Published in Cell on March 09, 2007
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
p53 and metabolism. Nat Rev Cancer (2009) 5.05
Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer (2008) 4.34
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. Cancer Cell (2013) 3.63
p53 polymorphisms: cancer implications. Nat Rev Cancer (2009) 3.33
Skin β-endorphin mediates addiction to UV light. Cell (2014) 2.61
The protective role of melanin against UV damage in human skin. Photochem Photobiol (2008) 2.45
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Nat Genet (2011) 2.43
Physiological factors that regulate skin pigmentation. Biofactors (2009) 1.93
p53 at a glance. J Cell Sci (2010) 1.88
UV and pigmentation: molecular mechanisms and social controversies. Pigment Cell Melanoma Res (2008) 1.78
Engineered telomere degradation models dyskeratosis congenita. Genes Dev (2008) 1.72
Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis. Cancer Cell (2009) 1.67
PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. Proc Natl Acad Sci U S A (2009) 1.50
Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res (2009) 1.38
UV radiation and the skin. Int J Mol Sci (2013) 1.37
The melanoma revolution: from UV carcinogenesis to a new era in therapeutics. Science (2014) 1.37
Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell (2010) 1.31
Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB. J Invest Dermatol (2010) 1.27
SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J Cell Mol Med (2008) 1.24
Indoor tanning--science, behavior, and policy. N Engl J Med (2010) 1.24
The regulation of the p53-mediated stress response by MDM2 and MDM4. Cold Spring Harb Perspect Biol (2010) 1.23
p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation. Pigment Cell Melanoma Res (2010) 1.21
Tanning and increased nevus development in very-light-skinned children without red hair. Arch Dermatol (2009) 1.17
Malignant melanoma in the 21st century: the emerging molecular landscape. Mayo Clin Proc (2008) 1.13
Melanocytes as instigators and victims of oxidative stress. J Invest Dermatol (2014) 1.13
PGC-1 coactivators regulate MITF and the tanning response. Mol Cell (2012) 1.07
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UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Proc Natl Acad Sci U S A (2013) 1.06
MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol Cell (2013) 1.05
UVA phototransduction drives early melanin synthesis in human melanocytes. Curr Biol (2011) 1.03
Indoor ultraviolet tanning and skin cancer: health risks and opportunities. Curr Opin Oncol (2009) 1.02
Resistance of mitochondrial p53 to dominant inhibition. Mol Cancer (2008) 1.01
Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r. Proc Natl Acad Sci U S A (2009) 1.00
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways. J Cell Biol (2008) 1.00
The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells. PLoS One (2012) 0.98
MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation. Pigment Cell Melanoma Res (2014) 0.97
Evidence that stress to the epidermal barrier influenced the development of pigmentation in humans. Pigment Cell Melanoma Res (2009) 0.96
Suppression of melanin production by expression of HSP70. J Biol Chem (2010) 0.96
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. J Biol Chem (2009) 0.95
{alpha}MSH and Cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism. J Biol Chem (2009) 0.95
Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res (2013) 0.95
The sunny side of p53. Cell (2007) 0.95
Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions. J Biomed Opt (2015) 0.94
Melanocyte-stimulating hormone directly enhances UV-Induced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism. Cancer Res (2010) 0.94
Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. J Invest Dermatol (2012) 0.93
Autophagy in DNA damage response. Int J Mol Sci (2015) 0.93
Perceived relevance of educative information on public (skin) health: a cross-sectional questionnaire survey. J Prev Med Public Health (2013) 0.93
Melanocortin MC₁ receptor in human genetics and model systems. Eur J Pharmacol (2011) 0.92
Forskolin protects keratinocytes from UVB-induced apoptosis and increases DNA repair independent of its effects on melanogenesis. J Invest Dermatol (2008) 0.91
Beneficial effects of UV radiation other than via vitamin D production. Dermatoendocrinol (2012) 0.91
DCAF4, a novel gene associated with leucocyte telomere length. J Med Genet (2015) 0.90
Public (Skin) Health perspectives of gender differences in tanning habits and sun protective behaviour: a cross-sectional questionnaire survey. Wien Klin Wochenschr (2014) 0.90
Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis. Pigment Cell Melanoma Res (2013) 0.89
Abnormal pigmentation within cutaneous scars: A complication of wound healing. Indian J Plast Surg (2012) 0.89
Theory-Driven Longitudinal Study Exploring Indoor Tanning Initiation in Teens Using a Person-Centered Approach. Ann Behav Med (2016) 0.89
Barrier requirements as the evolutionary "driver" of epidermal pigmentation in humans. Am J Hum Biol (2010) 0.89
RXRα ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes. J Invest Dermatol (2010) 0.88
Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation. Molecules (2014) 0.88
Melanocortin 1 Receptor: Structure, Function, and Regulation. Front Genet (2016) 0.88
UV signaling pathways within the skin. J Invest Dermatol (2014) 0.88
Modifying skin pigmentation - approaches through intrinsic biochemistry and exogenous agents. Drug Discov Today Dis Mech (2008) 0.88
Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas. Pigment Cell Melanoma Res (2010) 0.88
A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer. Cancer Causes Control (2008) 0.88
Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells. Dis Model Mech (2009) 0.87
Natural selection and functional genetic variation in the p53 pathway. Hum Mol Genet (2011) 0.87
Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts. J Cutan Pathol (2008) 0.87
p53 Induces skin aging by depleting Blimp1+ sebaceous gland cells. Cell Death Dis (2014) 0.86
Investigation of the novel lead of melanocortin 1 receptor for pigmentary disorders. Evid Based Complement Alternat Med (2014) 0.86
Solar UV exposure and mortality from skin tumors. Adv Exp Med Biol (2008) 0.86
Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin. Zebrafish (2009) 0.86
From melanocytes to melanomas. Nat Rev Cancer (2016) 0.85
Shining light on skin pigmentation: the darker and the brighter side of effects of UV radiation. Photochem Photobiol (2012) 0.85
Exosomes released by keratinocytes modulate melanocyte pigmentation. Nat Commun (2015) 0.85
Understanding the biology of melanoma and therapeutic implications. Hematol Oncol Clin North Am (2014) 0.85
Melanoma: from melanocyte to genetic alterations and clinical options. Scientifica (Cairo) (2013) 0.85
MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proc Natl Acad Sci U S A (2013) 0.81
High-throughput, high-content screening for novel pigmentation regulators using a keratinocyte/melanocyte co-culture system. Exp Dermatol (2014) 0.81
Perceived Relevance of Educative Information on Public (Skin) Health: Results of a Representative, Population-Based Telephone Survey. Int J Environ Res Public Health (2015) 0.81
Insights into the Role of PAX-3 in the Development of Melanocytes and Melanoma. Open Cancer J (2011) 0.81
Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk. Br J Dermatol (2008) 0.81
TBX2 expression is regulated by PAX3 in the melanocyte lineage. Pigment Cell Melanoma Res (2012) 0.81
POT of gold: modeling dyskeratosis congenita in the mouse. Genes Dev (2008) 0.81
Stronger laws are needed to protect teens from indoor tanning. Pediatrics (2013) 0.81
Teens and indoor tanning: a cancer prevention opportunity for pediatricians. Pediatrics (2013) 0.81
Red Hair, Light Skin, and UV-Independent Risk for Melanoma Development in Humans. JAMA Dermatol (2016) 0.80
Does p53 regulate skin pigmentation by controlling proopiomelanocortin gene transcription? Pigment Cell Res (2007) 0.80
p21-activated kinase 4 critically regulates melanogenesis via activation of the CREB/MITF and β-catenin/MITF pathways. J Invest Dermatol (2015) 0.80
Sunbed Use Prevalence and Associated Skin Health Habits: Results of a Representative, Population-Based Survey among Austrian Residents. Int J Environ Res Public Health (2016) 0.79
IFN-γ signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation. Proc Natl Acad Sci U S A (2014) 0.79
Purification and growth of melanocortin 1 receptor (Mc1r)- defective primary murine melanocytes is dependent on stem cell factor (SFC) from keratinocyte-conditioned media. In Vitro Cell Dev Biol Anim (2009) 0.78
(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression. PLoS One (2015) 0.78
The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology. Lab Invest (2017) 0.78
Census and evaluation of p53 target genes. Oncogene (2017) 0.77
Iron upregulates melanogenesis in cultured retinal pigment epithelial cells. Exp Eye Res (2014) 0.77
Pluripotency factor Nanog is tumorigenic by deregulating DNA damage response in somatic cells. Oncogene (2015) 0.77
UV light phototransduction depolarizes human melanocytes. Channels (Austin) (2013) 0.77
The mathematics of tanning. BMC Syst Biol (2009) 0.77
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature (2005) 15.28
Integrative analysis of the melanoma transcriptome. Genome Res (2010) 8.46
Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 5.40
High-throughput mapping of the chromatin structure of human promoters. Nat Biotechnol (2007) 5.24
Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res (2010) 4.71
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell (2006) 4.68
MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med (2006) 4.60
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res (2013) 4.28
Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev (2006) 4.24
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell (2009) 3.85
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell (2002) 3.72
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell (2013) 3.71
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol (2005) 3.68
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. Cancer Cell (2013) 3.63
Melanocyte biology and skin pigmentation. Nature (2007) 3.43
