Published in J Am Chem Soc on March 16, 2007
Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol (2007) 2.79
Foldamers with heterogeneous backbones. Acc Chem Res (2008) 1.96
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. Proc Natl Acad Sci U S A (2009) 1.87
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc (2011) 1.49
Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains. Angew Chem Int Ed Engl (2008) 1.35
Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly. Proc Natl Acad Sci U S A (2008) 1.35
Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes. Angew Chem Int Ed Engl (2015) 1.17
Sophistication of foldamer form and function in vitro and in vivo. Curr Opin Chem Biol (2007) 1.11
Biophysical and structural characterization of a robust octameric beta-peptide bundle. J Am Chem Soc (2007) 1.11
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04
Computational design of a self-assembling β-peptide oligomer. Org Lett (2010) 0.98
Detection and analysis of chimeric tertiary structures by backbone thioester exchange: packing of an alpha helix against an alpha/beta-peptide helix. Angew Chem Int Ed Engl (2010) 0.96
Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling. J Am Chem Soc (2012) 0.95
Synthesis of functionalised aromatic oligamide rods. Org Biomol Chem (2007) 0.95
Protein-like tertiary folding behavior from heterogeneous backbones. J Am Chem Soc (2013) 0.95
Structural consequences of beta-amino acid preorganization in a self-assembling alpha/beta-peptide: fundamental studies of foldameric helix bundles. J Am Chem Soc (2010) 0.93
Enhancement of α-helix mimicry by an α/β-peptide foldamer via incorporation of a dense ionic side-chain array. J Am Chem Soc (2012) 0.92
Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation. Nat Chem (2015) 0.91
Stereospecific synthesis of conformationally constrained gamma-amino acids: new foldamer building blocks that support helical secondary structure. J Am Chem Soc (2009) 0.90
Distinctive circular dichroism signature for 14-helix-bundle formation by beta-peptides. Org Lett (2008) 0.88
Quasiracemic crystallization as a tool to assess the accommodation of noncanonical residues in nativelike protein conformations. J Am Chem Soc (2012) 0.87
Protease-resistant peptide design-empowering nature's fragile warriors against HIV. Biopolymers (2012) 0.86
Structural mimicry of the α-helix in aqueous solution with an isoatomic α/β/γ-peptide backbone. J Am Chem Soc (2011) 0.86
An alpha/beta-peptide helix bundle with a pure beta3-amino acid core and a distinctive quaternary structure. J Am Chem Soc (2009) 0.86
Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure. Org Biomol Chem (2014) 0.85
Folding Thermodynamics of Protein-Like Oligomers with Heterogeneous Backbones. Chem Sci (2014) 0.85
Design, selection, and characterization of a split chorismate mutase. Protein Sci (2010) 0.79
Folding and function in α/β-peptides: targets and therapeutic applications. Curr Opin Chem Biol (2015) 0.78
Revealing the functionality of hypothetical protein KPN00728 from Klebsiella pneumoniae MGH78578: molecular dynamics simulation approaches. BMC Bioinformatics (2011) 0.78
Differential impact of β and γ residue preorganization on α/β/γ-peptide helix stability in water. J Am Chem Soc (2013) 0.78
α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells. J Am Chem Soc (2015) 0.77
Foldamers: Biomimetic and built to order. Nat Chem (2015) 0.75
Structure and Function of AApeptides. Biochemistry (2016) 0.75
β- and γ-Amino Acids at α-Helical Interfaces: Toward the Formation of Highly Stable Foldameric Coiled Coils. ACS Med Chem Lett (2014) 0.75
Effects of Single α-to-β Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization. J Am Chem Soc (2016) 0.75
Iterative non-proteinogenic residue incorporation yields α/β-peptides with a helix-loop-helix tertiary structure and high affinity for VEGF. Chembiochem (2016) 0.75
Heterogeneous-Backbone Foldamer Mimics of Zinc Finger Tertiary Structure. J Am Chem Soc (2017) 0.75
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
SSB as an organizer/mobilizer of genome maintenance complexes. Crit Rev Biochem Mol Biol (2008) 3.19
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nat Methods (2010) 2.77
High-resolution structure of the E.coli RecQ helicase catalytic core. EMBO J (2003) 2.61
Mimicry of antimicrobial host-defense peptides by random copolymers. J Am Chem Soc (2007) 2.12
Foldamers with heterogeneous backbones. Acc Chem Res (2008) 1.96
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. Proc Natl Acad Sci U S A (2009) 1.87
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75. Nat Struct Mol Biol (2008) 1.78
Targeting protein-protein interactions: lessons from p53/MDM2. Biopolymers (2007) 1.67
