Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial.

PubWeight™: 7.49‹?› | Rank: Top 0.1%

🔗 View Article (PMID 17426195)

Published in Chest on April 01, 2007

Authors

G Umberto Meduri1, Emmel Golden, Amado X Freire, Edwin Taylor, Muhammad Zaman, Stephanie J Carson, Mary Gibson, Reba Umberger

Author Affiliations

1: Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA. umeduri@utmem.edu

Articles citing this

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33

The acute respiratory distress syndrome. J Clin Invest (2012) 5.61

Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. Intensive Care Med (2014) 2.51

Preoperative and intraoperative predictors of postoperative acute respiratory distress syndrome in a general surgical population. Anesthesiology (2013) 2.22

Therapeutic strategies for severe acute lung injury. Crit Care Med (2010) 2.12

Exploring the heterogeneity of effects of corticosteroids on acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care (2014) 1.43

Glucocorticoid Receptor Expression in Peripheral WBCs of Critically Ill Children. Pediatr Crit Care Med (2015) 1.41

Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med (2007) 1.36

Do corticosteroids reduce the risk of fat embolism syndrome in patients with long-bone fractures? A meta-analysis. Can J Surg (2009) 1.24

Glucocorticoids for ARDS: Just Do It! Chest (2007) 1.21

Acute respiratory distress syndrome: epidemiology and management approaches. Clin Epidemiol (2012) 1.07

Corticosteroids for severe sepsis: an evidence-based guide for physicians. Ann Intensive Care (2011) 1.04

Steroids in late ARDS? Crit Care (2007) 1.03

Acute respiratory distress syndrome: A clinical review. Pulm Circ (2011) 1.02

Acute respiratory distress syndrome: pathophysiology and therapeutic options. J Clin Med Res (2012) 1.01

Pharmacological treatments in ARDS; a state-of-the-art update. BMC Med (2013) 0.99

The Japanese guidelines for the management of sepsis. J Intensive Care (2014) 0.99

Severe novel influenza A (H1N1) infection in cancer patients. Ann Oncol (2010) 0.98

Clinical review: Acute respiratory distress syndrome - clinical ventilator management and adjunct therapy. Crit Care (2013) 0.96

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J (2013) 0.95

Pulmonary complications in patients with severe brain injury. Crit Care Res Pract (2012) 0.93

Steroids for acute respiratory distress syndrome? Clin Chest Med (2014) 0.93

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care (2014) 0.93

Leptospirosis: An Unusual Cause of ARDS. Crit Care Res Pract (2010) 0.92

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury. Respir Res (2011) 0.92

The acute respiratory distress syndrome. Proc (Bayl Univ Med Cent) (2015) 0.90

Statins in the critically ill. Ann Intensive Care (2012) 0.90

Therapeutic targeting of acute lung injury and acute respiratory distress syndrome. Transl Res (2015) 0.90

Rapid induction of autoantibodies during ARDS and septic shock. J Transl Med (2010) 0.89

Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Am J Respir Crit Care Med (2011) 0.89

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun (2015) 0.87

Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol Appl Pharmacol (2013) 0.85

The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes. Crit Care Med (2013) 0.83

The effectiveness of Corticosteroids on mortality in patients with acute respiratory distress syndrome or acute lung injury: a secondary analysis. Sci Rep (2015) 0.83

Acute lung injury following exposure to nitric acid. Lung India (2009) 0.82

Stress-dose hydrocortisone reduces critical illness-related corticosteroid insufficiency associated with severe traumatic brain injury in rats. Crit Care (2013) 0.82

The pharmacology of acute lung injury in sepsis. Adv Pharmacol Sci (2011) 0.82

Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury. PLoS One (2013) 0.81

Acute lung failure. Semin Respir Crit Care Med (2011) 0.81

Sequential C-reactive protein measurements in patients with serious infections: does it help? Crit Care (2012) 0.81

Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. J Crit Care (2013) 0.81

Serum C-reactive protein concentrations in early abdominal and pulmonary sepsis. Rev Bras Ter Intensiva (2013) 0.80

Corticosteroid therapy in acute respiratory distress syndrome. CMAJ (2012) 0.80

Critical care medicine: extracorporeal oxygenation is feasible in Brazil? Rev Bras Ter Intensiva (2014) 0.80

Glucocorticosteroid in treatment of severe pneumonia. Mediators Inflamm (2013) 0.79

Approach to acute exacerbation of idiopathic pulmonary fibrosis. Ann Thorac Med (2013) 0.79

Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection. BMC Infect Dis (2014) 0.79

Defining and predicting severe community-acquired pneumonia. Curr Opin Infect Dis (2010) 0.78

The Role of Omega-3 Polyunsaturated Fatty Acids in the Treatment of Patients with Acute Respiratory Distress Syndrome: A Clinical Review. Biomed Res Int (2015) 0.78

A mortality score for acute respiratory distress syndrome: predicting the future without a crystal ball. J Thorac Dis (2016) 0.78

Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury. FASEB J (2015) 0.78

Clinical Aspects of Acute Lung Insufficiency (ALI/TRALI). Transfus Med Hemother (2008) 0.78

The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Crit Care (2016) 0.78

Acute respiratory failure in critically ill patients with interstitial lung disease. PLoS One (2014) 0.77

Dissociation between systemic and pulmonary anti-inflammatory effects of dexamethasone in humans. Br J Clin Pharmacol (2016) 0.77

Predictors of response to corticosteroid treatment in patients with early acute respiratory distress syndrome: results of a pilot study. Yonsei Med J (2015) 0.77

Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. Front Pediatr (2016) 0.77

Functional characterisation of human pulmonary monocyte-like cells in lipopolysaccharide-mediated acute lung inflammation. J Inflamm (Lond) (2014) 0.77

Corticosteroids and ARDS: A review of treatment and prevention evidence. Lung India (2011) 0.77

Defining severe pneumonia. Clin Chest Med (2011) 0.77

Protective effects of dexamethasone on early acute lung injury induced by oleic acid in rats. Int J Clin Exp Med (2014) 0.77

Hypothalamic-pituitary-adrenal axis in lethal canine Staphylococcus aureus pneumonia. Am J Physiol Endocrinol Metab (2014) 0.77

Albumin rather than C-reactive protein may be valuable in predicting and monitoring the severity and course of acute respiratory distress syndrome in critically ill patients with or at risk for the syndrome after new onset fever. BMC Pulm Med (2015) 0.76

Steroids in early ARDS? Crit Care (2007) 0.76

Lung protective strategy and prone ventilation resulting in successful outcome in a patient with ARDS due to H1N1. BMJ Case Rep (2011) 0.76

Low-dose steroids in ARDS. Chest (2007) 0.76

Steroids for early acute respiratory distress syndrome: critical appraisal of Meduri GU, Golden E, Freire AX, et al: Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007; 131:954-963. Pediatr Crit Care Med (2010) 0.76

Early application of low-dose glucocorticoid improves acute respiratory distress syndrome: A meta-analysis of randomized controlled trials. Exp Ther Med (2017) 0.76

Plasma Biomarker Analysis in Pediatric ARDS: Generating Future Framework from a Pilot Randomized Control Trial of Methylprednisolone: A Framework for Identifying Plasma Biomarkers Related to Clinical Outcomes in Pediatric ARDS. Front Pediatr (2016) 0.75

Dexamethasone inhibits endotoxin-induced coagulopathy in human lungs. J Thromb Haemost (2016) 0.75

Methylprednisolone infusion in early severe ARDS. Chest (2007) 0.75

Surfactant for acute respiratory failure in children: where should it fit in our treatment algorithm? Crit Care (2007) 0.75

Temporal Changes in Microrna Expression in Blood Leukocytes from Patients with the Acute Respiratory Distress Syndrome. Shock (2016) 0.75

