Published in Rev Endocr Metab Disord on December 01, 2006
Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev (2008) 2.64
Acromegaly pathogenesis and treatment. J Clin Invest (2009) 2.19
The Jak/STAT pathway is involved in synaptic plasticity. Neuron (2012) 2.02
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev (2013) 1.50
The growth hormone receptor: mechanism of activation and clinical implications. Nat Rev Endocrinol (2010) 1.44
Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Mol Cell Biol (2011) 1.36
Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Horm IGF Res (2009) 1.35
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. J Clin Invest (2011) 1.17
Growth hormone, IGF-I and insulin and their abuse in sport. Br J Pharmacol (2008) 1.15
Mapping the growth hormone--Stat5b--IGF-I transcriptional circuit. Trends Endocrinol Metab (2012) 1.07
Dispersed Chromosomal Stat5b-binding elements mediate growth hormone-activated insulin-like growth factor-I gene transcription. J Biol Chem (2010) 1.05
Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription. Mol Endocrinol (2010) 1.03
Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver. Mol Cell Biol (2013) 1.03
LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. J Clin Invest (2009) 1.02
Insulin, IGF-1 and longevity. Aging Dis (2010) 1.01
Computational and functional analysis of growth hormone (GH)-regulated genes identifies the transcriptional repressor B-cell lymphoma 6 (Bc16) as a participant in GH-regulated transcription. Endocrinology (2009) 0.94
Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol (2012) 0.93
Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice. Am J Physiol Gastrointest Liver Physiol (2008) 0.93
Reversal by growth hormone of homocysteine-induced epithelial-to-mesenchymal transition through membrane raft-redox signaling in podocytes. Cell Physiol Biochem (2011) 0.90
The intricate role of growth hormone in metabolism. Front Endocrinol (Lausanne) (2011) 0.89
Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. PLoS One (2011) 0.88
JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells. Mol Endocrinol (2008) 0.87
Insulin and GH signaling in human skeletal muscle in vivo following exogenous GH exposure: impact of an oral glucose load. PLoS One (2011) 0.87
A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinases. PLoS Comput Biol (2009) 0.87
Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription. Cell Signal (2011) 0.86
Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A (2016) 0.86
Diagnosis and treatment of growth hormone deficiency in adults. Nat Rev Endocrinol (2013) 0.84
Gene regulation by growth hormone. Pediatr Nephrol (2009) 0.84
Effects of GH in human muscle and fat. Pediatr Nephrol (2009) 0.82
GH modulates hepatic epidermal growth factor signaling in the mouse. J Endocrinol (2009) 0.82
Differential effects of STAT proteins on growth hormone-mediated IGF-I gene expression. Am J Physiol Endocrinol Metab (2014) 0.81
Biochemical characterization of diverse Stat5b-binding enhancers that mediate growth hormone-activated insulin-like growth factor-I gene transcription. PLoS One (2012) 0.80
Growth hormone-regulated mRNAs and miRNAs in chicken hepatocytes. PLoS One (2014) 0.79
The role of cytochrome P450-dependent metabolism in the regulation of mouse hepatic growth hormone signaling components and target genes by 3-methylcholanthrene. Drug Metab Dispos (2012) 0.79
Epiphora and proptosis as a presenting complaint in acromegaly: Report of two cases with review of literature. Indian J Endocrinol Metab (2013) 0.78
The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets. Infect Agent Cancer (2014) 0.78
The influence of estrogens on the biological and therapeutic actions of growth hormone in the liver. Pharmaceuticals (Basel) (2012) 0.77
Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity. Mol Endocrinol (2012) 0.77
Research resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics. Mol Endocrinol (2012) 0.77
Identifying growth hormone-regulated enhancers in the Igf1 locus. Physiol Genomics (2015) 0.77
Endotoxin-induced growth hormone resistance in skeletal muscle. Endocrinology (2009) 0.76
GH/STAT5 signaling during the growth period in livers of mice overexpressing GH. J Mol Endocrinol (2015) 0.76
Cryptochromes regulate IGF-1 production and signaling through control JAK2 dependent STAT5B phosphorylation. Mol Biol Cell (2017) 0.75
Growth hormone regulates the sensitization of developing peripheral nociceptors during cutaneous inflammation. Pain (2016) 0.75
Defining human insulin-like growth factor I gene regulation. Am J Physiol Endocrinol Metab (2016) 0.75
Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models. J Steroid Biochem Mol Biol (2017) 0.75
Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes (2008) 2.07
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms. Mol Endocrinol (2007) 1.96
Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol Cell Biol (2004) 1.55
Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. Mol Cell Biol (2004) 1.46
SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other. Trends Endocrinol Metab (2006) 1.26
Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor. Mol Cell Biol (2006) 1.12
SH2-B family members differentially regulate JAK family tyrosine kinases. J Biol Chem (2001) 1.09
SH2-Bbeta is a Rac-binding protein that regulates cell motility. J Biol Chem (2002) 1.04
Human SH2B1 mutations are associated with maladaptive behaviors and obesity. J Clin Invest (2012) 1.01
Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling. Mol Cell Biol (2009) 1.00
CaM kinase II-dependent phosphorylation of myogenin contributes to activity-dependent suppression of nAChR gene expression in developing rat myotubes. Cell Signal (2004) 1.00
SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10. Mol Endocrinol (2007) 0.98
Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state. Mol Cell Biol (2006) 0.97
YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling. J Biol Chem (2003) 0.94
Interaction of adipocyte fatty acid-binding protein (AFABP) and JAK2: AFABP/aP2 as a regulator of JAK2 signaling. J Biol Chem (2009) 0.94
Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes. Mol Endocrinol (2009) 0.93
Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation. Mol Cell Biol (2004) 0.92
C/EBPβ mediates growth hormone-regulated expression of multiple target genes. Mol Endocrinol (2011) 0.91
JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells. Mol Endocrinol (2008) 0.87
Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol Endocrinol (2010) 0.87
Glucose enhances leptin signaling through modulation of AMPK activity. PLoS One (2012) 0.84
SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells. J Biol Chem (2003) 0.83
Phosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distribution. J Cell Sci (2011) 0.81
Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number. J Cell Sci (2011) 0.81
Multiplexed detection of protein-peptide interaction and inhibition using capillary electrophoresis. Anal Chem (2007) 0.81
Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion. Infect Immun (2007) 0.81
Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motility. J Cell Sci (2013) 0.80
Capillary electrophoresis and fluorescence anisotropy for quantitative analysis of peptide-protein interactions using JAK2 and SH2-Bbeta as a model system. Anal Chem (2005) 0.80
The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor. J Biol Chem (2012) 0.79
Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1. Endocrinology (2014) 0.77
Research resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics. Mol Endocrinol (2012) 0.77
Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele. PLoS One (2013) 0.76
Meeting report: the 2012 FASEB Science Research Conference "The growth hormone/prolactin family in biology and disease" A novel biannual rendez-vous in the endocrinology landscape. Pediatr Endocrinol Rev (2013) 0.76
Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein. Mol Endocrinol (2013) 0.76
Regulation of Glucose Transport and c-fos and egr-1 Expression in Cells with Mutated or Endogenous Growth Hormone Receptors. Endocrinology (1998) 0.75