Published in Blood on November 09, 2006
The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells. J Clin Invest (2009) 1.15
The leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression. PLoS One (2011) 1.01
TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a. Blood (2010) 1.01
Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia. Leukemia (2013) 0.91
Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity. Cancers (Basel) (2011) 0.83
Role of the erythropoietin receptor in ETV6/RUNX1-positive acute lymphoblastic leukemia. Clin Cancer Res (2008) 0.83
Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein. PLoS One (2014) 0.82
ETV6/RUNX1 abrogates mitotic checkpoint function and targets its key player MAD2L1. Oncogene (2010) 0.79
A Double Negative Loop Comprising ETV6/RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21)-Positive Acute Lymphoblastic Leukemia. PLoS One (2015) 0.76
CD99 ligation upregulates HSP70 on acute lymphoblastic leukemia cells and concomitantly increases NK cytotoxicity. Cell Death Dis (2012) 0.76
The TEL-AML1 fusion protein of acute lymphoblastic leukemia modulates IRF3 activity during early B-cell differentiation. Oncogene (2015) 0.75
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27
HSP90 and the chaperoning of cancer. Nat Rev Cancer (2005) 11.98
Acute lymphoblastic leukemia. N Engl J Med (2004) 7.83
Validating survivin as a cancer therapeutic target. Nat Rev Cancer (2003) 5.73
Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer (2003) 4.58
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Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell (2003) 3.25
Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer (2002) 3.18
Heat-shock proteins as regulators of apoptosis. Oncogene (2003) 1.97
Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A (2003) 1.86
Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc Natl Acad Sci U S A (1998) 1.50
Origins of "late" relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes. Blood (2001) 1.50
Concomitant determination of absolute values of cellular protein amounts, synthesis rates, and turnover rates by quantitative proteome profiling. Mol Cell Proteomics (2002) 1.46
Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene (2002) 1.45
Late relapses evolve from slow-responding subclones in t(12;21)-positive acute lymphoblastic leukemia: evidence for the persistence of a preleukemic clone. Blood (2002) 1.32
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice. Proc Natl Acad Sci U S A (2004) 1.23
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. Oncogene (2004) 1.23
Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood (2005) 1.23
TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity. Blood (2004) 1.18
RNA interference in biology and disease. Blood (2005) 1.18
Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood (2002) 1.17
The therapeutic potential of RNA interference. FEBS Lett (2005) 1.17
Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model. Oncogene (2005) 1.10
Regulation of glucocorticoid receptor steroid binding and trafficking by the hsp90/hsp70-based chaperone machinery: implications for clinical intervention. Leukemia (2005) 0.92
RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell (2008) 3.15
Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A (2008) 2.74
A molecular function map of Ewing's sarcoma. PLoS One (2009) 1.69
The Candida albicans Cdr2p ATP-binding cassette (ABC) transporter confers resistance to caspofungin. Mol Microbiol (2003) 1.59
Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. Cancer Res (2006) 1.57
Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL. Blood (2002) 1.45
Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Mol Biol Cell (2003) 1.34
Cell death and autophagy: cytokines, drugs, and nutritional factors. Toxicology (2008) 1.31
Serum amyloid A in uremic HDL promotes inflammation. J Am Soc Nephrol (2012) 1.27
Published and perished? The influence of the searched protein database on the long-term storage of proteomics data. Mol Cell Proteomics (2011) 1.26
ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling. Blood (2011) 1.21
EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin. Oncogene (2005) 1.19
Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner. J Invest Dermatol (2002) 1.14
Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia indicates subclone formation during early stages of leukemia development. Genes Chromosomes Cancer (2004) 1.11
A novel technique to specifically analyze the secretome of cells and tissues. Electrophoresis (2005) 1.08
Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma. Clin Cancer Res (2010) 1.07
Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro. Cancer Res (2010) 1.05
Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B. J Proteome Res (2010) 1.02
MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells. PLoS One (2012) 1.01
TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a. Blood (2010) 1.01
Local complement activation triggers neutrophil recruitment to the site of thrombus formation in acute myocardial infarction. Thromb Haemost (2009) 1.00
Proteome maps of the main human peripheral blood constituents. J Proteome Res (2009) 0.97
Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview. Br J Nutr (2008) 0.96
Quantitative assessment of human serum high-abundance protein depletion. Electrophoresis (2008) 0.96
Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP-binding cassette transporter. Yeast (2003) 0.96
Extracellular matrix remodeling by bone marrow fibroblast-like cells correlates with disease progression in multiple myeloma. J Proteome Res (2013) 0.95
Caspase-9 plays a marginal role in serum starvation-induced apoptosis. Exp Cell Res (2005) 0.93
Prognostic relevance of dic(9;20)(p11;q13) in childhood B-cell precursor acute lymphoblastic leukaemia treated with Berlin-Frankfurt-Münster (BFM) protocols containing an intensive induction and post-induction consolidation therapy. Br J Haematol (2010) 0.92
Entering a new era of rational biomarker discovery for early detection of melanoma metastases: secretome analysis of associated stroma cells. J Proteome Res (2009) 0.90
Hydrogen peroxide mediates EGCG-induced antioxidant protection in human keratinocytes. Free Radic Biol Med (2010) 0.90
Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. PLoS One (2012) 0.89
Plasma from cancer patients featuring a characteristic protein composition mediates protection against apoptosis. Mol Cell Proteomics (2002) 0.88
Prognostic relevance of TLX3 (HOX11L2) expression in childhood T-cell acute lymphoblastic leukaemia treated with Berlin-Frankfurt-Münster (BFM) protocols containing early and late re-intensification elements. Br J Haematol (2009) 0.88
Automated, on-line two-dimensional nano liquid chromatography tandem mass spectrometry for rapid analysis of complex protein digests. Proteomics (2004) 0.88
Cytoplasmic proteome and secretome profiles of differently stimulated human dendritic cells. J Proteome Res (2009) 0.87
Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor. Proteomics (2005) 0.87
Glutamine deficiency renders human monocytic cells more susceptible to specific apoptosis triggers. Surgery (2002) 0.86
3,3',4,4',5,5'-hexahydroxystilbene impairs melanoma progression in a metastatic mouse model. J Invest Dermatol (2009) 0.86
Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma. J Pathol (2011) 0.86
Immune suppression by gammadelta T-cells as a potential regulatory mechanism after cancer vaccination with IL-12 secreting dendritic cells. J Immunother (2010) 0.85
Introducing the CPL/MUW proteome database: interpretation of human liver and liver cancer proteome profiles by referring to isolated primary cells. Electrophoresis (2009) 0.84
Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo. Cancer Res (2006) 0.84
Reduced stress tolerance of glutamine-deprived human monocytic cells is associated with selective down-regulation of Hsp70 by decreased mRNA stability. J Mol Med (Berl) (2005) 0.84
Acute monocytic leukaemia originating from MLL-MLLT3-positive pre-B cells. Br J Haematol (2010) 0.84
GPDE: A biological proteomic database for biomarker discovery and evaluation. Proteomics (2011) 0.83
Regulation of Tbx22 during facial and palatal development. Dev Dyn (2010) 0.83
Proteome signatures of inflammatory activated primary human peripheral blood mononuclear cells. J Proteomics (2012) 0.83
Role of the erythropoietin receptor in ETV6/RUNX1-positive acute lymphoblastic leukemia. Clin Cancer Res (2008) 0.83
Introducing a new parameter for quality control of proteome profiles: consideration of commonly expressed proteins. Electrophoresis (2009) 0.83
The first European interdisciplinary ewing sarcoma research summit. Front Oncol (2012) 0.82
Comprehensive assessment of proteins regulated by dexamethasone reveals novel effects in primary human peripheral blood mononuclear cells. J Proteome Res (2014) 0.82
Functional classification of cellular proteome profiles support the identification of drug resistance signatures in melanoma cells. J Proteome Res (2013) 0.82
A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype. Acta Neuropathol (2014) 0.82
Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD. J Clin Lab Anal (2009) 0.81
Leukemia-associated antigenic isoforms induce a specific immune response in children with T-ALL. Int J Cancer (2006) 0.81
Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode. PLoS One (2013) 0.81
Towards a standardized human proteome database: quantitative proteome profiling of living cells. Proteomics (2004) 0.81
The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells. PLoS One (2012) 0.81
Comparative platelet proteome analysis reveals an increase of monoamine oxidase-B protein expression in Alzheimer's disease but not in non-demented Parkinson's disease patients. J Proteomics (2012) 0.80
Proteome alterations induced in human white blood cells by consumption of Brussels sprouts: Results of a pilot intervention study. Proteomics Clin Appl (2008) 0.80
Screening for leukemia- and clone-specific markers at birth in children with T-cell precursor ALL suggests a predominantly postnatal origin. Blood (2007) 0.80
A proteomics study reveals a predominant change in MaoB expression in platelets of healthy volunteers after high protein meat diet: relationship to the methylation cycle. J Neural Transm (Vienna) (2011) 0.80
Pomegranate seed oil in women with menopausal symptoms: a prospective randomized, placebo-controlled, double-blinded trial. Menopause (2012) 0.80
A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. Hepatology (2002) 0.80
Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts. J Proteome Res (2014) 0.80
Determination of cell type-specific proteome signatures of primary human leukocytes, endothelial cells, keratinocytes, hepatocytes, fibroblasts and melanocytes by comparative proteome profiling. Electrophoresis (2014) 0.79
A combined proteomic and genetic analysis of the highly variable platelet proteome: from plasmatic proteins and SNPs. J Proteomics (2012) 0.79
Transcription of the caspase-14 gene in human epidermal keratinocytes requires AP-1 and NFkappaB. Biochem Biophys Res Commun (2008) 0.79
Quantification of cytokines secreted by primary human cells using multiple reaction monitoring: evaluation of analytical parameters. Anal Bioanal Chem (2015) 0.79
Knowledge-based proteome profiling: considering identified proteins to evaluate separation efficiency by 2-D PAGE. Electrophoresis (2006) 0.78
Proteomic profiling of acute coronary thrombosis reveals a local decrease in pigment epithelium-derived factor in acute myocardial infarction. Clin Sci (Lond) (2012) 0.78
Interaction of mesalasine (5-ASA) with translational initiation factors eIF4 partially explains 5-ASA anti-inflammatory and anti-neoplastic activities. Med Chem (2011) 0.78
bFGF rescues 423-cells from serum starvation-induced apoptosis downstream of activated caspase-3. FEBS Lett (2004) 0.78
Glucocorticoids in the treatment of children with acute lymphoblastic leukemia and hodgkin's disease: a pilot study on the adverse psychological reactions and possible associations with neurobiological, endocrine, and genetic markers. Clin Cancer Res (2007) 0.77
Proteomics reveals acute pro-inflammatory and protective responses in rat Kupffer cells and hepatocytes after chemical initiation of liver cancer and after LPS and IL-6. Proteomics Clin Appl (2009) 0.77
Glutamine starvation of monocytes inhibits the ubiquitin-proteasome proteolytic pathway. Biochim Biophys Acta (2003) 0.77
Consequences of acute and chronic oxidative stress upon the expression pattern of proteins in peripheral blood mononuclear cells. J Proteome Res (2008) 0.77
The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells. Blood (2008) 0.77
EGCG-meditated cyto- and genotoxicity in HaCat keratinocytes is impaired by cell-mediated clearance of auto-oxidation-derived H2O2: an algorithm for experimental setting correction. Toxicol Lett (2011) 0.77
Myofibroblasts are important contributors to human hepatocellular carcinoma: evidence for tumor promotion by proteome profiling. Electrophoresis (2013) 0.77
Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets. Amino Acids (2013) 0.77
Minimal residual disease analysis in children with t(12;21)-positive acute lymphoblastic leukemia: comparison of Ig/TCR rearrangements and the genomic fusion gene. Haematologica (2006) 0.76
Proteome profiling of keratinocytes transforming to malignancy. Electrophoresis (2015) 0.76
Divide and conquer: rat liver tissue proteomics based on the analysis of purified constituents. Electrophoresis (2006) 0.76
Phenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat livers. PLoS One (2013) 0.76
Bioanalysis 2010. Electrophoresis (2010) 0.75
Low frequency of clonotypic Ig and T-cell receptor gene rearrangements in t(4;11) infant acute lymphoblastic leukaemia and its implication for the detection of minimal residual disease. Br J Haematol (2002) 0.75
Fluconazole downregulates metallothionein expression and increases copper cytotoxicity in Microsporum canis. Biochem Biophys Res Commun (2002) 0.75