PubRank

James G Herman

Author PubWeight™ 280.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010 16.12
2 A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007 9.47
3 Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004 7.78
4 Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002 7.09
5 DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 2008 5.87
6 Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med 2006 5.80
7 A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 2002 5.38
8 Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov 2011 4.60
9 Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 2008 4.32
10 Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006 4.15
11 Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat Genet 2005 3.66
12 Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2006 3.54
13 Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet 2007 3.39
14 Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood 2009 3.35
15 Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res 2006 3.05
16 Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 2002 3.00
17 Low-level microsatellite instability in most colorectal carcinomas. Cancer Res 2002 2.87
18 PcG proteins, DNA methylation, and gene repression by chromatin looping. PLoS Biol 2008 2.85
19 Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res 2002 2.84
20 A systematic profile of DNA methylation in human cancer cell lines. Cancer Res 2003 2.75
21 Adoption of gene expression profile testing and association with use of chemotherapy among women with breast cancer. J Clin Oncol 2012 2.53
22 Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 2003 2.42
23 GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol 2003 2.42
24 Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. J Natl Cancer Inst 2002 2.38
25 Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell 2003 2.38
26 SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood 2002 2.34
27 Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res 2003 2.28
28 N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer. J Natl Cancer Inst 2009 2.22
29 BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors. J Clin Oncol 2010 2.18
30 Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer. Cancer Res 2008 2.16
31 Genomic and epigenomic integration identifies a prognostic signature in colon cancer. Clin Cancer Res 2011 2.06
32 Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Res 2003 2.04
33 Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res 2003 2.03
34 Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res 2003 2.03
35 Promoter hypermethylation of resected bronchial margins: a field defect of changes? Clin Cancer Res 2004 1.93
36 Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines. Cancer Biol Ther 2003 1.88
37 Defining a gene promoter methylation signature in sputum for lung cancer risk assessment. Clin Cancer Res 2012 1.80
38 Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer. Cancer Res 2009 1.80
39 The fundamental role of epigenetics in hematopoietic malignancies. Blood Rev 2005 1.79
40 Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas. Carcinogenesis 2003 1.78
41 GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clin Cancer Res 2009 1.78
42 Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet 2003 1.77
43 hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site. Cancer Res 2007 1.77
44 Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. PLoS Med 2008 1.70
45 Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells. Cancer Res 2008 1.69
46 Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types. Cancer Biol Ther 2007 1.69
47 Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care. J Acquir Immune Defic Syndr 2006 1.66
48 Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Cancer Res 2004 1.66
49 Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. J Natl Cancer Inst 2007 1.65
50 Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer. Ann Surg Oncol 2003 1.60
51 Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res 2008 1.51
52 Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer. Oncogene 2004 1.49
53 Colorectal cancer epigenetics: complex simplicity. J Clin Oncol 2011 1.47
54 Abnormalities of the APC/beta-catenin pathway in endometrial cancer. Oncogene 2002 1.46
55 Hypermethylation of the GATA genes in lung cancer. Clin Cancer Res 2004 1.45
56 Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer. Cancer Res 2002 1.45
57 SOX17 antagonizes WNT/β-catenin signaling pathway in hepatocellular carcinoma. Epigenetics 2010 1.45
58 Methylation-specific PCR unraveled. Cell Oncol 2004 1.44
59 Lung cancer in never smokers: molecular profiles and therapeutic implications. Clin Cancer Res 2009 1.44
60 The CpG island methylator phenotype in colorectal cancer: progress and problems. Biochim Biophys Acta 2011 1.43
61 Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int J Cancer 2003 1.43
62 Arsenic in drinking water and lung cancer: a systematic review. Environ Res 2008 1.43
