The mutational load with epistatic gene interactions in fitness.

PubWeight™: 7.75‹?› | Rank: Top 0.1%

🔗 View Article (PMID 17248359)

Published in Genetics on December 01, 1966

Authors

M Kimura1, T Maruyama

Author Affiliations

1: National Institute of Genetics, Mishima, Japan.

Articles citing this

(truncated to the top 100)

Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Genetics (1997) 20.93

The effect of deleterious mutations on neutral molecular variation. Genetics (1993) 20.07

Estimate of the mutation rate per nucleotide in humans. Genetics (2000) 15.08

Rates of spontaneous mutation. Genetics (1998) 14.89

The pattern of neutral molecular variation under the background selection model. Genetics (1995) 5.03

The genetic structure of natural populations of Drosophila melanogaster. V. Coupling-repulsion effect of spontaneous mutant polygenes controlling viability. Genetics (1968) 4.65

Deleterious background selection with recombination. Genetics (1995) 4.45

The high spontaneous mutation rate: is it a health risk? Proc Natl Acad Sci U S A (1997) 3.85

The effects of Hill-Robertson interference between weakly selected mutations on patterns of molecular evolution and variation. Genetics (2000) 3.24

The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. VII Synergistic Interaction of Spontaneous Mutant Polygenes Controlling Viability. Genetics (1969) 3.14

The solitary wave of asexual evolution. Proc Natl Acad Sci U S A (2003) 2.97

How can the low levels of DNA sequence variation in regions of the drosophila genome with low recombination rates be explained? Proc Natl Acad Sci U S A (1994) 2.61

Deleterious mutations, apparent stabilizing selection and the maintenance of quantitative variation. Genetics (1992) 2.59

Theory of lethal mutagenesis for viruses. J Virol (2007) 2.20

Selection, load and inbreeding depression in a large metapopulation. Genetics (2002) 2.05

The degeneration of asexual haploid populations and the speed of Muller's ratchet. Genetics (2000) 2.04

Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae. Genetics (2001) 2.03

Quasispecies theory in the context of population genetics. BMC Evol Biol (2005) 2.02

Rates and fitness consequences of new mutations in humans. Genetics (2012) 2.01

Muller's ratchet under epistatic selection. Genetics (1994) 2.01

Efficiency of truncation selection. Proc Natl Acad Sci U S A (1979) 2.00

The effect of deleterious alleles on adaptation in asexual populations. Genetics (2002) 1.94

Coevolution of costly mate choice and condition-dependent display of good genes. Proc Biol Sci (2002) 1.86

The approach to mutation-selection balance in an infinite asexual population, and the evolution of mutation rates. Proc Biol Sci (1999) 1.85

Evolution of recombination due to random drift. Genetics (2005) 1.83

Hamilton's indicators of the force of selection. Proc Natl Acad Sci U S A (2005) 1.81

Rates of nucleotide substitution in sexual and anciently asexual rotifers. Proc Natl Acad Sci U S A (2001) 1.76

Mechanisms of genetic robustness in RNA viruses. EMBO Rep (2006) 1.67

The effects of deleterious mutations on evolution at linked sites. Genetics (2012) 1.59

Selection for robustness in mutagenized RNA viruses. PLoS Genet (2007) 1.58

An experimental test for synergistic epistasis and its application in Chlamydomonas. Genetics (1997) 1.54

The evolution of mutation rate in finite asexual populations. Genetics (2005) 1.52

Inbreeding depression and inferred deleterious-mutation parameters in Daphnia. Genetics (1997) 1.52

Effective size and polymorphism of linked neutral loci in populations under directional selection. Genetics (1998) 1.52

Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7. Genetics (2002) 1.50

The evolution of sex: A new hypothesis based on mitochondrial mutational erosion: Mitochondrial mutational erosion in ancestral eukaryotes would favor the evolution of sex, harnessing nuclear recombination to optimize compensatory nuclear coadaptation. Bioessays (2015) 1.46

Imperfect genes, Fisherian mutation and the evolution of sex. Genetics (1997) 1.43

The evolution of genome compression and genomic novelty in RNA viruses. Genome Res (2007) 1.36

The fate of transposable elements in asexual populations. Genetics (2006) 1.28

The cost of replication fidelity in an RNA virus. Proc Natl Acad Sci U S A (2005) 1.28

Mutation load under vegetative reproduction and cytoplasmic inheritance. Genetics (1994) 1.23

Fitting background-selection predictions to levels of nucleotide variation and divergence along the human autosomes. Genome Res (2005) 1.22

