Published in Mol Microbiol on December 20, 2006
Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nat Rev Microbiol (2012) 3.52
The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation. PLoS Pathog (2015) 1.54
BosR (BB0647) governs virulence expression in Borrelia burgdorferi. Mol Microbiol (2009) 1.42
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. Mol Microbiol (2009) 1.37
Biology of infection with Borrelia burgdorferi. Infect Dis Clin North Am (2008) 1.35
A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity. PLoS Pathog (2009) 1.24
BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathog (2011) 1.22
Analysis of the HD-GYP domain cyclic dimeric GMP phosphodiesterase reveals a role in motility and the enzootic life cycle of Borrelia burgdorferi. Infect Immun (2011) 1.21
BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle. J Infect Dis (2009) 1.18
Reviewing molecular adaptations of Lyme borreliosis spirochetes in the context of reproductive fitness in natural transmission cycles. Vet Res (2009) 1.14
Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. J Bacteriol (2009) 1.14
Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice. Mol Microbiol (2009) 1.12
Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector. Future Microbiol (2013) 1.12
Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks. PLoS Pathog (2011) 1.08
The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission. Proc Natl Acad Sci U S A (2010) 1.07
Characterization of a conditional bosR mutant in Borrelia burgdorferi. Infect Immun (2009) 1.06
Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity. PLoS One (2008) 1.05
Analysis of the Borrelia burgdorferi cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulence. Infect Immun (2011) 1.03
Role of outer surface protein D in the Borrelia burgdorferi life cycle. Infect Immun (2007) 1.03
Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi. Infect Immun (2010) 1.03
A novel gene inactivation system reveals altered periplasmic flagellar orientation in a Borrelia burgdorferi fliL mutant. J Bacteriol (2011) 1.02
Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1. Infect Immun (2010) 1.00
Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation. Mol Microbiol (2014) 1.00
Who is the BosR around here anyway? Mol Microbiol (2009) 1.00
Overexpression of CsrA (BB0184) alters the morphology and antigen profiles of Borrelia burgdorferi. Infect Immun (2009) 0.94
Functional analysis of the Borrelia burgdorferi bba64 gene product in murine infection via tick infestation. PLoS One (2011) 0.92
EbfC (YbaB) is a new type of bacterial nucleoid-associated protein and a global regulator of gene expression in the Lyme disease spirochete. J Bacteriol (2012) 0.91
Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi. Infect Immun (2013) 0.91
Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccine. Vaccine (2011) 0.89
Interaction of the Lyme disease spirochete with its tick vector. Cell Microbiol (2016) 0.88
Emergence of Ixodes scapularis and Borrelia burgdorferi, the Lyme disease vector and agent, in Ohio. Front Cell Infect Microbiol (2014) 0.87
The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX. Mol Microbiol (2013) 0.87
The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Mol Microbiol (2011) 0.86
Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease. Infect Immun (2008) 0.86
Pyruvate protects pathogenic spirochetes from H2O2 killing. PLoS One (2014) 0.85
DNA Charge Transport: from Chemical Principles to the Cell. Cell Chem Biol (2016) 0.85
Persister Development by Borrelia burgdorferi Populations In Vitro. Antimicrob Agents Chemother (2015) 0.85
Borrelia burgdorferi oxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection. Mol Microbiol (2013) 0.85
The nucleotide excision repair system of Borrelia burgdorferi is the sole pathway involved in repair of DNA damage by UV light. J Bacteriol (2013) 0.84
EPR spectroscopy and catalase activity of manganese-bound DNA-binding protein from nutrient starved cells. J Biol Inorg Chem (2010) 0.83
Genetic transformation of Borrelia burgdorferi. Curr Protoc Microbiol (2011) 0.83
The BB0646 protein demonstrates lipase and haemolytic activity associated with Borrelia burgdorferi, the aetiological agent of Lyme disease. Mol Microbiol (2011) 0.82
Metal-dependent gene regulation in the causative agent of Lyme disease. Front Cell Infect Microbiol (2013) 0.81
The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts. Microbes Infect (2013) 0.80
Borrelia burgdorferi bba66 gene inactivation results in attenuated mouse infection by tick transmission. Infect Immun (2013) 0.80
DNA protection by the bacterial ferritin Dps via DNA charge transport. J Am Chem Soc (2013) 0.80
Crystal structures of Streptococcus pyogenes Dpr reveal a dodecameric iron-binding protein with a ferroxidase site. J Biol Inorg Chem (2009) 0.79
Borrelia burgdorferi CheD Promotes Various Functions in Chemotaxis and the Pathogenic Life Cycle of the Spirochete. Infect Immun (2016) 0.78
Gene bb0318 is critical for the oxidative stress response and infectivity of Borrelia burgdorferi. Infect Immun (2016) 0.77
The Fur homologue BosR requires Arg39 to activate rpoS transcription in Borrelia burgdorferi and thereby direct spirochaete infection in mice. Microbiology (2015) 0.77
Tick-specific borrelial antigens appear to be upregulated in American but not European patients with Lyme arthritis, a late manifestation of Lyme borreliosis. J Infect Dis (2013) 0.76
Toll-like receptor cascade and gene polymorphism in host-pathogen interaction in Lyme disease. J Inflamm Res (2016) 0.76
The Nucleotide Excision Repair Pathway Protects Borrelia burgdorferi from Nitrosative Stress in Ixodes scapularis Ticks. Front Microbiol (2016) 0.76
A histidine aspartate ionic lock gates the iron passage in miniferritins from Mycobacterium smegmatis. J Biol Chem (2014) 0.76
Use of an endogenous plasmid locus for stable in trans complementation in Borrelia burgdorferi. Appl Environ Microbiol (2014) 0.75
