A human 15-kDa IFN-induced protein induces the secretion of IFN-gamma.

PubWeight™: 1.47‹?› | Rank: Top 5%

🔗 View Article (PMID 1717569)

Published in J Immunol on October 15, 1991


M Recht1, E C Borden, E Knight

Author Affiliations

1: University of Wisconsin Clinical Cancer Center, Madison.

Articles citing this

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A (2007) 3.98

Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. J Virol (2005) 3.10

Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Mol Cell Biol (2004) 2.70

Immunoregulatory properties of ISG15, an interferon-induced cytokine. Proc Natl Acad Sci U S A (1996) 2.45

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells. J Exp Med (1993) 2.17

Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection. J Virol (2008) 1.73

ISG15 regulates peritoneal macrophages functionality against viral infection. PLoS Pathog (2013) 1.51

ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. J Virol (2008) 1.38

The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression. J Psychiatry Neurosci (2004) 1.24

Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy. Ann Neurol (2010) 1.16

Telomere length regulates ISG15 expression in human cells. Aging (Albany NY) (2009) 1.13

Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice. J Leukoc Biol (2008) 1.01

ISG15: leading a double life as a secreted molecule. Exp Mol Med (2013) 1.01

Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation. PLoS One (2013) 0.99

Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation? Am J Pathol (2007) 0.92

Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective. Oncotarget (2015) 0.91

ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle. J Virol (2014) 0.88

Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis. Infect Immun (2008) 0.88

Cynoglossus semilaevis ISG15: a secreted cytokine-like protein that stimulates antiviral immune response in a LRGG motif-dependent manner. PLoS One (2012) 0.87

Emerging roles for immunomodulatory functions of free ISG15. J Interferon Cytokine Res (2013) 0.86

Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation. J Biol Chem (2008) 0.83

Zebrafish ISG15 exerts a strong antiviral activity against RNA and DNA viruses and regulates the interferon response. J Virol (2013) 0.82

Antagonizing interferon-mediated immune response by porcine reproductive and respiratory syndrome virus. Biomed Res Int (2014) 0.82

Modulation of the host interferon response and ISGylation pathway by B. pertussis filamentous hemagglutinin. PLoS One (2011) 0.80

Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification. Nat Commun (2016) 0.79

Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity. Mol Ther (2015) 0.77

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1. Sci Rep (2016) 0.76

Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity. J Immunol (2016) 0.76

The impact of ISGylation during Mycobacterium tuberculosis infection in mice. Microbes Infect (2017) 0.75

Cell type-dependent regulation of free ISG15 levels and ISGylation. J Cell Commun Signal (2017) 0.75

Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease. Cell Rep (2017) 0.75

Articles by these authors

Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol (1996) 9.68

ATP-dependent reduction of azide and HCN by N2-fixing enzymes of Azotobacter vinelandii and Clostridium pasteurianum. Biochim Biophys Acta (1967) 5.81

Transcriptional induction of two genes in human cells by beta interferon. Proc Natl Acad Sci U S A (1984) 4.84

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61

Characterization of a new low molecular weight RNA in HeLa cell ribosomes. J Mol Biol (1968) 4.44

Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis (2003) 3.73

Reduction of N2O by biological N2-fixing systems. Biochem Biophys Res Commun (1966) 3.66

Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence. Science (1980) 2.77

Immunoregulatory properties of ISG15, an interferon-induced cytokine. Proc Natl Acad Sci U S A (1996) 2.45

Interferon: purification and initial characterization from human diploid cells. Proc Natl Acad Sci U S A (1976) 2.45

Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence. J Biol Chem (1986) 2.37

Interferon regulates c-myc gene expression in Daudi cells at the post-transcriptional level. Proc Natl Acad Sci U S A (1985) 2.24

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ (2004) 2.17

Human polyomavirus infections with JC virus and BK virus in renal transplant patients. Ann Intern Med (1980) 2.07

Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res (1998) 2.04

Fibroblast interferon induces synthesis of four proteins in human fibroblast cells. Proc Natl Acad Sci U S A (1979) 2.01

Neutrophilia and congestive heart failure after acute myocardial infarction. Am Heart J (2000) 2.01

In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine. J Immunol (1996) 1.98

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses. Cancer Res (1987) 1.87

Distribution of 5 s RNA in HeLa cells. J Mol Biol (1967) 1.78

Physicochemical and morphological relationships of some arthropod-borne viruses to bluetongue virus--a new taxonomic group. Physiocochemical and serological studies. J Gen Virol (1971) 1.78

An energy-dependent hydrogen-evolution from dithionite in nitrogen-fixing extracts of Clostridium pasteurianum. Biochem Biophys Res Commun (1965) 1.77

