Published in Proc Natl Acad Sci U S A on November 07, 2006
WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics (2008) 18.58
An anatomically comprehensive atlas of the adult human brain transcriptome. Nature (2012) 7.46
Mapping complex disease traits with global gene expression. Nat Rev Genet (2009) 7.44
Functional organization of the transcriptome in human brain. Nat Neurosci (2008) 7.02
Geometric interpretation of gene coexpression network analysis. PLoS Comput Biol (2008) 4.57
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat Rev Cancer (2010) 4.10
Eigengene networks for studying the relationships between co-expression modules. BMC Syst Biol (2007) 4.06
Gene network interconnectedness and the generalized topological overlap measure. BMC Bioinformatics (2007) 3.83
A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci U S A (2007) 3.78
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Primary microcephaly: do all roads lead to Rome? Trends Genet (2009) 3.60
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell (2009) 3.37
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol (2012) 3.31
Understanding network concepts in modules. BMC Syst Biol (2007) 3.28
Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol (2012) 3.05
A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosci (2008) 2.97
Is my network module preserved and reproducible? PLoS Comput Biol (2011) 2.91
Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci U S A (2010) 2.85
Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC Syst Biol (2008) 2.51
Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J Neurosci (2012) 2.46
Celsius: a community resource for Affymetrix microarray data. Genome Biol (2007) 2.38
Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts. Neuro Oncol (2009) 2.23
Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC Genomics (2009) 2.15
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res (2010) 2.06
Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas. Neuro Oncol (2009) 2.04
Integrative genome comparison of primary and metastatic melanomas. PLoS One (2010) 1.97
Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome. BMC Syst Biol (2008) 1.93
Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med (2010) 1.84
Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia. Genome Res (2010) 1.83
Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease. Genome Biol (2009) 1.77
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc Natl Acad Sci U S A (2010) 1.76
The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol (2009) 1.74
Fast R Functions for Robust Correlations and Hierarchical Clustering. J Stat Softw (2012) 1.72
Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients. BMC Genomics (2009) 1.72
Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. Mol Cancer (2008) 1.72
Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet (2011) 1.68
Gene networks and microRNAs implicated in aggressive prostate cancer. Cancer Res (2009) 1.68
Explaining human uniqueness: genome interactions with environment, behaviour and culture. Nat Rev Genet (2008) 1.67
Incorporating predictor network in penalized regression with application to microarray data. Biometrics (2009) 1.67
Connecting genes, coexpression modules, and molecular signatures to environmental stress phenotypes in plants. BMC Syst Biol (2008) 1.64
Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcome. BMC Cancer (2013) 1.61
ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Cancer Cell Int (2010) 1.54
MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells (2013) 1.49
Comparing statistical methods for constructing large scale gene networks. PLoS One (2012) 1.49
Comparison of co-expression measures: mutual information, correlation, and model based indices. BMC Bioinformatics (2012) 1.47
Identification of rare cancer driver mutations by network reconstruction. Genome Res (2009) 1.47
A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes. PLoS One (2012) 1.45
When is hub gene selection better than standard meta-analysis? PLoS One (2013) 1.41
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer. J Pathol (2015) 1.38
Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse. BMC Genomics (2010) 1.38
Functional molecular ecological networks. MBio (2010) 1.37
The discovery of integrated gene networks for autism and related disorders. Genome Res (2014) 1.35
Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res (2013) 1.31
Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Syst Biol (2011) 1.30
Random generalized linear model: a highly accurate and interpretable ensemble predictor. BMC Bioinformatics (2013) 1.29
Human ASPM participates in spindle organisation, spindle orientation and cytokinesis. BMC Cell Biol (2010) 1.29
Epigenetic transgenerational inheritance of somatic transcriptomes and epigenetic control regions. Genome Biol (2012) 1.29
Network inference, analysis, and modeling in systems biology. Plant Cell (2007) 1.27
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers. Mol Syst Biol (2012) 1.27
Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro Oncol (2011) 1.25
The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. BMC Med Genet (2008) 1.22
Is human blood a good surrogate for brain tissue in transcriptional studies? BMC Genomics (2010) 1.22
Correlation network analysis applied to complex biofilm communities. PLoS One (2011) 1.21
Incorporating gene co-expression network in identification of cancer prognosis markers. BMC Bioinformatics (2010) 1.20
Weighted frequent gene co-expression network mining to identify genes involved in genome stability. PLoS Comput Biol (2012) 1.19
Molecular stages of rapid and uniform neuralization of human embryonic stem cells. Cell Death Differ (2009) 1.19
Molecular ecological network analyses. BMC Bioinformatics (2012) 1.19
Modeling the functional genomics of autism using human neurons. Mol Psychiatry (2011) 1.17
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun (2014) 1.16
Disease gene characterization through large-scale co-expression analysis. PLoS One (2009) 1.15
Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. Nucleic Acids Res (2013) 1.15
Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. Arthritis Rheum (2009) 1.14
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders. Nat Rev Genet (2015) 1.14
A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther (2011) 1.13
A network of cancer genes with co-occurring and anti-co-occurring mutations. PLoS One (2010) 1.13
Genes and pathways underlying regional and cell type changes in Alzheimer's disease. Genome Med (2013) 1.12
