Published in FASEB J on April 30, 2007
Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol (2008) 2.57
Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet (2012) 2.16
Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am J Physiol Cell Physiol (2008) 1.80
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Cardiovasc Res (2012) 1.69
Caveolae, ion channels and cardiac arrhythmias. Prog Biophys Mol Biol (2009) 1.35
New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling. Am J Physiol Heart Circ Physiol (2012) 1.24
Membrane rafts and caveolae in cardiovascular signaling. Curr Opin Nephrol Hypertens (2009) 1.19
Lipid rafts and caveolae and their role in compartmentation of redox signaling. Antioxid Redox Signal (2009) 1.02
Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. J Biol Chem (2010) 0.99
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res (2012) 0.99
The genetics of pulmonary arterial hypertension. Circ Res (2014) 0.95
Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension. Am J Physiol Lung Cell Mol Physiol (2008) 0.95
Functional expression of transient receptor potential vanilloid-related channels in chronically hypoxic human pulmonary arterial smooth muscle cells. J Membr Biol (2008) 0.94
Vascular involvement in systemic sclerosis (scleroderma). J Inflamm Res (2011) 0.93
Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells. J Cell Mol Med (2011) 0.90
Pathogenesis of Systemic Sclerosis. Front Immunol (2015) 0.89
Calcium-sensing receptor modulates extracellular Ca(2+) entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells. Am J Physiol Cell Physiol (2011) 0.89
Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species. Free Radic Biol Med (2014) 0.88
Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension. J Biol Chem (2014) 0.88
Cell-specific dual role of caveolin-1 in pulmonary hypertension. Pulm Med (2011) 0.87
Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5. J Cell Mol Med (2011) 0.87
The role of caveolae and caveolin 1 in calcium handling in pacing and contraction of mouse intestine. J Cell Mol Med (2008) 0.85
Transcriptional repression of Caveolin-1 (CAV1) gene expression by GATA-6 in bladder smooth muscle hypertrophy in mice and human beings. Am J Pathol (2011) 0.85
Regulation of ca(2+) signaling in pulmonary hypertension. Korean J Physiol Pharmacol (2013) 0.85
Sarcolemmal cholesterol and caveolin-3 dependence of cardiac function, ischemic tolerance, and opioidergic cardioprotection. Am J Physiol Heart Circ Physiol (2014) 0.83
Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets. BMC Genomics (2007) 0.83
Protein trafficking dysfunctions: Role in the pathogenesis of pulmonary arterial hypertension. Pulm Circ (2011) 0.83
A novel insight into the mechanism of pulmonary hypertension involving caveolin-1 deficiency and endothelial nitric oxide synthase activation. Trends Cardiovasc Med (2009) 0.82
Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis. Am J Pathol (2010) 0.82
Caveolin and caveolae in age associated cardiovascular disease. J Geriatr Cardiol (2013) 0.82
Associated inflammation or increased flow-mediated shear stress, but not pressure alone, disrupts endothelial caveolin-1 in infants with pulmonary hypertension. Pulm Circ (2012) 0.81
Heritable forms of pulmonary arterial hypertension. Semin Respir Crit Care Med (2013) 0.81
Peroxisome Proliferator-Activated Receptor γ-Mediated Inhibition on Hypoxia-Triggered Store-Operated Calcium Entry. A Caveolin-1-Dependent Mechanism. Am J Respir Cell Mol Biol (2015) 0.80
Caveolin-1 Expression and Hemodynamics in COPD Patients. Open Respir Med J (2009) 0.79
Caveolin-1 enhances rapid mucosal restitution by activating TRPC1-mediated Ca2+ signaling. Physiol Rep (2014) 0.78
Serum Caveolin-1 as a Novel Biomarker in Idiopathic Pulmonary Artery Hypertension. Biomed Res Int (2015) 0.77
Regulation of Cell Signaling and Function by Endothelial Caveolins: Implications in Disease. Transl Med (Sunnyvale) (2012) 0.77
Caveolin-1 Promotes the Imbalance of Th17/Treg in Patients with Chronic Obstructive Pulmonary Disease. Inflammation (2016) 0.76
Pulmonary hypertension and metabolic syndrome: Possible connection, PPARγ and Caveolin-1. World J Cardiol (2014) 0.75
Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation. World J Cardiol (2015) 0.75
Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. Small (2017) 0.75
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science (2006) 6.00
Intellectual property. Enhanced: intellectual property landscape of the human genome. Science (2005) 4.67
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet (2002) 4.63
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron (2003) 4.04
A single amino acid mutation contributes to adaptive beach mouse color pattern. Science (2006) 3.99
Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75
Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 3.69
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell (2007) 3.58
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature (2011) 3.51
