Published in IEEE Trans Image Process on March 01, 2007
Bioimage informatics: a new area of engineering biology. Bioinformatics (2008) 6.26
Robust segmentation of overlapping cells in histopathology specimens using parallel seed detection and repulsive level set. IEEE Trans Biomed Eng (2011) 2.08
Invariant delineation of nuclear architecture in glioblastoma multiforme for clinical and molecular association. IEEE Trans Med Imaging (2012) 1.53
Stacked Sparse Autoencoder (SSAE) for Nuclei Detection on Breast Cancer Histopathology Images. IEEE Trans Med Imaging (2015) 1.37
Morphometic analysis of TCGA glioblastoma multiforme. BMC Bioinformatics (2011) 1.26
ACME: automated cell morphology extractor for comprehensive reconstruction of cell membranes. PLoS Comput Biol (2012) 1.19
Multireference level set for the characterization of nuclear morphology in glioblastoma multiforme. IEEE Trans Biomed Eng (2012) 1.05
Robust adaptive 3-D segmentation of vessel laminae from fluorescence confocal microscope images and parallel GPU implementation. IEEE Trans Med Imaging (2010) 1.03
Robust Nucleus/Cell Detection and Segmentation in Digital Pathology and Microscopy Images: A Comprehensive Review. IEEE Rev Biomed Eng (2016) 0.99
Iterative tensor voting for perceptual grouping of ill-defined curvilinear structures. IEEE Trans Med Imaging (2011) 0.97
Linking changes in epithelial morphogenesis to cancer mutations using computational modeling. PLoS Comput Biol (2010) 0.96
Segmentation of heterogeneous blob objects through voting and level set formulation. Pattern Recognit Lett (2007) 0.95
Chapter 17: bioimage informatics for systems pharmacology. PLoS Comput Biol (2013) 0.95
Cell-based quantification of molecular biomarkers in histopathology specimens. Histopathology (2011) 0.86
Robust Cell Detection and Segmentation in Histopathological Images Using Sparse Reconstruction and Stacked Denoising Autoencoders. Med Image Comput Comput Assist Interv (2015) 0.83
Automated profiling of individual cell-cell interactions from high-throughput time-lapse imaging microscopy in nanowell grids (TIMING). Bioinformatics (2015) 0.83
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res (2015) 0.83
An automated three-dimensional detection and segmentation method for touching cells by integrating concave points clustering and random walker algorithm. PLoS One (2014) 0.82
Automatic Myonuclear Detection in Isolated Single Muscle Fibers Using Robust Ellipse Fitting and Sparse Representation. IEEE/ACM Trans Comput Biol Bioinform (2015) 0.82
Deep Voting: A Robust Approach Toward Nucleus Localization in Microscopy Images. Med Image Comput Comput Assist Interv (2015) 0.81
Robust Cell Segmentation for Histological Images of Glioblastoma. Proc IEEE Int Symp Biomed Imaging (2016) 0.81
A fast, automatic segmentation algorithm for locating and delineating touching cell boundaries in imaged histopathology. Methods Inf Med (2012) 0.79
Beyond Classification: Structured Regression for Robust Cell Detection Using Convolutional Neural Network. Med Image Comput Comput Assist Interv (2015) 0.76
Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration. Nat Commun (2017) 0.75
An integrated framework for automatic Ki-67 scoring in pancreatic neuroendocrine tumor. Med Image Comput Comput Assist Interv (2013) 0.75
Multi-Pass Adaptive Voting for Nuclei Detection in Histopathological Images. Sci Rep (2016) 0.75
iCut: an Integrative Cut Algorithm Enables Accurate Segmentation of Touching Cells. Sci Rep (2015) 0.75
Coupled Segmentation of Nuclear and Membrane-bound Macromolecules through Voting and Multiphase Level Set. Pattern Recognit (2015) 0.75
Segmentation of the Clustered Cells with Optimized Boundary Detection in Negative Phase Contrast Images. PLoS One (2015) 0.75
Robust Cell Detection of Histopathological Brain Tumor Images Using Sparse Reconstruction and Adaptive Dictionary Selection. IEEE Trans Med Imaging (2016) 0.75
Detection of Nuclei in H&E Stained Sections Using Convolutional Neural Networks. IEEE EMBS Int Conf Biomed Health Inform (2017) 0.75
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol (2007) 5.81
Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array. BMC Genomics (2006) 5.59
Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2003) 4.07
Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst (2002) 3.39
Preperitoneal single-port transvesical enucleation of the prostate (STEP) for large-volume BPH: one-year follow-up of Qmax, IPSS, and QoL. Urology (2012) 2.78
China's facility-based birth strategy and neonatal mortality: a population-based epidemiological study. Lancet (2011) 2.64
CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov (2012) 2.51
Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res (2004) 2.33
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet (2011) 2.32
