Published in Mol Cancer on October 18, 2006
Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood (2007) 2.65
The stem cell factor antibody enhances the chemotherapeutic effect of adriamycin on chemoresistant breast cancer cells. Cancer Cell Int (2012) 1.44
Bone-induced c-kit expression in prostate cancer: a driver of intraosseous tumor growth. Int J Cancer (2014) 1.39
Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis. BMC Cancer (2008) 1.18
G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells. J Am Chem Soc (2011) 1.05
Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One (2010) 1.05
Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine. BMC Cancer (2012) 0.91
Mast cell exosomes promote lung adenocarcinoma cell proliferation - role of KIT-stem cell factor signaling. Cell Commun Signal (2014) 0.88
Synergistic effect of SCF and G-CSF on stem-like properties in prostate cancer cell lines. Tumour Biol (2012) 0.88
Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. J Transl Med (2008) 0.86
High expression of c-kit mRNA predicts unfavorable outcome in adult patients with t(8;21) acute myeloid leukemia. PLoS One (2015) 0.83
A Multi-institutional Phase 2 Study of Imatinib Mesylate and Gemcitabine for First-Line Treatment of Advanced Pancreatic Cancer. Gastrointest Cancer Res (2012) 0.82
Involvement of c-KIT mutation in the development of gastrointestinal stromal tumors through proliferation promotion and apoptosis inhibition. Onco Targets Ther (2014) 0.81
Molecular analysis of precursor lesions in familial pancreatic cancer. PLoS One (2013) 0.81
Pancreatic extra-gastrointestinal stromal tumour masquerading as a bleeding duodenal mass. BMJ Case Rep (2012) 0.78
Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer. Oncotarget (2016) 0.78
A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm). Am J Cancer Res (2016) 0.77
Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. PLoS One (2010) 0.77
Development of individualized anti-metastasis strategies by engineering nanomedicines. Chem Soc Rev (2015) 0.77
Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach. Biomed Res Int (2015) 0.77
Activation of PDGFr-β Signaling Pathway after Imatinib and Radioimmunotherapy Treatment in Experimental Pancreatic Cancer. Cancers (Basel) (2011) 0.76
Diagnostic Value of Serum Angiogenesis Markers in Ovarian Cancer Using Multiplex Immunoassay. Int J Mol Sci (2017) 0.75
Clinical and Prognostic Significances of Cytokeratin 19 and KIT Expression in Surgically Resectable Pancreatic Neuroendocrine Tumors. J Pathol Transl Med (2015) 0.75
The Chinese medicine JC-001 enhances the chemosensitivity of Lewis lung tumors to cisplatin by modulating the immune response. BMC Complement Altern Med (2017) 0.75
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science (1998) 21.13
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med (1996) 13.49
W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature (1995) 8.08
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J (1987) 7.32
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell (1988) 7.10
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther (2000) 5.09
Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell (1990) 5.06
The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell (1990) 4.91
Tyrosine kinase inhibition: an approach to drug development. Science (1995) 4.82
Identification of a ligand for the c-kit proto-oncogene. Cell (1990) 4.04
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest (1993) 3.57
A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin Cancer Res (2001) 3.55
The biology of stem cell factor and its receptor C-kit. Int J Biochem Cell Biol (1999) 2.57
Decreased production of mast cells in S1/S1d anemic mice. Blood (1979) 2.53
Steel locus defines new multipotent growth factor. Cell (1990) 2.31
Prognostic significance of c-kit mutation in localized gastrointestinal stromal tumors. Clin Cancer Res (2004) 2.27
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. EMBO J (1990) 1.94
Signal transduction from cell surface to nucleus in development and disease. FASEB J (1992) 1.75
Gastrointestinal stromal tumor workshop. Hum Pathol (2001) 1.70
Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J (1991) 1.63
Inhibition of cell survival and invasive potential of colorectal carcinoma cells by the tyrosine kinase inhibitor STI571. Cancer Biol Ther (2004) 1.55
