Activation events during thymic selection.

PubWeight™: 3.43‹?› | Rank: Top 1%

🔗 View Article (PMC 2119155)

Published in J Exp Med on March 01, 1992

Authors

A Bendelac1, P Matzinger, R A Seder, W E Paul, R H Schwartz

Author Affiliations

1: Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

Articles citing this

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med (1994) 7.35

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med (1994) 5.90

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J Exp Med (1995) 3.58

Characterization of the early stages of thymic NKT cell development. J Exp Med (2005) 2.84

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice. J Exp Med (1995) 2.70

Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci U S A (1998) 2.61

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J Exp Med (1996) 2.55

A fail-safe mechanism for maintaining self-tolerance. J Exp Med (1992) 2.10

TAP-independent, beta 2-microglobulin-dependent surface expression of functional mouse CD1.1. J Exp Med (1995) 1.96

Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants. Blood (2009) 1.95

Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med (2008) 1.94

Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4. Proc Natl Acad Sci U S A (1995) 1.94

How many thymocytes audition for selection? J Exp Med (1997) 1.90

Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J Exp Med (1994) 1.88

Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. J Exp Med (1994) 1.84

Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages. EMBO J (2010) 1.82

Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nat Immunol (2011) 1.82

Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J Exp Med (1999) 1.82

Murine thymic CD4+ T cell subsets: a subset (Thy0) that secretes diverse cytokines and overexpresses the V beta 8 T cell receptor gene family. J Exp Med (1992) 1.72

Quantitative impact of thymic clonal deletion on the T cell repertoire. J Exp Med (1997) 1.64

CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J (2008) 1.55

Murine thymic selection quantified using a unique method to capture deleted T cells. Proc Natl Acad Sci U S A (2013) 1.52

Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development. Proc Natl Acad Sci U S A (1995) 1.51

Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J Exp Med (1999) 1.45

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro. J Exp Med (1994) 1.44

Bax alpha perturbs T cell development and affects cell cycle entry of T cells. EMBO J (1996) 1.43

Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes. J Immunol (2005) 1.40

Cell adhesion and migration are regulated at distinct stages of thymic T cell development: the roles of fibronectin, VLA4, and VLA5. J Exp Med (1996) 1.39

Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. J Exp Med (2001) 1.33

NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. J Exp Med (2003) 1.33

A novel gene essential for the development of single positive thymocytes. Mol Cell Biol (2009) 1.32

The effect of in vivo IL-7 deprivation on T cell maturation. J Exp Med (1995) 1.30

Induction of the early growth response (Egr) family of transcription factors during thymic selection. J Exp Med (1997) 1.28

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor. J Exp Med (1995) 1.24

Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling. J Biol Chem (2011) 1.21

Differential role of SLP-76 domains in T cell development and function. Proc Natl Acad Sci U S A (2002) 1.20

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J (2005) 1.18

Constitutive activation of integrin alpha 4 beta 1 defines a unique stage of human thymocyte development. J Exp Med (1994) 1.18

A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase. J Exp Med (2003) 1.16

Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol (2011) 1.14

Thymus epithelium induces tissue-specific tolerance. J Exp Med (1993) 1.13

The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function. Mol Cell Biol (2005) 1.11

Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells. Mol Cell Biol (1996) 1.10

The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells. J Exp Med (1995) 1.09

Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J Exp Med (1996) 1.07

The action of Bax and bcl-2 on T cell selection. J Exp Med (1998) 1.04

Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis. J Exp Med (1996) 1.02

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc Natl Acad Sci U S A (1993) 1.02

Mercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin-4. J Clin Invest (1995) 1.01

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. J Exp Med (1995) 1.00

Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected by class I molecules. J Exp Med (1994) 1.00

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J Exp Med (1996) 0.99

The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J Immunol (2009) 0.98

ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes. J Exp Med (1999) 0.97

Exaggerated proinflammatory and Th1 responses in the absence of gamma/delta T cells after infection with Listeria monocytogenes. Infect Immun (2001) 0.97

LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection. EMBO J (2011) 0.94

9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation. J Exp Med (1997) 0.94

A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol (2009) 0.94

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage. J Exp Med (1993) 0.93

Phenotypic identification of the subgroups of murine T-cell receptor alphabeta+ CD4+ CD8- thymocytes and its implication in the late stage of thymocyte development. Immunology (1999) 0.92