63 Cruciferous vegetable consumption and lung cancer risk: a systematic review. Cancer Epidemiol Biomarkers Prev 2009 1.38
64 Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come. J Thorac Cardiovasc Surg 2005 1.37
65 Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res 2002 1.37
66 K-ras mutations and RASSF1A promoter methylation in colorectal cancer. Oncogene 2002 1.36
67 Analysis of promoter CpG island hypermethylation in cancer: location, location, location! Clin Cancer Res 2011 1.33
68 Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. Carcinogenesis 2007 1.32
69 Carotenoids and the risk of developing lung cancer: a systematic review. Am J Clin Nutr 2008 1.31
70 Cancer epigenetics and methylation. Science 2002 1.31
71 Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis 2008 1.29
72 MS-qFRET: a quantum dot-based method for analysis of DNA methylation. Genome Res 2009 1.28
73 Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus. Clin Cancer Res 2006 1.26
74 Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. Mod Pathol 2005 1.26
75 The epigenetic promise for prostate cancer diagnosis. Prostate 2011 1.26
76 Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme. J Neurooncol 2006 1.26
77 Hypermethylation in histologically distinct classes of breast cancer. Clin Cancer Res 2004 1.25
78 CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. Carcinogenesis 2005 1.23
79 Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. J Pathol 2014 1.22
80 Early life exposure to famine and colorectal cancer risk: a role for epigenetic mechanisms. PLoS One 2009 1.21
81 The CpG island methylator phenotype: what's in a name? Cancer Res 2013 1.20
82 Identification of epigenetically silenced genes in tumor endothelial cells. Cancer Res 2007 1.20
83 Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer. Cancer Res 2004 1.20
84 Beyond genetics: epigenetic code in chronic kidney disease. Kidney Int 2010 1.18
85 Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia. Ann Hematol 2005 1.17
86 Adulthood consumption of preserved and nonpreserved vegetables and the risk of nasopharyngeal carcinoma: a systematic review. Int J Cancer 2006 1.16
87 DNA methylation mapping by tag-modified bisulfite genomic sequencing. Anal Biochem 2006 1.15
88 Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat Genet 2003 1.14
89 Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung. Clin Cancer Res 2008 1.14
90 Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation. Leuk Lymphoma 2010 1.13
91 Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Cancer Res 2006 1.12
92 Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer 2006 1.12
93 Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. J Gastrointest Surg 2008 1.12
94 Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus. Cancer Res 2010 1.10
95 Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies. Cancer Res 2009 1.09
96 Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer. J Pathol 2013 1.09
97 DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus. Am J Gastroenterol 2009 1.08
98 Promoter methylation of HIN-1 in the progression to esophageal squamous cancer. Epigenetics 2008 1.08
99 Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation. Cancer Res 2002 1.07
100 Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics 2012 1.07
101 Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells. Cancer Biol Ther 2004 1.06
102 WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. Mol Biol Cell 2007 1.05
103 Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. J Pathol 2003 1.04
104 Promoter methylation precedes chromosomal alterations in colorectal cancer development. Cell Oncol 2006 1.03
105 Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21. Carcinogenesis 2009 1.03
106 Methylated tumor-specific DNA as a plasma biomarker in patients with glioma. Cancer Invest 2006 1.02
107 A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors. Clin Cancer Res 2009 1.02
108 Epigenetic inactivation of galanin receptor 1 in head and neck cancer. Clin Cancer Res 2008 1.02
109 Alcohol consumption and the risk of nasopharyngeal carcinoma: a systematic review. Nutr Cancer 2009 1.02
110 Cancer as a manifestation of aberrant chromatin structure. Cancer J 2007 1.01
111 Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. Ann Surg 2003 1.01
112 The clinical application of targeting cancer through histone acetylation and hypomethylation. Clin Cancer Res 2004 1.01
113 Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. Am J Pathol 2009 1.00
114 CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas. Blood 2002 0.99
115 CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC. Clin Cancer Res 2013 0.99
116 Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene 2005 0.99
117 Effect of DNA methylation on identification of aggressive prostate cancer. Urology 2008 0.98
118 Clustering of hypermethylated genes in neuroblastoma. Genes Chromosomes Cancer 2003 0.98
119 Methylation-specific polymerase chain reaction. Methods Mol Med 2005 0.98
120 Methylation-specific PCR. Methods Mol Biol 2009 0.97