Analysis of c-kit protein expression in small-cell lung carcinoma and its implication for prognosis. Hum Pathol (2002) 1.52
Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer. Oncogene (1991) 1.45
Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor. Cancer Res (1996) 1.30
Soluble stem cell factor in human serum. Blood (1993) 1.21
Prognostic significance of the expression of vascular endothelial growth factor (VEGF) and VEGF-C in gastric carcinoma. J Surg Oncol (2001) 1.18
Epidermal growth factor receptor inhibitors in development for the treatment of non-small cell lung cancer. Clin Cancer Res (2006) 1.13
Transformation of thyroid epithelium is associated with loss of c-kit receptor. Cancer Res (1995) 1.13
c-kit point mutation of extracellular domain in patients with myeloproliferative disorders. Br J Haematol (1995) 1.10
Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-beta 1. J Cell Physiol (1997) 1.08
Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group. Blood (1994) 1.08
Breast cancer is associated with loss of the c-kit oncogene product. Int J Cancer (1992) 1.05
Growth factors and their action in vivo and in vitro. J Pathol (1983) 1.03
The stem cell factor-c-kit system and mast cells in human pancreatic cancer. Lab Invest (2002) 1.03
Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis. Clin Cancer Res (2004) 1.01
Effects of STI571 (gleevec) on pancreatic cancer cell growth. Mol Cancer (2003) 0.98
Front-line therapy of advanced pancreatic cancer. Semin Oncol (2005) 0.96
Elevated SCF levels in the serum of patients with chronic renal failure. Br J Haematol (1998) 0.93
Plasma levels and production of soluble stem cell factor by marrow stromal cells in patients with aplastic anaemia. Br J Haematol (1997) 0.90
Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogene. Cancer Res (1993) 0.89
STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line, GIST-T1. World J Gastroenterol (2006) 0.86
Gastrointestinal stromal tumors and the evolution of targeted therapy. Clin Adv Hematol Oncol (2005) 0.82
Expression of the c-kit gene product in normal and neoplastic mast cells but not in neoplastic basophil/mast cell precursors from chronic myelogenous leukaemia. J Pathol (1995) 0.82
HER-2/neu and CD117 (C-kit) overexpression in hepatocellular and pancreatic carcinoma. Anticancer Res (2003) 0.81
Immunohistochemical expression of receptor-tyrosine kinase c-kit protein and TGF-beta1 in invasive ductal carcinoma of the pancreas. Anticancer Res (2005) 0.81
Immunohistochemical expression of receptor-tyrosine kinase c-kit protein in invasive ductal carcinoma of the pancreas. Anticancer Drugs (2003) 0.78
Sequence-specific error profile of Illumina sequencers. Nucleic Acids Res (2011) 6.88
MassBank: a public repository for sharing mass spectral data for life sciences. J Mass Spectrom (2010) 6.16
Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int (2010) 3.13
Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes (2003) 2.96
Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol (2011) 2.12
Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am J Respir Crit Care Med (2006) 1.98
Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A. J Immunol (2003) 1.91
A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease. Mod Rheumatol (2006) 1.91
Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis. Gastrointest Endosc (2011) 1.83
KNApSAcK family databases: integrated metabolite-plant species databases for multifaceted plant research. Plant Cell Physiol (2011) 1.82
Clinical and pathological characteristics of Mikulicz's disease (IgG4-related plasmacytic exocrinopathy). Autoimmun Rev (2004) 1.80
CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer (2009) 1.79
The prickle-related gene in vertebrates is essential for gastrulation cell movements. Curr Biol (2003) 1.76
Cinnamoyl-CoA reductase, a key enzyme in lignin biosynthesis, is an effector of small GTPase Rac in defense signaling in rice. Proc Natl Acad Sci U S A (2005) 1.75
Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation (2003) 1.62
Risk of malignancies in IgG4-related disease. Mod Rheumatol (2011) 1.61
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther (2010) 1.58
SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity. Lab Invest (2011) 1.52
Serum levels of pigmentation markers are elevated in patients undergoing hemodialysis. Blood Purif (2007) 1.46