The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. IX:a Prediction of Genetic Equilibrium. Genetics (1971) 1.17

Recessive mutations and the maintenance of sex in structured populations. Genetics (2001) 1.15

The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation. Genetics (2009) 1.12

Unpredictable fitness transitions between haploid and diploid strains of the genetically loaded yeast Saccharomyces cerevisiae. Genetics (1999) 1.12

Evolution at a high imposed mutation rate: adaptation obscures the load in phage T7. Genetics (2009) 1.11

Interactions between stressful environment and gene deletions alleviate the expected average loss of fitness in yeast. Genetics (2008) 1.09

The age-specific force of natural selection and biodemographic walls of death. Proc Natl Acad Sci U S A (2013) 1.09

A resolution of the mutation load paradox in humans. Genetics (2012) 1.07

Lethal mutagenesis of bacteria. Genetics (2008) 1.05

Epistasis and the mutation load: a measurement-theoretical approach. Genetics (2001) 1.03

Genetic linkage and natural selection. Philos Trans R Soc Lond B Biol Sci (2010) 1.02

Mutation and the evolution of recombination. Philos Trans R Soc Lond B Biol Sci (2010) 1.02

Epistasis in monkeyflowers. Genetics (2005) 1.02

Consequences of nonadaptive alterations in cancer. Mol Biol Cell (2003) 1.00

Muller's ratchet and the degeneration of Y chromosomes: a simulation study. Genetics (2008) 1.00

Evolutionary consequences of mutation and selection within an individual. Genetics (1995) 0.99

Genetic load in sexual and asexual diploids: segregation, dominance and genetic drift. Genetics (2007) 0.99

Evolution can favor antagonistic epistasis. Genetics (2007) 0.99

Parasites and mutational load: an experimental test of a pluralistic theory for the evolution of sex. Proc Biol Sci (2005) 0.98

Lethal mutagenesis and evolutionary epidemiology. Philos Trans R Soc Lond B Biol Sci (2010) 0.98

Highly fit ancestors of a partly sexual haploid population. Theor Popul Biol (2006) 0.97

Purifying selection in mitochondria, free-living and obligate intracellular proteobacteria. BMC Evol Biol (2007) 0.96

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice. Genome Res (2015) 0.96

The efficiency of close inbreeding to reduce genetic adaptation to captivity. Heredity (Edinb) (2014) 0.96

The evolution of condition-dependent sex in the face of high costs. Genetics (2007) 0.96

Does mutation rate depend on itself. PLoS Biol (2008) 0.96

King's formula for the mutation load with epistasis. Genetics (1988) 0.95

Gene duplication, gene conversion and the evolution of the Y chromosome. Genetics (2010) 0.94

Deleterious passengers in adapting populations. Genetics (2014) 0.94

Exact solution of the Eigen model with general fitness functions and degradation rates. Proc Natl Acad Sci U S A (2006) 0.94

Loss of least-loaded class in asexual populations due to drift and epistasis. Genetics (2008) 0.93

Fisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype space. Evolution (2013) 0.92

Phenotypic effect of mutations in evolving populations of RNA molecules. BMC Evol Biol (2010) 0.92

Stabilizing selection, purifying selection, and mutational bias in finite populations. Genetics (2013) 0.92

Interlocus nonrandom association of polymorphisms in Drosophila chemoreceptor genes. Proc Natl Acad Sci U S A (2004) 0.91

Quasispecies theory for horizontal gene transfer and recombination. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 0.89

Meiosis and the evolution of recombination at low mutation rates. Genetics (2000) 0.89

Spatial heterogeneity in the strength of selection against deleterious alleles and the mutation load. Heredity (Edinb) (2012) 0.89

A model for damage load and its implications for the evolution of bacterial aging. PLoS Genet (2010) 0.86

Evolutionary shaping of demographic schedules. Proc Natl Acad Sci U S A (2014) 0.83

A coalescent model of background selection with recombination, demography and variation in selection coefficients. Heredity (Edinb) (2012) 0.82

Lethal mutagenesis in a structured environment. J Theor Biol (2009) 0.82

Dynamic epistasis for different alleles of the same gene. Proc Natl Acad Sci U S A (2012) 0.82

Population genetics from 1966 to 2016. Heredity (Edinb) (2016) 0.82

Analytical solution of the evolution dynamics on a multiplicative-fitness landscape. J Math Biol (2003) 0.81

