Published in Development on December 21, 2006
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.90
Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science (2012) 3.45
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet (2008) 3.37
Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis. Science (2007) 3.26
A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45
Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell (2011) 2.36
Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology (2011) 2.33
Advances in understanding tissue regenerative capacity and mechanisms in animals. Nat Rev Genet (2010) 2.28
Slicing across kingdoms: regeneration in plants and animals. Cell (2008) 2.18
Apoptosis, stem cells, and tissue regeneration. Sci Signal (2010) 1.95
More than one way to skin . . . Genes Dev (2008) 1.95
A wound-induced Wnt expression program controls planarian regeneration polarity. Proc Natl Acad Sci U S A (2009) 1.88
Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration. Science (2011) 1.79
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response. Dev Biol (2010) 1.68
Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation. Dev Cell (2008) 1.66
Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration. Proc Natl Acad Sci U S A (2011) 1.66
Mitotic and mitogenic Wnt signalling. EMBO J (2012) 1.62
New concepts in liver regeneration. J Gastroenterol Hepatol (2011) 1.55
A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep (2010) 1.52
The zebrafish as a model for complex tissue regeneration. Trends Genet (2013) 1.45
Canonical Wnt signaling dynamically controls multiple stem cell fate decisions during vertebrate body formation. Dev Cell (2012) 1.43
Regeneration and reprogramming compared. BMC Biol (2010) 1.42
Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell Mol Life Sci (2012) 1.40
From individual Wnt pathways towards a Wnt signalling network. Philos Trans R Soc Lond B Biol Sci (2008) 1.37
Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem (2012) 1.33
Wnt signalling in development and disease. Max Delbrück Center for Molecular Medicine meeting on Wnt signaling in Development and Disease. EMBO Rep (2008) 1.31
A histone demethylase is necessary for regeneration in zebrafish. Proc Natl Acad Sci U S A (2009) 1.31
Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors. Proc Natl Acad Sci U S A (2013) 1.31
Wnt signaling and injury repair. Cold Spring Harb Perspect Biol (2012) 1.30
The role of apoptosis-induced proliferation for regeneration and cancer. Cold Spring Harb Perspect Biol (2012) 1.28
Wnt/beta-catenin signaling has an essential role in the initiation of limb regeneration. Dev Biol (2007) 1.25
Regulation of zebrafish fin regeneration by microRNAs. Proc Natl Acad Sci U S A (2008) 1.23
Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Dev Biol (2008) 1.22
Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Dev Biol (2009) 1.21
Fgfs control homeostatic regeneration in adult zebrafish fins. Development (2008) 1.19
Beta-catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain. Stem Cells (2010) 1.18
Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling. Dev Biol (2007) 1.18
Building the posterior lateral line system in zebrafish. Dev Neurobiol (2012) 1.18
Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. Sci Rep (2013) 1.18
Proteomic analysis of blastema formation in regenerating axolotl limbs. BMC Biol (2009) 1.16
Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium. Development (2011) 1.13
Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish. Proc Natl Acad Sci U S A (2010) 1.13
Emerging patterns in planarian regeneration. Curr Opin Genet Dev (2009) 1.13
Targeting Wnt pathways in disease. Cold Spring Harb Perspect Biol (2012) 1.11
Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina. Nat Cell Biol (2012) 1.11
β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina. Neural Dev (2012) 1.11
Tissue homeostasis in the wing disc of Drosophila melanogaster: immediate response to massive damage during development. PLoS Genet (2013) 1.10
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mech Dev (2008) 1.09
Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Dev Cell (2012) 1.09
Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling. PLoS Biol (2011) 1.09
Wnt activation promotes neuronal differentiation of glioblastoma. Cell Death Dis (2013) 1.08
Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB J (2008) 1.07
TGF-beta signaling is required for multiple processes during Xenopus tail regeneration. Dev Biol (2008) 1.06
Macrophages modulate adult zebrafish tail fin regeneration. Development (2014) 1.05
Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature (2015) 1.04
Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program. PLoS One (2013) 1.04
Identification of genes associated with regenerative success of Xenopus laevis hindlimbs. BMC Dev Biol (2008) 1.03
Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. J Cell Biol (2010) 1.03
Molecular signaling networks that choreograph epimorphic fin regeneration in zebrafish - a mini-review. Gerontology (2009) 1.03
Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration. J Biol Chem (2009) 1.02
Canonical Wnt signaling is required for the maintenance of dorsal retinal identity. Development (2008) 1.02
Three genes control the timing, the site and the size of blastema formation in Drosophila. Dev Biol (2008) 1.01
The emerging role of Wnt/PCP signaling in organ formation. Zebrafish (2009) 1.00
Advanced identification of proteins in uncharacterized proteomes by pulsed in vivo stable isotope labeling-based mass spectrometry. Mol Cell Proteomics (2010) 1.00
Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud. Dev Biol (2009) 0.99
Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. Dev Cell (2013) 0.99
Restriction of hepatic competence by Fgf signaling. Development (2011) 0.97
Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear. Dev Biol (2011) 0.97
Keeping at arm's length during regeneration. Dev Cell (2014) 0.96
Regulated tissue fluidity steers zebrafish body elongation. Development (2013) 0.96
The aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism. Biochem Pharmacol (2008) 0.96
AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration. Biochem Pharmacol (2008) 0.96
Localization and characterization of STRO-1 cells in the deer pedicle and regenerating antler. PLoS One (2008) 0.95
Gene expression patterns specific to the regenerating limb of the Mexican axolotl. Biol Open (2012) 0.95
Regeneration and transdetermination: the role of wingless and its regulation. Dev Biol (2010) 0.95
Wnt/ß-catenin signaling is required for radial glial neurogenesis following spinal cord injury. Dev Biol (2015) 0.95
Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Elife (2015) 0.95
The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. Dis Model Mech (2010) 0.93
Wnt signaling is required for early development of zebrafish swimbladder. PLoS One (2011) 0.92
New regulators of vertebrate appendage regeneration. Curr Opin Genet Dev (2008) 0.92
Simple, economical heat-shock devices for zebrafish housing racks. Zebrafish (2011) 0.92
