Published in Nat Methods on October 22, 2006
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol (2009) 7.93
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
Target profiling of small molecules by chemical proteomics. Nat Chem Biol (2009) 3.20
The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. Plant Cell (2011) 3.03
An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Mol Syst Biol (2009) 2.92
The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell (2014) 2.22
Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol (2009) 2.17
Functional proteomics to dissect tyrosine kinase signalling pathways in cancer. Nat Rev Cancer (2010) 1.97
Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Mol Syst Biol (2010) 1.91
Viral immune modulators perturb the human molecular network by common and unique strategies. Nature (2012) 1.86
A primary microcephaly protein complex forms a ring around parental centrioles. Nat Genet (2011) 1.80
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J (2008) 1.76
CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med (2010) 1.64
Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. J Biol Chem (2011) 1.63
Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin. Nucleic Acids Res (2011) 1.57
Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease. Biochim Biophys Acta (2008) 1.55
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat Struct Mol Biol (2010) 1.47
CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. J Cell Biol (2010) 1.43
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics (2010) 1.41
A MultiSite Gateway Toolkit for Rapid Cloning of Vertebrate Expression Constructs with Diverse Research Applications. PLoS One (2016) 1.41
Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A (2009) 1.37
Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65. J Virol (2007) 1.36
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes Dev (2012) 1.33
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods (2013) 1.30
Loss of centrioles causes chromosomal instability in vertebrate somatic cells. J Cell Biol (2013) 1.28
Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control. Mol Cell Biol (2008) 1.26
Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell (2014) 1.23
Protein networks markedly improve prediction of subcellular localization in multiple eukaryotic species. Nucleic Acids Res (2008) 1.22
The genetic and biochemical basis of FANCD2 monoubiquitination. Mol Cell (2014) 1.22
Inhibition of the ubiquitin-proteasome system prevents vaccinia virus DNA replication and expression of intermediate and late genes. J Virol (2009) 1.22
PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root. Plant Physiol (2012) 1.20
Pentatricopeptide repeat domain protein 1 lowers the levels of mitochondrial leucine tRNAs in cells. Nucleic Acids Res (2009) 1.19
TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner. J Neurosci (2011) 1.17
Auxin-dependent cell cycle reactivation through transcriptional regulation of Arabidopsis E2Fa by lateral organ boundary proteins. Plant Cell (2011) 1.17
Functional dissection of the TBK1 molecular network. PLoS One (2011) 1.16
Tandem affinity purification of functional TAP-tagged proteins from human cells. Nat Protoc (2007) 1.15
Profiling of protein interaction networks of protein complexes using affinity purification and quantitative mass spectrometry. Mol Cell Proteomics (2010) 1.13
POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A (2011) 1.12
Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO J (2013) 1.12
Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (2013) 1.11
Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells. Nucleic Acids Res (2007) 1.10
The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid insensitive1 in Arabidopsis. Plant Cell (2013) 1.08
Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage. J Proteome Res (2010) 1.08
Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2. Mol Cell Biol (2012) 1.05
Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells. Proc Natl Acad Sci U S A (2013) 1.05
New perspective for phage display as an efficient and versatile technology of functional proteomics. Appl Microbiol Biotechnol (2009) 1.04
ANGUSTIFOLIA3 binds to SWI/SNF chromatin remodeling complexes to regulate transcription during Arabidopsis leaf development. Plant Cell (2014) 1.01
GABAB receptor constituents revealed by tandem affinity purification from transgenic mice. J Biol Chem (2010) 1.01
Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives. Biotechniques (2015) 1.00
REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase. J Exp Med (2011) 0.99
A protein phosphatase 2A complex spatially controls plant cell division. Nat Commun (2013) 0.98
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Oncogene (2010) 0.98
Proteomics-based methods for discovery, quantification, and validation of protein-protein interactions. Anal Chem (2012) 0.98