Fixation probability of rare nonmutator and evolution of mutation rates. Ecol Evol (2016) 0.81

How does epistasis influence the response to selection? Heredity (Edinb) (2016) 0.81

Distortions in genealogies due to purifying selection and recombination. Genetics (2013) 0.81

AprioriGWAS, a new pattern mining strategy for detecting genetic variants associated with disease through interaction effects. PLoS Comput Biol (2014) 0.80

The disparity mutagenesis model predicts rescue of living things from catastrophic errors. Front Genet (2014) 0.80

Disentangling mechanisms involved in the adaptation of photosynthetic microorganisms to the extreme sulphureous water from Los Baños de Vilo (S Spain). Microb Ecol (2013) 0.79

Benefits of a Recombination-Proficient Escherichia coli System for Adaptive Laboratory Evolution. Appl Environ Microbiol (2016) 0.79

The optimal burst of mutation to create a phenotype. J Theor Biol (2008) 0.78

Rapid adaptation of some phytoplankton species to osmium as a result of spontaneous mutations. Ecotoxicology (2013) 0.77

The structure of allelic diversity in the presence of purifying selection. Theor Popul Biol (2011) 0.77

The Effects of Background and Interference Selection on Patterns of Genetic Variation in Subdivided Populations. Genetics (2015) 0.77

Empirical complexities in the genetic foundations of lethal mutagenesis. Genetics (2013) 0.77

On the (un)predictability of a large intragenic fitness landscape. Proc Natl Acad Sci U S A (2016) 0.76

Articles by these authors

(truncated to the top 100)

The Average Number of Generations until Fixation of a Mutant Gene in a Finite Population. Genetics (1969) 21.57

Effective number of alleles in a subdivided population. Theor Popul Biol (1970) 8.14

The substitutional load in a finite population. Heredity (Edinb) (1969) 7.56

Attainment of Quasi Linkage Equilibrium When Gene Frequencies Are Changing by Natural Selection. Genetics (1965) 7.43

Population bottlenecks and nonequilibrium models in population genetics. II. Number of alleles in a small population that was formed by a recent bottleneck. Genetics (1985) 5.35

Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament. Spine (Phila Pa 1976) (1981) 4.95

An approach to population and evolutionary genetic theory for genes in mitochondria and chloroplasts, and some results. Genetics (1983) 4.85

Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res (1986) 4.83

Pattern of neutral polymorphism in a geographically structured population. Genet Res (1971) 4.65

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol (2000) 4.27

Codon usage tabulated from the GenBank Genetic Sequence Data. Nucleic Acids Res (1988) 4.26

Organelle gene diversity under migration, mutation, and drift: equilibrium expectations, approach to equilibrium, effects of heteroplasmic cells, and comparison to nuclear genes. Genetics (1989) 3.96

Population bottlenecks and nonequilibrium models in population genetics. I. Allele numbers when populations evolve from zero variability. Genetics (1984) 3.13

Rate of decrease of genetic variability in a two-dimensional continuous population of finite size. Genetics (1972) 2.90

Analysis of population structure. II. Two-dimensional stepping stone models of finite length and other geographically structured populations. Ann Hum Genet (1971) 2.86

Letters to the editors: Lewontin-Krakauer test for neutral genes. Genetics (1975) 2.59

Models of evolution of reproductive isolation. Genetics (1983) 2.58

Metabolic assessment of gliomas using 11C-methionine, [18F] fluorodeoxyglucose, and 11C-choline positron-emission tomography. AJNR Am J Neuroradiol (2008) 2.55

Aeropyrum pernix gen. nov., sp. nov., a novel aerobic hyperthermophilic archaeon growing at temperatures up to 100 degrees C. Int J Syst Bacteriol (1996) 2.52

On the fixation probability of mutant genes in a subdivided population. Genet Res (1970) 2.45

Polymorphism and loss of duplicate gene expression: a theoretical study with application of tetraploid fish. Proc Natl Acad Sci U S A (1979) 2.40

TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet (2001) 2.37

Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev Biol (1996) 2.30

The first successful isolations and identification of Yersinia enterocolitica from human cases in Japan. Jpn J Microbiol (1972) 2.10

The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology (2000) 2.08

An outbreak of enteritis due to Yersinia enterocolitica occurring at a junior high school. Jpn J Microbiol (1973) 2.02

Recent development of the neutral theory viewed from the Wrightian tradition of theoretical population genetics. Proc Natl Acad Sci U S A (1991) 1.93

