Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs.

PubWeight™: 7.34‹?› | Rank: Top 0.1%

🔗 View Article (PMC 1855172)

Published in Genome Res on March 26, 2007

Authors

Jasmina Ponjavic1, Chris P Ponting, Gerton Lunter

Author Affiliations

1: MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom.

Articles citing this

(truncated to the top 100)

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A (2009) 20.66

Long non-coding RNAs: insights into functions. Nat Rev Genet (2009) 19.61

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev (2011) 16.77

The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res (2012) 15.41

A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell (2010) 12.27

Genome regulation by long noncoding RNAs. Annu Rev Biochem (2012) 11.70

Non-coding RNAs in human disease. Nat Rev Genet (2011) 11.40

lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature (2011) 11.31

Long noncoding RNAs: functional surprises from the RNA world. Genes Dev (2009) 9.14

Modular regulatory principles of large non-coding RNAs. Nature (2012) 7.42

Specific expression of long noncoding RNAs in the mouse brain. Proc Natl Acad Sci U S A (2008) 7.19

The genetic signatures of noncoding RNAs. PLoS Genet (2009) 6.72

lincRNAs: genomics, evolution, and mechanisms. Cell (2013) 6.50

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Res (2008) 6.43

Long noncoding RNAs: cellular address codes in development and disease. Cell (2013) 6.01

A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol (2010) 6.01

Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. Cell (2011) 5.65

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet (2011) 5.62

Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol (2009) 5.45

Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis. Genome Res (2011) 3.81

Noncoding RNA in development. Mamm Genome (2008) 3.42

Genomic and transcriptional co-localization of protein-coding and long non-coding RNA pairs in the developing brain. PLoS Genet (2009) 3.38

On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE. Genome Biol Evol (2013) 3.00

Transcribed dark matter: meaning or myth? Hum Mol Genet (2010) 2.87

Genome-wide computational identification and manual annotation of human long noncoding RNA genes. RNA (2010) 2.85

Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness. Genome Biol (2009) 2.70

Long non-coding RNAs in nervous system function and disease. Brain Res (2010) 2.53

Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet (2013) 2.46

Annotating non-coding regions of the genome. Nat Rev Genet (2010) 2.38

Toggle involving cis-interfering noncoding RNAs controls variegated gene expression in yeast. Proc Natl Acad Sci U S A (2009) 2.36

Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome. Genome Biol (2007) 2.35

Transposable elements reveal a stem cell-specific class of long noncoding RNAs. Genome Biol (2012) 2.22

Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. Genome Biol (2010) 2.20

Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs. PLoS Genet (2013) 2.07

Rapid turnover of long noncoding RNAs and the evolution of gene expression. PLoS Genet (2012) 2.05

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. RNA (2011) 2.03

Noncoding RNA and Polycomb recruitment. RNA (2013) 2.00

Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis. Plant Cell (2012) 1.99

DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs. Nucleic Acids Res (2012) 1.94

New perspectives for the elucidation of genetic disorders. Am J Hum Genet (2007) 1.89

Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep (2012) 1.82

Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet (2015) 1.81

Generic eukaryotic core promoter prediction using structural features of DNA. Genome Res (2007) 1.80

Evolutionary conservation of long non-coding RNAs; sequence, structure, function. Biochim Biophys Acta (2013) 1.79

DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene (2011) 1.76

Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome. Genome Biol Evol (2012) 1.69

Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals. Genome Res (2014) 1.69

lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs. Nucleic Acids Res (2014) 1.69

Origin and evolution of spliceosomal introns. Biol Direct (2012) 1.65

The genomic landscape shaped by selection on transposable elements across 18 mouse strains. Genome Biol (2012) 1.63

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. Elife (2013) 1.63

A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. PLoS One (2008) 1.57

Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution. Genome Biol (2015) 1.56

Long non-coding RNAs as a source of new peptides. Elife (2014) 1.56

Long noncoding RNAs: fresh perspectives into the RNA world. Trends Biochem Sci (2013) 1.55

Mining mammalian transcript data for functional long non-coding RNAs. PLoS One (2010) 1.46

Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. RNA (2009) 1.44

Regulation of transcription by long noncoding RNAs. Annu Rev Genet (2014) 1.43

Chromatin signatures at transcriptional start sites separate two equally populated yet distinct classes of intergenic long noncoding RNAs. Genome Biol (2013) 1.41

Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. Br J Cancer (2013) 1.40

A central role for long non-coding RNA in cancer. Front Genet (2012) 1.40

Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk. Carcinogenesis (2011) 1.37