From murine to human nude/SCID: the thymus, T-cell development and the missing link. Clin Dev Immunol (2012) 0.89

The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. Front Immunol (2015) 0.89

Transient control of interleukin-4-producing natural killer T cells in the livers of Listeria monocytogenes-infected mice by interleukin-12. Infect Immun (1997) 0.88

Questionable thymic nurse cell. Microbiol Mol Biol Rev (2001) 0.88

Asynchronous coreceptor downregulation after positive thymic selection: prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor. J Exp Med (1997) 0.88

Visualization of CD4/CD8 T cell commitment. J Exp Med (1998) 0.87

Specific CD45 isoforms differentially regulate T cell receptor signaling. EMBO J (1994) 0.86

Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J (2011) 0.86

Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines (2008) 0.86

A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. Proc Natl Acad Sci U S A (2005) 0.85

Distinct expression patterns of CD69 in mucosal and systemic lymphoid tissues in primary SIV infection of rhesus macaques. PLoS One (2011) 0.84

Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation. Mol Cell Biol (2005) 0.84

T-cell apoptosis and differential human leucocyte antigen class II expression in human thymus. Immunology (2000) 0.83

Thymic re-entry of mature activated T cells and increased negative selection in vascularized allograft recipients. Clin Exp Immunol (2002) 0.83

Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells. Proc Natl Acad Sci U S A (1995) 0.81

Heterogeneity in the CD4 T Cell Compartment and the Variability of Neonatal Immune Responsiveness. Curr Immunol Rev (2007) 0.79

Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences. Immunology (2003) 0.79

Membrane association of the CD3ε signaling domain is required for optimal T cell development and function. J Immunol (2014) 0.79

Distinct requirements for CD1d intracellular transport for development of V(alpha)14 iNKT cells. J Immunol (2009) 0.78

Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration. Exp Mol Med (2009) 0.78

Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection. Mol Cell Biol (2002) 0.78

Review article: thymus organ cultures and T-cell receptor repertoire development. Immunology (2000) 0.77

The microRNA biogenesis machinery modulates lineage commitment during αβ T cell development. J Immunol (2014) 0.76

Important biological information uncovered in previously unaligned reads from chromatin immunoprecipitation experiments (ChIP-Seq). Sci Rep (2015) 0.75

Co-ordinate expression of the pre-T-cell receptor complex and a novel immature thymocyte-specific antigen, IMT-1, during thymocyte development. Immunology (1999) 0.75

Susceptibility to Entamoeba histolytica intestinal infection is related to reduction in natural killer T-lymphocytes in C57BL/6 mice. Infect Dis Rep (2012) 0.75

Vaccination and heterologous immunity: educating the immune system. Trans R Soc Trop Med Hyg (2015) 0.75

Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection. Proc Natl Acad Sci U S A (2003) 0.75

Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes. J Immunol (2017) 0.75

Articles cited by this

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol (1986) 35.41

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature (1985) 11.55

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med (1987) 10.61

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J Immunol (1981) 9.86

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors. J Immunol (1989) 8.19

IL-4 directs the development of Th2-like helper effectors. J Immunol (1990) 7.20

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09

Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction. J Exp Med (1980) 5.50

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur J Immunol (1978) 5.35

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. J Immunol (1987) 5.07

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent. J Immunol (1988) 4.38

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell (1990) 4.23

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J Immunol (1989) 4.20

Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur J Immunol (1980) 3.84

Molecular and cellular events of T cell development. Adv Immunol (1989) 3.50

On the complexity of self. Nature (1991) 3.43

Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics (1982) 3.18

Reentry of T cells to the adult thymus is restricted to activated T cells. J Exp Med (1991) 2.81

Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C. J Immunol (1989) 2.81

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med (1991) 2.78

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells. J Immunol (1988) 2.70

The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol (1984) 2.60

Intrathymic and extrathymic T cell maturation. Immunol Rev (1978) 2.47

Selectively increased production of interferon-gamma by subsets of Lyt-2+ and L3T4+ T cells identified by expression of Pgp-1. J Immunol (1987) 2.39

Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma. J Exp Med (1991) 2.23

Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J Immunol (1988) 2.17

CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro. J Immunol (1990) 2.08

A novel MHC class II epitope expressed in thymic medulla but not cortex. Nature (1989) 2.06

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production. J Immunol (1990) 2.03

Cell kinetics in the fetal mouse thymus: precursor cell input, proliferation, and emigration. J Immunol (1987) 1.98