Site-selective protein-modification chemistry for basic biology and drug development. Nat Chem (2015) 0.96
DNA ends alter the molecular composition and localization of Ku multicomponent complexes. Mol Cell Proteomics (2012) 0.96
Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor. J Biol Chem (2013) 0.96
A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry. Nat Protoc (2012) 0.95
A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer. Nat Commun (2016) 0.95
Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells. Mol Cell Proteomics (2009) 0.95
Hepatic lipase maturation: a partial proteome of interacting factors. J Lipid Res (2009) 0.95
bHLH003, bHLH013 and bHLH017 are new targets of JAZ repressors negatively regulating JA responses. PLoS One (2014) 0.94
Protein-protein and protein-membrane associations in the lignin pathway. Plant Cell (2012) 0.94
Proteome-wide identification of novel binding partners to the oncogenic fusion gene protein, NPM-ALK, using tandem affinity purification and mass spectrometry. Am J Pathol (2009) 0.94
Identification and characterization of equine herpesvirus type 1 pUL56 and its role in virus-induced downregulation of major histocompatibility complex class I. J Virol (2012) 0.93
Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). J Biol Chem (2012) 0.90
A highly efficient multifunctional tandem affinity purification approach applicable to diverse organisms. Mol Cell Proteomics (2012) 0.89
Investigation of stable and transient protein-protein interactions: Past, present, and future. Proteomics (2013) 0.88
Plant protein-protein interaction network and interactome. Curr Genomics (2010) 0.88
Identification of protein interacting partners using tandem affinity purification. J Vis Exp (2012) 0.88
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G. J Biol Chem (2014) 0.88
Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus. PLoS One (2012) 0.87
SnAvi--a new tandem tag for high-affinity protein-complex purification. Nucleic Acids Res (2010) 0.87
Estrogen receptor alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity. Mol Cell Proteomics (2012) 0.87
The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor. PLoS One (2014) 0.86
Bimolecular affinity purification (BAP): tandem affinity purification using two protein baits. Cold Spring Harb Protoc (2009) 0.85
Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions. Mol Cell Proteomics (2009) 0.85
NF90 in posttranscriptional gene regulation and microRNA biogenesis. Int J Mol Sci (2013) 0.85
hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. Nucleic Acids Res (2014) 0.84
Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase. Protein Sci (2011) 0.84
Getting a grip on complexes. Curr Genomics (2009) 0.84
Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells. Mol Biol Cell (2013) 0.83
Biotin tagging coupled with amino acid-coded mass tagging for efficient and precise screening of interaction proteome in mammalian cells. Proteomics (2009) 0.83
Protein-protein-interaction network organization of the hypusine modification system. Mol Cell Proteomics (2012) 0.82
Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex. J Proteome Res (2009) 0.81
The structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits. Acta Crystallogr D Biol Crystallogr (2013) 0.81
Identification of testis 14-3-3 binding proteins by tandem affinity purification. Spermatogenesis (2011) 0.81
PP2A-3 interacts with ACR4 and regulates formative cell division in the Arabidopsis root. Proc Natl Acad Sci U S A (2016) 0.80
Absolute quantitation of isoforms of post-translationally modified proteins in transgenic organism. Mol Cell Proteomics (2012) 0.80
Disrupting the Acyl Carrier Protein/SpoT interaction in vivo: identification of ACP residues involved in the interaction and consequence on growth. PLoS One (2012) 0.80
The proteomics big challenge for biomarkers and new drug-targets discovery. Int J Mol Sci (2012) 0.79
Interaction network of proteins associated with human cytomegalovirus IE2-p86 protein during infection: a proteomic analysis. PLoS One (2013) 0.79
Transient dsDNA breaks during pre-replication complex assembly. Nucleic Acids Res (2009) 0.79
Genome-wide search reveals the existence of a limited number of thyroid hormone receptor alpha target genes in cerebellar neurons. PLoS One (2012) 0.79
Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes. J Integr OMICS (2012) 0.79
Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. J Biol Chem (2013) 0.79
Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila. PLoS Genet (2014) 0.79
Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons. Cell Death Differ (2010) 0.79
Identifying protein-protein interaction in Drosophila adult heads by Tandem Affinity Purification (TAP). J Vis Exp (2013) 0.79
