Published in Proc Natl Acad Sci U S A on February 12, 2007
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol (2010) 4.22
Coronary arteries form by developmental reprogramming of venous cells. Nature (2010) 3.95
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol (2010) 3.61
Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol (2011) 3.25
Pancreatic carcinogenesis. Pancreatology (2008) 2.60
The many facets of Notch ligands. Oncogene (2008) 2.57
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol (2010) 2.37
Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1. Dev Cell (2011) 2.23
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev Cell (2012) 2.14
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature (2012) 2.13
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol (2011) 2.09
Fluid forces control endothelial sprouting. Proc Natl Acad Sci U S A (2011) 2.09
Identification and functional analysis of endothelial tip cell-enriched genes. Blood (2010) 2.02
Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther (2013) 1.96
Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene (2008) 1.95
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev (2007) 1.86
Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood (2010) 1.84
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood (2008) 1.83
The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. J Cell Biol (2008) 1.82
Three-dimensional analysis of vascular development in the mouse embryo. PLoS One (2008) 1.74
Local guidance of emerging vessel sprouts requires soluble Flt-1. Dev Cell (2009) 1.72
Congenic fine-mapping identifies a major causal locus for variation in the native collateral circulation and ischemic injury in brain and lower extremity. Circ Res (2013) 1.68
Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes Dev (2011) 1.63
VEGF and endothelial guidance in angiogenic sprouting. Organogenesis (2008) 1.63
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell (2012) 1.62
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60
Angiogenesis and vascular remodelling in normal and cancerous tissues. J Math Biol (2008) 1.55
VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis. Br J Cancer (2008) 1.55
BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood (2012) 1.53
Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52
Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50
Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages. J Immunol (2010) 1.49
Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood (2008) 1.47
DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest (2015) 1.45
Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development (2011) 1.44
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. Proc Natl Acad Sci U S A (2013) 1.44
Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis. Development (2008) 1.43
Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way. Nat Rev Clin Oncol (2009) 1.43
Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo. EMBO Rep (2011) 1.40
Novel therapeutic strategies for targeting liver cancer stem cells. Int J Biol Sci (2011) 1.39
VEGF and Notch in tip and stalk cell selection. Cold Spring Harb Perspect Med (2013) 1.38
EGFL7: a unique angiogenic signaling factor in vascular development and disease. Blood (2011) 1.33
miR-221 is required for endothelial tip cell behaviors during vascular development. Dev Cell (2012) 1.28
HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification. PLoS Genet (2008) 1.25
Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice. Blood (2011) 1.22
Regulation of endothelial cell differentiation and specification. Circ Res (2013) 1.20
Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc Cell (2011) 1.20
VEGF and Notch signaling: the yin and yang of angiogenic sprouting. Cell Adh Migr (2007) 1.19
Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Am J Pathol (2010) 1.17
Signal transduction in vasculogenesis and developmental angiogenesis. Int J Dev Biol (2011) 1.17
Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis. Adv Cancer Res (2012) 1.17
Vascular development in the zebrafish. Cold Spring Harb Perspect Med (2012) 1.16
VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. Cardiovasc Res (2007) 1.16
Novel insights into the differential functions of Notch ligands in vascular formation. J Angiogenes Res (2009) 1.16
Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. BMC Cancer (2010) 1.14
Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin. J Biol Chem (2011) 1.14
Notch regulates the angiogenic response via induction of VEGFR-1. J Angiogenes Res (2010) 1.12
EGFL7 meets miRNA-126: an angiogenesis alliance. J Angiogenes Res (2010) 1.12
TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. Gene (2009) 1.11
Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting. BMC Syst Biol (2009) 1.10
A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures. PLoS One (2011) 1.09
Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis. BMC Syst Biol (2010) 1.09
Multiscale mechanisms of cell migration during development: theory and experiment. Development (2012) 1.07
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (2013) 1.07
Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control. Dev Cell (2013) 1.07
VEGF-directed blood vessel patterning: from cells to organism. Cold Spring Harb Perspect Med (2012) 1.05
Molecular parallels between neural and vascular development. Cold Spring Harb Perspect Med (2013) 1.05
Notch: a key regulator of tumor angiogenesis and metastasis. Histol Histopathol (2012) 1.05
Common cues regulate neural and vascular patterning. Curr Opin Genet Dev (2007) 1.04
Distinct Notch signaling outputs pattern the developing arterial system. Development (2014) 1.02
Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell Metab (2014) 1.02
Understanding vascular development. Wiley Interdiscip Rev Dev Biol (2012) 1.02
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia. PLoS Pathog (2009) 1.02
Role of the cytoskeleton in formation and maintenance of angiogenic sprouts. J Vasc Res (2011) 1.01
Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling. Biomaterials (2009) 1.00
Regulation of ocular angiogenesis by Notch signaling: implications in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci (2011) 1.00
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures. Blood (2011) 1.00
Control of endothelial sprouting by a Tel-CtBP complex. Nat Cell Biol (2010) 0.99
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nat Commun (2015) 0.99
Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol (2008) 0.99
NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth. Cancer Discov (2014) 0.99
Collective cell migration in development. J Cell Biol (2016) 0.99
VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci U S A (2015) 0.98
Cellular and physical mechanisms of branching morphogenesis. Development (2014) 0.98
Fbxw7 controls angiogenesis by regulating endothelial Notch activity. PLoS One (2012) 0.97
Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions. PLoS One (2011) 0.97
Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting. J Clin Invest (2013) 0.96
Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest (2012) 0.96
Tumor endothelial marker 8 amplifies canonical Wnt signaling in blood vessels. PLoS One (2011) 0.95
Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol (2016) 0.95
Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Elife (2015) 0.95
Cell lineages and early patterns of embryonic CNS vascularization. Cell Adh Migr (2009) 0.94
Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching. Proc Natl Acad Sci U S A (2013) 0.94
The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. J Clin Invest (2011) 0.93
The role of extracellular matrix in vascular branching morphogenesis. Cell Adh Migr (2012) 0.93
Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. Cell Signal (2010) 0.93
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 18.47
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (1996) 16.92
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol (2003) 12.96
VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol (2006) 12.09
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell (2002) 5.66
Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development (2001) 5.46
Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci (1995) 4.97
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet (1999) 4.55
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem (2001) 4.45
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41
Retinal angiogenesis in development and disease. Nature (2005) 4.18
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A (2004) 4.06
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev (2000) 3.86
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature (2004) 3.77
Angiogenic network formation in the developing vertebrate trunk. Development (2003) 3.66
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood (2005) 2.91
Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev (2001) 2.69
Notch function in the vasculature: insights from zebrafish, mouse and man. Bioessays (2004) 2.59
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc Res (2002) 2.10
Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells. J Neurosci (1996) 1.94
Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo. Development (2001) 1.81
Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns (2005) 1.63
Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes. Development (2005) 1.41
Periodic Delta-like 4 expression in developing retinal arteries. Gene Expr Patterns (2004) 1.38
Abnormal blood vessel development in mice lacking presenilin-1. Mech Dev (2003) 1.31
Expression of angiogenesis-related genes during retinal development. Gene Expr Patterns (2005) 1.17
Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa. Blood (2004) 0.97
Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature (2008) 5.15
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature (2004) 3.77
A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry. Brain (2010) 3.53
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med (2010) 2.88
Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development (2002) 2.68
Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development (2003) 2.43
Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol (2010) 2.37
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med (2008) 2.17
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev Cell (2012) 2.14
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature (2012) 2.13
Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res (2006) 2.12
Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice. Nat Protoc (2010) 2.12
Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI. Brain Topogr (2011) 2.12
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A (2013) 2.10
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol (2011) 2.09
The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol (2006) 2.06
Identification and functional analysis of endothelial tip cell-enriched genes. Blood (2010) 2.02
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood (2007) 2.01
Guidance of vascular development: lessons from the nervous system. Circ Res (2009) 2.00
The shunt problem: control of functional shunting in normal and tumour vasculature. Nat Rev Cancer (2010) 1.97
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev (2007) 1.86
A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis. Cytokine Growth Factor Rev (2005) 1.81
Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol (2010) 1.72
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell (2012) 1.66
Accessing key steps of human tumor progression in vivo by using an avian embryo model. Proc Natl Acad Sci U S A (2005) 1.65
What determines blood vessel structure? Genetic prespecification vs. hemodynamics. Physiology (Bethesda) (2006) 1.53
Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood (2008) 1.47
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci (2006) 1.46
DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest (2015) 1.45
Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development (2011) 1.44
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. Genes Dev (2011) 1.35
Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis. Development (2010) 1.32
Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Dev Cell (2011) 1.29
Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos. Development (2008) 1.27
Endothelial ERK signaling controls lymphatic fate specification. J Clin Invest (2013) 1.24
Transcranial magnetic stimulation: a neuroscientific probe of cortical function in schizophrenia. Biol Psychiatry (2011) 1.22
Neuronal clues to vascular guidance. Exp Cell Res (2005) 1.22
Notch controls retinal blood vessel maturation and quiescence. Development (2013) 1.20
Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J (2012) 1.19
In vivo imaging of cerebral microvascular plasticity from birth to death. J Cereb Blood Flow Metab (2012) 1.17
Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophrenia. Schizophr Res (2010) 1.17
Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. BMC Cancer (2010) 1.14
Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Circ Res (2012) 1.12
Physical therapy in critically ill adult patients: recommendations from the Brazilian Association of Intensive Care Medicine Department of Physical Therapy. Rev Bras Ter Intensiva (2012) 1.10
Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem (2009) 1.10
Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell (2012) 1.08
A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep (2004) 1.08
Selective binding of lectins to embryonic chicken vasculature. J Histochem Cytochem (2003) 1.07
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (2013) 1.07
Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation (2012) 1.06
Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences. PLoS One (2009) 1.02
Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding. Curr Opin Hematol (2010) 1.01
Dynamics of vascular branching morphogenesis: the effect of blood and tissue flow. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 0.98
Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. Dev Biol (2008) 0.98
Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons. Science (2013) 0.96
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest (2013) 0.95
Netrins and UNC5 receptors in angiogenesis. Angiogenesis (2008) 0.95
State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association. Circ Res (2015) 0.94
Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood (2013) 0.92
Negative regulators of vessel patterning. Novartis Found Symp (2007) 0.90
Netrin-1 controls sympathetic arterial innervation. J Clin Invest (2014) 0.86
miR-30a regulates endothelial tip cell formation and arteriolar branching. Hypertension (2013) 0.86
Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages. Angiogenesis (2012) 0.86
Jagged gives endothelial tip cells an edge. Cell (2009) 0.85
Modulatory effects of theta burst stimulation on cerebellar nonsomatic functions. Cerebellum (2011) 0.85
Arteriogenesis is modulated by bradykinin receptor signaling. Circ Res (2011) 0.84
Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis. PLoS One (2011) 0.83
Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells. Blood (2004) 0.83
Nephropathy and defective spermatogenesis in mice transgenic for a single isoform of the Wilms' tumour suppressor protein, WT1-KTS, together with one disrupted Wt1 allele. Mol Reprod Dev (2007) 0.82