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells. J Exp Med (1991) 1.97

The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell (1989) 1.91

In vivo thymocyte maturation. BUdR labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model. J Immunol (1986) 1.88

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J Exp Med (1990) 1.79

Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity. J Exp Med (1989) 1.78

Thymic cytotoxic T lymphocytes are primed in vivo to minor histocompatibility antigens. J Exp Med (1984) 1.63

Expression of an unusual T cell receptor (TCR)-V beta repertoire by Ly-6C+ subpopulations of CD4+ and/or CD8+ thymocytes. Evidence for a developmental relationship between Ly-6C+ thymocytes and CD4-CD8-TCR-alpha beta+ thymocytes. J Immunol (1991) 1.58

Induction of neonatal tolerance to Mlsa antigens by CD8+ T cells. Science (1990) 1.47

Simultaneous production of interleukin 2, interleukin 4 and interferon-gamma by activated human blood lymphocytes. Eur J Immunol (1990) 1.44

Analysis of recent thymic emigrants with subset- and maturity-related markers. Int Immunol (1990) 1.43

Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens. J Exp Med (1983) 1.42

Rare peripheral T cells migrate to and persist in normal mouse thymus. J Exp Med (1988) 1.35

A novel class II MHC molecule with unusual tissue distribution. Nature (1991) 1.33

Increased frequency of interleukin 4-producing T cells as a result of polyclonal priming. Use of a single-cell assay to detect interleukin 4-producing cells. Eur J Immunol (1991) 1.31

Intrathymic selection of murine TCR alpha beta+CD4-CD8- thymocytes. Int Immunol (1990) 1.29

Constitutive expression of a phosphorylated activation antigen (Leu 23) by CD3bright human thymocytes. J Immunol (1988) 1.22

Intrathymic proliferation of perinatal mouse alpha beta and gamma delta T cell receptor-expressing mature T cells. Int Immunol (1990) 1.12

Immunohistological analysis of immigration of thymocyte-precursors into the thymus: evidence for immigration of peripheral T cells into the thymic medulla. Cell Immunol (1989) 1.10

Entry of antivirally active T lymphocytes into the thymus of virus-infected mice. J Immunol (1991) 1.07

Cell proliferation and differentiation in the fetal and early postnatal mouse thymus. J Immunol (1989) 1.04

Th0 cells in the thymus: the question of T-helper lineages. Immunol Rev (1991) 1.02

Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiation. Eur J Immunol (1989) 0.98

Limiting dilution analysis of interleukin-2-producing mature T cells. Interleukin 2 secretion is an exclusive property of L3T4+ lymphocytes. Scand J Immunol (1988) 0.93

Developmental regulation of the intrathymic T cell precursor population. J Immunol (1991) 0.89

Articles by these authors

Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science (1987) 13.03

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature (1998) 12.07

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature (1985) 11.55

Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med (1982) 9.49

Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol (1994) 8.43

Lymphocyte responses and cytokines. Cell (1994) 8.35

Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol (1990) 7.93

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80

Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol (1989) 7.69

Natural adjuvants: endogenous activators of dendritic cells. Nat Med (1999) 7.10

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09

T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol (1985) 6.98

The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol (1999) 6.19

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature (1996) 6.17

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol (1986) 6.16

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci U S A (1993) 6.12

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med (1994) 5.90

Carrier function in anti-hapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody responses by carrier preimmunization. J Exp Med (1970) 5.71

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med (1987) 5.48

Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science (1996) 5.31

Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (1989) 5.10

Regulation of B-cell growth and differentiation by soluble factors. Annu Rev Immunol (1983) 5.09

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A (2001) 4.76

NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75

Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity. Science (2011) 4.72

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 4.69

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63

The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs. J Exp Med (1966) 4.58

DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol (2000) 4.51

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J Exp Med (1985) 4.47

Functional specificity of thymus- dependent lymphocytes. Science (1977) 4.31

Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med (1971) 4.29

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J Immunol (1989) 4.20

Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science (1989) 4.19

B cells turn off virgin but not memory T cells. Science (1992) 4.12

Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science (1993) 4.08

Medicinal applications of delta-9-tetrahydrocannabinol and marijuana. Ann Intern Med (1997) 4.08

B-cell stimulatory factor-1/interleukin 4. Annu Rev Immunol (1987) 4.04

IL-4 is required to generate and sustain in vivo IgE responses. J Immunol (1988) 4.04

