Published in Proc Natl Acad Sci U S A on December 01, 1991
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc Natl Acad Sci U S A (1993) 9.47
Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein. Protein Sci (1998) 1.45
Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract. Nucleic Acids Res (2004) 1.39
Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent. Proc Natl Acad Sci U S A (2002) 1.26
Use of a fusion protein to obtain crystals suitable for X-ray analysis: crystallization of a GST-fused protein containing the DNA-binding domain of DNA replication-related element-binding factor, DREF. Protein Sci (1997) 0.99
RNase H requirements for the second strand transfer reaction of human immunodeficiency virus type 1 reverse transcription. J Virol (1999) 0.97
Biophysical and enzymatic properties of the simian and prototype foamy virus reverse transcriptases. Retrovirology (2010) 0.95
Antibody fragments as tools in crystallography. Clin Exp Immunol (2011) 0.94
Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions. J Virol (2009) 0.94
Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA. J Virol (2004) 0.92
Recent horizontal intron transfer to a chloroplast genome. Nucleic Acids Res (2004) 0.90
Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis. Nucleic Acids Res (2006) 0.89
Asymmetric subunit organization of heterodimeric Rous sarcoma virus reverse transcriptase alphabeta: localization of the polymerase and RNase H active sites in the alpha subunit. J Virol (2000) 0.87
Structural prediction of A- and B-DNA duplexes based on coordinates of the phosphorus atoms. Biophys J (1996) 0.82
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science (1989) 15.19
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature (1985) 8.46
Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. Science (1986) 6.53
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives. Nature (1990) 5.70
Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science (1990) 5.49
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science (1991) 5.42
Molecular targets for AIDS therapy. Science (1990) 4.28
Antibody-antigen complexes. Annu Rev Biochem (1990) 3.91
Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants. Proc Natl Acad Sci U S A (1988) 3.53
Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities. J Biol Chem (1991) 2.36
HIV reverse transcriptase structure-function relationships. Biochemistry (1991) 1.90
HIV-1 reverse transcriptase purified from a recombinant strain of Escherichia coli. AIDS Res Hum Retroviruses (1990) 1.39
HIV-1 reverse transcriptase: crystallization and analysis of domain structure by limited proteolysis. Biochemistry (1988) 1.38
Immunologic and proteolytic analysis of HIV-1 reverse transcriptase structure. Virology (1990) 1.38
Preparation and crystallization of a human immunodeficiency virus p24-Fab complex. Proc Natl Acad Sci U S A (1990) 1.13
Crystal density measurements using aqueous ficoll solutions. Methods Enzymol (1985) 1.11
Effect of errors, redundancy, and solvent content in the molecular replacement procedure for the structure determination of biological macromolecules. Proc Natl Acad Sci U S A (1986) 0.94
Crystallization of Sendai virus HN protein complexed with monoclonal antibody Fab fragments. Virology (1989) 0.92
Human immunodeficiency virus structure: implications for antiviral design. Adv Virus Res (1991) 0.92
Expression, purification, and crystallization of the HIV-1 reverse transcriptase (RT). AIDS Res Hum Retroviruses (1990) 0.84
Many crystal forms of human immunodeficiency virus reverse transcriptase. J Mol Biol (1991) 0.80
The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum (1990) 27.50
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell (1978) 13.33
Structure of a human common cold virus and functional relationship to other picornaviruses. Nature (1985) 12.90
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc Natl Acad Sci U S A (1993) 9.47
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell (1978) 7.46
Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. J Virol (1987) 6.88
Identification of clones that encode chicken tropomyosin by direct immunological screening of a cDNA expression library. Proc Natl Acad Sci U S A (1983) 6.00
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature (1986) 5.88
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell (2000) 5.23
Fetal growth and perinatal viability in California. Obstet Gynecol (1982) 5.23
Mefloquine (WR 142,490) in the treatment of human malaria. Science (1975) 5.20
Identifying the sources of the recent decline in perinatal mortality rates in California. N Engl J Med (1982) 4.64
The nucleotide sequence of the chick cytoplasmic beta-actin gene. Nucleic Acids Res (1983) 4.62
A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity. J Med Genet (1989) 4.42
The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating. Science (1986) 4.40
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Natl Acad Sci U S A (1995) 4.37
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. EMBO J (2001) 4.36
The atomic structure of Mengo virus at 3.0 A resolution. Science (1987) 4.34
The first night effect: an EEG study of sleep. Psychophysiology (1966) 3.86
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. J Mol Biol (1994) 3.85
Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature (1999) 3.81
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell (2000) 3.68
Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants. Proc Natl Acad Sci U S A (1988) 3.53
cis-Acting RNA packaging locus in the 115-nucleotide direct repeat of Rous sarcoma virus. J Virol (1983) 3.34
Retroviral reverse transcription and integration: progress and problems. Annu Rev Cell Biol (1992) 3.26
Effect of luminal growth factor preservation on intestinal growth. Lancet (1993) 3.25
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution. J Mol Biol (1998) 3.14
Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta. Nature (1996) 3.11
Cesarean section, fetal monitoring, and perinatal mortality in California. Am J Public Health (1979) 3.04
Pregnancy outcomes among Spanish-surname women in California. Am J Public Health (1986) 3.04
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Proc Natl Acad Sci U S A (1999) 3.03
Implications of the picornavirus capsid structure for polyprotein processing. Proc Natl Acad Sci U S A (1987) 2.99
The EV-O-derived cell line DF-1 supports the efficient replication of avian leukosis-sarcoma viruses and vectors. Virology (1998) 2.96
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. J Virol (2001) 2.95
Corn pollen deposition on milkweeds in and near cornfields. Proc Natl Acad Sci U S A (2001) 2.94
Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1. J Virol (1992) 2.89
Cesarean section in California--1960 through 1975. Am J Obstet Gynecol (1979) 2.81
Copper metallothionein of yeast, structure of the gene, and regulation of expression. Proc Natl Acad Sci U S A (1984) 2.74
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure (1996) 2.69
Reducing black neonatal mortality. Will improvement in birth weight be enough? JAMA (1985) 2.56
Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not. Proc Natl Acad Sci U S A (1994) 2.56
Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases. Cell (1979) 2.55
Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell (1993) 2.52
Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations. Nature (1992) 2.52
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Mol Cell (2001) 2.47
Computer analysis of Staphylococcus aureus phage typing data from 1957 to 1975, citing epidemiological trends and natural evolution within the phage typing system. Appl Environ Microbiol (1980) 2.40
ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost (2007) 2.38
Splicing of intervening sequences introduced into an infectious retroviral vector. J Mol Appl Genet (1982) 2.36
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase. J Virol (2001) 2.35
Thrombophilia in pregnancy: a systematic review. Br J Haematol (2006) 2.33
Sequence of the circle junction of human immunodeficiency virus type 1: implications for reverse transcription and integration. J Virol (1990) 2.24
The vertebrate homolog of the putative transforming gene of avian myelocytomatosis virus: characteristics of the DNA locus and its RNA transcript. Virology (1980) 2.22
A systematic review of tension-free urethropexy for stress urinary incontinence: intravaginal slingplasty and the tension-free vaginal tape procedures. BJU Int (2001) 2.21
Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC). J Virol (2001) 2.14
Antibiotic susceptibility profiles for group B streptococci isolated from neonates, 1995-1998. Clin Infect Dis (2000) 2.10
Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles. J Med Chem (1997) 2.08
Early prediction of pre-eclampsia by measurement of kallikrein and creatinine on a random urine sample. Br J Obstet Gynaecol (1996) 2.08
Dose-related sleep disturbances induced by coffee and caffeine. Clin Pharmacol Ther (1976) 2.04
Capsular polysaccharide types of group B streptococcal isolates from neonates with early-onset systemic infection. J Infect Dis (1998) 2.01
A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors. Proc Natl Acad Sci U S A (1994) 1.99
Bias and 'overcall' in interpreting chest radiographs in young febrile children. Pediatrics (1992) 1.97
Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am J Physiol (1994) 1.95
Replication-competent retrovirus vectors for the transfer and expression of gene cassettes in avian cells. J Virol (1991) 1.95
Polypurine tract adjacent to the U3 region of the Rous sarcoma virus genome provides a cis-acting function. J Virol (1982) 1.94
Anorexia nervosa in the elderly. Br J Psychiatry (1991) 1.94
Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase. Biochemistry (1995) 1.93
HIV reverse transcriptase structure-function relationships. Biochemistry (1991) 1.90
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum. J Med Chem (1992) 1.89
Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell (1975) 1.87
Links between passive smoking and disease: a best-evidence synthesis. A report of the Working Group on Passive Smoking. Clin Invest Med (1990) 1.87
Retroviral gene delivery. Methods Cell Biol (1997) 1.82
Serotyping of Pseudomonas aeruginosa isolates from patients with cystic fibrosis of the pancreas. J Clin Microbiol (1975) 1.81
HIV-1 reverse transcriptase: structure predictions for the polymerase domain. AIDS Res Hum Retroviruses (1990) 1.80
Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptase. Virology (1990) 1.79