Steroids for ARDS: still an open issue. Chest (2007) 0.75

Corticosteroids in septic shock: a systematic review and network meta-analysis. Crit Care (2017) 0.75

Methylprednisolone infusion in early severe ARDS: it is pretty, but is it art? Chest (2007) 0.75

Argument against the Routine Use of Steroids for Pediatric Acute Respiratory Distress Syndrome. Front Pediatr (2016) 0.75

Is There Any Role of Inhalational Corticosteroids in the Prophylaxis of Post-Traumatic Fat Embolism Syndrome? Cureus (2015) 0.75

Corticosteroid treatment for community-acquired pneumonia--the STEP trial: study protocol for a randomized controlled trial. Trials (2014) 0.75

Pregnancy with severe influenza A (H1N1) related acute respiratory distress syndrome: Report of three cases from a rural critical care unit in India. Indian J Crit Care Med (2015) 0.75

Corticosteroids and acute respiratory distress syndrome: the debate continues. Crit Care Med (2013) 0.75

FJU-C4, a new 2-pyridone compound, attenuates lipopolysaccharide-induced systemic inflammation via p38MAPK and NF-κB in mice. PLoS One (2013) 0.75

Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial. Crit Care (2016) 0.75

Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS. Case Rep Crit Care (2017) 0.75

Salmonella Typhi-Induced Septic Shock and Acute Respiratory Distress Syndrome in a Previously Healthy Teenage Patient Treated With High-Dose Dexamethasone. J Investig Med High Impact Case Rep (2016) 0.75

Steroids in Early ARDS. Chest (2007) 0.75

Pre-analytic factors and initial biomarker levels in community-acquired pneumonia patients. BMC Anesthesiol (2014) 0.75

Acute lung injury following the use of granulocyte-macrophage colony-stimulating factor. Int J Crit Illn Inj Sci (2013) 0.75

The effects of dexamethasone and oxygen in ventilated adult sheep with early phase acute respiratory distress syndrome. Lung (2014) 0.75

Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Crit Care Med (2017) 0.75

Clinical evidence of early acute lung injury often precedes the diagnosis of ALI. J Intensive Care Med (2012) 0.75

Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol (2016) 0.75

Evaluating the efficacy of dexamethasone in the treatment of patients with persistent acute respiratory distress syndrome: study protocol for a randomized controlled trial. Trials (2016) 0.75

Preadmission Oral Corticosteroids Are Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults With Sepsis. Crit Care Med (2017) 0.75

Low dose dexmedetomidine for the prophylaxis of perioperative ICU delirium-how much evidence is enough? J Thorac Dis (2016) 0.75

Clinical Practice Guideline of Acute Respiratory Distress Syndrome. Tuberc Respir Dis (Seoul) (2016) 0.75

Enterobacter cloacae Sacroiliitis with Acute Respiratory Distress Syndrome in an Adolescent. Infect Chemother (2015) 0.75

Use of corticosteroids in acute respiratory distress syndrome: Perspective from an Indian intensive care unit. Med J Armed Forces India (2016) 0.75

The clinical practice guideline for the management of ARDS in Japan. J Intensive Care (2017) 0.75

Articles by these authors

Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med (2004) 4.58

Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med (2012) 3.54

H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment. Intensive Care Med (2009) 3.13

Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol (2006) 3.01

Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. Am J Med (2004) 2.47

Evidence for strict inpatient blood glucose control: time to revise glycemic goals in hospitalized patients. Metabolism (2008) 1.18

Treatment of diabetic ketoacidosis with subcutaneous insulin aspart. Diabetes Care (2004) 1.16

Clinical epidemiology of acute lung injury and acute respiratory distress syndrome: incidence, diagnosis, and outcomes. Clin Chest Med (2006) 1.08

Abdominal pain in patients with hyperglycemic crises. J Crit Care (2002) 1.03

The use of alkali therapy in severe diabetic ketoacidosis. Diabetes Care (2002) 0.99