A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family. Nature (1987) 3.96

Functional heterogeneity of murine lymphoid cells. I. Responsiveness to and surface binding of concanavalin A and phytohemagglutinin. J Immunol (1972) 3.96

Danger signals: SOS to the immune system. Curr Opin Immunol (2001) 3.91

Monoclonal antibody against an Ir gene product? J Exp Med (1980) 3.88

A subset of CD4+ thymocytes selected by MHC class I molecules. Science (1994) 3.87

Histocompatibility-linked immune response gene function in guinea pigs. Specific inhibition of antigen-induced lymphocyte proliferation by alloantisera. J Exp Med (1972) 3.81

X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells. J Exp Med (1975) 3.70

Interaction between antigen-presenting cells and primed T lymphocytes: an assessment of Ir gene expression in the antigen-presenting cell. Immunol Rev (1978) 3.67

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proc Natl Acad Sci U S A (1983) 3.66

T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 3.56

Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43

The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell (1982) 3.38

Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science (1995) 3.37

Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates. J Exp Med (1971) 3.30

Frequency of B lymphocytes responsive to anti-immunoglobulin. J Exp Med (1982) 3.30

B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol (1987) 3.18

T cell memory is short-lived in the absence of antigen. J Exp Med (1991) 3.16

B-cell stimulatory factor 1 activates resting B cells. Proc Natl Acad Sci U S A (1985) 3.16

Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens? Cell Immunol (1977) 3.13

Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J Exp Med (1987) 3.12

Gamma chain required for naïve CD4+ T cell survival but not for antigen proliferation. Nat Immunol (2000) 3.10

Functional heterogeneity of murine lymphoid cells. 3. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A as a probe for T cell subsets. J Immunol (1973) 3.04

X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect. J Exp Med (1975) 3.03

Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells. J Exp Med (1982) 3.01

Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci U S A (1991) 3.01

Secondary antibody responses in haptenic systems: cell population selection by antigen. J Immunol (1967) 3.01

Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes. Science (1972) 2.98

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature (1987) 2.94

Receptors on immunocompetent cells. II. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding lymphocytes of normal guinea pigs. J Exp Med (1971) 2.92

Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response. J Exp Med (1978) 2.86

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J Immunol (1987) 2.85

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage. Nature (1988) 2.84

Differential regulation of IgG1 and IgE synthesis by interleukin 4. J Exp Med (1988) 2.84

T-lymphocyte response to cytochrome c. I. Demonstration of a T-cell heteroclitic proliferative response and identification of a topographic antigenic determinant on pigeon cytochrome c whose immune recognition requires two complementing major histocompatibility complex-linked immune response genes. J Exp Med (1979) 2.84

Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med (1997) 2.81

Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation. J Exp Med (1984) 2.71

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A (1997) 2.67

T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera. J Immunol (1976) 2.64

Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation. J Exp Med (1982) 2.58

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc Natl Acad Sci U S A (1987) 2.57

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules. Proc Natl Acad Sci U S A (1983) 2.57

Diagnosis and management of group A streptococcal pharyngitis: a practice guideline. Infectious Diseases Society of America. Clin Infect Dis (1997) 2.54

Carrier function in anti-hapten immune responses. II. Specific properties of carrier cells capable of enhancing anti-hapten antibody responses. J Exp Med (1970) 2.54

Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype. J Exp Med (1979) 2.53

Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol (2000) 2.52

Successful T cell priming in B cell-deficient mice. J Exp Med (1995) 2.52

T cell regulation of IgG subclass antibody production in response to T-independent antigens. J Exp Med (1981) 2.50

Surface immunoglobulin D as a functional receptor for a subclass of B lymphocytes. Immunol Rev (1977) 2.50

H-2-linked immune response (Ir) genes. Independent loci for Ir-IgG and Ir-IgA genes. J Exp Med (1972) 2.50

Determination of antibody-hapten equilibrium constants by an ammonium sulfate precipitation technique. J Immunol (1969) 2.49

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells. J Immunol (1988) 2.48

B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens. J Exp Med (1977) 2.44

B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell (1987) 2.44

Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A (1991) 2.41

DNP-Lys-ficoll: a T-independent antigen which elicits both IgM and IgG anti-DNP antibody-secreting cells. J Immunol (1975) 2.40

Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes. Science (1986) 2.40

Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int Immunol (1992) 2.39