The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence. Neuro Oncol (2011) 1.10
Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer. BMC Med Genomics (2009) 1.09
Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma. Front Oncol (2015) 1.05
Gene bionetwork analysis of ovarian primordial follicle development. PLoS One (2010) 1.04
Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross. PLoS One (2010) 1.04
Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. MBio (2013) 1.04
Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseases. PLoS Comput Biol (2009) 0.99
Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis? FASEB J (2012) 0.96
Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients. Lung Cancer (2013) 0.96
MELK-a conserved kinase: functions, signaling, cancer, and controversy. Clin Transl Med (2015) 0.95
PPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption. Neuropharmacology (2014) 0.95
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling. BMC Bioinformatics (2010) 0.95
Systems-level analysis of genome-wide association data. G3 (Bethesda) (2013) 0.95
Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells. Cancer Biol Ther (2013) 0.95
Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway. J Biol Chem (2008) 0.95
arrayMap: a reference resource for genomic copy number imbalances in human malignancies. PLoS One (2012) 0.95
Analytical tools and current challenges in the modern era of neuroepigenomics. Nat Neurosci (2014) 0.94
Adult pallium transcriptomes surprise in not reflecting predicted homologies across diverse chicken and mouse pallial sectors. Proc Natl Acad Sci U S A (2013) 0.94
A systems level, functional genomics analysis of chronic epilepsy. PLoS One (2011) 0.94
Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. Nat Immunol (2015) 0.93
Predicting glioblastoma prognosis networks using weighted gene co-expression network analysis on TCGA data. BMC Bioinformatics (2012) 0.93
Systems genetic analysis of osteoblast-lineage cells. PLoS Genet (2012) 0.93
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Emergence of scaling in random networks Science (1999) 89.38
Gene expression profiling predicts clinical outcome of breast cancer. Nature (2002) 71.36
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Identification of human brain tumour initiating cells. Nature (2004) 38.87
Network biology: understanding the cell's functional organization. Nat Rev Genet (2004) 36.62
Lethality and centrality in protein networks. Nature (2001) 29.64
Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02
Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature (2005) 19.56
Singular value decomposition for genome-wide expression data processing and modeling. Proc Natl Acad Sci U S A (2000) 18.42
A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol (2005) 17.23
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med (2005) 15.42
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res (2004) 14.73
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst (2006) 14.60
Evidence for dynamically organized modularity in the yeast protein-protein interaction network. Nature (2004) 13.27
A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60
Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A (2003) 10.56
A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell (2003) 9.81
Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci U S A (2004) 9.42
A module map showing conditional activity of expression modules in cancer. Nat Genet (2004) 8.57
Targeted cancer therapy. Nature (2004) 7.81
Gene expression profiling of gliomas strongly predicts survival. Cancer Res (2004) 7.79
Systems biology and new technologies enable predictive and preventative medicine. Science (2004) 7.59
Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens. Science (2005) 5.55
ASPM is a major determinant of cerebral cortical size. Nat Genet (2002) 4.57
Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene (2003) 4.52
Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC Genomics (2006) 3.87
Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res (2003) 3.36
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc Natl Acad Sci U S A (2006) 3.03
PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J Natl Cancer Inst (2001) 2.90
Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings. Am J Hum Genet (2005) 2.86
Genomic approaches to hematologic malignancies. Blood (2004) 2.03
Protein-truncating mutations in ASPM cause variable reduction in brain size. Am J Hum Genet (2003) 1.89
The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. Hum Mol Genet (2005) 1.88
Techniques to assess the proliferative potential of brain tumors. J Neurooncol (2005) 1.81
Aurora kinases: shining lights on the therapeutic horizon? Oncogene (2005) 1.76
The EZH2 polycomb transcriptional repressor--a marker or mover of metastatic prostate cancer? Cancer Cell (2002) 1.56
Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion. PLoS Biol (2004) 1.54
Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma. Oncogene (2005) 1.50
Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin Cancer Res (2002) 1.46
Evolution of primary microcephaly genes and the enlargement of primate brains. Curr Opin Genet Dev (2005) 1.40
Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells. Mol Cancer (2005) 1.34
BRCA1 regulates gene expression for orderly mitotic progression. Cell Cycle (2005) 1.24
Microarrays and clinical investigations. N Engl J Med (2004) 1.17
Functional genomic analysis of cancer metastasis: biologic insights and clinical implications. Expert Rev Mol Diagn (2005) 1.06
DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde? Pathol Oncol Res (1999) 1.02
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase. Cell (1982) 25.10
Identification and characterization of the familial adenomatous polyposis coli gene. Cell (1991) 14.46
A human genome diversity cell line panel. Science (2002) 14.11
miR-21-mediated tumor growth. Oncogene (2006) 9.90
Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis (2000) 9.45
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
Ssn6-Tup1 is a general repressor of transcription in yeast. Cell (1992) 8.54
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem (1998) 8.46
A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science (1986) 7.73
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A (2001) 6.99
Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection. Trends Genet (1992) 6.97
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science (2001) 6.84
