide dissemination of OXA-23-producing carbapenem-resistant Acinetobacter baumannii clonal complex 22 in multiple cities of China. J Antimicrob Chemother (2010) 1.56

A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Hum Mol Genet (2004) 1.56

Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. J Gastrointest Surg (2009) 1.54

Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol (2010) 1.54

Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype. J Biol Chem (2007) 1.53

Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat Med (2007) 1.51

Role of CD36 in membrane transport of long-chain fatty acids. Curr Opin Clin Nutr Metab Care (2002) 1.51

Comparison of single-surgeon series of transperitoneal laparoendoscopic single-site surgery and standard laparoscopic adrenalectomy. Urology (2012) 1.51

Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins Leukot Essent Fatty Acids (2011) 1.46

Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiol Behav (2004) 1.43

ITFP: an integrated platform of mammalian transcription factors. Bioinformatics (2008) 1.43

Fatty acid transport across membranes: relevance to nutrition and metabolic pathology. Annu Rev Nutr (2002) 1.42

Ultra-deep sequencing enables high-fidelity recovery of biodiversity for bulk arthropod samples without PCR amplification. Gigascience (2013) 1.42

CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem (2008) 1.41

Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization. J Biol Chem (2009) 1.41

CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue. Diabetes (2007) 1.41

Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. Hum Mol Genet (2010) 1.40

Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China. Antimicrob Agents Chemother (2011) 1.40

Retracted Gene-gene interaction network analysis of ovarian cancer using TCGA data. J Ovarian Res (2013) 1.40

Perioperative outcomes and cosmesis analysis of patients undergoing laparoendoscopic single-site adrenalectomy: a comparison of transumbilical, transperitoneal subcostal, and retroperitoneal subcostal approaches. Urology (2013) 1.39

GATA4 is essential for jejunal function in mice. Gastroenterology (2008) 1.39

Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice. Endocrinology (2010) 1.38

Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 1.35

Evidence of Arabidopsis salt acclimation induced by up-regulation of HY1 and the regulatory role of RbohD-derived reactive oxygen species synthesis. Plant J (2011) 1.35

Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet. J Biol Chem (2008) 1.31

Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem (2011) 1.30

Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size. Biochemistry (2004) 1.29

Binocular coordination of saccades in children with strabismus before and after surgery. Invest Ophthalmol Vis Sci (2002) 1.29

Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. Am J Physiol Regul Integr Comp Physiol (2007) 1.27

Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. J Biol Chem (2003) 1.27

Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.26

Ordered nanowire array blue/near-UV light emitting diodes. Adv Mater (2010) 1.25

Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. Diabetes (2006) 1.25

Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Diabetes (2005) 1.24

Epigenetic regulation, somatic homologous recombination, and abscisic acid signaling are influenced by DNA polymerase epsilon mutation in Arabidopsis. Plant Cell (2009) 1.23

Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol (2005) 1.23

Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J Affect Disord (2010) 1.23

Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats. J Physiol (2008) 1.22

Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. J Biol Chem (2008) 1.22

Assessment of feeding behavior in laboratory mice. Cell Metab (2010) 1.22

Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake. J Biol Chem (2010) 1.22

MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. Neuroimage (2007) 1.20

Dissemination of imipenem-resistant Acinetobacter baumannii strains carrying the ISAba1 blaOXA-23 genes in a Chinese hospital. J Med Microbiol (2007) 1.20

Carbon monoxide enhances salt tolerance by nitric oxide-mediated maintenance of ion homeostasis and up-regulation of antioxidant defence in wheat seedling roots. Plant Cell Environ (2008) 1.20

MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model. J Magn Reson Imaging (2008) 1.20

GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol (2005) 1.18

Why does the gut choose apolipoprotein B48 but not B100 for chylomicron formation? Am J Physiol Gastrointest Liver Physiol (2007) 1.18

Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res (2008) 1.17

Clonal spread of imipenem-resistant Acinetobacter baumannii among different cities of China. J Clin Microbiol (2007) 1.17

FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms. J Biol Chem (2005) 1.17

A non-human primate model for gluten sensitivity. PLoS One (2008) 1.17

CD36 protein is involved in store-operated calcium flux, phospholipase A2 activation, and production of prostaglandin E2. J Biol Chem (2011) 1.17