Analysis of the retina in the zebrafish model. Methods Cell Biol (2010) 0.78
Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature (2002) 45.19
Proteome survey reveals modularity of the yeast cell machinery. Nature (2006) 20.77
Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med (2013) 9.65
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol (2009) 7.93
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol (2004) 7.23
ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res (2003) 6.86
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Peroxisomes are signaling platforms for antiviral innate immunity. Cell (2010) 5.24
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol (2011) 4.18
Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. Blood (2007) 3.59
A myristoyl/phosphotyrosine switch regulates c-Abl. Cell (2003) 3.48
Target profiling of small molecules by chemical proteomics. Nat Chem Biol (2009) 3.20
RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell (2008) 3.15
Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat Rev Mol Cell Biol (2004) 3.10
Structure-based assembly of protein complexes in yeast. Science (2004) 2.89
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature (2011) 2.64
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol (2010) 2.53
The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A (2007) 2.51
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Rediscovering the sweet spot in drug discovery. Drug Discov Today (2003) 2.45
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol (2009) 2.39
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell (2004) 2.13
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell (2011) 2.11
Mass spectrometry-based functional proteomics: from molecular machines to protein networks. Nat Methods (2007) 2.06
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol (2002) 1.98
Autoinhibition of c-Abl. Cell (2002) 1.93
Viral immune modulators perturb the human molecular network by common and unique strategies. Nature (2012) 1.86
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol (2012) 1.77
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J (2008) 1.76
Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J (2006) 1.64
CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med (2010) 1.64
Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib. Leuk Lymphoma (2008) 1.63
SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations. Hum Mutat (2012) 1.61
Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature (2013) 1.58
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat Struct Mol Biol (2010) 1.47
Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia? Biochem Pharmacol (2007) 1.44
c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. EMBO J (2002) 1.41
Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers. Fertil Steril (2013) 1.41
Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A (2009) 1.37
Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics (2006) 1.32
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods (2013) 1.30
Protein complexes and proteome organization from yeast to man. Curr Opin Chem Biol (2003) 1.30
Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl. Mol Cell (2005) 1.21
Caspase-dependent cleavage of c-Abl contributes to apoptosis. Mol Cell Biol (2003) 1.20
BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib. Blood (2010) 1.19
General statistical modeling of data from protein relative expression isobaric tags. J Proteome Res (2011) 1.18
Initial characterization of the human central proteome. BMC Syst Biol (2011) 1.18
A complex prediction: three-dimensional model of the yeast exosome. EMBO Rep (2002) 1.18
Proteomic analysis of human cataract aqueous humour: Comparison of one-dimensional gel LCMS with two-dimensional LCMS of unlabelled and iTRAQ®-labelled specimens. J Proteomics (2010) 1.18
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2). BMC Struct Biol (2009) 1.18
A reversible gene trap collection empowers haploid genetics in human cells. Nat Methods (2013) 1.17
Functional dissection of the TBK1 molecular network. PLoS One (2011) 1.16
Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. Mol Cell Proteomics (2003) 1.08
FAM111A mutations result in hypoparathyroidism and impaired skeletal development. Am J Hum Genet (2013) 1.06
The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood (2008) 1.05
Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis. Dev Cell (2012) 1.04
The TLR-independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature. Eur J Immunol (2009) 1.04
Acid elution and one-dimensional shotgun analysis on an Orbitrap mass spectrometer: an application to drug affinity chromatography. J Proteome Res (2009) 1.03
Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. Arthritis Rheum (2010) 1.03
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum Mol Genet (2014) 1.03