Published in Circ Res on April 19, 2007
Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett (2007) 3.65
Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med (2008) 3.38
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol (2008) 3.15
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res (2010) 2.57
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation (2010) 2.19
SIRT1: recent lessons from mouse models. Nat Rev Cancer (2010) 2.07
MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation (2010) 2.03
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem (2010) 2.00
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
The cardiomyocyte circadian clock: emerging roles in health and disease. Circ Res (2010) 1.94
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature (2014) 1.94
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab (2013) 1.90
Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest (2010) 1.90
Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol (2008) 1.87
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. J Biol Chem (2009) 1.86
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One (2011) 1.81
Calorie restriction and sirtuins revisited. Genes Dev (2013) 1.79
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res (2009) 1.74
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem (2010) 1.65
SIRT6 in DNA repair, metabolism and ageing. J Intern Med (2008) 1.61
The intersection between aging and cardiovascular disease. Circ Res (2012) 1.61
Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem (2008) 1.61
Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal (2012) 1.60
From sirtuin biology to human diseases: an update. J Biol Chem (2012) 1.60
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
MicroRNA-34a Plays a Key Role in Cardiac Repair and Regeneration Following Myocardial Infarction. Circ Res (2015) 1.58
SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J (2010) 1.54
Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circ Res (2012) 1.53
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med (2009) 1.53
Mitochondria and cardiovascular aging. Circ Res (2012) 1.46
Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. J Biol Chem (2010) 1.45
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol (2009) 1.44
Sirtuins at a glance. J Cell Sci (2011) 1.41
Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One (2010) 1.41
Cardiac aging: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.40
Resveratrol, sirtuins, and the promise of a DR mimetic. Mech Ageing Dev (2010) 1.39
Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes (2009) 1.39
Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res (2010) 1.38
Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia. Circulation (2010) 1.37
Sirtuins: guardians of mammalian healthspan. Trends Genet (2014) 1.36
Iron and diabetes risk. Cell Metab (2013) 1.36
Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1. Am J Physiol Heart Circ Physiol (2008) 1.36
Chromatin remodeling in cardiovascular development and physiology. Circ Res (2011) 1.34
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin. EMBO Mol Med (2013) 1.30
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats. Mech Ageing Dev (2009) 1.29
Forkhead transcription factors and cardiovascular biology. Circ Res (2008) 1.28
Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One (2012) 1.23
Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress. FASEB J (2012) 1.23
MicroRNA Regulation of SIRT1. Front Physiol (2012) 1.21
Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci U S A (2008) 1.19
Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med (2013) 1.17
Sirtuins and their relevance to the kidney. J Am Soc Nephrol (2010) 1.15
The peroxisome: an update on mysteries. Histochem Cell Biol (2012) 1.15
SIRT1: new avenues of discovery for disorders of oxidative stress. Expert Opin Ther Targets (2012) 1.14
Roles and targets of class I and IIa histone deacetylases in cardiac hypertrophy. J Biomed Biotechnol (2010) 1.14
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol (2013) 1.12
The sirtuin family's role in aging and age-associated pathologies. J Clin Invest (2013) 1.12
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med (2011) 1.10
Oxidative stress and microRNAs in vascular diseases. Int J Mol Sci (2013) 1.10
Mechanisms involved in the aging-induced vascular dysfunction. Front Physiol (2012) 1.09
Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY) (2009) 1.09
Mitochondrial SIRT3 and heart disease. Cardiovasc Res (2010) 1.09
The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9. Mol Cell Biol (2011) 1.09
Emerging beneficial roles of sirtuins in heart failure. Basic Res Cardiol (2012) 1.08
PPARα-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway. Cell Metab (2011) 1.08
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci (2013) 1.07
Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. Circ Res (2014) 1.06
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06
Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol (2010) 1.05
KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS One (2010) 1.05
Mammalian target of rapamycin signaling in diabetic cardiovascular disease. Cardiovasc Diabetol (2012) 1.04
The "O" class: crafting clinical care with FoxO transcription factors. Adv Exp Med Biol (2009) 1.04
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy. J Mol Cell Cardiol (2011) 1.03
Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. Circ Res (2014) 1.03
PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO. PPAR Res (2012) 1.03
Effects of myostatin deletion in aging mice. Aging Cell (2009) 1.02
SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02
Redox regulation of FoxO transcription factors. Redox Biol (2015) 1.01
Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response. J Biol Chem (2010) 1.01
Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00