Mimicry of host-defense peptides by unnatural oligomers: antimicrobial beta-peptides. J Am Chem Soc (2002) 1.66
A central role for SSB in Escherichia coli RecQ DNA helicase function. J Biol Chem (2007) 1.66
Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases. Structure (2012) 1.64
Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. J Biol Chem (2003) 1.57
(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions. J Am Chem Soc (2007) 1.56
Translocation of a beta-peptide across cell membranes. J Am Chem Soc (2002) 1.55
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc (2011) 1.49
Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I. Proc Natl Acad Sci U S A (2008) 1.42
Domain mapping of Escherichia coli RecQ defines the roles of conserved N- and C-terminal regions in the RecQ family. Nucleic Acids Res (2003) 1.41
Interplay among folding, sequence, and lipophilicity in the antibacterial and hemolytic activities of alpha/beta-peptides. J Am Chem Soc (2007) 1.40
Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain. Structure (2005) 1.40
Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. J Am Chem Soc (2005) 1.39
Dual mechanism of bacterial lethality for a cationic sequence-random copolymer that mimics host-defense antimicrobial peptides. J Mol Biol (2008) 1.37
Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains. Angew Chem Int Ed Engl (2008) 1.35
Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing. Proc Natl Acad Sci U S A (2005) 1.35
Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly. Proc Natl Acad Sci U S A (2008) 1.35
High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl (2009) 1.34
Structure of the calcium-rich signature domain of human thrombospondin-2. Nat Struct Mol Biol (2005) 1.33
Crystal structure of the Deinococcus radiodurans single-stranded DNA-binding protein suggests a mechanism for coping with DNA damage. Proc Natl Acad Sci U S A (2004) 1.33
Rational development of beta-peptide inhibitors of human cytomegalovirus entry. J Biol Chem (2005) 1.32
The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain. Mol Cell Biol (2004) 1.30
Structure and function of RecQ DNA helicases. Crit Rev Biochem Mol Biol (2004) 1.29
Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns. Science (2011) 1.27
A hand-off mechanism for primosome assembly in replication restart. Mol Cell (2007) 1.27
Structure-activity studies of 14-helical antimicrobial beta-peptides: probing the relationship between conformational stability and antimicrobial potency. J Am Chem Soc (2002) 1.27
Structure-activity relationships among random nylon-3 copolymers that mimic antibacterial host-defense peptides. J Am Chem Soc (2009) 1.26
Preferred side-chain constellations at antiparallel coiled-coil interfaces. Proc Natl Acad Sci U S A (2008) 1.26
Application of microwave irradiation to the synthesis of 14-helical beta-peptides. Org Lett (2005) 1.24
Structure of the SSB-DNA polymerase III interface and its role in DNA replication. EMBO J (2011) 1.23
Role of membrane lipids in the mechanism of bacterial species selective toxicity by two alpha/beta-antimicrobial peptides. Biochim Biophys Acta (2006) 1.23
Diphenylprolinol methyl ether: a highly enantioselective catalyst for Michael addition of aldehydes to simple enones. Org Lett (2005) 1.22
Antifungal activity from 14-helical beta-peptides. J Am Chem Soc (2006) 1.21
Protein prosthesis: a semisynthetic enzyme with a beta-peptide reverse turn. J Am Chem Soc (2002) 1.20
Identification of the SSB binding site on E. coli RecQ reveals a conserved surface for binding SSB's C terminus. J Mol Biol (2009) 1.20
Two helical conformations from a single foldamer backbone: "split personality" in short alpha/beta-peptides. Angew Chem Int Ed Engl (2004) 1.17
Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator. J Mol Biol (2009) 1.17
Access to poly-beta-peptides with functionalized side chains and end groups via controlled ring-opening polymerization of beta-lactams. J Am Chem Soc (2009) 1.17
Residue requirements for helical folding in short alpha/beta-peptides: crystallographic characterization of the 11-helix in an optimized sequence. J Am Chem Soc (2005) 1.17
Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL. Chembiochem (2007) 1.16
PriB stimulates PriA helicase via an interaction with single-stranded DNA. J Biol Chem (2005) 1.15
Analysis of the factors that stabilize a designed two-stranded antiparallel beta-sheet. Protein Sci (2002) 1.14
Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation. J Am Chem Soc (2005) 1.13
Biocidal activity of polystyrenes that are cationic by virtue of protonation. Org Lett (2004) 1.10