Interferon-induced indoleamine 2,3-dioxygenase activity inhibits Chlamydia psittaci replication in human macrophages. J Interferon Res (1989) 1.74

Interferon-induced proteins. Purification and characterization of a 15,000-dalton protein from human and bovine cells induced by interferon. J Biol Chem (1984) 1.74

Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines. Clin Cancer Res (2001) 1.73

Induction of tryptophan degradation in vitro and in vivo: a gamma-interferon-stimulated activity. J Interferon Res (1986) 1.70

Selective reduction of c-myc mRNA in Daudi cells by human beta interferon. Proc Natl Acad Sci U S A (1984) 1.65

Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell cultures. J Immunol (1987) 1.65

Heterogeneity of purified mouse interferons. J Biol Chem (1975) 1.61

Support, mutual aid and recovery from dual diagnosis. Community Ment Health J (2000) 1.61

Physicochemical and morphological relationships of some arthropod-borne viruses to bluetongue virus--a new taxonomic group. Electron microscopic studies. J Gen Virol (1971) 1.56

Concepts of fever: recent advances and lingering dogma. Clin Infect Dis (1997) 1.50

A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. Anal Biochem (1997) 1.47

Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas. J Clin Oncol (1987) 1.42

Rapid detection and identification of JC virus and BK virus in human urine by using immunofluorescence microscopy. J Clin Microbiol (1980) 1.42

Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes. J Leukoc Biol (1989) 1.41

Pathologic analysis of advanced adult soft tissue sarcomas, bone sarcomas, and mesotheliomas. The Eastern Cooperative Oncology Group (ECOG) experience. Cancer (1989) 1.38

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J Neurosci (1998) 1.34

The interferon refractory state: in vivo and in vitro studies of its mechanism. J Immunol (1971) 1.34

Interferons and indoleamine 2,3-dioxygenase: role in antimicrobial and antitumor effects. Experientia (1989) 1.33

Clumsiness in children--do they grow out of it? A 10-year follow-up study. Dev Med Child Neurol (1991) 1.29

Comparative antiproliferative activity in vitro of natural interferons alpha and beta for diploid and transformed human cells. Cancer Res (1982) 1.25

Recovery challenges among dually diagnosed individuals. J Subst Abuse Treat (2000) 1.24

Isolation and characteristics of flavodoxin from nitrogen-fixing Clostridium pasteurianum. J Biol Chem (1966) 1.23

Consumers as peer specialists on intensive case management teams: impact on client outcomes. Psychiatr Serv (1995) 1.22

Beta interferon inhibits Toxoplasma gondii growth in human monocyte-derived macrophages. Infect Immun (1989) 1.20

A direct comparison of biological response modulation and clinical side effects by interferon-beta ser, interferon-gamma, or the combination of interferons beta ser and gamma in humans. J Clin Invest (1990) 1.20

Human fibroblast interferon. An improved purification. J Biol Chem (1981) 1.18

In vivo and in vitro synthesis of human rhinovirus type 2 ribonucleic acid. J Virol (1972) 1.18

A cell surface alteration in mouse L cells induced by interferon. Biochem Biophys Res Commun (1977) 1.18

Antiviral and cell growth inhibitory activities reside in the same glycoprotein of human fibroblast interferon. Nature (1976) 1.18

Orthopaedic intervention in early rheumatoid arthritis. Occurrence and predictive factors in an inception cohort of 1064 patients followed for 5 years. Rheumatology (Oxford) (2004) 1.16

Further clinical studies with intrahepatic arterial infusion with 5-fluorouracil. Cancer (1975) 1.16

An overview of the interferon system: signal transduction and mechanisms of action. Cancer Invest (1996) 1.14

Streptovaricins inhibit focus formation by MSV (MLV) complex. Nat New Biol (1971) 1.14

Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer. Br J Cancer (2006) 1.13

Proceedings: Aortic valve replacement using fresh unstented homografts. Thoraxchir Vask Chir (1973) 1.11

Activation of human natural killer cells cytotoxic for human leukemia cells by purified interferon. J Immunol (1979) 1.09

Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS. Adv Exp Med Biol (1991) 1.08

Randomized comparison of cyclophosphamide, imidazole carboxamide, and adriamycin versus cyclophosphamide and adriamycin in patients with advanced stage malignant mesothelioma: a Sarcoma Intergroup Study. J Clin Oncol (1987) 1.08

Flavodoxin: a flavoprotein with ferredoxin activity from Clostrium pasteurianum. Biochim Biophys Acta (1966) 1.08