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res (2004) 3.20
Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol (2008) 3.16
Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science (2004) 3.12
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature (2011) 2.96
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell (2004) 2.80
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature (2009) 2.77
Melanoma: from mutations to medicine. Genes Dev (2012) 2.59
Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases. Am J Surg Pathol (2008) 2.58
From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer (2012) 2.46
Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development (2003) 2.42
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell (2011) 2.41
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature (2012) 2.35
Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene (2003) 2.19
PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proc Natl Acad Sci U S A (2011) 2.14
Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. J Clin Oncol (2013) 2.11
Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature (2006) 2.09
Lymphoma of the ocular adnexa: A study of 353 cases. Am J Surg Pathol (2007) 2.08
Key roles for transforming growth factor beta in melanocyte stem cell maintenance. Cell Stem Cell (2010) 2.06
Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol (2002) 2.00
Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Cancer Cell (2011) 1.99
Integrative genome comparison of primary and metastatic melanomas. PLoS One (2010) 1.97
An oncogenic role for ETV1 in melanoma. Cancer Res (2010) 1.94
TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res (2007) 1.93
MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol (2003) 1.90
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell (2010) 1.86
NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell (2002) 1.79
UV and pigmentation: molecular mechanisms and social controversies. Pigment Cell Melanoma Res (2008) 1.78
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway. Cell (2013) 1.75
Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res (2008) 1.73
Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc Natl Acad Sci U S A (2003) 1.73
BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc Natl Acad Sci U S A (2013) 1.72
Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease. Curr Mol Med (2002) 1.69
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med (2008) 1.67
Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res (2004) 1.64
Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem (2005) 1.62
Regulation of MITF stability by the USP13 deubiquitinase. Nat Commun (2011) 1.62
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res (2011) 1.62
Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit. Genes Dev (2010) 1.61
American Society for Radiation Oncology (ASTRO) 2012 Workforce Study: the radiation oncologists' and residents' perspectives. Int J Radiat Oncol Biol Phys (2013) 1.58
Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development (2004) 1.58
Non-bullous neutrophilic dermatosis: an uncommon dermatologic manifestation in patients with lupus erythematosus. J Cutan Pathol (2006) 1.57
Cutaneous rosai-dorfman disease is a distinct clinical entity. Am J Dermatopathol (2002) 1.56
Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol (2005) 1.54
Endothelial-targeted gene transfer of hypoxia-inducible factor-1alpha augments ischemic neovascularization following systemic administration. Mol Ther (2008) 1.49
Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer. J Clin Oncol (2011) 1.47
Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. J Invest Dermatol (2008) 1.42
c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem (2006) 1.42
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell (2006) 1.41
Sumoylation of MITF and its related family members TFE3 and TFEB. J Biol Chem (2004) 1.40
Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform. Gene (2005) 1.35
How sunlight causes melanoma. Curr Oncol Rep (2010) 1.34
A new era: melanoma genetics and therapeutics. J Pathol (2010) 1.32
Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell (2010) 1.31
Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations. Am J Clin Pathol (2002) 1.30
An assessment of the current US radiation oncology workforce: methodology and global results of the American Society for Radiation Oncology 2012 Workforce Study. Int J Radiat Oncol Biol Phys (2013) 1.29
SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res (2003) 1.22
Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell (2010) 1.22
Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage. Pigment Cell Melanoma Res (2008) 1.21
SOX2 contributes to melanoma cell invasion. Lab Invest (2011) 1.21
Feed-forward microprocessing and splicing activities at a microRNA-containing intron. PLoS Genet (2011) 1.18
Pathways and therapeutic targets in melanoma. Oncotarget (2014) 1.17
Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res (2013) 1.16
Identification of Aim-1 as the underwhite mouse mutant and its transcriptional regulation by MITF. J Biol Chem (2001) 1.16