Molecular evolutionary clock and the neutral theory. J Mol Evol (1987) 1.90

Population bottlenecks and nonequilibrium models in population genetics. III. Genic homozygosity in populations which experience periodic bottlenecks. Genetics (1985) 1.84

Isolation of Yersinia enterocolitica and Yersinia pseudotuberculosis from swine, cattle and rats at an abattoir. Jpn J Microbiol (1974) 1.82

The neutral theory of molecular evolution: a review of recent evidence. Jpn J Genet (1991) 1.78

The age of an allele in a finite population. Genet Res (1974) 1.74

Genetic drift in a cline. Genetics (1975) 1.72

Direct detection of Bacillus anthracis DNA in animals by polymerase chain reaction. J Clin Microbiol (1993) 1.70

Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res (1999) 1.65

Correlation between epithelial cell infectivity in vitro and O-antigen groups of Yersinia enterocolitica. Microbiol Immunol (1977) 1.64

Retinal complications during interferon therapy for chronic hepatitis C. Am J Gastroenterol (1996) 1.60

Thermotoga petrophila sp. nov. and Thermotoga naphthophila sp. nov., two hyperthermophilic bacteria from the Kubiki oil reservoir in Niigata, Japan. Int J Syst Evol Microbiol (2001) 1.58

Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists. Biochem Pharmacol (2001) 1.56

Evidence for the neutral hypothesis of protein polymorphism. Science (1972) 1.54

The extent of lymph node dissection for colon carcinoma: the potential impact on laparoscopic surgery. Cancer (1997) 1.49

Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma. Br J Cancer (2013) 1.48

A case of infantile Dubin-Johnson syndrome with high CT attenuation in the liver. Pediatr Radiol (1997) 1.47

Effects of uremic toxins and fatty acids on serum protein binding of furosemide: possible mechanism of the binding defect in uremia. Clin Chem (1997) 1.47

Sinus arrest during tacrolimus (FK506) and digitalis treatment in a bone marrow transplant recipient. Transplantation (1997) 1.46

Archeology, population genetics and studies of human racial ancestry. Am J Phys Anthropol (1976) 1.46

A simple proof that certain quantities are independent of the geographical structure of population. Theor Popul Biol (1974) 1.46

Growth requirements of hyperthermophilic sulfur-dependent heterotrophic archaea isolated from a shallow submarine geothermal system with reference to their essential amino acids. Appl Environ Microbiol (1994) 1.44

Rare variant alleles in the light of the neutral theory. Mol Biol Evol (1983) 1.44

Kinetic properties of the pentobarbitone-gated chloride current in frog sensory neurones. J Physiol (1987) 1.43

A proposal for grading nasomucosal injury as a complication of transnasal endoscopy. Endoscopy (2008) 1.42

Bracing for scoliosis in 2014: state of the art. Eur J Phys Rehabil Med (2014) 1.41

Should we discard the graft? Analysis of the renal grafts with a total ischemia time of more than 24 hours donated after cardiac death. Am J Transplant (2007) 1.40

Observation of B(0)(s)-->Psi(2S)Phi and measurement of the ratio of branching fractions Beta(B(0)(s)-->Psi(2S)Phi)/Beta(B(0)(s)-->J/PsiPhi). Phys Rev Lett (2006) 1.40

An outbreak of acute enteritis due to Campylobacter fetus subspecies jejuni at a nursery school of Tokyo. Microbiol Immunol (1980) 1.40

Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development. Gut (2004) 1.39

The number of neutral alleles maintained in a finite, geographically structured population. Theor Popul Biol (1971) 1.37

Analysis of population structure. I. One-dimensional stepping-stone models of finite length. Ann Hum Genet (1970) 1.37

Direct and rapid detection of Erysipelothrix rhusiopathiae DNA in animals by PCR. J Clin Microbiol (1994) 1.35

Heterozygous effects of x-ray induced mutations on viability of Drosophila melanogaster. Mutat Res (1975) 1.34

'SOSORT consensus paper on brace action: TLSO biomechanics of correction (investigating the rationale for force vector selection)'. Scoliosis (2006) 1.33

Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset. Diabetologia (2009) 1.33

Detection of cardiovascular risk factors by indices of obesity obtained from anthropometry and dual-energy X-ray absorptiometry in Japanese individuals. Int J Obes Relat Metab Disord (2003) 1.32

Effects of periodic selection on gene diversity in organelle genomes and other systems without recombination. Genetics (1991) 1.30