Need for preoperative computed tomography-guided localization in video-assisted thoracoscopic surgery pulmonary resections of metastatic pulmonary nodules. Ann Thorac Surg (2010) 1.46
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res (2008) 1.45
Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling. Stem Cells Dev (2010) 1.44
Tophaceous gout in the cervical spine. Intern Med (2012) 1.40
Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. Int J Rheumatol (2012) 1.39
Current aspects of the pathophysiology of acute pancreatitis and therapeutic effects of an inflammatory cell infiltration inhibitor. J Gastroenterol (2003) 1.39
Activation of a Rac GTPase by the NLR family disease resistance protein Pit plays a critical role in rice innate immunity. Cell Host Microbe (2010) 1.38
A web-based interactive developmental table for the ascidian Ciona intestinalis, including 3D real-image embryo reconstructions: I. From fertilized egg to hatching larva. Dev Dyn (2007) 1.38
A combination of plaque components analyzed by integrated backscatter intravascular ultrasound and serum pregnancy-associated plasma protein a levels predict the no-reflow phenomenon during percutaneous coronary intervention. Catheter Cardiovasc Interv (2014) 1.38
Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury. J Atheroscler Thromb (2014) 1.38
Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. J Immunol (2006) 1.35
The clinical course of patients with IgG4-related kidney disease. Kidney Int (2013) 1.35
Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival. BMC Gastroenterol (2008) 1.34
High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure. J Card Fail (2007) 1.33
Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A. J Biol Chem (2004) 1.33
Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases. Mod Rheumatol (2011) 1.33
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet (2012) 1.32
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation. Nucleic Acids Res (2010) 1.30
Reactive lymphoid hyperplasia of the liver in a patient with colon cancer: report of two cases. BMC Gastroenterol (2006) 1.23
PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Biochem Biophys Res Commun (2003) 1.22
A novel concept of Mikulicz's disease as IgG4-related disease. Auris Nasus Larynx (2011) 1.21
Surfactant protein A inhibits peptidoglycan-induced tumor necrosis factor-alpha secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2. J Biol Chem (2001) 1.21
Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor. J Immunol (2004) 1.21
Outcomes in patients with interrupted aortic arch and associated anomalies: a 20-year experience. Eur J Cardiothorac Surg (2006) 1.21
Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. Cancer Res (2005) 1.17
Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells. J Cell Physiol (2011) 1.16
The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Cancer Res (2005) 1.14
Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat Med (2005) 1.13
Dynamic nuclear polarization experiments at 14.1 T for solid-state NMR. Phys Chem Chem Phys (2010) 1.12
Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas (2008) 1.12
Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Mol Cancer (2005) 1.11
Laparoscopic surgery for diagnosis and treatment of bowel obstruction: case report of paracecal hernia. Med Sci Monit (2007) 1.10
PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Mol Cell Biochem (2009) 1.09
Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med (2003) 1.09
Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. Clin Endocrinol (Oxf) (2010) 1.08
Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors. J Biol Chem (2008) 1.07
Vascular endothelial growth factor C (VEGF-C) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis. J Exp Clin Cancer Res (2010) 1.07
Contemporary outcomes after endovascular treatment for aorto-iliac artery disease. Circ J (2012) 1.07
IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells. J Surg Res (2008) 1.07
Cystatin C, a novel measure of renal function, is an independent predictor of cardiac events in patients with heart failure. J Card Fail (2005) 1.06
Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers. Surgery (2005) 1.06
The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial. Respir Res (2011) 1.06
Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth. Pancreas (2008) 1.06
Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity. Cancer Sci (2008) 1.05