Predictors of mortality in elderly subjects with obstructive airway disease: the PILE score. Ann Epidemiol (2010) 0.95

Alteration of cellular behavior and response to PI3K pathway inhibition by culture in 3D collagen gels. PLoS One (2012) 0.92

A case of clinical tetanus in a patient with protective antitetanus antibody level. South Med J (2007) 0.90

A comparison study of continuous insulin infusion protocols in the medical intensive care unit: computer-guided vs. standard column-based algorithms. J Hosp Med (2010) 0.90

Evaluation of microdilution and disk diffusion methods for antifungal susceptibility testing of dermatophytes. Med Mycol (2007) 0.87

Ungual and trans-ungual iontophoretic delivery of terbinafine for the treatment of onychomycosis. J Pharm Sci (2009) 0.85

Rhabdomyolysis in a patient with West Nile encephalitis and flaccid paralysis. Tenn Med (2008) 0.83

Diagnosis of Trichophyton rubrum from onychomycotic nail samples using polymerase chain reaction and calcofluor white microscopy. J Am Podiatr Med Assoc (2008) 0.83

Corticosteroid treatment in severe community-acquired pneumonia: duration of treatment affects control of systemic inflammation and clinical improvement. Intensive Care Med (2011) 0.82

Sarcoidosis mimicking disseminated testicular cancer. South Med J (2005) 0.80

How "sweet" complexity is and how "bitter" variability can be; the new aspect of intensive care unit hyperglycemia. Crit Care Med (2010) 0.79

Bone mineral density patterns in vitamin D deficient African American men with sickle cell disease. Am J Med Sci (2014) 0.78

Abdominal pathology in patients with diabetes ketoacidosis. Am J Med Sci (2012) 0.78

In vitro pharmacodynamic characteristics of griseofulvin against dermatophyte isolates of Trichophyton tonsurans from tinea capitis patients. Med Mycol (2009) 0.78

Pathways to care: duration of untreated psychosis from Karachi, Pakistan. PLoS One (2009) 0.77

Subdiffusion of proteins and oligomers on membranes. J Chem Phys (2012) 0.77

Dual time point positron emission tomography/computed tomography scan in evaluation of intrathoracic lesions in an area endemic for histoplasmosis and with high prevalence of sarcoidosis. Am J Med Sci (2013) 0.77

Methylprednisolone infusion in early severe ARDS results of a randomized controlled trial. 2007. Chest (2009) 0.77

Respiratory failure in an 83-year-old man with multiple myeloma. Pulmonary alveolar proteinosis. Tenn Med (2009) 0.76

Integrin clustering in two and three dimensions. Langmuir (2012) 0.76

Parenteral nutrition: lipid (soybean) versus lipid (olive oil); same… or maybe not? Crit Care Med (2012) 0.75

The ICU "golden hour" vs morning admissions: do they compete? Chest (2009) 0.75

Hypoglycemia risk: a cause for concern in the intensive care unit hyperglycemia control debate. Crit Care Med (2007) 0.75

Intensive care unit (short) and 1-year (long-term) prognosis: data are in for patients with ischemic stroke. Crit Care Med (2009) 0.75

Intravenous gammaglobulin as rescue therapy in a patient with sickle cell and septic shock. Tenn Med (2013) 0.75

An elderly man with rheumatoid arthritis and dyspnea. Chest (2009) 0.75

Marriage of cousins: Congenital diseases and people's perceptions in Pakistan, a public health challenge. J Public Health Policy (2010) 0.75

Psychiatric disorder does not preclude adequate continuous positive airway pressure titration. Am J Med Sci (2013) 0.75

Lung scedosporiosis in human immunodeficiency virus/acquired immunodeficiency syndrome. Am J Med Sci (2010) 0.75

Diabetic ketoacidosis presenting with acute pancreatitis and visceral vein thrombosis. Tenn Med (2011) 0.75