Amino Acid Requirements of Two Hyperthermophilic Archaeal Isolates from Deep-Sea Vents, Desulfurococcus Strain SY and Pyrococcus Strain GB-D. Appl Environ Microbiol (1993) 1.28

Host-dependent evolution of three papova viruses. Nature (1980) 1.28

Theoretical study of genetic variability, assuming stepwise production of neutral and very slightly deleterious mutations. Proc Natl Acad Sci U S A (1978) 1.26

Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol (1997) 1.25

Effects and virulences of recombinant vaccinia viruses derived from attenuated strains that express the human T-cell leukemia virus type I envelope gene. J Virol (1988) 1.23

Relationship between the presence of 44 megadalton plasmid and calcium dependency or autoagglutination to serotype O3 strains of Yersinia enterocolitica. Nihon Juigaku Zasshi (1986) 1.23

Event based and time based prospective memory in Parkinson's disease. J Neurol Neurosurg Psychiatry (2003) 1.22

Development of heat-stable recombinant rinderpest vaccine. Arch Virol (1989) 1.22

Outbreaks of acute enteritis due to heat-stable enterotoxin-producing strains of Escherichia coli. Microbiol Immunol (1977) 1.21

Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides. Proc Natl Acad Sci U S A (1991) 1.20

Barnacle cement proteins. Importance of disulfide bonds in their insolubility. J Biol Chem (2000) 1.20

The effect of D-glucose on the electrical potential profile across the proximal tubule of newt kidney. Biochim Biophys Acta (1972) 1.20

Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon. J Pharm Sci (1997) 1.18

The age of a rare mutant gene in a large population. Am J Hum Genet (1974) 1.18

The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. IX:a Prediction of Genetic Equilibrium. Genetics (1971) 1.17

Observations on the correlation between pathogenicity and serovars of Yersinia enterocolitica by the assay applying cell culture system and experimental mouse infection. Contrib Microbiol Immunol (1979) 1.17

Hyperamylasaemia after duodenoscopy and retrograde cholangiopancreatography. Gut (1976) 1.17

Partial sequence of ribulose-1,5-bisphosphate carboxylase/oxygenase and the phylogeny of Prochloron and Prochlorococcus (Prochlorales). J Mol Evol (1995) 1.17

The neutral theory of molecular evolution and the world view of the neutralists. Genome (1989) 1.16

Different contribution of class II HLA in fulminant and typical autoimmune type 1 diabetes mellitus. Diabetologia (2005) 1.16

Kawasaki disease followed by haemophagocytic syndrome. Eur J Pediatr (1998) 1.15

Degradation of the cyanobacterial hepatotoxin microcystin by a new bacterium isolated from a hypertrophic lake. Environ Toxicol (2001) 1.15

PCR-based random amplified polymorphic DNA fingerprinting of Yersinia pseudotuberculosis and its practical applications. J Clin Microbiol (1994) 1.14

Theoretical bases for karyotype evolution. II. The fusion burst in man and mouse. Jpn J Genet (1988) 1.14

The average number and the variance of generations at particular gene frequency in the course of fixation of a mutant gene in a finite population. Genet Res (1972) 1.14

[Biological characteristics and pathogenicity of Yersinia enterocolitica. 2. Experimental infection in monkeys and pathological observation]. Nihon Saikingaku Zasshi (1973) 1.14

Multipotent marrow stromal cell line is able to induce hematopoiesis in vivo. J Cell Physiol (1992) 1.13

A new method for direct detection of Listeria monocytogenes from foods by PCR. Appl Environ Microbiol (1995) 1.11

Geographical unifromity of selectively neutral polymorphisms. Nature (1974) 1.11

Beta 1 integrin-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients. J Exp Med (1993) 1.11

First observation of the decay Bs0-->Ds-Ds+ and measurement of its branching ratio. Phys Rev Lett (2008) 1.11

Distribution of gene frequencies in a geographically structured finite population. I. Distribution of neutral genes and of genes with small efect. Ann Hum Genet (1972) 1.11

Role of arg-410 and tyr-411 in human serum albumin for ligand binding and esterase-like activity. Biochem J (2000) 1.10

Radiofrequency catheter ablation of left ventricular outflow tract tachycardia: report of two cases. J Cardiovasc Electrophysiol (1998) 1.10

Phenogram enumeration: the number of regular genotype-phenotype correspondences in genetic systems. J Theor Biol (1968) 1.09

Serotypes of Erysipelothrix rhusiopathiae strains isolated from slaughter pigs affected with chronic erysipelas. Nihon Juigaku Zasshi (1984) 1.08