Genetics of arterial hypertension and hypotension.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMID 17262198)

Published in Naunyn Schmiedebergs Arch Pharmacol on January 30, 2007

Authors

Dieter Rosskopf1, Markus Schürks, Christian Rimmbach, Rafael Schäfers

Author Affiliations

1: Department Pharmacology, Research Center for Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University Greifswald, Friedrich Loeffler Str. 23d, 17487 Greifswald, Germany. dieter.rosskopf@uni-greifswald.de

Articles citing this

Rgs5 targeting leads to chronic low blood pressure and a lean body habitus. Mol Cell Biol (2008) 1.19

Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade. Pharmacogenomics J (2015) 0.89

Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension. BMC Genet (2011) 0.88

Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. J Biol Chem (2012) 0.84

Construction and analysis of the protein-protein interaction network related to essential hypertension. BMC Syst Biol (2013) 0.82

Sex differences in the blood antioxidant defense system in juvenile rats with various genetic predispositions to hypertension. Hypertens Res (2015) 0.78

Are "functionally related polymorphisms" of renin-angiotensin-aldosterone system gene polymorphisms associated with hypertension? BMC Cardiovasc Disord (2010) 0.77

Network-based analysis of the sphingolipid metabolism in hypertension. Front Genet (2015) 0.77

Pharmacogenomics and migraine: possible implications. J Headache Pain (2008) 0.76

Anacardium occidentale Linn. (Anacardiaceae) stem bark extract induces hypotensive and cardio-inhibitory effects in experimental animal models. Afr J Tradit Complement Altern Med (2011) 0.75

β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant. Pharmacogenomics (2010) 0.75

Association of G-protein β3 subunit C825T polymorphism with essential hypertension: evidence from 63 729 subjects. J Hum Hypertens (2017) 0.75

Articles cited by this

(truncated to the top 100)

A comprehensive review of genetic association studies. Genet Med (2002) 16.75

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest (1990) 10.35

Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension (2000) 8.84

Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71

Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol (2003) 8.68

Molecular basis of human hypertension: role of angiotensinogen. Cell (1992) 6.07

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet (1996) 5.95

Hypertension treatment and control in five European countries, Canada, and the United States. Hypertension (2003) 5.63

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature (1992) 5.56

Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell (1994) 5.29

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J (1996) 5.24

Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45

Mammalian G proteins and their cell type specific functions. Physiol Rev (2005) 4.40

Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry (1994) 4.33

Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science (1987) 4.32

Three ways to make a vesicle. Nat Rev Mol Cell Biol (2000) 3.98

Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation (1998) 3.89

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet (1996) 3.84

A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet (1993) 3.78

Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitelman syndromes. J Pediatr (1992) 3.78

Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. Nat Genet (1996) 3.71

WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest (2003) 3.67

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet (2006) 3.57

Genome-wide mapping of human loci for essential hypertension. Lancet (2003) 3.53

Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet (1997) 3.51

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A (2003) 3.48

A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature (1992) 3.40

Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation (2005) 3.14

Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med (1994) 3.11

Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet (1998) 2.98

Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science (1988) 2.93

Freely associating. Nat Genet (1999) 2.91

Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure. Nat Genet (2001) 2.87

Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med (1994) 2.80

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem (1993) 2.78

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem (1999) 2.78

Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet (1997) 2.78

A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. Am J Hypertens (2003) 2.76

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68

Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet (1987) 2.50

Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell (1995) 2.47

Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension (1994) 2.41

Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J (1996) 2.39

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med (2003) 2.33

Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. Hypertension (2004) 2.32

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Hum Mol Genet (2005) 2.27

A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest (1997) 2.23

Posterior fossa neurovascular anomalies in essential hypertension. Lancet (1994) 2.22

Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science (2000) 2.21

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. FASEB J (2001) 2.13

Localization of a small genomic region associated with elevated ACE. Am J Hum Genet (2000) 2.13

A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci U S A (1995) 2.10

The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis. J Biol Chem (1997) 2.10

Mutations in the Na-Cl cotransporter reduce blood pressure in humans. Hypertension (2001) 1.99

RGS2/G0S8 is a selective inhibitor of Gqalpha function. Proc Natl Acad Sci U S A (1997) 1.98

Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther (2003) 1.96

Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J Clin Invest (1998) 1.94

ACE polymorphisms. Circ Res (2006) 1.92

ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites. Arterioscler Thromb Vasc Biol (2000) 1.92

Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet (2000) 1.90

G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci U S A (2002) 1.87

Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. J Clin Invest (1996) 1.83

Pharmacogenomics of blood pressure response to antihypertensive treatment. J Hypertens (2005) 1.77

Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol (1999) 1.76

Brief report: Liddle's syndrome revisited--a disorder of sodium reabsorption in the distal tubule. N Engl J Med (1994) 1.74

A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med (2005) 1.74

Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nat Genet (1998) 1.73

Adducin: structure, function and regulation. Cell Mol Life Sci (2000) 1.71

The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol (1977) 1.70

Polymorphisms of the beta2 -adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studies. J Hypertens (2002) 1.68

Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males. Circulation (1998) 1.65

An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gbeta3 C825T polymorphism. J Hypertens (2003) 1.64

The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects. Clin Sci (Lond) (2000) 1.64

RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III. Nature (2001) 1.62

Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci (1998) 1.62

Intrarenal dopamine: a key signal in the interactive regulation of sodium metabolism. Annu Rev Physiol (2000) 1.61

Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension (2006) 1.61

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects. Pharmacol Ther (1990) 1.61

Dopamine-induced endocytosis of Na+,K+-ATPase is initiated by phosphorylation of Ser-18 in the rat alpha subunit and Is responsible for the decreased activity in epithelial cells. J Biol Chem (1999) 1.59

Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. Can Med Assoc J (1966) 1.58

Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke. Circulation (1999) 1.57

RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. J Biol Chem (2004) 1.57

Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. Nat Genet (1992) 1.55

Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER Project. J Hypertens (2003) 1.52

Mutation in the CYP21B gene (Ile-172----Asn) causes steroid 21-hydroxylase deficiency. Proc Natl Acad Sci U S A (1988) 1.50

Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet (1995) 1.50

Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. Am J Hum Genet (1996) 1.50

Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. Clin Pharmacol Ther (2003) 1.49

A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels. Physiol Genomics (2003) 1.46

A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet (2002) 1.46

Genetic contribution to the acute effects of angiotensin II type 1 receptor blockade. J Hypertens (2005) 1.45

A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families. Nat Genet (1996) 1.44

Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populations. Am J Hum Genet (2001) 1.43

Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation (1994) 1.43

Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London. Lancet (1998) 1.42

The adrenogenital syndrome. N Engl J Med (1963) 1.40

Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet (1997) 1.39

Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking. J Cardiovasc Pharmacol (2002) 1.38

Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking. Proc Natl Acad Sci U S A (2000) 1.38

Articles by these authors

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21

Migraine and risk of haemorrhagic stroke in women: prospective cohort study. BMJ (2010) 2.63

Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ (2008) 2.48

Migraine frequency and risk of cardiovascular disease in women. Neurology (2009) 2.47

Migraine, migraine aura, and cervical artery dissection: a systematic review and meta-analysis. Cephalalgia (2011) 2.07

Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet (2011) 1.98

Comment on "A common genetic variant is associated with adult and childhood obesity". Science (2007) 1.93

A genome-wide association study identifies three loci associated with mean platelet volume. Am J Hum Genet (2008) 1.81

Vascular risk factors, cardiovascular disease, and restless legs syndrome in women. Am J Med (2013) 1.28

Vascular risk factors, cardiovascular disease, and restless legs syndrome in men. Am J Med (2013) 1.23

Restless legs syndrome and risk of incident cardiovascular disease in women and men: prospective cohort study. BMJ Open (2012) 1.16

Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation. J Biol Chem (2006) 1.12

Migraine and functional outcome from ischemic cerebral events in women. Circulation (2010) 0.99

Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1. Pharmacogenet Genomics (2008) 0.91

Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. Prog Neuropsychopharmacol Biol Psychiatry (2009) 0.89

Safety of telmisartan in patients with arterial hypertension : an open-label observational study. Drug Saf (2004) 0.89

Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme. BMC Cancer (2013) 0.89

Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil. Drug Metab Dispos (2010) 0.88

A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility. Neurogenetics (2012) 0.88

Migraine and restless legs syndrome in men. Cephalalgia (2012) 0.87

Epigenetics in primary headaches: a new avenue for research. J Headache Pain (2008) 0.85

Selection of a common multipotent cardiovascular stem cell using the 3.4-kb MesP1 promoter fragment. Basic Res Cardiol (2012) 0.84

Low dehydroepiandrosterone sulfate is associated with increased risk of ischemic stroke among women. Stroke (2013) 0.84

Newest aspects on the association between migraine and cardiovascular disease: the role of modifying factors. Curr Pain Headache Rep (2009) 0.84

Signal transduction of somatostatin in human B lymphoblasts. Am J Physiol Cell Physiol (2002) 0.82

Restless legs syndrome and all-cause mortality in four prospective cohort studies. BMJ Open (2012) 0.81

An X chromosome association scan of the Norfolk Island genetic isolate provides evidence for a novel migraine susceptibility locus at Xq12. PLoS One (2012) 0.81

Enhanced stem cell migration mediated by VCAM-1/VLA-4 interaction improves cardiac function in virus-induced dilated cardiomyopathy. Basic Res Cardiol (2013) 0.81

Migraine, headache, and the risk of depression: Prospective cohort study. Cephalalgia (2013) 0.80

Aminoglycoside-induced suppression of CYP2C19*3 premature stop codon. Pharmacogenet Genomics (2011) 0.78

Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet (2016) 0.77

Increased numbers of bone marrow-derived cells in parathyroid adenoma. Eur J Clin Invest (2014) 0.77

Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort. Pharmacogenet Genomics (2015) 0.76

Alcohol and cluster headaches. Headache (2009) 0.76

Circulating fetuin-A and risk of ischemic stroke in women. Clin Chem (2013) 0.76

Common mechanisms in migraine and epilepsy: a comment. Arch Neurol (2008) 0.75

Migraine frequency and risk of cardiovascular disease in women. Neurology (2010) 0.75

Correction: Selectivity in Genetic Association with Sub-classified Migraine in Women. PLoS Genet (2015) 0.75

Response to: 'Association between migraine and cardiovascular mortality: Is there a temporal trend?' by Rossi et al. Cephalalgia (2013) 0.75

Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population. Thyroid (2009) 0.75

Is migraine a predictor for identifying patients at risk of stroke? Expert Rev Neurother (2011) 0.75