Augmenting endogenous Wnt signaling improves skin wound healing. PLoS One (2013) 0.92
Wnt signaling during cochlear development. Semin Cell Dev Biol (2013) 0.91
Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. BMC Dev Biol (2010) 0.91
Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Nat Commun (2017) 0.91
The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1. Development (2012) 0.91
Fgf and Sdf-1 pathways interact during zebrafish fin regeneration. PLoS One (2009) 0.91
BMP, Wnt and FGF signals are integrated through evolutionarily conserved enhancers to achieve robust expression of Pax3 and Zic genes at the zebrafish neural plate border. Development (2012) 0.91
ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/β-catenin. Elife (2014) 0.90
β-Catenin inactivation is a pre-requisite for chick retina regeneration. PLoS One (2014) 0.90
Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver. Mech Dev (2012) 0.90
Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation. Development (2012) 0.89
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell (2003) 7.93
Liver regeneration. Hepatology (2006) 7.52
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer (2013) 6.64
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol (2003) 6.60
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell (2009) 5.34
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science (2007) 5.08
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature (2006) 4.96
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91
Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A (2004) 3.95
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.90
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol (2003) 3.53
Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium (2005) 3.46
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem (2007) 3.24
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol (2006) 3.22
The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat Cell Biol (2002) 3.13
A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet (2002) 2.90
Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell (2005) 2.86
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell (2012) 2.81
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (2002) 2.61
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med (2005) 2.60
A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Dev Biol (2002) 2.46
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature (2003) 2.42
Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A (2009) 2.41
Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation. Nat Cell Biol (2011) 2.32
Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev (2007) 2.31
Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell (2002) 2.28
Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc Natl Acad Sci U S A (2005) 2.28
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science (2008) 2.22
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci (2007) 2.22
Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes. Am J Pathol (2007) 2.18
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res (2006) 2.14
Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes. Arterioscler Thromb Vasc Biol (2006) 2.13
The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. Curr Biol (2005) 2.09
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol (2003) 2.07
The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem (2003) 1.97
Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nat Cell Biol (2003) 1.96
Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Sci Signal (2012) 1.95
Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. Proc Natl Acad Sci U S A (2012) 1.93
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol (2008) 1.90
New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal (2008) 1.88
Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell (2011) 1.86
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.84
Hepatitis C virus and liver disease: global transcriptional profiling and identification of potential markers. Hepatology (2003) 1.80
Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood (2007) 1.79
Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs. Methods Mol Biol (2008) 1.77
Reiterated Wnt signaling during zebrafish neural crest development. Development (2004) 1.75
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A (2003) 1.72
Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. Blood (2013) 1.70
Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science (2002) 1.69
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol (2011) 1.68
Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proc Natl Acad Sci U S A (2002) 1.62
Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. J Exp Med (2007) 1.62
CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors. J Invest Dermatol (2008) 1.60
Liver regeneration. J Hepatol (2012) 1.59
Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation. PLoS One (2011) 1.59
Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes. Hepatology (2003) 1.58
Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis. Virol J (2006) 1.58
Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest (2002) 1.58
Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. J Virol (2003) 1.56
New concepts in liver regeneration. J Gastroenterol Hepatol (2011) 1.55
Crystal structure of a full-length beta-catenin. Structure (2008) 1.55
A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep (2010) 1.52
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci U S A (2013) 1.51
Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation. Hepatology (2007) 1.50
Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J Hepatol (2008) 1.44
Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration. J Biol Chem (2004) 1.44
In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Dev Biol (2012) 1.43
Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma. Cancer Res (2003) 1.40
Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress. Am J Pathol (2003) 1.39
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development (2005) 1.38
Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients. Gastroenterology (2006) 1.38
Inactivation of Chibby affects function of motile airway cilia. J Cell Biol (2009) 1.38
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest (2013) 1.37
Two tcf3 genes cooperate to pattern the zebrafish brain. Development (2003) 1.36
Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology (2005) 1.35
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis. Cell Res (2009) 1.35
Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Development (2004) 1.32
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet (2009) 1.31
Adult zebrafish heart as a model for human heart? An electrophysiological study. J Mol Cell Cardiol (2009) 1.29
When Wnts antagonize Wnts. J Cell Biol (2003) 1.29
Mechanisms of liver regeneration and their clinical implications. J Hepatobiliary Pancreat Surg (2005) 1.29
Wnt/beta-catenin signaling has an essential role in the initiation of limb regeneration. Dev Biol (2007) 1.25
Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. J Immunol (2006) 1.25