Design of non-cysteine-containing antimicrobial beta-hairpins: structure-activity relationship studies with linear protegrin-1 analogues. Biochemistry (2002) 1.10
Environment-independent 14-helix formation in short beta-peptides: striking a balance between shape control and functional diversity. J Am Chem Soc (2003) 1.09
Genetic recombination in Bacillus subtilis: a division of labor between two single-strand DNA-binding proteins. Nucleic Acids Res (2012) 1.08
A rationally designed aldolase foldamer. Angew Chem Int Ed Engl (2009) 1.08
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain. Protein Sci (2008) 1.08
α-Helix mimicry with α/β-peptides. Methods Enzymol (2013) 1.07
Structure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQ. Nucleic Acids Res (2008) 1.07
Stabilizing and destabilizing effects of phenylalanine --> F5-phenylalanine mutations on the folding of a small protein. J Am Chem Soc (2006) 1.06
Catalytic transamidation reactions compatible with tertiary amide metathesis under ambient conditions. J Am Chem Soc (2009) 1.06
Efficient synthesis of enantiomerically pure beta2-amino acids via chiral isoxazolidinones. J Org Chem (2003) 1.06
Molecular architecture with functionalized beta-peptide helices. Angew Chem Int Ed Engl (2003) 1.06
Tandem facial amphiphiles for membrane protein stabilization. J Am Chem Soc (2010) 1.05
Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res (2006) 1.05
Structural mechanisms of PriA-mediated DNA replication restart. Proc Natl Acad Sci U S A (2013) 1.05
Three HRDC domains differentially modulate Deinococcus radiodurans RecQ DNA helicase biochemical activity. J Biol Chem (2006) 1.05
Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome. Structure (2010) 1.05
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04
Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochem Biophys Res Commun (2011) 1.03
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone. Proc Natl Acad Sci U S A (2010) 1.03
Unexpected relationships between structure and function in alpha,beta-peptides: antimicrobial foldamers with heterogeneous backbones. J Am Chem Soc (2004) 1.03
Enantioselective organocatalytic Michael additions of aldehydes to enones with imidazolidinones: cocatalyst effects and evidence for an enamine intermediate. J Am Chem Soc (2005) 1.02
Glycotripod amphiphiles for solubilization and stabilization of a membrane-protein superassembly: importance of branching in the hydrophilic portion. Chembiochem (2008) 1.01
Catalytic transamidation under moderate conditions. J Am Chem Soc (2003) 1.01
Coupling DNA-binding and ATP hydrolysis in Escherichia coli RecQ: role of a highly conserved aromatic-rich sequence. Nucleic Acids Res (2005) 1.00
Discrete heterogeneous quaternary structure formed by alpha/beta-peptide foldamers and alpha-peptides. J Am Chem Soc (2007) 1.00
Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in beta-peptides. Org Lett (2007) 1.00
Antimicrobial 14-helical beta-peptides: potent bilayer disrupting agents. Biochemistry (2004) 1.00
Parallel β-sheet vibrational couplings revealed by 2D IR spectroscopy of an isotopically labeled macrocycle: quantitative benchmark for the interpretation of amyloid and protein infrared spectra. J Am Chem Soc (2012) 0.99
Crystal structure of PriB, a component of the Escherichia coli replication restart primosome. Structure (2004) 0.98
An antiparallel alpha-helical coiled-coil model system for rapid assessment of side-chain recognition at the hydrophobic interface. J Am Chem Soc (2006) 0.98
Effect of sequence and structural properties on 14-helical beta-peptide activity against Candida albicans planktonic cells and biofilms. ACS Chem Biol (2009) 0.97
Structure and cellular dynamics of Deinococcus radiodurans single-stranded DNA (ssDNA)-binding protein (SSB)-DNA complexes. J Biol Chem (2012) 0.97
H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding. Anal Chem (2007) 0.97
PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein. J Biol Chem (2013) 0.97
Parallel synthesis of peptide libraries using microwave irradiation. Nat Protoc (2007) 0.97
Rising from the Ashes: DNA Repair in Deinococcus radiodurans. PLoS Genet (2010) 0.97
The BLM dissolvasome in DNA replication and repair. Cell Mol Life Sci (2013) 0.97
Selective binding of TAR RNA by a Tat-derived beta-peptide. Org Lett (2003) 0.96
Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome. Proc Natl Acad Sci U S A (2012) 0.96
Peptide inhibitors identify roles for SSB C-terminal residues in SSB/exonuclease I complex formation. Biochemistry (2009) 0.96
Structure-guided rational design of α/β-peptide foldamers with high affinity for BCL-2 family prosurvival proteins. Chembiochem (2013) 0.96
A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo. J Am Chem Soc (2014) 0.96