The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science (1988) 6.51
Mutants of yeast defective in sucrose utilization. Genetics (1981) 6.20
Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics (1984) 6.09
The earliest angiosperms: evidence from mitochondrial, plastid and nuclear genomes. Nature (1999) 5.85
Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci (1997) 5.78
Identification of deletion mutations and three new genes at the familial polyposis locus. Cell (1991) 5.42
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science (2001) 5.40
The autism genetic resource exchange: a resource for the study of autism and related neuropsychiatric conditions. Am J Hum Genet (2001) 5.23
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev (1998) 5.14
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest (2001) 4.98
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
RESOURCERER: a database for annotating and linking microarray resources within and across species. Genome Biol (2001) 4.79
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell (1998) 4.77
Use of oral corticosteroids and risk of fractures. J Bone Miner Res (2000) 4.75
Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt Lett (1997) 4.48
A three-hybrid system to detect RNA-protein interactions in vivo. Proc Natl Acad Sci U S A (1996) 4.44
Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity. Opt Lett (2000) 4.33
neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron (1998) 4.25
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med (2000) 4.18
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci U S A (1995) 4.16
DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature (2004) 4.12
Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev (1992) 4.10
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science (1998) 4.07
MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology (2006) 4.06
Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proc Natl Acad Sci U S A (1995) 4.06
The secreted form of invertase in Saccharomyces cerevisiae is synthesized from mRNA encoding a signal sequence. Mol Cell Biol (1983) 3.96
The three-dimensional structure of canine parvovirus and its functional implications. Science (1991) 3.87
Alleles of the APC gene: an attenuated form of familial polyposis. Cell (1993) 3.84
Cloning and genetic mapping of SNF1, a gene required for expression of glucose-repressible genes in Saccharomyces cerevisiae. Mol Cell Biol (1984) 3.81
A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics (1984) 3.81
The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development (1999) 3.74
Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways. Plant Cell (2001) 3.60
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5. Am J Hum Genet (1988) 3.58
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol (1989) 3.58
Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae. Mol Cell Biol (1987) 3.57
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56
Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation. Proc Natl Acad Sci U S A (1991) 3.55
Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology (2008) 3.54
The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation. Genes Dev (1993) 3.50
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron (1999) 3.49
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry (2007) 3.49
Occupational therapy for independent-living older adults. A randomized controlled trial. JAMA (1997) 3.47
Enrichment of gene-coding sequences in maize by genome filtration. Science (2003) 3.41
Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala. Science (1999) 3.40
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol (1995) 3.36
A protein kinase substrate identified by the two-hybrid system. Science (1992) 3.34
Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States). Cancer Causes Control (2002) 3.27
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem (2001) 3.27
A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (1997) 3.26
A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem (2000) 3.26
Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J Biol Chem (1994) 3.18
The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol (2001) 3.17
Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke (1996) 3.16
Whole genome amplification using a degenerate oligonucleotide primer allows hundreds of genotypes to be performed on less than one nanogram of genomic DNA. Proc Natl Acad Sci U S A (1996) 3.15
Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase. Mol Cell Biol (1989) 3.13
Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci U S A (1997) 3.07
Upstream region required for regulated expression of the glucose-repressible SUC2 gene of Saccharomyces cerevisiae. Mol Cell Biol (1984) 3.06
Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein. Mol Cell Biol (1989) 3.06
Genetically engineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose. Appl Environ Microbiol (1998) 3.05
Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol Cell Biol (1993) 3.00
The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein. Proc Natl Acad Sci U S A (1988) 2.99
Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. Genes Dev (1996) 2.97
Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev (1998) 2.97
Effect of trends on detrended fluctuation analysis. Phys Rev E Stat Nonlin Soft Matter Phys (2001) 2.95
Evidence for an important role of WRKY DNA binding proteins in the regulation of NPR1 gene expression. Plant Cell (2001) 2.90
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest (2001) 2.90
Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol (1996) 2.90
Evolution of the dispersed SUC gene family of Saccharomyces by rearrangements of chromosome telomeres. Mol Cell Biol (1985) 2.88
The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes. Mol Cell Biol (1990) 2.87
Nucleotide sequence of the yeast SUC2 gene for invertase. Nucleic Acids Res (1983) 2.86
Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. Anal Chem (2000) 2.81
An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family. Mol Cell Biol (1992) 2.78
The SNF3 gene is required for high-affinity glucose transport in Saccharomyces cerevisiae. J Bacteriol (1987) 2.77
Biomedical applications of collagen. Int J Pharm (2001) 2.76
Positional cloning of the mouse saccharin preference (Sac) locus. Chem Senses (2001) 2.75
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med (1999) 2.74
Structural basis for self-association and receptor recognition of human TRAF2. Nature (1999) 2.74