Published in Nat Genet on April 08, 2007
Treatment of Staphylococcus Aureus Colonization in Hand Eczema | NCT01591785
A diversity profile of the human skin microbiota. Genome Res (2008) 7.65
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res (2012) 3.71
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet (2009) 2.96
Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol (2014) 2.95
Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci (2009) 2.71
Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev (2011) 2.62
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J Allergy Clin Immunol (2009) 2.20
Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol (2008) 2.11
One remarkable molecule: filaggrin. J Invest Dermatol (2011) 2.10
Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. Am J Hum Genet (2009) 2.02
Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect. J Invest Dermatol (2011) 1.97
New perspectives for the elucidation of genetic disorders. Am J Hum Genet (2007) 1.89
Isolated populations and complex disease gene identification. Genome Biol (2008) 1.83
Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. J Allergy Clin Immunol (2010) 1.78
An update on the genetics of atopic dermatitis: scratching the surface in 2009. J Allergy Clin Immunol (2010) 1.73
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol (2011) 1.68
"Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J Invest Dermatol (2008) 1.64
Mast cells in atopic dermatitis. Curr Opin Immunol (2009) 1.63
Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy (2011) 1.59
Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol (2009) 1.52
The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort. J Allergy Clin Immunol (2012) 1.52
Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis. JAMA Dermatol (2014) 1.48
Warm, humid, and high sun exposure climates are associated with poorly controlled eczema: PEER (Pediatric Eczema Elective Registry) cohort, 2004-2012. J Invest Dermatol (2013) 1.46
Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLoS Med (2008) 1.43
Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis. Br J Dermatol (2013) 1.43
Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation. Eur J Immunol (2016) 1.42
Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. Am J Pathol (2011) 1.41
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J Clin Invest (2012) 1.38
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med (2009) 1.35
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol (2013) 1.30
Recent advances in asthma genetics. Respir Res (2008) 1.23
Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes. J Allergy Clin Immunol (2010) 1.23
Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting. Nat Genet (2013) 1.17
Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects. J Allergy Clin Immunol (2013) 1.12
Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res (2012) 1.11
Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children. Br J Dermatol (2009) 1.10
Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders. Adv Dermatol (2007) 1.09
Microbial ecology of the skin in the era of metagenomics and molecular microbiology. Cold Spring Harb Perspect Med (2013) 1.07
Antimicrobial peptides, skin infections, and atopic dermatitis. Semin Cutan Med Surg (2008) 1.06
Loss of corneodesmosin leads to severe skin barrier defect, pruritus, and atopy: unraveling the peeling skin disease. Am J Hum Genet (2010) 1.05
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation. Proc Natl Acad Sci U S A (2011) 1.05
SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing. EMBO Mol Med (2011) 1.02
Inherited ichthyoses/generalized Mendelian disorders of cornification. Eur J Hum Genet (2012) 1.02
A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis. Hum Mol Genet (2010) 0.99
Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants. J Invest Dermatol (2013) 0.98
South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin. J Allergy Clin Immunol (2014) 0.97
Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations. J Allergy Clin Immunol (2010) 0.97
Filaggrin gene defects are independent risk factors for atopic asthma in a Polish population: a study in ECAP cohort. PLoS One (2011) 0.97
Whole-genome sequencing in an autism multiplex family. Mol Autism (2013) 0.97
Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy. J Allergy Clin Immunol (2014) 0.96
Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis. J Allergy Clin Immunol (2014) 0.96
Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model. Allergy (2012) 0.94
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. J Allergy Clin Immunol (2015) 0.91
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics (2016) 0.90
Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age. PLoS One (2012) 0.90
Deimination of human filaggrin-2 promotes its proteolysis by calpain 1. J Biol Chem (2011) 0.89
Modeling atopic dermatitis with increasingly complex mouse models. J Invest Dermatol (2008) 0.88
Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status. J Allergy Clin Immunol (2013) 0.87
Mutations in the Filaggrin are Predisposing Factor in Korean Children With Atopic Dermatitis. Allergy Asthma Immunol Res (2013) 0.87
Mast cells are required for full expression of allergen/SEB-induced skin inflammation. J Invest Dermatol (2013) 0.86
Pharmacogenetics and personal genomes. Per Med (2009) 0.86
Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat Commun (2015) 0.86
Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris. PLoS One (2011) 0.85
Mast Cells Regulate Epidermal Barrier Function and the Development of Allergic Skin Inflammation. J Invest Dermatol (2016) 0.84
Regulation of the dynamic chromatin architecture of the epidermal differentiation complex is mediated by a c-Jun/AP-1-modulated enhancer. J Invest Dermatol (2014) 0.83
Genetic Polymorphism of FLG in Korean Ichthyosis Vulgaris Patients. Ann Dermatol (2011) 0.82
Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis. J Biol Chem (2010) 0.82
The allergy gene: how a mutation in a skin protein revealed a link between eczema and asthma. F1000 Med Rep (2011) 0.81
Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge. J Allergy Clin Immunol (2014) 0.80
Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins. Exp Dermatol (2015) 0.80
Research statistics in atopic eczema: what disease is this? Ital J Pediatr (2012) 0.80
Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol (2008) 0.80
Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin. J Invest Dermatol (2012) 0.79
Association between P478S polymorphism of the filaggrin gene & atopic dermatitis. Indian J Med Res (2013) 0.79
Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance. PLoS Genet (2015) 0.79
Atopic dermatitis in children: clinical features, pathophysiology, and treatment. Immunol Allergy Clin North Am (2014) 0.79
Filaggrin null mutations are not a protective factor for acne vulgaris. J Invest Dermatol (2011) 0.79
Barrier repair trumps immunology in the pathogenesis and therapy of atopic dermatitis. Drug Discov Today Dis Mech (2008) 0.79
Recent advances in understanding ichthyosis pathogenesis. F1000Res (2016) 0.78
Old King coal - molecular mechanisms underlying an ancient treatment for atopic eczema. J Clin Invest (2013) 0.78
Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis. PLoS One (2012) 0.78
In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation. J Control Release (2014) 0.78
The frequency of polymorphic variants of filaggrin gene and clinical atopic dermatitis. Postepy Dermatol Alergol (2016) 0.78
Acceptability and efficacy of an emollient containing ceramide-precursor lipids and moisturizing factors for atopic dermatitis in pediatric patients. Drugs R D (2013) 0.77
Overcoming the Barrier Treatment of Ichthyosis: A Combination-therapy Approach. J Clin Aesthet Dermatol (2010) 0.77
Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol (2016) 0.77
Genetic susceptibility for cow's milk allergy in Dutch children: the start of the allergic march? Clin Transl Allergy (2016) 0.77
Common FLG mutation K4671X not associated with atopic dermatitis in Han Chinese in a family association study. PLoS One (2012) 0.77
Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression. J Invest Dermatol (2016) 0.77
Probiotics and Atopic Dermatitis: An Overview. Front Microbiol (2016) 0.76
Lower prevalence of common filaggrin mutations in a community sample of atopic eczema: is disease severity important? Wien Klin Wochenschr (2010) 0.76
Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study. Contact Dermatitis (2013) 0.76
Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep. Genome Biol Evol (2016) 0.76
An Analysis of the Filaggrin Gene Polymorphism in Korean Atopic Dermatitis Patients. J Korean Med Sci (2016) 0.75
Spontaneous atopic dermatitis-like symptoms in a/a ma ft/ma ft/J flaky tail mice appear early after birth. PLoS One (2013) 0.75
Sebaceous gland, hair shaft, and epidermal barrier abnormalities in keratosis pilaris with and without filaggrin deficiency. Am J Pathol (2015) 0.75
Skin-Derived C-Terminal Filaggrin-2 Fragments Are Pseudomonas aeruginosa-Directed Antimicrobials Targeting Bacterial Replication. PLoS Pathog (2015) 0.75
Skin Barrier Function and Staphylococcus aureus Colonization in Vestibulum Nasi and Fauces in Healthy Infants and Infants with Eczema: A Population-Based Cohort Study. PLoS One (2015) 0.75
Retapamulin 1% Ointment and Clobetasol Propionate 0.05% Foam is More Efficacious than Vehicle Ointment and Clobetasol 0.05% Propionate Foam in the Treatment of Hand/Foot Dermatitis: A Single Center, Randomized, Double-blind Study. J Clin Aesthet Dermatol (2014) 0.75
Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort. PLoS One (2009) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet (2006) 9.99
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science (2009) 7.64
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet (2008) 5.93
An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med (2008) 5.88
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial. Lancet Oncol (2013) 4.75
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Surgical excision versus Mohs' micrographic surgery for primary and recurrent basal-cell carcinoma of the face: a prospective randomised controlled trial with 5-years' follow-up. Lancet Oncol (2008) 4.60
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes (2008) 4.57
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet (2006) 4.55
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Measuring European population stratification with microarray genotype data. Am J Hum Genet (2007) 4.03
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
African pastoralism: genetic imprints of origins and migrations. Science (2002) 3.66
Birt-Hogg-Dubé syndrome: diagnosis and management. Lancet Oncol (2009) 3.60
Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet (2007) 3.58
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
Ancient DNA, pig domestication, and the spread of the Neolithic into Europe. Proc Natl Acad Sci U S A (2007) 3.45
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
Filaggrin mutations associated with skin and allergic diseases. N Engl J Med (2011) 3.40
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
Documenting domestication: the intersection of genetics and archaeology. Trends Genet (2006) 3.27
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem (2003) 3.19
West Nile virus 5'-cap structure is formed by sequential guanine N-7 and ribose 2'-O methylations by nonstructural protein 5. J Virol (2006) 3.07
DNA markers reveal the complexity of livestock domestication. Nat Rev Genet (2003) 3.07
Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study. Lancet Neurol (2012) 3.04
Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. Am J Hum Genet (2004) 2.99
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet (2009) 2.96
Structure and function of flavivirus NS5 methyltransferase. J Virol (2007) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Sorèze 2009. J Am Acad Dermatol (2010) 2.87
A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum Mol Genet (2007) 2.84
Intermediate filament proteins and their associated diseases. N Engl J Med (2004) 2.84
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Ferroportin disease: a systematic meta-analysis of clinical and molecular findings. J Hepatol (2010) 2.82
Eculizumab for atypical hemolytic-uremic syndrome. N Engl J Med (2009) 2.80
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73
A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science (2005) 2.72
Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci (2009) 2.71
GJB2 mutations and degree of hearing loss: a multicenter study. Am J Hum Genet (2005) 2.63
Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochs. Proc Biol Sci (2007) 2.61
Genetic evidence for the convergent evolution of light skin in Europeans and East Asians. Mol Biol Evol (2006) 2.54
The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study. J Allergy Clin Immunol (2008) 2.53
Clinical and pathological features of pachyonychia congenita. J Investig Dermatol Symp Proc (2005) 2.45
Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). Hum Mol Genet (2002) 2.41