Published in Am J Physiol Endocrinol Metab on February 06, 2007
Neuroprotection in diet-induced ketotic rat brain after focal ischemia. J Cereb Blood Flow Metab (2008) 1.44
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The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol (2008) 1.29
Ketogenic diet improves forelimb motor function after spinal cord injury in rodents. PLoS One (2013) 0.93
Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. Neurobiol Dis (2010) 0.91
Carbohydrate-biased control of energy metabolism: the darker side of the selfish brain. Front Neuroenergetics (2011) 0.91
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Ketones suppress brain glucose consumption. Adv Exp Med Biol (2009) 0.90
Diet-induced ketosis improves cognitive performance in aged rats. Adv Exp Med Biol (2010) 0.89
Cellular Links between Neuronal Activity and Energy Homeostasis. Front Pharmacol (2012) 0.85
Cerebral Ketone Body Oxidation Is Facilitated by a High Fat Diet Enriched with Advanced Glycation End Products in Normal and Diabetic Rats. Front Neurosci (2016) 0.78
Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain. J Neurochem (2014) 0.76
Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring. Brain Behav (2014) 0.76
Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: an integrated study using (1)H- and (13)C-NMR spectroscopy. J Cereb Blood Flow Metab (2015) 0.76
The impact of acute and chronic catecholamines on respiratory responses to hypoxic stress in the rat. Pflugers Arch (2013) 0.76
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron (2003) 4.11
Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol (2009) 2.46
O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45
Resolving the motional modes that code for RNA adaptation. Science (2006) 2.15
Emergence of orphan drugs in the United States: a quantitative assessment of the first 25 years. Nat Rev Drug Discov (2010) 2.05
Topology links RNA secondary structure with global conformation, dynamics, and adaptation. Science (2010) 2.00
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J Biol Chem (2005) 1.95
Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. Int J Geriatr Psychiatry (2007) 1.81
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci (2006) 1.80
Sustained spinal cord compression: part I: time-dependent effect on long-term pathophysiology. J Bone Joint Surg Am (2003) 1.52
Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice. J Nucl Med (2002) 1.44
Neuroprotection in diet-induced ketotic rat brain after focal ischemia. J Cereb Blood Flow Metab (2008) 1.44
Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1. J Neurosci (2002) 1.43
Brain tissue oxygen concentration measurements. Antioxid Redox Signal (2007) 1.42
Hypoxic regulation of angiopoietin-2 expression in endothelial cells. J Biol Chem (2003) 1.41
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis (2009) 1.37
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol (2007) 1.36
NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings. Biopolymers (2007) 1.36
Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem (2004) 1.33
Physiologic angiodynamics in the brain. Antioxid Redox Signal (2007) 1.32
The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathol (2002) 1.29
Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia. J Appl Physiol (1985) (2002) 1.24
Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells. J Biol Chem (2002) 1.23
Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia. Mol Cell Neurosci (2008) 1.20
Characteristics of orphan drug applications that fail to achieve marketing approval in the USA. Drug Discov Today (2010) 1.18
Cerebral angiogenic factors, angiogenesis, and physiological response to chronic hypoxia differ among four commonly used mouse strains. J Appl Physiol (1985) (2007) 1.18
Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochem (2009) 1.17
Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels. Am J Physiol Regul Integr Comp Physiol (2005) 1.16
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. J Neuropathol Exp Neurol (2009) 1.15
Executive dysfunction in homebound older people with diabetes mellitus. J Am Geriatr Soc (2006) 1.09
Structure-activity relationships of novel, highly potent, selective, and orally active CCR1 antagonists. Bioorg Med Chem Lett (2007) 1.09
The Complete Mitochondrial Genome of Ctenoptilum vasava (Lepidoptera: Hesperiidae: Pyrginae) and Its Phylogenetic Implication. Comp Funct Genomics (2012) 1.09
Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells. Comp Biochem Physiol A Mol Integr Physiol (2002) 1.06
Probing Na(+)-induced changes in the HIV-1 TAR conformational dynamics using NMR residual dipolar couplings: new insights into the role of counterions and electrostatic interactions in adaptive recognition. Biochemistry (2007) 1.05
C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. Am J Physiol Regul Integr Comp Physiol (2002) 1.05
Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease. Neurology (2003) 1.04
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. J Neurol Sci (2009) 1.04
Orphan products: an emerging trend in drug approvals. Nat Rev Drug Discov (2010) 1.04
Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function. Am J Physiol Heart Circ Physiol (2013) 1.01
What the Orphan Drug Act has done lately for children with rare diseases: a 10-year analysis. Pediatrics (2012) 1.00
