Published in RNA Biol on January 19, 2005
Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev (2010) 4.75
HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41
Diverse molecular functions of Hu proteins. Cell Mol Life Sci (2008) 4.09
Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A (2008) 2.29
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20
Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines. Nucleic Acids Res (2009) 1.86
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology (2012) 1.66
Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest (2009) 1.58
Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability. Mol Cell Biol (2005) 1.50
The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res (2009) 1.41
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene (2008) 1.41
Phosphorylated HuR shuttles in cycles. Cell Cycle (2008) 1.38
Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation. Mol Biol Cell (2009) 1.38
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. Hum Mol Genet (2008) 1.36
Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis. Int J Mol Sci (2013) 1.28
RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage. Nucleic Acids Res (2011) 1.27
Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites. J Biol Chem (2011) 1.24
Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation. Aging (Albany NY) (2009) 1.20
The RNA-binding protein HuR opposes the repression of ERBB-2 gene expression by microRNA miR-331-3p in prostate cancer cells. J Biol Chem (2011) 1.20
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest (2011) 1.15
Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis. Biochem J (2010) 1.11
The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer. BMC Cancer (2010) 1.10
miR-195 competes with HuR to modulate stim1 mRNA stability and regulate cell migration. Nucleic Acids Res (2013) 1.09
HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium. Br J Cancer (2011) 1.09
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. Hepatology (2010) 1.03
Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function. Nucleic Acids Res (2011) 1.02
HuR is exported to the cytoplasm in oral cancer cells in a different manner from that of normal cells. Br J Cancer (2009) 0.99
Factors interacting with HIF-1alpha mRNA: novel therapeutic targets. Curr Pharm Des (2009) 0.99
Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis. Cell Cycle (2010) 0.98
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol (2012) 0.98
Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. Mol Cancer (2012) 0.98
Mechanistic aspects of COX-2 expression in colorectal neoplasia. Recent Results Cancer Res (2013) 0.95
Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function. J Biol Chem (2012) 0.95
HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells. Cancer Biol Ther (2012) 0.95
Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. J Biol Chem (2009) 0.94
Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer. J Oncol (2009) 0.93
Differential protein occupancy profiling of the mRNA transcriptome. Genome Biol (2014) 0.92
Fragile X protein family member FXR1P is regulated by microRNAs. RNA (2010) 0.92
ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. Blood (2011) 0.90
Protecting the stress response, guarding the MKP-1 mRNA. Cell Cycle (2008) 0.89
HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity. Hepatology (2009) 0.89
Comparative 3'UTR analysis allows identification of regulatory clusters that drive Eph/ephrin expression in cancer cell lines. PLoS One (2008) 0.87
Transcriptional control of human antigen R by bone morphogenetic protein. J Biol Chem (2009) 0.87
Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation. Nat Commun (2014) 0.86
Expression of the RNA-stabilizing protein HuR in ischemia-reperfusion injury of rat kidney. Am J Physiol Renal Physiol (2009) 0.86
Hu antigen R and tristetraprolin: counter-regulators of rat apical sodium-dependent bile acid transporter by way of effects on messenger RNA stability. Hepatology (2011) 0.86
Adaptive and maladaptive expression of the mRNA regulatory protein HuR. World J Biol Chem (2013) 0.85
dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial. Cancer Biol Ther (2014) 0.85
MicroRNA and AU-rich element regulation of prostaglandin synthesis. Cancer Metastasis Rev (2011) 0.84
HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop. J Cell Physiol (2013) 0.84
Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs. Biomolecules (2015) 0.84
Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res (2014) 0.83
Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model. J Biol Chem (2010) 0.83
HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ΔNp63. PLoS One (2012) 0.82
Over-represented sequences located on 3' UTRs are potentially involved in regulatory functions. RNA Biol (2008) 0.81
All three RNA recognition motifs and the hinge region of HuC play distinct roles in the regulation of alternative splicing. Nucleic Acids Res (2013) 0.81
The RNA stability regulator HuR regulates L1 protein expression in vivo in differentiating cervical epithelial cells. Virology (2008) 0.80
The flip-flop HuR: part of the problem or the solution in fighting cancer? J Clin Invest (2011) 0.80
Method for the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts using RIP-Chip. J Vis Exp (2012) 0.79
HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemotherapy for pancreatic cancer. World J Gastroenterol (2015) 0.78
RNA binding protein HuR regulates the expression of ABCA1. J Lipid Res (2014) 0.78
HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration and invasion in lung cancer. Cancer Gene Ther (2015) 0.78
Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR. Cell Physiol Biochem (2014) 0.78
Only a subset of the PAB1-mRNP proteome is present in mRNA translation complexes. Protein Sci (2014) 0.78
microRNA-200b as a Switch for Inducible Adult Angiogenesis. Antioxid Redox Signal (2015) 0.78
Tax 1-independent induction of vascular endothelial growth factor in adult T-cell leukemia caused by human T-cell leukemia virus type 1. J Virol (2010) 0.77
HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells. Mol Cancer Res (2016) 0.77
Post-transcriptional regulation of meprin α by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP). J Biol Chem (2012) 0.76
HuRrying colon cancer progression. Cancer Biol Ther (2007) 0.76
Association of CELF2 polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population. Oncotarget (2015) 0.76
In Vivo Interaction of the Hepatitis Delta Virus Small Antigen with the ELAV-Like Protein HuR. Open Virol J (2011) 0.76
HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy. Oncotarget (2016) 0.76
Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer. Acta Oncol (2015) 0.76
HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA. Int J Mol Sci (2014) 0.76
Identification of tumorigenesis-related mRNAs associated with RNA-binding protein HuR in thyroid cancer cells. Oncotarget (2016) 0.75
Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways. Front Genet (2015) 0.75
Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment. Neoplasia (2016) 0.75
Gene expression profiles in Rana pirica tadpoles following exposure to a predation threat. BMC Genomics (2015) 0.75
AU-rich elements in the 3'-UTR regulate the stability of the 141 amino acid isoform of parathyroid hormone-related protein mRNA. Mol Cell Endocrinol (2012) 0.75
Cytoskeleton-Dependent Transport as a Potential Target for Interfering with Post-transcriptional HuR mRNA Regulons. Front Pharmacol (2016) 0.75
HuR-regulated mRNAs associated with nuclear hnRNP A1-RNP complexes. Int J Mol Sci (2013) 0.75
Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis. Hepatoma Res (2016) 0.75
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A (2004) 5.15
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J (2004) 4.45
HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A (2003) 4.34
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
Desperately seeking microRNA targets. Nat Struct Mol Biol (2010) 3.85
Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08
miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One (2009) 2.97
MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res (2010) 2.83
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol (2005) 2.83
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc Natl Acad Sci U S A (2008) 2.76
Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene (2003) 2.69
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem (2006) 2.67
miR-519 suppresses tumor growth by reducing HuR levels. Cell Cycle (2010) 2.63
Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence. Biol Chem (2008) 2.60
Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59
Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet (2013) 2.59
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest (2013) 2.50
P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. J Biol Chem (2003) 2.38
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J (2005) 2.33
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A (2008) 2.29
MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol (2008) 2.26
Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle (2007) 2.25
Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs. Mol Cell Biol (2007) 2.24
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20
Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics (2005) 2.18
Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev (2008) 2.14
AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol (2002) 2.14
GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover. Mol Cell (2008) 2.08
Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol (2006) 2.05
Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99
Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Sci Signal (2009) 1.97
Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem (2003) 1.95
Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol (2003) 1.93
microRNA expression patterns reveal differential expression of target genes with age. PLoS One (2010) 1.92
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe (2009) 1.90
The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. Cancer Res (2009) 1.88
Translational repression by RNA-binding protein TIAR. Mol Cell Biol (2006) 1.87
Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol (2012) 1.87
Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J (2009) 1.87
HuR function in disease. Front Biosci (Landmark Ed) (2012) 1.86
Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines. Nucleic Acids Res (2009) 1.86
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol (2003) 1.83
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2010) 1.75
Functional interplay between RNA-binding protein HuR and microRNAs. Curr Protein Pept Sci (2012) 1.71
Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs. J Biol Chem (2006) 1.69
Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Nat Commun (2013) 1.62
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61
Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. J Immunol (2003) 1.57
Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet (2011) 1.55
MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging (Albany NY) (2010) 1.53
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52
Posttranscriptional derepression of GADD45alpha by genotoxic stress. Mol Cell (2006) 1.50
NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif. Nucleic Acids Res (2009) 1.50
RNA-binding protein nucleolin in disease. RNA Biol (2012) 1.47
Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase. Mol Cell Biol (2003) 1.47
Stability regulation of mRNA and the control of gene expression. Ann N Y Acad Sci (2005) 1.46
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nat Neurosci (2013) 1.46
AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem (2004) 1.46
An in vitro model of caloric restriction. Exp Gerontol (2003) 1.46
Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. Mol Cell Biol (2007) 1.44
miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol Cell Biol (2010) 1.43
The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res (2009) 1.41
Global mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response. Mol Cell Biol (2004) 1.38
Phosphorylated HuR shuttles in cycles. Cell Cycle (2008) 1.38
Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation. Mol Biol Cell (2009) 1.38
Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. Glia (2013) 1.37
von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays. Mol Cell Biol (2003) 1.37
HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay. Mol Cell Biol (2010) 1.35
Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR. J Biol Chem (2004) 1.35
Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells. Mol Biol Cell (2007) 1.28
Competitive regulation of nucleolin expression by HuR and miR-494. Mol Cell Biol (2011) 1.28
miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies. Mol Biol Cell (2011) 1.26
RNA-binding protein HuD controls insulin translation. Mol Cell (2012) 1.25
Translational control of TOP2A influences doxorubicin efficacy. Mol Cell Biol (2011) 1.25
Identification of a signature motif in target mRNAs of RNA-binding protein AUF1. Nucleic Acids Res (2008) 1.25
Increased stability of the p16 mRNA with replicative senescence. EMBO Rep (2005) 1.24
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. J Cell Biol (2005) 1.22
Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J (2011) 1.21