Published in J Neurosci Methods on November 02, 2006
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev (2008) 3.51
Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc Natl Acad Sci U S A (2008) 1.41
Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin Drug Discov (2009) 1.22
Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification. J Proteome Res (2008) 1.06
The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1. Br J Pharmacol (2009) 0.94
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties. Bioorg Med Chem Lett (2016) 0.75
Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem (2005) 3.06
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin. Nat Biotechnol (2007) 2.53
Structural characterization of a soluble amyloid beta-peptide oligomer. Biochemistry (2009) 2.31
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A (2002) 2.24
Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78. Cancer Res (2005) 1.94
The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism. J Biol Chem (2003) 1.61
Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states. Pain (2006) 1.55
Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology (2007) 1.53
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. Proc Natl Acad Sci U S A (2007) 1.45
Molecular determinants of species-specific activation or blockade of TRPA1 channels. J Neurosci (2008) 1.42
A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation. Proc Natl Acad Sci U S A (2008) 1.33
A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models. Biochem Pharmacol (2007) 1.27
Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain. Behav Brain Res (2005) 1.25
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener. J Med Chem (2006) 1.23
Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans. J Biomol Screen (2008) 1.20
Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun (2013) 1.20
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management. J Med Chem (2008) 1.10
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies. Chem Biol Drug Des (2007) 1.08
TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics. Pain (2002) 1.08
Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction. Anal Biochem (2004) 1.07
Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors. Mol Pharmacol (2006) 1.04
Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release. Neuropharmacology (2005) 1.03
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett (2010) 1.02
Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury. Brain Res (2004) 1.02
A high-throughput soft agar assay for identification of anticancer compound. J Biomol Screen (2007) 1.01
1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem (2011) 1.00
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid. J Pharmacol Exp Ther (2005) 0.99
Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket. Bioorg Med Chem Lett (2009) 0.98
Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A. J Biol Chem (2011) 0.97
Role of Rho kinase pathway in chondroitin sulfate proteoglycan-mediated inhibition of neurite outgrowth in PC12 cells. J Neurosci Res (2008) 0.96
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain (2011) 0.96
Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes. Biochem Pharmacol (2007) 0.93
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597). Mol Pharmacol (2007) 0.93
Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists. J Med Chem (2007) 0.91
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization. J Pharmacol Exp Ther (2002) 0.91
Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure. Protein Sci (2005) 0.91
Homogeneous time-resolved fluorescence quenching assay (LANCE) for caspase-3. J Biomol Screen (2002) 0.91
A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen. J Biomol Screen (2004) 0.91
Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase. J Biomol Screen (2004) 0.90
Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery. J Comput Aided Mol Des (2007) 0.87
A fluorescence polarization-based assay for peptidyl prolyl cis/trans isomerase cyclophilin A. Anal Biochem (2006) 0.87
Acidification of rat TRPV1 alters the kinetics of capsaicin responses. Mol Pain (2005) 0.86
Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage. Protein Expr Purif (2010) 0.85
Application of Micro Arrayed Compound Screening (microARCS) to identify inhibitors of caspase-3. J Biomol Screen (2002) 0.85
[3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors. J Pharmacol Exp Ther (2004) 0.85
Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain. Pain (2003) 0.85
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R). Bioorg Med Chem Lett (2008) 0.85
Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition. J Proteome Res (2008) 0.85
Functional characterization of adenosine receptors and coupling to ATP-sensitive K+ channels in Guinea pig urinary bladder smooth muscle. J Pharmacol Exp Ther (2002) 0.85
SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore. Bioorg Med Chem Lett (2012) 0.85
Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands. J Med Chem (2008) 0.84
Microarray compound screening (microARCS) to identify inhibitors of HIV integrase. J Biomol Screen (2002) 0.84
Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states. J Pain (2008) 0.83
Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure. Arch Biochem Biophys (2004) 0.83
Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury. PLoS One (2010) 0.83
Quantification of TRPV1 protein levels in rat tissues to understand its physiological roles. J Mol Neurosci (2012) 0.83
[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding. Mol Pharmacol (2003) 0.83
Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists. J Med Chem (2006) 0.82
Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists. J Biomol Screen (2006) 0.82
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity. Bioorg Med Chem (2012) 0.82
A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. J Biomol Screen (2010) 0.82
Functional characterization and high-throughput screening of positive allosteric modulators of α7 nicotinic acetylcholine receptors in IMR-32 neuroblastoma cells. Assay Drug Dev Technol (2011) 0.82
Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration. Neuropharmacology (2002) 0.82
Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett (2003) 0.82
Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry. Assay Drug Dev Technol (2003) 0.81
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists. Bioorg Med Chem (2008) 0.81
A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors. Anal Biochem (2003) 0.81
High- and low-sensitivity subforms of alpha4beta2 and alpha3beta2 nAChRs. J Mol Neurosci (2006) 0.81
Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder. Bioorg Med Chem Lett (2004) 0.81
Characterization of protein kinase A phosphorylation: multi-technique approach to phosphate mapping. Anal Biochem (2004) 0.81
Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain. Neurosci Lett (2004) 0.81
Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett (2008) 0.80
Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel. J Gen Physiol (2011) 0.80
Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms. Anal Biochem (2004) 0.80
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers. Bioorg Med Chem Lett (2012) 0.79
Nicotinic acetylcholine receptor-mediated [3H]dopamine release from hippocampus. J Pharmacol Exp Ther (2004) 0.79
Longer wavelength fluorescence resonance energy transfer depsipeptide substrates for hepatitis C virus NS3 protease. Anal Biochem (2007) 0.79
Interactions of two monoclonal antibodies with BNP: high resolution epitope mapping using fluorescence correlation spectroscopy. Biochemistry (2006) 0.79
An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics. Assay Drug Dev Technol (2012) 0.79