Transcriptional regulatory functions of nuclear long noncoding RNAs. Trends Genet (2014) 1.36

Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer. Am J Transl Res (2012) 1.33

Role of H3K27 methylation in the regulation of lncRNA expression. Cell Res (2010) 1.33

The sequence, structure and evolutionary features of HOTAIR in mammals. BMC Evol Biol (2011) 1.30

GAT: a simulation framework for testing the association of genomic intervals. Bioinformatics (2013) 1.27

Computational identification and functional predictions of long noncoding RNA in Zea mays. PLoS One (2012) 1.25

Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications. Trends Genet (2014) 1.25

The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression. Mol Cancer (2015) 1.24

Negative correlation between expression level and evolutionary rate of long intergenic noncoding RNAs. Genome Biol Evol (2011) 1.23

NONCODE 2016: an informative and valuable data source of long non-coding RNAs. Nucleic Acids Res (2015) 1.21

Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma. Oncotarget (2015) 1.19

The long non-coding RNA Paupar regulates the expression of both local and distal genes. EMBO J (2014) 1.19

Regulation of neural macroRNAs by the transcriptional repressor REST. RNA (2008) 1.18

Long noncoding RNAs: a potential novel class of cancer biomarkers. Front Genet (2015) 1.17

The Long Non-Coding RNAs: A New (P)layer in the "Dark Matter". Front Genet (2012) 1.15

Long non-coding RNA expression profiling of mouse testis during postnatal development. PLoS One (2013) 1.15

NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer. Oncotarget (2015) 1.13

Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease. Front Genet (2014) 1.11

Long noncoding RNAs: Re-writing dogmas of RNA processing and stability. Biochim Biophys Acta (2015) 1.08

Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs. Epigenetics (2013) 1.08

Long noncoding RNAs: new players in the molecular mechanism for maintenance and differentiation of pluripotent stem cells. Stem Cells Dev (2013) 1.07

The RIDL hypothesis: transposable elements as functional domains of long noncoding RNAs. RNA (2014) 1.06

Getting to the heart of the matter: long non-coding RNAs in cardiac development and disease. EMBO J (2013) 1.06

RNA splicing control: yet another gene regulatory role for long nuclear noncoding RNAs. RNA Biol (2011) 1.03

Long noncoding RNAs as enhancers of gene expression. Cold Spring Harb Symp Quant Biol (2011) 1.02

Conserved introns reveal novel transcripts in Drosophila melanogaster. Genome Res (2009) 1.01

The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease. Philos Trans R Soc Lond B Biol Sci (2014) 1.01

Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer. J Exp Clin Cancer Res (2013) 1.01

Genomic landscape of developing male germ cells. Birth Defects Res C Embryo Today (2009) 1.00

Developmental transcriptome analysis of human erythropoiesis. Hum Mol Genet (2014) 0.99

lnCeDB: database of human long noncoding RNA acting as competing endogenous RNA. PLoS One (2014) 0.98

Functional transcriptomics in the post-ENCODE era. Genome Res (2013) 0.98

Unexpected selection to retain high GC content and splicing enhancers within exons of multiexonic lncRNA loci. RNA (2015) 0.97

Genetic and epigenetic regulation of human lincRNA gene expression. Am J Hum Genet (2013) 0.97

Human genetics and genomics a decade after the release of the draft sequence of the human genome. Hum Genomics (2011) 0.95

Evolution of coding and non-coding genes in HOX clusters of a marsupial. BMC Genomics (2012) 0.95

Conserved expression of lincRNA during human and macaque prefrontal cortex development and maturation. RNA (2014) 0.94

Articles cited by this

Basic local alignment search tool. J Mol Biol (1990) 659.07

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

Prediction of complete gene structures in human genomic DNA. J Mol Biol (1997) 58.76

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res (2005) 44.08

Finishing the euchromatic sequence of the human genome. Nature (2004) 41.40

The transcriptional landscape of the mammalian genome. Science (2005) 37.63

Human-mouse alignments with BLASTZ. Genome Res (2003) 35.49

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Global identification of human transcribed sequences with genome tiling arrays. Science (2004) 17.85

Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19

Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Science (2005) 16.82

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell (2004) 16.15

Interspersed repeats and other mementos of transposable elements in mammalian genomes. Curr Opin Genet Dev (1999) 14.64

Large-scale transcriptional activity in chromosomes 21 and 22. Science (2002) 14.01

Noise in eukaryotic gene expression. Nature (2003) 13.01

CRITICA: coding region identification tool invoking comparative analysis. Mol Biol Evol (1999) 12.64