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci U S A (2010) 2.27
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet (2011) 1.95
Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. Am J Pathol (2002) 1.88
Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res (2004) 1.84
Establishing a nationwide emergency department-based syndromic surveillance system for better public health responses in Taiwan. BMC Public Health (2008) 1.81
TGF-beta biology in mammary development and breast cancer. Cold Spring Harb Perspect Biol (2011) 1.75
CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology (2006) 1.67
Establishing a clinical decision rule of severe acute respiratory syndrome at the emergency department. Ann Emerg Med (2004) 1.61
Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res (2007) 1.60
Intramuscular vascular endothelial growth factor gene therapy in patients with chronic critical leg ischemia. Am J Med (2003) 1.58
Wide dissemination of OXA-23-producing carbapenem-resistant Acinetobacter baumannii clonal complex 22 in multiple cities of China. J Antimicrob Chemother (2010) 1.56
The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia. J Hypertens (2008) 1.55
Invariant delineation of nuclear architecture in glioblastoma multiforme for clinical and molecular association. IEEE Trans Med Imaging (2012) 1.53
Comparison of single-surgeon series of transperitoneal laparoendoscopic single-site surgery and standard laparoscopic adrenalectomy. Urology (2012) 1.51
Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement. Mol Cell (2007) 1.49
Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species. Radiat Res (2006) 1.47
Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. PLoS Comput Biol (2010) 1.46
ITFP: an integrated platform of mammalian transcription factors. Bioinformatics (2008) 1.43
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res (2006) 1.42
Ultra-deep sequencing enables high-fidelity recovery of biodiversity for bulk arthropod samples without PCR amplification. Gigascience (2013) 1.42
Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China. Antimicrob Agents Chemother (2011) 1.40
Retracted Gene-gene interaction network analysis of ovarian cancer using TCGA data. J Ovarian Res (2013) 1.40
Two Perspectives. Radiat Res (2015) 1.39
Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 1.35
Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice. Am J Pathol (2005) 1.35
Evidence of Arabidopsis salt acclimation induced by up-regulation of HY1 and the regulatory role of RbohD-derived reactive oxygen species synthesis. Plant J (2011) 1.35
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β. Cancer Res (2012) 1.34
TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Clin Cancer Res (2011) 1.30
Binocular coordination of saccades in children with strabismus before and after surgery. Invest Ophthalmol Vis Sci (2002) 1.29
Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. Am J Physiol Regul Integr Comp Physiol (2007) 1.27
Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. J Biol Chem (2003) 1.27
Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLoS Comput Biol (2007) 1.26
Morphometic analysis of TCGA glioblastoma multiforme. BMC Bioinformatics (2011) 1.26
Ordered nanowire array blue/near-UV light emitting diodes. Adv Mater (2010) 1.25
Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type. Cancer Cell (2011) 1.25
COMPARISON OF SPARSE CODING AND KERNEL METHODS FOR HISTOPATHOLOGICAL CLASSIFICATION OF GLIOBASTOMA MULTIFORME. Proc IEEE Int Symp Biomed Imaging (2011) 1.24
Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. Cancer Res (2002) 1.23
Epigenetic regulation, somatic homologous recombination, and abscisic acid signaling are influenced by DNA polymerase epsilon mutation in Arabidopsis. Plant Cell (2009) 1.23
Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats. J Physiol (2008) 1.22
Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart. J Biomed Sci (2005) 1.22
MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. Neuroimage (2007) 1.20
Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat. Cardiovasc Res (2002) 1.20
Dissemination of imipenem-resistant Acinetobacter baumannii strains carrying the ISAba1 blaOXA-23 genes in a Chinese hospital. J Med Microbiol (2007) 1.20
Carbon monoxide enhances salt tolerance by nitric oxide-mediated maintenance of ion homeostasis and up-regulation of antioxidant defence in wheat seedling roots. Plant Cell Environ (2008) 1.20
MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model. J Magn Reson Imaging (2008) 1.20
GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol (2005) 1.18
Why does the gut choose apolipoprotein B48 but not B100 for chylomicron formation? Am J Physiol Gastrointest Liver Physiol (2007) 1.18