Lyme disease: aetiopathogenesis, factors for disease development and control. Inflammopharmacology (2012) 0.75
A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species. PLoS Pathog (2017) 0.75
Characterization of the DNA-Mediated Oxidation of Dps, A Bacterial Ferritin. J Am Chem Soc (2016) 0.75
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49
The ankyrin repeat as molecular architecture for protein recognition. Protein Sci (2004) 5.07
RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93
Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background. Infect Immun (2002) 3.65
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity (2012) 3.43
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38
A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell (2009) 3.27
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol (2003) 3.17
Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med (2004) 3.02
The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66
Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol (2010) 2.63
TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell (2004) 2.62
Host feeding patterns of Culex mosquitoes and West Nile virus transmission, northeastern United States. Emerg Infect Dis (2006) 2.58
Molecular adaptation of Borrelia burgdorferi in the murine host. J Exp Med (2002) 2.49
Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle. Mol Microbiol (2007) 2.32
Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the lyme disease spirochaete. Mol Microbiol (2002) 2.28
aadA confers streptomycin resistance in Borrelia burgdorferi. J Bacteriol (2003) 2.22
Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. J Virol (2006) 2.20
Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20
A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host Microbe (2007) 2.17
Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. Vector Borne Zoonotic Dis (2004) 2.15
Rab 5 is required for the cellular entry of dengue and West Nile viruses. J Virol (2007) 2.12
Human Borrelia miyamotoi infection in the United States. N Engl J Med (2013) 2.11
Silent substitutions predictably alter translation elongation rates and protein folding efficiencies. J Mol Biol (2012) 2.04
IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. J Immunol (2003) 2.03
Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol (2009) 2.00
RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect Immun (2004) 1.94
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol (2008) 1.93
Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol (2006) 1.84
Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses. Infect Immun (2004) 1.82
Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks. J Clin Invest (2009) 1.78
West Nile virus: a growing concern? J Clin Invest (2004) 1.77
Efficacy of interferon alpha-2b and ribavirin against West Nile virus in vitro. Emerg Infect Dis (2002) 1.75
Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation. Immunity (2002) 1.75
A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet (2013) 1.73
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine (2009) 1.72
Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus. J Virol (2005) 1.72
Slowing bacterial translation speed enhances eukaryotic protein folding efficiency. J Mol Biol (2010) 1.70
A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. J Infect Dis (2007) 1.68
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. J Clin Microbiol (2003) 1.65
Detection of human anti-flavivirus antibodies with a west nile virus recombinant antigen microsphere immunoassay. J Clin Microbiol (2004) 1.59
Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J Clin Invest (2007) 1.57
Disruption of Ixodes scapularis anticoagulation by using RNA interference. Proc Natl Acad Sci U S A (2004) 1.56
Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle. Infect Immun (2004) 1.55
IL-27 promotes T cell-dependent colitis through multiple mechanisms. J Exp Med (2010) 1.54
Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans. J Immunol (2003) 1.53
Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infect Immun (2004) 1.52
Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. J Immunol (2002) 1.52
Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect Immun (2006) 1.52
Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. J Virol (2008) 1.49
Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin Infect Dis (2002) 1.49
Increasing health burden of human babesiosis in endemic sites. Am J Trop Med Hyg (2003) 1.47
Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. PLoS Pathog (2009) 1.47
Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Med (2008) 1.46
Single-dose prophylaxis against Lyme disease. Lancet Infect Dis (2007) 1.45
A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host Microbe (2011) 1.44
Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J Bacteriol (2005) 1.44
Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathog (2008) 1.43
Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding. J Bacteriol (2002) 1.43
BosR (BB0647) governs virulence expression in Borrelia burgdorferi. Mol Microbiol (2009) 1.42
PCR-based identification of bacteria associated with endodontic infections. J Clin Microbiol (2002) 1.42
Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production. Infect Immun (2007) 1.42
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med (2010) 1.41
Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes Infect (2003) 1.41
Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes. J Bacteriol (2005) 1.40
Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell (2011) 1.39
Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15. J Immunol (2006) 1.39
West Nile Virus: biology, transmission, and human infection. Clin Microbiol Rev (2012) 1.38
Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis (2011) 1.38
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol (2010) 1.38
A paradoxical role for neutrophils in the pathogenesis of West Nile virus. J Infect Dis (2010) 1.37