Ensembl 2006. Nucleic Acids Res (2006) 11.66

Empirical analysis of transcriptional activity in the Arabidopsis genome. Science (2003) 11.62

Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution. Genome Res (2003) 11.12

The UCSC Genome Browser Database: update 2006. Nucleic Acids Res (2006) 11.05

Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences. J Mol Biol (1990) 8.75

TFBS: Computational framework for transcription factor binding site analysis. Bioinformatics (2002) 8.45

Characterization of the piRNA complex from rat testes. Science (2006) 7.86

The CpG dinucleotide and human genetic disease. Hum Genet (1988) 7.86

The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature (2002) 7.37

Placental mammal diversification and the Cretaceous-Tertiary boundary. Proc Natl Acad Sci U S A (2003) 6.29

The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell (1992) 6.26

Genomewide comparison of DNA sequences between humans and chimpanzees. Am J Hum Genet (2002) 5.80

Estimating the pattern of nucleotide substitution. J Mol Evol (1994) 5.74

Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function. Trends Genet (2005) 5.07

Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res (2005) 4.86

A new generation of JASPAR, the open-access repository for transcription factor binding site profiles. Nucleic Acids Res (2006) 4.32

Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome. Genome Res (2005) 3.85

Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus. Mol Cell (2000) 3.75

The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. Proc Natl Acad Sci U S A (1990) 3.56

The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene. Science (2006) 3.50

Comprehensive splice-site analysis using comparative genomics. Nucleic Acids Res (2006) 3.30

Genome-wide identification of human functional DNA using a neutral indel model. PLoS Comput Biol (2006) 3.16

DNA methylation and chromatin modification. Curr Opin Genet Dev (1999) 3.14

Mechanisms of transcription-coupled DNA repair. Nat Rev Mol Cell Biol (2002) 3.12

Mouse transcriptome: neutral evolution of 'non-coding' complementary DNAs. Nature (2004) 3.00

RNAdb--a comprehensive mammalian noncoding RNA database. Nucleic Acids Res (2005) 2.84

Non-coding RNAs: hope or hype? Trends Genet (2005) 2.74

Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection. Genome Res (2003) 2.63

Computational gene prediction using multiple sources of evidence. Genome Res (2004) 2.58

Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48

The scale of mutational variation in the murid genome. Genome Res (2005) 1.95

Clusters of internally primed transcripts reveal novel long noncoding RNAs. PLoS Genet (2006) 1.95

Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters. Genome Biol (2006) 1.87

Non-coding RNAs in the nervous system. J Physiol (2006) 1.87

The expanding transcriptome: the genome as the 'Book of Sand'. EMBO J (2006) 1.73

CDS annotation in full-length cDNA sequence. Genome Res (2003) 1.70

A complex population of RNAs exists in human ejaculate spermatozoa: implications for understanding molecular aspects of spermiogenesis. Gene (1999) 1.09

Signatures of adaptive evolution within human non-coding sequence. Hum Mol Genet (2006) 1.03

Allelic IGF2R repression does not correlate with expression of antisense RNA in human extraembryonic tissues. Genomics (2001) 1.02

Gene regulation: a reason for reading nonsense. Nature (2004) 0.92

Articles by these authors

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

The variant call format and VCFtools. Bioinformatics (2011) 25.88

Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res (2002) 25.06

The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40

Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04

SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37

Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01

InterPro, progress and status in 2005. Nucleic Acids Res (2005) 17.53

Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66

A systematic survey of loss-of-function variants in human protein-coding genes. Science (2012) 12.25

Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86

Dindel: accurate indel calls from short-read data. Genome Res (2010) 8.62

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature (2007) 7.91

The genome of a songbird. Nature (2010) 5.90

Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74

Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol (2009) 5.45

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat Genet (2006) 5.26

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24

The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19

A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res (2010) 4.77

Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep (2013) 4.72

Bias of selection on human copy-number variants. PLoS Genet (2006) 4.44

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell (2003) 4.33

Insights into hominid evolution from the gorilla genome sequence. Nature (2012) 4.12

Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83

Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes. Proc Natl Acad Sci U S A (2003) 3.73

Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genet (2009) 3.60

Systematic identification of novel protein domain families associated with nuclear functions. Genome Res (2002) 3.50

The reality of pervasive transcription. PLoS Biol (2011) 3.41

Genomic and transcriptional co-localization of protein-coding and long non-coding RNA pairs in the developing brain. PLoS Genet (2009) 3.38

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38

The genome of the green anole lizard and a comparative analysis with birds and mammals. Nature (2011) 3.32