Dexmedetomidine and cardiac arrest. Anesthesiology (2004) 3.49
Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology (2009) 3.26
Pulmonary endarterectomy: experience and lessons learned in 1,500 cases. Ann Thorac Surg (2003) 3.04
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci U S A (2004) 2.79
The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol (2004) 2.70
Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits. Am J Respir Crit Care Med (2003) 2.59
Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol (2008) 2.57
GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell (2009) 2.54
Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell (2011) 2.51
Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med (2003) 2.36
Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem (2006) 2.31
Impact of anesthesia on cardiac function during echocardiography in mice. Am J Physiol Heart Circ Physiol (2002) 2.27
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation (2009) 2.17
Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis. Am J Respir Crit Care Med (2014) 2.16
Gender differences in patenting in the academic life sciences. Science (2006) 2.14
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood (2012) 2.14
Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol (2002) 2.13
Adenylyl cyclase increases survival in cardiomyopathy. Circulation (2002) 2.10
Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension. Am J Respir Crit Care Med (2010) 2.09
Slit diaphragms contain tight junction proteins. J Am Soc Nephrol (2009) 2.08
L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension (2013) 2.05
Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J (2007) 2.04
Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc Natl Acad Sci U S A (2004) 2.02
Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest (2009) 2.02
Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation (2010) 1.97
Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology (2011) 1.95
PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol (2003) 1.91
Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal (2010) 1.91
Development and pathology of pulmonary hypertension. J Am Coll Cardiol (2009) 1.88
Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol (2008) 1.88
Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol (2005) 1.85
GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. Mol Cell Biol (2006) 1.85
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One (2008) 1.84
G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem (2005) 1.82
GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A (2009) 1.81
The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. J Invest Dermatol (2008) 1.79
Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood (2004) 1.77
Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.77
Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med (2009) 1.77
Autonomic nervous system pharmacogenomics: a progress report. Pharmacol Rev (2004) 1.73
A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell (2010) 1.72
Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2006) 1.71
Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem (2005) 1.71
Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem (2008) 1.67
Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension. Microvasc Res (2004) 1.65
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Proc Natl Acad Sci U S A (2005) 1.64
Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension (2006) 1.64
A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am J Respir Crit Care Med (2012) 1.63
Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension (2006) 1.61
Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J (2009) 1.61
The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem (2004) 1.57
Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood (2010) 1.56
Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation (2008) 1.56
Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest (2009) 1.56
beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics (2002) 1.54
Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation (2007) 1.53
Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A (2005) 1.52
Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells. J Am Soc Nephrol (2004) 1.52
Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Am J Physiol Heart Circ Physiol (2006) 1.52
Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension (2005) 1.52
Activation of K+ channels: an essential pathway in programmed cell death. Am J Physiol Lung Cell Mol Physiol (2004) 1.51
Endothelial expression of bone morphogenetic protein receptor type 1a is required for atrioventricular valve formation. Ann Thorac Surg (2008) 1.51
Lung cancer and radiofrequency ablation. J Vasc Interv Radiol (2006) 1.51
Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J (2010) 1.50
Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A (2010) 1.49
Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases. Blood (2011) 1.49