Published in J Immunol on March 15, 2007
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res (2009) 3.40
Molecular pathology of age-related macular degeneration. Prog Retin Eye Res (2008) 3.35
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02
Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H. Clin Exp Immunol (2008) 2.19
Systemic complement activation in age-related macular degeneration. PLoS One (2008) 2.18
Immunology of age-related macular degeneration. Nat Rev Immunol (2013) 2.14
Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol (2010) 1.68
Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular health. Invest Ophthalmol Vis Sci (2014) 1.65
Immunopathological aspects of age-related macular degeneration. Semin Immunopathol (2008) 1.63
Atypical hemolytic uremic syndrome. Semin Nephrol (2013) 1.56
Translational mini-review series on complement factor H: structural and functional correlations for factor H. Clin Exp Immunol (2008) 1.52
Complement activation by bisretinoid constituents of RPE lipofuscin. Invest Ophthalmol Vis Sci (2008) 1.47
Allelic variants of complement genes associated with dense deposit disease. J Am Soc Nephrol (2011) 1.38
Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina. J Biol Chem (2010) 1.36
Dense deposit disease. Mol Immunol (2011) 1.31
The connection between C-reactive protein and atherosclerosis. Ann Med (2008) 1.29
Basal laminar drusen caused by compound heterozygous variants in the CFH gene. Am J Hum Genet (2008) 1.27
p53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancer. Cancer Epidemiol Biomarkers Prev (2010) 1.24
Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation. Mol Immunol (2008) 1.21
The complex nature of serum C3 and C4 as biomarkers of lupus renal flare. Lupus (2010) 1.21
Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. Prog Retin Eye Res (2014) 1.17
The role of the immune response in age-related macular degeneration. Int J Inflam (2013) 1.16
Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations. J Biol Chem (2009) 1.15
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. J Biol Chem (2008) 1.15
Complement therapy in atypical haemolytic uraemic syndrome (aHUS). Mol Immunol (2013) 1.14
Mechanism of inflammation in age-related macular degeneration. Mediators Inflamm (2012) 1.14
The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application. Graefes Arch Clin Exp Ophthalmol (2010) 1.12
Treatment options for C3 glomerulopathy. Curr Opin Nephrol Hypertens (2013) 1.07
The role of complement in ocular pathology. Semin Immunopathol (2008) 1.07
Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. J Immunol (2013) 1.06
Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. Mol Aspects Med (2012) 1.03
Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. PLoS One (2008) 1.03
Multiplex immunoassay analysis of biomarkers in clinically accessible quantities of human aqueous humor. Mol Vis (2009) 1.01
Factor h: a complement regulator in health and disease, and a mediator of cellular interactions. Biomolecules (2012) 0.99
Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci (2016) 0.97
Identification of acidic pH-dependent ligands of pentameric C-reactive protein. J Biol Chem (2010) 0.96
Comparative functional evolution of human and mouse CR1 and CR2. J Immunol (2008) 0.95
Role of ocular complement factor H in a murine model of choroidal neovascularization. Am J Pathol (2010) 0.95
Association between variant Y402H in age-related macular degeneration (AMD) susceptibility gene CFH and treatment response of AMD: a meta-analysis. PLoS One (2012) 0.94
Gene variants as determinants of longevity: focus on the inflammatory factors. Pflugers Arch (2009) 0.92
C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. Ophthalmology (2010) 0.92
Lack of complement inhibitors in the outer intracranial artery aneurysm wall associates with complement terminal pathway activation. Am J Pathol (2010) 0.92
Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks. Mediators Inflamm (2013) 0.91
Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration. J Immunol (2014) 0.91
Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population. Mol Vis (2008) 0.90
The protective function of human C-reactive protein in mouse models of Streptococcus pneumoniae infection. Endocr Metab Immune Disord Drug Targets (2008) 0.89
Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus. Arthritis Res Ther (2011) 0.87
Interaction of complement factor h and fibulin3 in age-related macular degeneration. PLoS One (2013) 0.86
Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors. Curr Opin Organ Transplant (2011) 0.86
Complement pathway biomarkers and age-related macular degeneration. Eye (Lond) (2015) 0.86
Inflammatory cytokines protect retinal pigment epithelial cells from oxidative stress-induced death. PLoS One (2013) 0.86
Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration. Mol Vis (2008) 0.85
Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study. Am J Hypertens (2008) 0.84
Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study. Clin Exp Immunol (2009) 0.84
Impact of loading phase, initial response and CFH genotype on the long-term outcome of treatment for neovascular age-related macular degeneration. PLoS One (2012) 0.83
Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism. Mol Vis (2012) 0.81
Comprehensive analysis of Copy Number Variation of genes at chromosome 1 and 10 loci associated with late age related macular degeneration. PLoS One (2012) 0.81
Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF. Mol Vis (2010) 0.80
The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA). Clin Exp Immunol (2011) 0.79
The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model. Invest Ophthalmol Vis Sci (2013) 0.79
Complement factor H: using atomic resolution structure to illuminate disease mechanisms. Adv Exp Med Biol (2008) 0.79
Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation? J Clin Med (2014) 0.78
Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk. JAMA Ophthalmol (2015) 0.78
Complement factor H in host defense and immune evasion. Cell Mol Life Sci (2016) 0.78
Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration. Exp Eye Res (2016) 0.77
Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants. Sci Rep (2016) 0.77
Bioactive lysophospholipids generated by hepatic lipase degradation of lipoproteins lead to complement activation via the classical pathway. Invest Ophthalmol Vis Sci (2014) 0.76
Systemic and Ocular Long Pentraxin 3 in Patients with Age-Related Macular Degeneration. PLoS One (2015) 0.76
Pentraxins in the activation and regulation of innate immunity. Immunol Rev (2016) 0.76
A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice. Invest Ophthalmol Vis Sci (2015) 0.76
Genetic diversity and medicinal drug response in eye care. Graefes Arch Clin Exp Ophthalmol (2010) 0.76
Interaction of human complement factor H variants Tyr⁴⁰² and His⁴⁰² with Leptospira spp. Front Immunol (2011) 0.76
Anti-complement-factor H-associated glomerulopathies. Nat Rev Nephrol (2016) 0.76
Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro. J Biol Chem (2016) 0.76
Anticomplement therapy. Biologics (2008) 0.76
Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population. PLoS One (2012) 0.76
Complement factor H polymorphism rs1061170 and the effect of cigarette smoking on the risk of lung cancer. Contemp Oncol (Pozn) (2015) 0.76
Functional transformation of C-reactive protein by hydrogen peroxide. J Biol Chem (2017) 0.75
Genome-wide association studies: applications and insights gained in Ophthalmology. Eye (Lond) (2014) 0.75
The stereotypical molecular cascade in neovascular age-related macular degeneration: the role of dynamic reciprocity. Eye (Lond) (2015) 0.75
Joint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population. J Ophthalmol (2015) 0.75
C-reactive protein and complement factor H polymorphism interaction in advanced exudative age-related macular degeneration. Int Ophthalmol (2016) 0.75
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Global data on visual impairment in the year 2002. Bull World Health Organ (2004) 28.05
Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95
Complement factor H polymorphism and age-related macular degeneration. Science (2005) 17.79
Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol (2004) 13.78
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res (2001) 8.38
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet (2006) 8.33
Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv Immunol (1983) 7.47
A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol (2002) 5.57
Association between C-reactive protein and age-related macular degeneration. JAMA (2004) 4.16
A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Nat Genet (2006) 3.96
Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H. Proc Natl Acad Sci U S A (1990) 2.79
The regulators of complement activation (RCA) gene cluster. Adv Immunol (1989) 2.63
Accumulation of cholesterol with age in human Bruch's membrane. Invest Ophthalmol Vis Sci (2001) 2.54
C-reactive protein and the acute phase response. Adv Intern Med (1982) 2.20
Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. JAMA (2006) 2.15
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. J Biol Chem (2003) 2.02
The factor H protein family. Immunopharmacology (1999) 1.96
Three dimensional structure of human C-reactive protein. Nat Struct Biol (1996) 1.87
Each of the three binding sites on complement factor H interacts with a distinct site on C3b. J Biol Chem (2000) 1.82
Regulation of complement activation by C-reactive protein. Immunopharmacology (1999) 1.78
A common site within factor H SCR 7 responsible for binding heparin, C-reactive protein and streptococcal M protein. Eur J Immunol (2003) 1.77
Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. EMBO J (2006) 1.72
Solution structure of a pair of complement modules by nuclear magnetic resonance. J Mol Biol (1993) 1.68
Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H. J Immunol (1996) 1.68
Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid. Proc Natl Acad Sci U S A (2006) 1.63
Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11. J Immunol (1999) 1.42
Analysis of the recognition mechanism of the alternative pathway of complement by monoclonal anti-factor H antibodies: evidence for multiple interactions between H and surface bound C3b. FEBS Lett (1996) 1.38
Interaction of C-reactive protein with artificial phosphatidylcholine bilayers and complement. J Immunol (1981) 1.22
Interdomain contact regions and angles between adjacent short consensus repeat domains. J Mol Biol (2004) 0.97
C-reactive protein binds to the 3beta-OH group of cholesterol in LDL particles. Biochem Biophys Res Commun (2005) 0.96
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet (2006) 8.33
Identification of a variant associated with adult-type hypolactasia. Nat Genet (2002) 7.49
A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol (2002) 5.57
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol (2005) 3.57
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res (2009) 3.40
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02
Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. Ann Med (2006) 2.99
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome. J Clin Invest (2003) 2.96
A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27. Am J Hum Genet (2002) 2.74
The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci U S A (2002) 2.74
Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. PLoS Genet (2012) 2.65
Monkey malaria in a European traveler returning from Malaysia. Emerg Infect Dis (2008) 2.32
Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp Eye Res (2004) 2.32
Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab (Avastin). Retina (2006) 2.23