The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell (2010) 3.26

Genome-wide identification of human functional DNA using a neutral indel model. PLoS Comput Biol (2006) 3.16

Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and human. PLoS Comput Biol (2006) 3.07

Natural genetic variation caused by small insertions and deletions in the human genome. Genome Res (2011) 3.00

A fine-scale chimpanzee genetic map from population sequencing. Science (2012) 2.83

The African coelacanth genome provides insights into tetrapod evolution. Nature (2013) 2.78

Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness. Genome Biol (2009) 2.70

InterPro: an integrated documentation resource for protein families, domains and functional sites. Brief Bioinform (2002) 2.66

Elevated rates of protein secretion, evolution, and disease among tissue-specific genes. Genome Res (2004) 2.58

The bonobo genome compared with the chimpanzee and human genomes. Nature (2012) 2.49

EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa. Nat Genet (2008) 2.46

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet (2003) 2.21

Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. Genome Biol (2010) 2.20

Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet (2003) 2.16

A transcriptomic atlas of mouse neocortical layers. Neuron (2011) 2.08

Rapid turnover of long noncoding RNAs and the evolution of gene expression. PLoS Genet (2012) 2.05

Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes. Genome Biol (2004) 2.05

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99

Predicting protein cellular localization using a domain projection method. Genome Res (2002) 1.98

Common ancestry of the CENP-A chaperones Scm3 and HJURP. Cell (2009) 1.96

Homology explains the functional similarities of Treslin/Ticrr and Sld3. Curr Biol (2010) 1.94

Massive turnover of functional sequence in human and other mammalian genomes. Genome Res (2010) 1.89

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88

The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol (2013) 1.87

Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways. Am J Hum Genet (2008) 1.86

The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes. Genome Res (2013) 1.83

Comparison of the genomes of human and mouse lays the foundation of genome zoology. Hum Mol Genet (2003) 1.83

Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell (2010) 1.82

Accurate distinction of pathogenic from benign CNVs in mental retardation. PLoS Comput Biol (2010) 1.75

Occurrence and consequences of coding sequence insertions and deletions in Mammalian genomes. Genome Res (2004) 1.73

Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes. Genome Res (2007) 1.71

Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome. Genome Biol Evol (2012) 1.69

High levels of RNA-editing site conservation amongst 15 laboratory mouse strains. Genome Biol (2012) 1.68

Novel type IV secretion system involved in propagation of genomic islands. J Bacteriol (2006) 1.64

Genome assembly quality: assessment and improvement using the neutral indel model. Genome Res (2010) 1.64

The genomic landscape shaped by selection on transposable elements across 18 mouse strains. Genome Biol (2012) 1.63

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. Elife (2013) 1.63

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. Genome Res (2011) 1.62

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Curr Biol (2011) 1.54

Reduced purifying selection prevails over positive selection in human copy number variant evolution. Genome Res (2008) 1.54

Hotspots of mutation and breakage in dog and human chromosomes. Genome Res (2005) 1.54

Vitamin K epoxide reductase: homology, active site and catalytic mechanism. Trends Biochem Sci (2004) 1.52

Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Mol Cell (2006) 1.48

UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA. Curr Biol (2009) 1.45

Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell (2011) 1.43

Chromatin signatures at transcriptional start sites separate two equally populated yet distinct classes of intergenic long noncoding RNAs. Genome Biol (2013) 1.41

Estimating divergence time and ancestral effective population size of Bornean and Sumatran orangutan subspecies using a coalescent hidden Markov model. PLoS Genet (2011) 1.37

Improved workflows for high throughput library preparation using the transposome-based Nextera system. BMC Biotechnol (2013) 1.37

Defensins and the convergent evolution of platypus and reptile venom genes. Genome Res (2008) 1.37

Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy. Am J Hum Genet (2007) 1.33

Sexual selection and the adaptive evolution of mammalian ejaculate proteins. Mol Biol Evol (2007) 1.28

GAT: a simulation framework for testing the association of genomic intervals. Bioinformatics (2013) 1.27

TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains? Trends Biochem Sci (2002) 1.24

Preparation of high-quality next-generation sequencing libraries from picogram quantities of target DNA. Genome Res (2011) 1.24

Meisetz and the birth of the KRAB motif. Bioinformatics (2006) 1.24

Forging links between human mental retardation-associated CNVs and mouse gene knockout models. PLoS Genet (2009) 1.23

A new isolation with migration model along complete genomes infers very different divergence processes among closely related great ape species. PLoS Genet (2012) 1.23

Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus. BMC Biol (2011) 1.21