Adenosine treatment delays postischemic hippocampal CA1 loss after cardiac arrest and resuscitation in rats. Brain Res (2006) 0.99
Inactivation of neuronal forebrain A receptors protects dopaminergic neurons in a mouse model of Parkinson's disease. J Neurochem (2009) 0.98
Performance characteristics of plasma amyloid-beta 40 and 42 assays. J Alzheimers Dis (2009) 0.98
Involvement of HIF-1 in invasion of Mum2B uveal melanoma cells. Clin Exp Metastasis (2006) 0.98
Reperfusion brain injury: focus on cellular bioenergetics. Neurology (2012) 0.97
Transcriptional regulation by the estrogen receptor of antioxidative stress enzymes and its functional implications. Oncogene (2004) 0.97
Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors. J Neurosci (2002) 0.97
Improvement of neurological recovery and stimulation of neural progenitor cell proliferation by intrathecal administration of Sonic hedgehog. J Neurosurg (2012) 0.95
Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain. Brain Res (2010) 0.95
Increased sensitivity to transient global ischemia in aging rat brain. Adv Exp Med Biol (2007) 0.95
Therapies for inborn errors of metabolism: what has the orphan drug act delivered? Pediatrics (2010) 0.94
Inactivation of adenosine A2A receptors selectively attenuates amphetamine-induced behavioral sensitization. Neuropsychopharmacology (2003) 0.94
High-throughput cloning of human liver complete open reading frames using homologous recombination in Escherichia coli. Anal Biochem (2009) 0.94
Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurol Res (2003) 0.94
Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease. PLoS One (2012) 0.93
Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain. Am J Physiol Regul Integr Comp Physiol (2009) 0.91
Accelerating orphan drug development. Nat Rev Drug Discov (2010) 0.91
The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A (2002) 0.91
Dedifferentiation derived cells exhibit phenotypic and functional characteristics of epidermal stem cells. J Cell Mol Med (2010) 0.90
Ketosis proportionately spares glucose utilization in brain. J Cereb Blood Flow Metab (2013) 0.90
Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells. Am J Physiol Regul Integr Comp Physiol (2002) 0.90
A New Surrogate-Assisted Interactive Genetic Algorithm With Weighted Semisupervised Learning. IEEE Trans Cybern (2013) 0.90
Renormalization of regional brain blood flow during prolonged mild hypoxic exposure in rats. Brain Res (2004) 0.90
HIF-1 alpha and VEGF expression after transient global cerebral ischemia. Adv Exp Med Biol (2003) 0.89
Diet-induced ketosis improves cognitive performance in aged rats. Adv Exp Med Biol (2010) 0.89
Identification of novel series of human CCR1 antagonists. Bioorg Med Chem Lett (2007) 0.87
Decreased VEGF expression and microvascular density, but increased HIF-1 and 2α accumulation and EPO expression in chronic moderate hyperoxia in the mouse brain. Brain Res (2012) 0.86
Protection of dopaminergic cells by urate requires its accumulation in astrocytes. J Neurochem (2012) 0.86
Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation. Mol Cancer (2014) 0.86
Mitochondrial dysfunction in aging rat brain following transient global ischemia. Adv Exp Med Biol (2008) 0.86
8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. J Biol Chem (2002) 0.86
The third signal in T cell-mediated autoimmune disease? J Immunol (2004) 0.86
Comparison of glucose influx and blood flow in retina and brain of diabetic rats. J Cereb Blood Flow Metab (2004) 0.85
2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists. Bioorg Med Chem Lett (2007) 0.85
Transcription factors C/EBP-beta and -delta regulate IL-6 production in IL-1beta-stimulated human enterocytes. J Cell Physiol (2002) 0.84
Reliability of quantitative ultrasonic assessment of normal-tissue toxicity in breast cancer radiotherapy. Int J Radiat Oncol Biol Phys (2011) 0.83
Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle. J Surg Res (2002) 0.83
Can hematopoietic stem cells be an alternative source for skin regeneration? Ageing Res Rev (2009) 0.83
Decreased brainstem function following cardiac arrest and resuscitation in aged rat. Brain Res (2010) 0.83
Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy. Mol Neurobiol (2014) 0.82
Adaptation to chronic hypoxia during diet-induced ketosis. Adv Exp Med Biol (2005) 0.82
Enhanced adsorption of acidic gases (CO2, NO2 and SO2) on light metal decorated graphene oxide. Phys Chem Chem Phys (2014) 0.82
Block-based image compression with parameter-assistant inpainting. IEEE Trans Image Process (2010) 0.82
Contribution of brain glucose and ketone bodies to oxidative metabolism. Adv Exp Med Biol (2013) 0.82
Kidney EPO expression during chronic hypoxia in aged mice. Adv Exp Med Biol (2013) 0.82
The toppler mouse: a novel mutant exhibiting loss of Purkinje cells. J Comp Neurol (2004) 0.82
Edge-oriented uniform intra prediction. IEEE Trans Image Process (2008) 0.82
Regulatory considerations for developing drugs for rare diseases: orphan designations and early phase clinical trials. Discov Med (2011) 0.82
Hypoxia-inducible factor-1alpha accumulation in the rat brain in response to hypoxia and ischemia is attenuated during aging. Adv Exp Med Biol (2003) 0.81
The stress response decreases NF-kappaB activation in liver of endotoxemic mice. Shock (2002) 0.81
Is cycloxygenase-2 (COX-2) a major component of the mechanism responsible for microvascular remodeling in the brain? Adv Exp Med Biol (2006) 0.81