PubRank

Ellen R Laird

Author PubWeight™ 14.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties. J Med Chem 2012 0.96
2 Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry 2003 0.88
3 Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. Bioorg Med Chem Lett 2005 0.86
4 Potent, selective pyrimidinetrione-based inhibitors of MMP-13. Bioorg Med Chem Lett 2006 0.86
5 Engineering autoactivating forms of matrix metalloproteinase-9 and expression of the active enzyme in cultured cells and transgenic mouse brain. Biochemistry 2002 0.84
6 Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase. Bioorg Med Chem Lett 2013 0.83
7 Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett 2009 0.80
8 Non-oxime pyrazole based inhibitors of B-Raf kinase. Bioorg Med Chem Lett 2010 0.80
9 The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase. Bioorg Med Chem Lett 2012 0.78
10 Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors. Bioorg Med Chem Lett 2012 0.78
11 Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships. Bioorg Med Chem Lett 2011 0.78
12 Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors. J Med Chem 2011 0.77
13 Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors. Bioorg Med Chem Lett 2002 0.77
14 Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration. J Med Chem 2009 0.77
15 Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg Med Chem Lett 2010 0.77
16 Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13. Bioorg Med Chem Lett 2007 0.76
17 Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development. Bioorg Med Chem Lett 2006 0.76
18 5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor. Future Med Chem 2013 0.76
19 The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors. Bioorg Med Chem Lett 2010 0.75
20 Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity. J Med Chem 2007 0.75
21 Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase. J Med Chem 2005 0.75
22 Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett 2007 0.75
23 Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett 2009 0.75
24 Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties. Bioorg Med Chem Lett 2011 0.75