Published in Curr Biol on February 08, 2007
TKM 080301 for Primary or Secondary Liver Cancer | NCT01437007
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell (2009) 8.64
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell (2011) 4.49
Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov (2009) 4.16
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov (2010) 3.84
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proc Natl Acad Sci U S A (2009) 2.61
Mitosis is not a key target of microtubule agents in patient tumors. Nat Rev Clin Oncol (2011) 2.61
Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell (2007) 2.38
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal (2011) 2.33
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol (2014) 2.28
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol (2010) 2.26
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. Cell (2016) 2.26
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest (2009) 2.13
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biol (2009) 2.02
Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov (2011) 2.01
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. PLoS One (2009) 1.79
Polo-like kinase 1 licenses CENP-A deposition at centromeres. Cell (2014) 1.78
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol (2009) 1.78
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell (2010) 1.72
Mitosis-targeted anti-cancer therapies: where they stand. Cell Death Dis (2012) 1.60
The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. PLoS Biol (2010) 1.60
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem (2008) 1.54
A chemical biology strategy to analyze rheostat-like protein kinase-dependent regulation. Chem Biol (2013) 1.50
Mitotic Control of Planar Cell Polarity by Polo-like Kinase 1. Dev Cell (2015) 1.45
Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission. J Cell Biol (2010) 1.43
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol (2007) 1.42
Feedback control in sensing chromosome biorientation by the Aurora B kinase. Curr Biol (2011) 1.40
Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover. Nat Cell Biol (2010) 1.39
Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol (2008) 1.29
Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. ACS Chem Biol (2014) 1.29
Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy. Leukemia (2014) 1.28
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol (2011) 1.27
Targeting protein serine/threonine phosphatases for drug development. Mol Pharmacol (2009) 1.25
Understanding the Polo Kinase machine. Oncogene (2015) 1.23
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress. Mol Cell Biol (2011) 1.21
Bioorthogonal probes for polo-like kinase 1 imaging and quantification. Angew Chem Int Ed Engl (2011) 1.21
Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy. Blood (2014) 1.21
Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors. Oncotarget (2011) 1.19
A MEK-independent role for CRAF in mitosis and tumor progression. Nat Med (2011) 1.17
Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks. J Biol Chem (2009) 1.15
Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation. J Biol Chem (2011) 1.12
Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells. Nat Commun (2011) 1.12
Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS. J Biol Chem (2009) 1.11
Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells. J Invest Dermatol (2009) 1.10
Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A. J Virol (2010) 1.09
A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays. PLoS One (2013) 1.09
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. EMBO Mol Med (2010) 1.08
Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle. J Biol Chem (2014) 1.07
Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells. J Biol Chem (2009) 1.05
Plk1-dependent microtubule dynamics promotes androgen receptor signaling in prostate cancer. Prostate (2013) 1.04
Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis. Mol Cell (2013) 1.03
Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo. Am J Pathol (2011) 1.03
PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos. PLoS Genet (2011) 1.02
The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Nucleic Acids Res (2010) 1.02
PLK1 down-regulates parainfluenza virus 5 gene expression. PLoS Pathog (2009) 1.02
Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells. PLoS Genet (2012) 1.01
Chemical visualization of phosphoproteomes on membrane. Mol Cell Proteomics (2012) 1.01
Characterization of kinases involved in the phosphorylation of aggregated α-synuclein. J Neurosci Res (2010) 1.00
The balance of Polo-like kinase 1 in tumorigenesis. Cell Div (2009) 1.00
Phase i study of the Plk1 inhibitor BI 2536 administered intravenously on three consecutive days in advanced solid tumours. Curr Oncol (2012) 1.00
A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage. Mol Biol Cell (2010) 0.99
Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells. J Biol Chem (2010) 0.97
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. PLoS One (2010) 0.97
A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets. Br J Pharmacol (2012) 0.97
Polo-like kinase 1 inhibitors, mitotic stress and the tumor suppressor p53. Cell Cycle (2013) 0.97
PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2. Nat Cell Biol (2015) 0.96
Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication. Hepatology (2011) 0.96
Polo-like kinase 1 as predictive marker and therapeutic target for radiotherapy in rectal cancer. Am J Pathol (2010) 0.95
Polo-like kinase-activating kinases: Aurora A, Aurora B and what else? Cell Cycle (2012) 0.94
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases. J Biol Chem (2011) 0.94
Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease. Aging (Albany NY) (2011) 0.94
High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells. J Biol Chem (2012) 0.94
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep (2013) 0.93
Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer (2013) 0.93
Golgi partitioning controls mitotic entry through Aurora-A kinase. Mol Biol Cell (2010) 0.93
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1. PLoS One (2009) 0.93
The Plk1 inhibitor BI 2536 temporarily arrests primary cardiac fibroblasts in mitosis and generates aneuploidy in vitro. PLoS One (2010) 0.93
Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis. J Cell Biol (2014) 0.93
Gene signatures in hepatocellular carcinoma (HCC). Semin Cancer Biol (2010) 0.93
Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy. J Biol Chem (2010) 0.92
Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1. ACS Med Chem Lett (2011) 0.92
Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells. Breast Cancer Res (2012) 0.92
Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression. Hepatology (2009) 0.92
Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases. Cancer Res (2013) 0.92
