Published in Autophagy on May 23, 2007
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86
Endocytic mechanisms for targeted drug delivery. Adv Drug Deliv Rev (2007) 2.38
Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. Hum Mol Genet (2008) 2.15
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet (2012) 1.80
Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat Cell Biol (2008) 1.70
Lysosomes in iron metabolism, ageing and apoptosis. Histochem Cell Biol (2008) 1.60
Monitoring autophagy in lysosomal storage disorders. Methods Enzymol (2009) 1.40
Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models. Methods Enzymol (2009) 1.36
Mitophagy and Parkinson's disease: the PINK1-parkin link. Biochim Biophys Acta (2010) 1.34
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The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol (2013) 1.27
Review of clinical presentation and diagnosis of mucopolysaccharidosis IVA. Mol Genet Metab (2013) 1.17
Autophagy and protein aggregation after brain ischemia. J Neurochem (2010) 1.15
Pathophysiology of neuropathic lysosomal storage disorders. J Inherit Metab Dis (2010) 1.13
Changes in autophagy after traumatic brain injury. J Cereb Blood Flow Metab (2007) 1.10
The pathogenesis of Niemann-Pick type C disease: a role for autophagy? Expert Rev Mol Med (2008) 1.10
Abnormal autophagy, ubiquitination, inflammation and apoptosis are dependent upon lysosomal storage and are useful biomarkers of mucopolysaccharidosis VI. Pathogenetics (2009) 1.06
ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiol Dis (2011) 1.06
17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy. PLoS One (2010) 1.01
Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models. Mitochondrion (2009) 0.98
The intracellular Ca²⁺ channels of membrane traffic. Channels (Austin) (2012) 0.93
Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice. Neuron (2015) 0.93
Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis. PLoS One (2012) 0.91
Aberrant Ca2+ handling in lysosomal storage disorders. Cell Calcium (2010) 0.91
Dysregulated autophagy contributes to podocyte damage in Fabry's disease. PLoS One (2013) 0.91
Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol (2012) 0.90
Mucopolysaccharide diseases: a complex interplay between neuroinflammation, microglial activation and adaptive immunity. J Inherit Metab Dis (2013) 0.89
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TRPML: transporters of metals in lysosomes essential for cell survival? Cell Calcium (2011) 0.88
Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis. BMC Cell Biol (2010) 0.85
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. Cell Rep (2015) 0.85
Mitochondrial Ca2+ homeostasis in lysosomal storage diseases. Cell Calcium (2008) 0.84
Impact of age at administration, lysosomal storage, and transgene regulatory elements on AAV2/8-mediated rat liver transduction. PLoS One (2012) 0.83
Transition metals activate TFEB in overexpressing cells. Biochem J (2015) 0.82
Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses. PLoS Comput Biol (2010) 0.81
Aging in the canine and feline brain. Vet Clin North Am Small Anim Pract (2014) 0.79
Astrocytes and lysosomal storage diseases. Neuroscience (2015) 0.78
Systematic screens for proteins that interact with the mucolipidosis type IV protein TRPML1. PLoS One (2013) 0.78
Gaucher disease: transcriptome analyses using microarray or mRNA sequencing in a Gba1 mutant mouse model treated with velaglucerase alfa or imiglucerase. PLoS One (2013) 0.78
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells. Dis Model Mech (2014) 0.78
Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins. Cells (2012) 0.76
A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biol (2014) 0.76
Protection against neurotoxicity by an autophagic mechanism. Braz J Med Biol Res (2012) 0.75
Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients. PLoS One (2016) 0.75
Lysosomal Storage Diseases-Regulating Neurodegeneration. J Exp Neurosci (2016) 0.75
Retinal Dystrophy and Optic Nerve Pathology in the Mouse Model of Mucolipidosis IV. Am J Pathol (2015) 0.75
Age-dependent development of liver fibrosis in Glmp (gt/gt) mice. Fibrogenesis Tissue Repair (2016) 0.75
Mitochondrial Dysfunction in Lysosomal Storage Disorders. Diseases (2016) 0.75
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science (2004) 10.77
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol (2006) 9.36
The role of autophagy in cancer development and response to therapy. Nat Rev Cancer (2005) 8.18
Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ (2005) 5.40
Autophagy and aging: the importance of maintaining "clean" cells. Autophagy (2005) 4.61
Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem (2006) 3.74
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol (2007) 3.29
Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy (2005) 3.27
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The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem (2002) 2.67
Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet (2006) 2.57
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Mitochondria as all-round players of the calcium game. J Physiol (2000) 2.47
Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem (2006) 2.34
Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol (2006) 2.17
Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat Neurosci (1998) 2.14
Consequences of NPC1 and NPC2 loss of function in mammalian neurons. Biochim Biophys Acta (2004) 2.00
Broad screening test for sphingolipid-storage diseases. Lancet (1999) 1.97
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic. Traffic (2006) 1.92
Neuronal macroautophagy: from development to degeneration. Mol Aspects Med (2006) 1.69
GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis. Mol Cell (2004) 1.64
Mitochondrial aberrations in mucolipidosis Type IV. J Biol Chem (2006) 1.61
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain. Int J Biochem Cell Biol (2004) 1.57
A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration. J Neurosci (2004) 1.56
Mitochondrial fusion and fission in the control of apoptosis. Trends Cell Biol (2005) 1.50
Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C disease. Hepatology (2005) 1.48
Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction. Am J Physiol Cell Physiol (2006) 1.44
Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease. Mol Genet Metab (2005) 1.32
Mitochondrial membrane dynamics, cristae remodelling and apoptosis. Biochim Biophys Acta (2006) 1.20
Glucosylceramide modulates membrane traffic along the endocytic pathway. J Lipid Res (2002) 1.17
Endocytic trafficking of glycosphingolipids in sphingolipid storage diseases. Philos Trans R Soc Lond B Biol Sci (2003) 1.16
Mitochondrial regulation of intracellular Ca2+ signaling: more than just simple Ca2+ buffers. News Physiol Sci (2003) 1.02
Mucolipidosis IV: morphology and histochemistry of an autopsy case. J Neuropathol Exp Neurol (1995) 1.02
Testing the "garbage" accumulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy. Biogerontology (2005) 0.97
Mitochondrial Ca2+ homeostasis in health and disease. Biol Res (2004) 0.96
Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain. Autophagy (2007) 0.89
Lysosomal transport disorders. J Inherit Metab Dis (2000) 0.89
Diffuse neuroaxonal involvement in mucolipidosis IV as assessed by proton magnetic resonance spectroscopic imaging. J Child Neurol (2003) 0.87
Biosynthesis of lysosomal proteinases in health and disease. Biol Chem (2002) 0.86
Neuronal cell death caused by inhibition of intracellular cholesterol trafficking is caspase dependent and associated with activation of the mitochondrial apoptosis pathway. J Neurochem (2006) 0.85
Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease; implications for neuronal loss in Gaucher disease. Exp Mol Med (2006) 0.83
U18666A-mediated apoptosis in cultured murine cortical neurons: role of caspases, calpains and kinases. Cell Signal (2006) 0.83
Mouse gene knockout models for the CLN2 and CLN3 forms of ceroid lipofuscinosis. Eur J Paediatr Neurol (2001) 0.83
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol (2007) 3.29
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum Mol Genet (2010) 1.99
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol (2007) 1.95
Kinase signaling cascades in the mitochondrion: a matter of life or death. Free Radic Biol Med (2005) 1.93
Regulation of the autophagy protein LC3 by phosphorylation. J Cell Biol (2010) 1.86
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol (2003) 1.75
TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J Biol Chem (2005) 1.75
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy (2008) 1.74
Mitochondrial aberrations in mucolipidosis Type IV. J Biol Chem (2006) 1.61
In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage. J Bone Joint Surg Am (2010) 1.59
Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo. Am J Physiol Cell Physiol (2013) 1.51
Starving neurons show sex difference in autophagy. J Biol Chem (2008) 1.49
Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases. Am J Pathol (2002) 1.43
Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab (2007) 1.33
6-Hydroxydopamine induces mitochondrial ERK activation. Free Radic Biol Med (2007) 1.32
Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol Learn Mem (2006) 1.32
Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis. J Exp Med (2008) 1.31
Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol (2008) 1.31
Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells. J Biol Chem (2006) 1.25
Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content. J Orthop Res (2010) 1.23
Nuclear transport, oxidative stress, and neurodegeneration. Int J Clin Exp Pathol (2011) 1.22
The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons. J Neurosci (2004) 1.21
Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains. J Biol Chem (2005) 1.19
Arthroscopic microscopy of articular cartilage using optical coherence tomography. Am J Sports Med (2004) 1.17
After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy (2013) 1.17
Mitochondrial dysfunction in Parkinson's disease. J Alzheimers Dis (2010) 1.16
Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am J Pathol (2012) 1.16
Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A. J Neurochem (2013) 1.16
Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade. J Neurosci (2011) 1.13
Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy (2007) 1.12
Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis. J Bioenerg Biomembr (2009) 1.11
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol Dis (2009) 1.11
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest (2014) 1.06
ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiol Dis (2011) 1.06
Role of reactive oxygen species in extracellular signal-regulated protein kinase phosphorylation and 6-hydroxydopamine cytotoxicity. J Biosci (2003) 1.02
Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models. Mitochondrion (2009) 0.98
Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol (2011) 0.97
It's a cell-eat-cell world: autophagy and phagocytosis. Am J Pathol (2013) 0.95
Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease. J Biol Chem (2009) 0.94
Intracranial extramedullary hematopoiesis associated with pilocytic astrocytoma: a case report. Acta Neuropathol (2003) 0.94
Monitoring mitophagy in neuronal cell cultures. Methods Mol Biol (2011) 0.93
Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion. Cardiovasc Res (2013) 0.93
TRP_2, a lipid/trafficking domain that mediates diacylglycerol-induced vesicle fusion. J Biol Chem (2008) 0.92
Mitochondrial autophagy as a compensatory response to PINK1 deficiency. Autophagy (2009) 0.89
Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy? Neurobiol Dis (2010) 0.88
To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease. Antioxid Redox Signal (2011) 0.87
Chordoid glioma: a case report and molecular characterization of five cases. Brain Pathol (2008) 0.84
Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. Stem Cell Res Ther (2014) 0.83
Multiple motifs regulate apical sorting of p75 via a mechanism that involves dimerization and higher-order oligomerization. Mol Biol Cell (2013) 0.82
Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health. Antioxid Redox Signal (2015) 0.82
PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells. PLoS One (2013) 0.82
Acanthamoeba keratitis: a clinicopathologic case report and review of the literature. Hum Pathol (2013) 0.80
Evidence for core 2 to core 1 O-glycan remodeling during the recycling of MUC1. Glycobiology (2013) 0.80
Autophagy in different flavors: dysregulated protein degradation in neurological diseases. Neurobiol Dis (2011) 0.78
Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1. BMC Chem Biol (2010) 0.78
Altered transcription factor trafficking in oxidatively-stressed neuronal cells. Biochim Biophys Acta (2012) 0.78
Introduction. Autophagy dysregulation in neuropathology. Brain Pathol (2012) 0.76
Mitochondria and Parkinson's disease. Parkinsons Dis (2012) 0.76
Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion. Neurobiol Dis (2003) 0.76
Potential clinical importance of the activation peptide of prostate-specific antigen. Int J Clin Exp Pathol (2009) 0.75
Asymptomatic giant-cell (temporal) arteritis involving the bilateral adnexa: case report and literature review. Int J Gynecol Pathol (2007) 0.75
INTRAOCULAR SYNOVIAL SARCOMA. Retin Cases Brief Rep (2016) 0.75
Pseudogout of the craniocervical junction. Arch Pathol Lab Med (2003) 0.75