Synergistic antitumor effects of a combination of interferons and retinoic acid on human tumor cells in vitro and in vivo. Clin Cancer Res (1997) 1.06

Enhancement of T cell cytotoxic responses by purified human fibroblast interferon. J Immunol (1978) 1.05

Metastatic ocular and cutaneous melanoma: a comparison of patient characteristics and prognosis. Arch Ophthalmol (1996) 1.05

Aquanititave semimicro, semiautomated colorimetric assay for interferon. J Lab Clin Med (1977) 1.04

Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine. Cancer Res (1992) 1.04

Leukocyte-derived interferon (alpha) in human breast carcinoma. The American Cancer Society phase II trial. Ann Intern Med (1982) 1.03

Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL. Oncogene (2007) 1.03

Selective inhibition by streptovaricin of splenomegaly induced Rauscher leukaemia by virus. Nat New Biol (1971) 1.03

Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma. N Engl J Med (1992) 1.03

Modulation of interferon (IFN)-inducible gene expression by retinoic acid. Up-regulation of STAT1 protein in IFN-unresponsive cells. J Biol Chem (1996) 1.02

Selective interferon-induced enhancement of tumor-associated antigens on a spectrum of freshly isolated human adenocarcinoma cells. J Natl Cancer Inst (1989) 1.02

Mechanistic studies of polyene enhancement of interferon production by polyriboinosinic-polyribocytidylic acid. Antimicrob Agents Chemother (1978) 1.01

Phase I trial of an oral immunomodulator and interferon inducer in cancer patients. Cancer Res (1993) 0.99

Growth inhibitory effects of interferon-beta but not interferon-alpha on human glioma cells: correlation of receptor binding, 2',5'-oligoadenylate synthetase and protein kinase activity. J Interferon Res (1990) 0.98

The effect of interferon on the metabolism of LDLs. Arterioscler Thromb (1992) 0.98

Chronic nutmeg psychosis. J R Soc Med (1993) 0.97

Flavodoxin. Chemical and biological properties. J Biol Chem (1967) 0.97

Studies on the poxvirus Cotia. J Gen Virol (1980) 0.97

Measurement of 2',5'-oligoadenylate synthetase in patients receiving interferon-alpha. J Interferon Res (1985) 0.97

o,p'-DDD (mitotane) therapy of adrenal cortical carcinoma: observations on drug dosage, toxicity, and steroid replacement. Cancer (1978) 0.97

A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth. Oncogene (2012) 0.96

Retinoic acid and interferon in human cancer: mechanistic and clinical studies. Semin Hematol (1994) 0.96

Orthodeoxia: a new finding in interstitial fibrosis. Am Rev Respir Dis (1987) 0.94

Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in vivo and in vitro. Cancer Res (1989) 0.94

Synergistic antitumor effects of a combination of interferon and tamoxifen on estrogen receptor-positive and receptor-negative human tumor cell lines in vivo and in vitro. J Interferon Cytokine Res (1997) 0.93

Oral anticoagulation in atrial fibrillation: A pan-European patient survey. Eur J Intern Med (2007) 0.93

2',5'-oligoadenylate synthetase, neopterin and beta 2-microglobulin in asymptomatic HIV-infected individuals. AIDS (1991) 0.93

The use of "fresh" unstented homograft valves for replacement of the aortic valve: analysis of 6 1/2 years experience. Circulation (1977) 0.93

An Eastern Cooperative Oncology Group phase I-II pilot study of polyriboinosinic-polyribocytidylic acid poly-L-lysine complex in patients with metastatic malignant melanoma. J Biol Response Mod (1985) 0.93

Low doses of interferon alpha result in more effective clinical natural killer cell activation. J Clin Invest (1985) 0.93

Phase II trial of 6-diazo-5-oxo-L-norleucine versus aclacinomycin-A in advanced sarcomas and mesotheliomas. Invest New Drugs (1990) 0.92

Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma. Br J Cancer (2011) 0.91

Mitochondria-associated ribonucleic acid of the HeLa cell. Effect of ethidium bromide on the synthesis of ribosomal and 4S ribonucleic acid. Biochemistry (1969) 0.91

Interferons: biochemical, cell growth inhibitory, and immunological effects. Prog Hematol (1981) 0.91

The interferon refractory state. II. Biological characterization of a refractoriness-inducing protein. J Immunol (1975) 0.91

Interferons: rationale for clinical trials in neoplastic disease. Ann Intern Med (1979) 0.90

Effects of interferons beta or gamma on neopterin biosynthesis and tryptophan degradation by human alveolar macrophages in vitro: synergy with lipopolysaccharide. Am J Respir Cell Mol Biol (1992) 0.90