121 Methylation of TFPI-2 is an early event of esophageal carcinogenesis. Epigenomics 2012 0.95
122 Frequent inactivation of cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines. Clin Cancer Res 2013 0.94
123 Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms. Surgery 2003 0.94
124 Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. Int J Cancer 2007 0.93
125 SOX17 methylation inhibits its antagonism of Wnt signaling pathway in lung cancer. Discov Med 2012 0.93
126 An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1. Gastroenterology 2008 0.92
127 Aberrant DNA methylation of the transcription factor C/EBPalpha in acute myelogenous leukemia. Leuk Res 2008 0.92
128 Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density. Genome Res 2002 0.92
129 Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia. Epigenetics 2010 0.91
130 Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. Int J Cancer 2011 0.91
131 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer. J Mol Diagn 2012 0.90
132 Epigenetic silencing of CXCL14 induced colorectal cancer migration and invasion. Discov Med 2013 0.89
133 Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine. Cancer Metastasis Rev 2014 0.89
134 Gefitinib-sensitizing mutation in esophageal carcinoma cell line Kyse450. Cancer Biol Ther 2006 0.89
135 DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant 2014 0.88
136 Single-tube analysis of DNA methylation with silica superparamagnetic beads. Clin Chem 2010 0.87
137 Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection. Chembiochem 2010 0.87
138 Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-β signalling. J Cell Mol Med 2014 0.87
139 Promoter CpG island methylation markers in colorectal cancer: the road ahead. Epigenomics 2012 0.87
140 DNA methylation analysis on a droplet-in-oil PCR array. Lab Chip 2009 0.86
141 Promoter hypermethylation in sentinel lymph nodes as a marker for breast cancer recurrence. Breast Cancer Res Treat 2008 0.86
142 Predictive value of CHFR and MLH1 methylation in human gastric cancer. Gastric Cancer 2014 0.86
143 CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer. Int J Cancer 2013 0.85
144 Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior. J Gastrointest Surg 2003 0.84
145 Array-based DNA methylation profiling in acute myeloid leukaemia. Br J Haematol 2011 0.84
146 Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer. Clin Cancer Res 2014 0.83
147 Epigenetic silencing of multiple genes in primary CNS lymphoma. Int J Cancer 2006 0.83
148 DNA-intercalators causing rapid re-expression of methylated and silenced genes in cancer cells. Oncotarget 2013 0.82
149 Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. Chest 2010 0.82
150 Can we improve the cytologic examination of malignant pleural effusions using molecular analysis? Ann Thorac Surg 2005 0.81
151 Epigenetic changes associated with neoplasms of the exocrine and endocrine pancreas. Discov Med 2014 0.81
152 Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma. Genes Chromosomes Cancer 2009 0.81
153 Epigenetic changes and functional study of HOXA11 in human gastric cancer. Epigenomics 2015 0.81
154 Standardized approach for microsatellite instability detection in gastric carcinomas. Hum Pathol 2004 0.80
155 Semiautomatic detection of DNA methylation at CpG islands. Biotechniques 2005 0.80
156 Methylation-associated dysregulation of the suppressor of cytokine signaling-3 gene in multiple myeloma. Epigenetics 2011 0.79
157 Prospective CT screening for lung cancer in a high-risk population: HIV-positive smokers. J Thorac Oncol 2014 0.78
158 Common genetic evolutionary pathways in familial adenomatous polyposis tumors. Cancer Res 2003 0.78
159 Pharmacoepigenomics in colorectal cancer: a step forward in predicting prognosis and treatment response. Pharmacogenomics 2008 0.78
160 Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer. Epigenetics 2015 0.78
161 Alterations of the p16/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus. Hum Pathol 2002 0.78
162 Distinct epigenetic mechanisms distinguish TMPRSS2-ERG fusion-positive and -negative prostate cancers. Cancer Discov 2012 0.77
163 Viewing the epigenetics of colorectal cancer through the window of folic acid effects. Cancer Prev Res (Phila) 2010 0.77
164 CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer. Cancer Biol Ther 2012 0.77
165 Sequence of administration and methylation of SOCS3 may govern response to gemtuzumab ozogamicin in combination with conventional chemotherapy in patients with refractory or relapsed acute myelogenous leukemia (AML). Am J Hematol 2010 0.76
166 Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence. Cancer Prev Res (Phila) 2011 0.76
167 Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma. Epigenetics 2010 0.76
168 p53 expression after treatment with zebularine is not due to demethylation. Cancer Res 2006 0.75
169 P15INK4B is not mutated in adult familial myelodysplastic syndromes. Br J Haematol 2002 0.75
170 Correction: A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET). Oncotarget 2017 0.75
171 Welcome to Epigenomics. Epigenomics 2009 0.75