Published in J Pain on November 01, 2006
Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun (2006) 2.00
Targeting astrocyte signaling for chronic pain. Neurotherapeutics (2010) 1.88
"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev (2007) 1.62
Supraspinal glial-neuronal interactions contribute to descending pain facilitation. J Neurosci (2008) 1.61
Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. J Exp Med (2007) 1.32
Do glial cells control pain? Neuron Glia Biol (2007) 1.30
A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res (2008) 1.26
Silencing the Kir4.1 potassium channel subunit in satellite glial cells of the rat trigeminal ganglion results in pain-like behavior in the absence of nerve injury. J Neurosci (2008) 1.21
Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity. Brain (2011) 1.20
Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain (2010) 1.19
Spinal astrocyte gap junctions contribute to oxaliplatin-induced mechanical hypersensitivity. J Pain (2013) 1.16
Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain. Exp Neurol (2009) 1.01
Targeting p38 Mitogen-activated Protein Kinase to Reduce the Impact of Neonatal Microglial Priming on Incision-induced Hyperalgesia in the Adult Rat. Anesthesiology (2015) 0.94
Contribution of the chemokine (C-C motif) ligand 2 (CCL2) to mechanical hypersensitivity after surgical incision in rats. Anesthesiology (2010) 0.88
Spinal astrogliosis in pain models: cause and effects. Cell Mol Neurobiol (2009) 0.85
Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat. J Neurophysiol (2012) 0.83
Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion. Sleep (2014) 0.82
Spinal glia modulate both adaptive and pathological processes. Brain Behav Immun (2009) 0.82
Repetitive Treatment with Diluted Bee Venom Attenuates the Induction of Below-Level Neuropathic Pain Behaviors in a Rat Spinal Cord Injury Model. Toxins (Basel) (2015) 0.82
Shifts in cell-type expression accompany a diminishing role of spinal p38-mapkinase activation over time during prolonged postoperative pain. Anesthesiology (2011) 0.80
IL-4, JAK-STAT signaling, and pain. JAKSTAT (2014) 0.79
Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord. Mediators Inflamm (2014) 0.78
Glucocorticoid-Potentiated Spinal Microglia Activation Contributes to Preoperative Anxiety-Induced Postoperative Hyperalgesia. Mol Neurobiol (2016) 0.76
Regulatory effects of inhibiting the activation of glial cells on retinal synaptic plasticity. Neural Regen Res (2014) 0.76
Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain. Int J Clin Exp Pathol (2013) 0.75
Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat. J Pain (2015) 0.75
Pain-related mediators underlie incision-induced mechanical nociception in the dorsal root ganglia. Neural Regen Res (2013) 0.75
ATP-sensitive potassium channels alleviate postoperative pain through JNK-dependent MCP-1 expression in spinal cord. Int J Mol Med (2015) 0.75
Prevention and reversal of latent sensitization of dorsal horn neurons by glial blockers in a model of low back pain in male rats. J Neurophysiol (2017) 0.75
Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain (2008) 3.08
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology (2007) 1.96
Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Anesthesiology (2015) 1.52
Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study. Anesth Analg (2009) 1.50
Multifactorial preoperative predictors for postcesarean section pain and analgesic requirement. Anesthesiology (2006) 1.50
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology (2008) 1.48
Data fabrication and article retraction: how not to get lost in the woods. Anesthesiology (2009) 1.47
Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain. Anesthesiology (2004) 1.43
Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran. Anesthesiology (2004) 1.43
Patterns of cocaine self-administration in rats produced by various access conditions under a discrete trials procedure. Drug Alcohol Depend (2002) 1.42
Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial. J Anesth (2014) 1.38
Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology (2007) 1.30
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology (2007) 1.27
Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin. Anesthesiology (2013) 1.27
Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury. Anesthesiology (2006) 1.25
Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia. Anesth Analg (2003) 1.24
Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Anesthesiology (2003) 1.23
Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats. Pain (2007) 1.19
Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain (2010) 1.19
Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain. Pain (2003) 1.17
Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. Eur J Neurosci (2002) 1.16
Subtype-selective conopeptides targeted to nicotinic receptors: Concerted discovery and biomedical applications. Channels (Austin) (2008) 1.12
Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochem Pharmacol (2009) 1.11
Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice. Brain Res (2003) 1.07
Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci (2005) 1.06
Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology (2010) 1.04
Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain. Anesth Analg (2005) 1.03
Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. Brain Res (2002) 1.01
Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord. Brain Res (2005) 0.99
Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain. Anesthesiology (2003) 0.99
Age-dependent responses to nerve injury-induced mechanical allodynia. Anesthesiology (2006) 0.98
Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain. Anesthesiology (2005) 0.98
Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function. Anesth Analg (2007) 0.98
Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery. Anesthesiology (2004) 0.96
Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol (2011) 0.96
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. Anesthesiology (2007) 0.95
Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. Anesthesiology (2003) 0.95
Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neurosci Lett (2011) 0.94
Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation. Brain Res (2003) 0.94
Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats. Pain (2005) 0.94
Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain. Pain (2002) 0.93
Preventing chronic pain after surgery: who, how, and when? Reg Anesth Pain Med (2006) 0.93
Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury. Anesthesiology (2002) 0.93
Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. J Pain (2011) 0.92
Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun (2006) 0.92
Chronic estrogen sensitizes a subset of mechanosensitive afferents innervating the uterine cervix. J Neurophysiol (2005) 0.92
Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther (2003) 0.92
Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain (2002) 0.92
Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats. J Neurophysiol (2010) 0.91
Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia. Pharmacol Biochem Behav (2004) 0.90
alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats. Anesthesiology (2005) 0.90
Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res (2010) 0.90
Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation. Pain (2006) 0.90
The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor. Anesth Analg (2009) 0.89
Predicting acute pain after cesarean delivery using three simple questions. Anesthesiology (2013) 0.89
Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation. Neurosci Res (2004) 0.89
Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects. Anesth Analg (2004) 0.89
Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology (2002) 0.89
Immunocytochemical localization of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic acetylcholine receptor subunits in the locus coeruleus of the rat. Brain Res (2003) 0.88
Contribution of the chemokine (C-C motif) ligand 2 (CCL2) to mechanical hypersensitivity after surgical incision in rats. Anesthesiology (2010) 0.88
Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated? Anesth Analg (2004) 0.87
Note of editorial concern. Anesthesiology (2011) 0.87
Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury. J Neurophysiol (2005) 0.87
Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation. Exp Neurol (2003) 0.86
Intravenous butorphanol, meperidine, and their combination relieve pain and distress in women in labor. Anesthesiology (2005) 0.86
Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia. Anesthesiology (2002) 0.86
Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain Res (2010) 0.85
Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol (2011) 0.85
Epidural neostigmine: will it replace lipid soluble opioids for postoperative and labor analgesia? Anesth Analg (2009) 0.85
Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats. Pain (2005) 0.85
Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus. Anesthesiology (2015) 0.84
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology (2012) 0.84
Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord. Anesthesiology (2003) 0.84
Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain. Reg Anesth Pain Med (2005) 0.84
Peripheral nerve injury alters spinal nicotinic acetylcholine receptor pharmacology. Eur J Pharmacol (2008) 0.84
Spinal alpha3beta2* nicotinic acetylcholine receptors tonically inhibit the transmission of nociceptive mechanical stimuli. Brain Res (2008) 0.84
ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors. J Pharmacol Exp Ther (2007) 0.84
Electrical field stimulation to study inhibitory mechanisms in individual sensory neurons in culture. Anesthesiology (2004) 0.84
Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat. J Neurophysiol (2012) 0.83
Pregnancy increases excitability of mechanosensitive afferents innervating the uterine cervix. Anesthesiology (2008) 0.83
Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Anesth Analg (2006) 0.83
Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac. Anesthesiology (2003) 0.83
Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. Anesthesiology (2002) 0.83
Predictors of headache before, during, and after pregnancy: a cohort study. Headache (2012) 0.83
Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor. Anesthesiology (2005) 0.82
Developmental differences in spinal cyclooxygenase 1 expression after surgical incision. Anesthesiology (2006) 0.82
Uterine cervical afferents in thoracolumbar dorsal root ganglia express transient receptor potential vanilloid type 1 channel and calcitonin gene-related peptide, but not P2X3 receptor and somatostatin. Anesthesiology (2006) 0.82
Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain? Anesthesiology (2004) 0.82
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology (2014) 0.82
Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. Anesthesiology (2007) 0.81
Developmental differences in peripheral glabrous skin mechanosensory nerve receptive field and intracellular electrophysiologic properties: phenotypic characterization in infant and juvenile rats. Int J Dev Neurosci (2011) 0.81
Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain. Anesthesiology (2004) 0.81
Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action. Anesth Analg (2011) 0.80
Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain. J Neurochem (2005) 0.80