Involvement of the up-regulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress. J Biol Chem (2012) 1.00
HDAC-dependent ventricular remodeling. Trends Cardiovasc Med (2013) 1.00
The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology. Circ Res (2009) 1.00
Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs. J Mol Cell Cardiol (2014) 1.00
Mediterranean diet and cardioprotection: the role of nitrite, polyunsaturated fatty acids, and polyphenols. Nutrition (2011) 1.00
Aging and Autophagy in the Heart. Circ Res (2016) 1.00
SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep (2011) 0.99
Effects of red wine and vodka on collateral-dependent perfusion and cardiovascular function in hypercholesterolemic swine. Circulation (2012) 0.99
The role of sirtuins in modulating redox stressors. Free Radic Biol Med (2011) 0.99
FoxO proteins: cunning concepts and considerations for the cardiovascular system. Clin Sci (Lond) (2009) 0.99
Downregulation of Sirt1 as aging change in advanced heart failure. J Biomed Sci (2014) 0.99
ROS and RNS signaling in heart disorders: could antioxidant treatment be successful? Oxid Med Cell Longev (2011) 0.99
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res (2007) 8.44
Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Proc Natl Acad Sci U S A (2009) 5.13
Cardiac myosin activation: a potential therapeutic approach for systolic heart failure. Science (2011) 4.36
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
Biased alternative polyadenylation in human tissues. Genome Biol (2005) 3.96
Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A (2005) 3.55
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res (2009) 3.53
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem (2006) 3.40
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A (2002) 3.18
Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation. RNA (2005) 3.08
Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell (2007) 2.96
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A (2010) 2.95
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res (2004) 2.82
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res (2010) 2.65
Reprogramming of 3' untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types. PLoS One (2009) 2.64
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res (2010) 2.57
Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation (2006) 2.50
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell (2008) 2.47
Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma. Cancer Res (2006) 2.34
Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development. Circ Res (2002) 2.32
PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes. Nucleic Acids Res (2007) 2.22
Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res (2007) 2.22
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest (2003) 2.20
Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation (2010) 2.19
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest (2003) 2.19
Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion. Circ Res (2011) 2.10
Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation (2008) 2.09
Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ Res (2004) 2.08
Inhalation treatment with glutathione in patients with cystic fibrosis. A randomized clinical trial. Am J Respir Crit Care Med (2013) 2.07
Isotopic evidence for glaciation during the Cretaceous supergreenhouse. Science (2008) 2.04
PolyA_DB: a database for mammalian mRNA polyadenylation. Nucleic Acids Res (2005) 1.99
MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem (2010) 1.94
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med (2013) 1.93
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases. Biochem J (2004) 1.90
Prediction of mRNA polyadenylation sites by support vector machine. Bioinformatics (2006) 1.82
Analysis of alternative cleavage and polyadenylation by 3' region extraction and deep sequencing. Nat Methods (2012) 1.80
Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res (2011) 1.79
Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal (2011) 1.76
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res (2009) 1.74
Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. Toxicol Appl Pharmacol (2003) 1.72
Prediction of remission as a combination of symptomatic and functional remission and adequate subjective well-being in 2960 patients with schizophrenia. J Clin Psychiatry (2006) 1.69
Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res (2007) 1.66
Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci U S A (2003) 1.64
Alternative polyadenylation of cyclooxygenase-2. Nucleic Acids Res (2005) 1.61
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Cardiovasc Res (2008) 1.59
Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res (2014) 1.59
Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci U S A (2008) 1.58
Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure. Circ Heart Fail (2010) 1.57
Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging. Circ Res (2010) 1.56
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest (2002) 1.56
Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation (2012) 1.56
Megacity emissions and lifetimes of nitrogen oxides probed from space. Science (2011) 1.54
Lats2 is a negative regulator of myocyte size in the heart. Circ Res (2008) 1.53
Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability. Mol Cell Biol (2005) 1.50
Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells. PLoS One (2010) 1.49
Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia. Cardiovasc Res (2011) 1.49
A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence. EMBO J (2010) 1.49
Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus. Circ Res (2005) 1.48
Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem (2003) 1.47
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy (2008) 1.46
Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. J Clin Invest (2005) 1.45