Published in Oncogene on October 30, 2006
NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell (2009) 4.73
Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33
The role of inflammation in epilepsy. Nat Rev Neurol (2010) 3.89
Structural basis for recognition of diubiquitins by NEMO. Mol Cell (2009) 2.73
Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer (2011) 2.41
Oxidative stress and antioxidant defense. World Allergy Organ J (2012) 2.35
Bone marrow microenvironment and the identification of new targets for myeloma therapy. Leukemia (2008) 2.29
Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity. J Allergy Clin Immunol (2008) 1.93
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 1.85
PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis. Cell Death Differ (2009) 1.81
Aging mice show a decreasing correlation of gene expression within genetic modules. PLoS Genet (2009) 1.78
Mechanism of hypoxia-induced NF-kappaB. Mol Cell Biol (2010) 1.74
Modulation of NF-κB signalling by microbial pathogens. Nat Rev Microbiol (2011) 1.64
PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol Cell (2009) 1.53
Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem Pharmacol (2010) 1.52
Angiotensin II upregulates endothelial lipase expression via the NF-kappa B and MAPK signaling pathways. PLoS One (2014) 1.49
Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. Oncogene (2009) 1.48
Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity. Cell (2016) 1.44
Co-culture of Retinal and Endothelial Cells Results in the Modulation of Genes Critical to Retinal Neovascularization. Vasc Cell (2011) 1.44
Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex. J Mol Biol (2008) 1.44
The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res (2008) 1.43
Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells. J Biol Chem (2008) 1.42
Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism. PLoS One (2016) 1.40
Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits. Genome Biol (2011) 1.40
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. Eur Heart J (2010) 1.40
Cell fate regulated by nuclear factor-κB- and activator protein-1-dependent signalling in human melanocytes exposed to ultraviolet A and ultraviolet B. Br J Dermatol (2014) 1.39
Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation. Am J Hum Genet (2009) 1.38
Signal Integration by the IκB Protein Pickle Shapes Drosophila Innate Host Defense. Cell Host Microbe (2016) 1.37
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A (2011) 1.36
PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers. Proc Natl Acad Sci U S A (2011) 1.30
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. Science (2011) 1.30
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70. Anesthesiology (2008) 1.29
Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. J Hepatol (2012) 1.28
The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. FASEB J (2008) 1.28
NF-κB in Aging and Disease. Aging Dis (2011) 1.28
Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. PLoS One (2011) 1.27
NF-κB regulation: lessons from structures. Immunol Rev (2012) 1.26
NF-kappaB and STAT3 signaling in glioma: targets for future therapies. Expert Rev Neurother (2010) 1.25
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis. Mol Cell Biol (2011) 1.25
IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. PLoS One (2010) 1.22
Interactive transcriptome analysis of malaria patients and infecting Plasmodium falciparum. Genome Res (2014) 1.20
Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages. J Biol Chem (2010) 1.19
Sequence- and species-dependence of proteasomal processivity. ACS Chem Biol (2012) 1.18
PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB. Proc Natl Acad Sci U S A (2013) 1.17
Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3. PLoS One (2011) 1.17
Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16
IKK-dependent, NF-κB-independent control of autophagic gene expression. Oncogene (2010) 1.16
IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo. J Exp Med (2010) 1.15
Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice. J Invest Dermatol (2010) 1.14
Platelets and megakaryocytes contain functional nuclear factor-kappaB. Arterioscler Thromb Vasc Biol (2009) 1.13
Two alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activities. PLoS One (2009) 1.12
MALT1 protease: a new therapeutic target in B lymphoma and beyond? Clin Cancer Res (2011) 1.12
Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells. Mol Syst Biol (2015) 1.11
Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola. Org Lett (2010) 1.10
BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells. Blood (2009) 1.10
May oxidative stress contribute to autoimmune hepatitis pathogenesis, and can antioxidants be of value as adjuvant therapy for refractory patients? Dig Dis Sci (2013) 1.09
An integrative clustering and modeling algorithm for dynamical gene expression data. Bioinformatics (2011) 1.08
Structural studies of NF-κB signaling. Cell Res (2010) 1.07
A dynamic network of transcription in LPS-treated human subjects. BMC Syst Biol (2009) 1.07
NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis. Blood (2007) 1.07
Molecular mechanisms underlying chronic inflammation-associated cancers. Cancer Lett (2013) 1.06
Warts and all: human papillomavirus in primary immunodeficiencies. J Allergy Clin Immunol (2012) 1.06
Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model. Br J Cancer (2014) 1.06
Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth. Breast Cancer Res Treat (2008) 1.06
Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype. Proc Natl Acad Sci U S A (2012) 1.05
Human astrocytes: secretome profiles of cytokines and chemokines. PLoS One (2014) 1.05
The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila. PLoS One (2008) 1.05
From MALT lymphoma to the CBM signalosome: three decades of discovery. Cell Cycle (2011) 1.05
NF-kappa B: a new player in angiostatic therapy. Angiogenesis (2008) 1.04
Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. J Biomed Sci (2012) 1.04
Protease activity of the API2-MALT1 fusion oncoprotein in MALT lymphoma development and treatment. Future Oncol (2011) 1.03
How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation. PLoS Comput Biol (2013) 1.03
Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria. PLoS One (2010) 1.02
Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway. Curr Med Chem (2013) 1.01
The c-Rel Transcription Factor in Development and Disease. Genes Cancer (2011) 1.01
Mechanisms of action of isothiocyanates in cancer chemoprevention: an update. Food Funct (2011) 1.01
Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB: insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha. J Mol Biol (2009) 1.01
Inferring activity changes of transcription factors by binding association with sorted expression profiles. BMC Bioinformatics (2007) 1.01
Diabetes and alpha lipoic Acid. Front Pharmacol (2011) 1.01
Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells. Mol Cancer Ther (2010) 1.00
Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis. Int J Mol Sci (2011) 1.00
Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression. J Biol Chem (2008) 1.00
NEMO-binding domain peptide inhibits constitutive NF-κB activity and reduces tumor burden in a canine model of relapsed, refractory diffuse large B-cell lymphoma. Clin Cancer Res (2011) 1.00
NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues. J Exp Clin Cancer Res (2008) 0.99
Nuclear factor-kappaB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury. Curr Opin Nephrol Hypertens (2008) 0.99
The mechanistic basis of arsenicosis: pathogenesis of skin cancer. Cancer Lett (2014) 0.99
Nuclear trafficking in health and disease. Curr Opin Cell Biol (2014) 0.98
STAT-3 activates NF-kappaB in chronic lymphocytic leukemia cells. Mol Cancer Res (2011) 0.98
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling. Nat Cell Biol (2014) 0.98
Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. PLoS Pathog (2012) 0.98
Suppression of MAPK and NF-κB pathways by limonene contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury. Inflammation (2013) 0.97
Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB. Neuroscience (2013) 0.97
Herpes simplex virus 1 E3 ubiquitin ligase ICP0 protein inhibits tumor necrosis factor alpha-induced NF-κB activation by interacting with p65/RelA and p50/NF-κB1. J Virol (2013) 0.97
Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action. J Nutr Metab (2012) 0.97
AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts. J Biol Chem (2011) 0.97
Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-κB activation. J Virol (2014) 0.96
Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation. Biochem J (2010) 0.96
Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells. Mol Carcinog (2008) 0.96
Inhibitors of NF-kappaB signaling: 785 and counting. Oncogene (2006) 2.33