Clonal spread of imipenem-resistant Acinetobacter baumannii among different cities of China. J Clin Microbiol (2007) 1.17
Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts. Radiat Res (2006) 1.16
c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. Stem Cells (2007) 1.16
Design and implementation of the first nationwide, web-based Chinese Renal Data System (CNRDS). BMC Med Inform Decis Mak (2012) 1.14
Are health care providers still smoking? Data from the 2003 and 2006/2007 Tobacco Use Supplement-Current Population Surveys. Nicotine Tob Res (2010) 1.14
Multidimensional profiling of cell surface proteins and nuclear markers. IEEE/ACM Trans Comput Biol Bioinform (2010) 1.13
Widespread occurrence of aminoglycoside resistance due to ArmA methylase in imipenem-resistant Acinetobacter baumannii isolates in China. J Antimicrob Chemother (2007) 1.13
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol (2011) 1.12
Impacts on wetlands of large-scale land-use changes by agricultural development: the Small Sanjiang Plain, China. Ambio (2004) 1.11
Direct coupling of plasmonic and photonic nanowires for hybrid nanophotonic components and circuits. Nano Lett (2009) 1.11
Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia (2013) 1.11
Integrated genome sequence and linkage map of physic nut (Jatropha curcas L.), a biodiesel plant. Plant J (2015) 1.11
Chronic spontaneous activity generated in the somata of primary nociceptors is associated with pain-related behavior after spinal cord injury. J Neurosci (2010) 1.10
Typing and characterization of carbapenem-resistant Acinetobacter calcoaceticus-baumannii complex in a Chinese hospital. J Med Microbiol (2004) 1.10
Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity. Endocrinology (2004) 1.09
Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. Am J Physiol Gastrointest Liver Physiol (2004) 1.09
Stimulation of incretin secretion by dietary lipid: is it dose dependent? Am J Physiol Gastrointest Liver Physiol (2009) 1.08
Dynamic DNA methylation and histone modifications contribute to lentiviral transgene silencing in murine embryonic carcinoma cells. J Virol (2005) 1.08
Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells. J Biol Chem (2005) 1.08
Evidence for the location of the allosteric activation switch in the multisubunit phosphorylase kinase complex from mass spectrometric identification of chemically crosslinked peptides. J Mol Biol (2006) 1.07
New rationales for using TGFbeta inhibitors in radiotherapy. Int J Radiat Biol (2007) 1.07
Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP). J Biol Chem (2004) 1.06
Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors. Stem Cells (2014) 1.05
Clinical carbapenem-resistant Acinetobacter baylyi strain coharboring blaSIM-1 and blaOXA-23 from China. Antimicrob Agents Chemother (2011) 1.05
Epigenetic repression of phosphatidylethanolamine N-methyltransferase (PEMT) in BRCA1-mutated breast cancer. Oncotarget (2014) 1.05
Multireference level set for the characterization of nuclear morphology in glioblastoma multiforme. IEEE Trans Biomed Eng (2012) 1.05
Laparoendoscopic single-site adrenalectomy versus conventional laparoscopic surgery: a systematic review and meta-analysis of observational studies. J Endourol (2013) 1.04
The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate. Am J Physiol Gastrointest Liver Physiol (2007) 1.04
Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha. Am J Physiol Heart Circ Physiol (2007) 1.04
The calmodulin-binding domain of the catalytic gamma subunit of phosphorylase kinase interacts with its inhibitory alpha subunit: evidence for a Ca2+ sensitive network of quaternary interactions. J Biol Chem (2002) 1.04
Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer. BMC Cancer (2013) 1.04
Aberrant expression of microRNAs in gastric cancer and biological significance of miR-574-3p. Int Immunopharmacol (2012) 1.03
Food prices and consumer demand: differences across income levels and ethnic groups. PLoS One (2013) 1.03
One-step solution-based catalytic route to fabricate novel alpha-MnO2 hierarchical structures on a large scale. Chem Commun (Camb) (2004) 1.02
Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation. Mol Cancer (2014) 1.02
Apolipoprotein A-IV regulates chylomicron metabolism-mechanism and function. Am J Physiol Gastrointest Liver Physiol (2011) 1.01
Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway. J Mol Cell Cardiol (2004) 1.01
CXCR4 nuclear localization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal cell carcinoma. Oncol Rep (2009) 1.01
TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A (2014) 1.01
BioSig: an imaging bioinformatics system for phenotypic analysis. IEEE Trans Syst Man Cybern B Cybern (2003) 1.00
Mapping mammary gland architecture using multi-scale in situ analysis. Integr Biol (Camb) (2008) 1.00