Published in EMBO J on February 22, 2007
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JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol Cell (2011) 1.61
Dissecting the binding mechanism of the linker histone in live cells: an integrated FRAP analysis. EMBO J (2010) 1.29
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. Proc Natl Acad Sci U S A (2009) 1.14
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Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. J Biol Chem (2011) 0.98
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Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity. J Biol Chem (2008) 0.95
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Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells. J Biol Chem (2010) 0.90
Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling. Nucleic Acids Res (2013) 0.90
Geminin is partially localized to the centrosome and plays a role in proper centrosome duplication. Biol Cell (2009) 0.89
Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle. EMBO J (2015) 0.89
PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage. Nucleic Acids Res (2014) 0.87
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Homeotic proteins participate in the function of human-DNA replication origins. Nucleic Acids Res (2010) 0.85
Multi-step loading of human minichromosome maintenance proteins in live human cells. J Biol Chem (2013) 0.85
Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A (2013) 0.83
Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs. PLoS One (2012) 0.83
Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes. J Biol Chem (2009) 0.81
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A high ratio of G1 to G0 phase cells and an accumulation of G1 phase cells before S phase progression after injurious stimuli in the proximal tubule. Physiol Rep (2014) 0.75
Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex. Cell Cycle (2016) 0.75
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Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol Cell Biol (2004) 4.41
Regulation of early events in chromosome replication. Curr Biol (2004) 3.97
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol (2004) 3.72
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A p53-dependent checkpoint pathway prevents rereplication. Mol Cell (2003) 3.42
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nat Cell Biol (2005) 3.18
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PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J Biol Chem (2006) 2.96
Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells. Science (2003) 2.61
The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J Biol Chem (2001) 2.38
Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochem (2001) 2.36
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem (2003) 2.36
Control of DNA replication licensing in a cell cycle. Genes Cells (2002) 2.34
Direct interaction of geminin and Six3 in eye development. Nature (2004) 2.32
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The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature (2004) 2.19
Geminin regulates neuronal differentiation by antagonizing Brg1 activity. Genes Dev (2005) 1.99
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J Biol Chem (2004) 1.96
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J Biol Chem (2004) 1.91
Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene (2002) 1.91
Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo. Mol Cell (2002) 1.90
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J (2004) 1.88
Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle. EMBO J (2001) 1.72
Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region. J Biol Chem (2004) 1.61
Mammalian nuclei become licensed for DNA replication during late telophase. J Cell Sci (2002) 1.51
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Nature (2004) 1.50
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. Mol Cell (2004) 1.48
Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. J Biol Chem (2004) 1.46
Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J Biol Chem (2002) 1.43
A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus. EMBO J (2006) 1.40
Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus. Mol Biol Cell (2002) 1.38
Expression of geminin as a marker of cell proliferation in normal tissues and malignancies. Am J Pathol (2002) 1.24
Fluorescence recovery after photobleaching: application to nuclear proteins. Adv Biochem Eng Biotechnol (2005) 1.20
Functional domains of the Xenopus replication licensing factor Cdt1. Nucleic Acids Res (2005) 1.16
Antiandrogens prevent stable DNA-binding of the androgen receptor. J Cell Sci (2005) 1.16
Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle. Exp Cell Res (2005) 0.95
Getting a grip on licensing: mechanism of stable Mcm2-7 loading onto replication origins. Mol Cell (2006) 0.92
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol (2007) 4.75
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J (2006) 3.53
Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum. Science (2002) 3.12
Protein analysis on a proteomic scale. Nature (2003) 3.12
CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. Dev Cell (2006) 2.99
Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling. Nat Cell Biol (2007) 2.91
Retracted Cytohesins are cytoplasmic ErbB receptor activators. Cell (2010) 2.74
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell (2010) 2.72
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A (2006) 2.71
Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol (2007) 2.54
EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation. Nat Cell Biol (2003) 2.49
Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. EMBO J (2002) 2.45
Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol (2005) 2.44
Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol (2010) 2.37
Control of DNA replication licensing in a cell cycle. Genes Cells (2002) 2.34
Heterochromatin protein 1 is recruited to various types of DNA damage. J Cell Biol (2009) 2.26
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Genes Dev (2006) 2.22
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron (2009) 1.96
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J Biol Chem (2004) 1.91
Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo. Mol Cell (2002) 1.90
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol (2011) 1.87
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res (2007) 1.79
Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions. Mol Cell Biol (2003) 1.68
Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors. Curr Opin Cell Biol (2006) 1.64
Activation of multiple DNA repair pathways by sub-nuclear damage induction methods. J Cell Sci (2007) 1.62
Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region. J Biol Chem (2004) 1.61
Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol (2010) 1.55
Imaging activation of two Ras isoforms simultaneously in a single cell. Chembiochem (2005) 1.54
Recruitment of Eph receptors into signaling clusters does not require ephrin contact. J Cell Biol (2004) 1.52
DNA damage stabilizes interaction of CSB with the transcription elongation machinery. J Cell Biol (2004) 1.42
Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC. J Cell Sci (2007) 1.42
Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B. Science (2007) 1.36
Condensed chromatin domains in the mammalian nucleus are accessible to large macromolecules. EMBO Rep (2003) 1.35
In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays. Nat Methods (2010) 1.34
Global analysis of time correlated single photon counting FRET-FLIM data. Opt Express (2009) 1.34
Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC. J Cell Sci (2008) 1.30
Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage. Mol Cell (2013) 1.30
Multiple ORC-binding sites are required for efficient MCM loading and origin firing in fission yeast. EMBO J (2003) 1.29
Signaling from the living plasma membrane. Cell (2011) 1.29
Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines. Eur J Biochem (2004) 1.27
Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function. Mol Cell Biol (2004) 1.25
Compartmentalization of androgen receptor protein-protein interactions in living cells. J Cell Biol (2007) 1.25
easyFRAP: an interactive, easy-to-use tool for qualitative and quantitative analysis of FRAP data. Bioinformatics (2012) 1.25
Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH. Mol Cell Biol (2006) 1.24
UTF1 is a chromatin-associated protein involved in ES cell differentiation. J Cell Biol (2007) 1.24
Coordinate-based colocalization analysis of single-molecule localization microscopy data. Histochem Cell Biol (2011) 1.23
Chemically induced photoswitching of fluorescent probes--a general concept for super-resolution microscopy. Molecules (2011) 1.22
RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor. J Biol Chem (2002) 1.18
RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. J Cell Biol (2013) 1.17
Imaging phosphorylation dynamics of the epidermal growth factor receptor. J Biol Chem (2004) 1.16
Chromatin structure and DNA damage repair. Epigenetics Chromatin (2008) 1.16
Antiandrogens prevent stable DNA-binding of the androgen receptor. J Cell Sci (2005) 1.16
Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells. Am J Physiol Endocrinol Metab (2003) 1.15
Chromatin interaction of TATA-binding protein is dynamically regulated in human cells. J Cell Sci (2010) 1.14
Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. J Biol Chem (2007) 1.11
The androgen receptor ligand-binding domain stabilizes DNA binding in living cells. J Struct Biol (2004) 1.11
Cdt1 interactions in the licensing process: a model for dynamic spatiotemporal control of licensing. Cell Cycle (2007) 1.10
Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity. Proc Natl Acad Sci U S A (2008) 1.10
Mathematical modeling of nucleotide excision repair reveals efficiency of sequential assembly strategies. Mol Cell (2005) 1.09
Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain. J Biol Chem (2006) 1.08
Early and late outcome of cardiac surgery in patients with liver cirrhosis. Liver Transpl (2007) 1.08
Imaging in situ protein-DNA interactions in the cell nucleus using FRET-FLIM. Exp Cell Res (2005) 1.06
UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells. DNA Repair (Amst) (2009) 1.05
Red-edge anisotropy microscopy enables dynamic imaging of homo-FRET between green fluorescent proteins in cells. J Struct Biol (2004) 1.04
Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin. Mol Cell Biol (2003) 1.03
Control over DNA replication in time and space. FEBS Lett (2012) 1.02
Quantitative microscopy and systems biology: seeing the whole picture. Histochem Cell Biol (2008) 1.02
Stepwise androgen receptor dimerization. J Cell Sci (2012) 1.02
Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment. Mol Cell Biol (2010) 1.02
Nuclear proteins: finding and binding target sites in chromatin. Chromosome Res (2011) 1.01