Cell death signaling and anticancer therapy. Front Oncol (2011) 0.91
Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. J Biol Chem (2011) 0.91
Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J Cell Sci (2012) 0.91
Liaisons between survivin and Plk1 during cell division and cell death. J Biol Chem (2010) 0.91
Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death. Cell Cycle (2013) 0.90
Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation. Eur J Cancer (2013) 0.90
Biological targets and mechanisms of action of natural products from marine cyanobacteria. Nat Prod Rep (2015) 0.90
PLK1 inhibitors: setting the mitotic death trap. Curr Biol (2007) 0.90
Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity. Mol Cells (2011) 0.90
Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype. Mol Cancer Ther (2012) 0.89
Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1. Mol Biol Cell (2014) 0.89
Mitosis as an anti-cancer drug target. Chromosoma (2013) 0.88
Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis. Sci Rep (2015) 0.88
Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation. Cell Calcium (2009) 0.88
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol (2005) 11.46
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol (2007) 6.17
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest (2004) 5.06
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature (2005) 4.57
Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1. Dev Cell (2008) 4.01
Wapl controls the dynamic association of cohesin with chromatin. Cell (2006) 3.83
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature (2006) 3.81
Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol (2005) 3.72
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J (2003) 3.54
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol (2005) 3.33
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr Biol (2004) 3.29
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet (2009) 3.25
Distinct functions of condensin I and II in mitotic chromosome assembly. J Cell Sci (2004) 3.14
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J (2007) 3.11
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol (2009) 2.98
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol (2002) 2.97
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol (2010) 2.91
The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. Mol Cell (2005) 2.77
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res (2008) 2.76
A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res (2003) 2.73
Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell (2007) 2.72
TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Curr Biol (2003) 2.71
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science (2009) 2.69
Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells. Curr Biol (2006) 2.69
Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest (2006) 2.68
Expression profiling of epithelial plasticity in tumor progression. Oncogene (2003) 2.67
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59
Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication. Curr Biol (2006) 2.47
Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev Cell (2004) 2.39
Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell (2003) 2.17
Regulation of sister chromatid cohesion between chromosome arms. Curr Biol (2004) 2.16
Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell (2010) 2.12
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol Cell (2005) 2.09
Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol (2006) 2.04
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biol (2009) 2.02
Polo and Aurora kinases: lessons derived from chemical biology. Curr Opin Cell Biol (2008) 1.92
Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature (2013) 1.92
Microarray gene expression profiling of B-cell chronic lymphocytic leukemia subgroups defined by genomic aberrations and VH mutation status. J Clin Oncol (2004) 1.92
BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin Cancer Res (2009) 1.90
A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies. Blood (2011) 1.87
Regulation of human separase by securin binding and autocleavage. Curr Biol (2002) 1.86
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat Struct Mol Biol (2010) 1.85
Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera. J Clin Microbiol (2013) 1.80
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol (2006) 1.80
Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol (2007) 1.79
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci (2007) 1.78
Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development. Curr Opin Cell Biol (2008) 1.76
Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase. Curr Biol (2010) 1.72
How cohesin and CTCF cooperate in regulating gene expression. Chromosome Res (2009) 1.62
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Invest (2011) 1.61
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J (2009) 1.58
Cellular immune responses to HCV core increase and HCV RNA levels decrease during successful antiretroviral therapy. Gut (2010) 1.53
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature (2012) 1.48
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19. Dev Cell (2003) 1.48
In utero tractography of fetal white matter development. Neuroimage (2008) 1.46
Cohesin and DNA damage repair. Exp Cell Res (2006) 1.41
Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. Curr Biol (2003) 1.41
Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis. Dev Cell (2011) 1.40
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol (2012) 1.40
The complete removal of cohesin from chromosome arms depends on separase. J Cell Sci (2007) 1.40
Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem (2002) 1.40
Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin. Cancer Immun (2005) 1.38
Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes. Diabetes Care (2011) 1.36
The role of compartment penetration in PI-monotherapy: the Atazanavir-Ritonavir Monomaintenance (ATARITMO) Trial. AIDS (2007) 1.34
Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal (2011) 1.31
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions. FEBS Lett (2004) 1.30
A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database. Genome Biol (2007) 1.29
Shock efficacy of subcutaneous implantable cardioverter-defibrillator for prevention of sudden cardiac death: initial multicenter experience. Circ Arrhythm Electrophysiol (2012) 1.26
Dynamics of nuclear pore complex organization through the cell cycle. Curr Opin Cell Biol (2004) 1.25
Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis. Nat Protoc (2006) 1.21
Reduced NAA-levels in the NAWM of patients with MS is a feature of progression. A study with quantitative magnetic resonance spectroscopy at 3 Tesla. PLoS One (2010) 1.18
Relaxation times of 31P-metabolites in human calf muscle at 3 T. Magn Reson Med (2003) 1.18