Review of cases with the emerging fifth human malaria parasite, Plasmodium knowlesi. Clin Infect Dis (2011) 2.14
Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. J Immunol (2002) 2.06
Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? J Clin Oncol (2005) 1.93
Perifoveal müller cell depletion in a case of macular telangiectasia type 2. Ophthalmology (2010) 1.92
Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration. Am J Pathol (2005) 1.92
Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H. J Immunol (2002) 1.87
A common site within factor H SCR 7 responsible for binding heparin, C-reactive protein and streptococcal M protein. Eur J Immunol (2003) 1.77
Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression. J Virol (2006) 1.75
Drusen-associated degeneration in the retina. Invest Ophthalmol Vis Sci (2003) 1.75
Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein. J Immunol (2007) 1.74
Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. EMBO J (2006) 1.72
Association between complement factor H and proteoglycans in early human coronary atherosclerotic lesions: implications for local regulation of complement activation. Arterioscler Thromb Vasc Biol (2003) 1.68
IFN-alpha enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression. J Immunol (2005) 1.67
Identification of two AGTR2 mutations in male patients with non-syndromic mental retardation. Hum Genet (2003) 1.59
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc Natl Acad Sci U S A (2011) 1.58
Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families. Ann Neurol (2006) 1.57
Complement resistance mechanisms of streptococci. Mol Immunol (2003) 1.56
Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity. J Biol Chem (2003) 1.55
Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. Invest Ophthalmol Vis Sci (2005) 1.53
Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans. Am J Hum Genet (2007) 1.51
Analysis of four neuroligin genes as candidates for autism. Eur J Hum Genet (2005) 1.48
De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome. Hum Mutat (2006) 1.46
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. Genome Med (2012) 1.46
Late development of vitelliform lesions and flecks in a patient with best disease: clinicopathologic correlation. Arch Ophthalmol (2005) 1.42
Complement, age-related macular degeneration and a vision of the future. Arch Ophthalmol (2010) 1.42
Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi. J Immunol (2005) 1.42
Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site. Am J Pathol (2005) 1.40
Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis. J Immunol (2005) 1.38
Yersinia enterocolitica serum resistance proteins YadA and ail bind the complement regulator C4b-binding protein. PLoS Pathog (2008) 1.36
Streptococcus pneumoniae capsular serotype 19F is more resistant to C3 deposition and less sensitive to opsonophagocytosis than serotype 6B. Infect Immun (2008) 1.33
Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H. J Immunol (2002) 1.32
Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2011) 1.30
Genome-wide scan of exfoliation syndrome. Invest Ophthalmol Vis Sci (2007) 1.26
Verteporfin therapy of subfoveal minimally classic choroidal neovascularization in age-related macular degeneration: 2-year results of a randomized clinical trial. Arch Ophthalmol (2005) 1.26
Association of LOXL1 gene with Finnish exfoliation syndrome patients. J Hum Genet (2009) 1.24
Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation. J Immunol (2008) 1.23
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest (2014) 1.23
Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway. Hum Mol Genet (2004) 1.22
Regulation of complement activation at the C3-level by serum resistant leptospires. Microb Pathog (2005) 1.21
Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome. J Biol Chem (2009) 1.21
Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection. Proc Natl Acad Sci U S A (2005) 1.20
Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H. J Immunol (2004) 1.20
Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion. J Immunol (2009) 1.18
Exfoliation syndrome: prevalence and inheritance in a subisolate of the Finnish population. Acta Ophthalmol Scand (2007) 1.17
Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications. Invest Ophthalmol Vis Sci (2010) 1.17
Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous. J Clin Oncol (2005) 1.14
Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med (2008) 1.14
Musical aptitude is associated with AVPR1A-haplotypes. PLoS One (2009) 1.13
Vitamin D status and early age-related macular degeneration in postmenopausal women. Arch Ophthalmol (2011) 1.13
Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis. Vaccine (2011) 1.12
Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture. Neurosurgery (2006) 1.11
Visual function index (VF-14) in exudative age-related macular degeneration of long duration. Am J Ophthalmol (2003) 1.10
Comparison of surface recognition and C3b binding properties of mouse and human complement factor H. Mol Immunol (2005) 1.10
Characterization of complement factor H binding to Yersinia enterocolitica serotype O:3. Infect Immun (2008) 1.10
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. Hum Genomics (2011) 1.08
Species-specific interaction of Streptococcus pneumoniae with human complement factor H. J Immunol (2008) 1.08
The SERPING1 gene and age-related macular degeneration. Lancet (2009) 1.08
Yin and Yang: complement activation and regulation in Alzheimer's disease. Prog Neurobiol (2003) 1.08
Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form. Eur J Immunol (2004) 1.07
Retinal basement membrane abnormalities and the retinopathy of Alport syndrome. Invest Ophthalmol Vis Sci (2009) 1.06
Interaction of pneumococcal histidine triad proteins with human complement. Infect Immun (2010) 1.05