Published in Mol Biol Cell on May 16, 2007
Signal recognition particle: an essential protein-targeting machine. Annu Rev Biochem (2013) 1.74
Signal sequences activate the catalytic switch of SRP RNA. Science (2009) 1.44
The crystal structure of the signal recognition particle in complex with its receptor. Science (2011) 1.41
SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol (2008) 1.16
Molecular mechanism of co-translational protein targeting by the signal recognition particle. Traffic (2011) 1.09
Interaction of signal-recognition particle 54 GTPase domain and signal-recognition particle RNA in the free signal-recognition particle. Proc Natl Acad Sci U S A (2007) 1.08
Signal recognition particle-ribosome binding is sensitive to nascent chain length. J Biol Chem (2014) 0.95
The 4.5S RNA component of the signal recognition particle is required for group A Streptococcus virulence. Microbiology (2010) 0.93
Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. PLoS One (2008) 0.91
A distinct mechanism to achieve efficient signal recognition particle (SRP)-SRP receptor interaction by the chloroplast srp pathway. Mol Biol Cell (2009) 0.89
Exploring the interactions between signal sequences and E. coli SRP by two distinct and complementary crosslinking methods. Biopolymers (2009) 0.87
Prediction of biological functions of Shewanella-like protein phosphatases (Shelphs) across different domains of life. Funct Integr Genomics (2011) 0.84
Co-translational protein targeting to the bacterial membrane. Biochim Biophys Acta (2013) 0.83
Use of synthetic signal sequences to explore the protein export machinery. Biopolymers (2008) 0.82
Fingerloop activates cargo delivery and unloading during cotranslational protein targeting. Mol Biol Cell (2012) 0.80
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature (1982) 7.80
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol (1982) 5.20
The signal recognition particle. Annu Rev Biochem (2001) 4.47
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Crystal structure of the ribonucleoprotein core of the signal recognition particle. Science (2000) 3.88
An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science (1990) 3.55
The E. coli ffh gene is necessary for viability and efficient protein export. Nature (1992) 3.45
Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Nature (2004) 3.31
The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins. Cell (1997) 3.09
Substrate twinning activates the signal recognition particle and its receptor. Nature (2004) 2.91
Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell (1998) 2.44
Heterodimeric GTPase core of the SRP targeting complex. Science (2004) 2.36
Targeting proteins to membranes: structure of the signal recognition particle. Curr Opin Struct Biol (2005) 2.18
Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases. Science (1995) 2.17
Following the signal sequence from ribosomal tunnel exit to signal recognition particle. Nature (2006) 2.11
Role of SRP RNA in the GTPase cycles of Ffh and FtsY. Biochemistry (2001) 2.07
Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor. Science (2000) 2.06
Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor. EMBO J (1997) 1.99
Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. Science (1991) 1.94
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation. Nature (1993) 1.88
The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal. Proc Natl Acad Sci U S A (2001) 1.85
Signal recognition particle receptor exposes the ribosomal translocon binding site. Science (2006) 1.77
Structure of the E. coli signal recognition particle bound to a translating ribosome. Nature (2006) 1.74
Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication. Proc Natl Acad Sci U S A (2003) 1.55
The signal recognition particle database (SRPDB). Nucleic Acids Res (1993) 1.43
Conformational changes in the bacterial SRP receptor FtsY upon binding of guanine nucleotides and SRP. J Mol Biol (2000) 1.39
Induced nucleotide specificity in a GTPase. Proc Natl Acad Sci U S A (2003) 1.29
Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY. RNA (2001) 1.25
RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle. Nat Struct Mol Biol (2005) 1.24
GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding. J Cell Biol (1993) 1.22
SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting. RNA (2006) 1.16
Genetic screen yields mutations in genes encoding all known components of the Escherichia coli signal recognition particle pathway. J Bacteriol (2002) 1.16
Physiological basis for conservation of the signal recognition particle targeting pathway in Escherichia coli. J Bacteriol (2001) 1.11
Conformations of the signal recognition particle protein Ffh from Escherichia coli as determined by FRET. J Mol Biol (2005) 1.09
Domain rearrangement of SRP protein Ffh upon binding 4.5S RNA and the SRP receptor FtsY. RNA (2005) 0.98
The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy. Mol Biol Cell (2006) 0.79
Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06
IRE1 signaling affects cell fate during the unfolded protein response. Science (2007) 9.01
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol (2006) 6.47
An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science (2009) 6.14
Painful publishing. Science (2008) 5.17
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature (2008) 4.70
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science (2009) 4.58
Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol (2006) 4.55
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 4.25
Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol (2008) 4.10
The unfolded protein response signals through high-order assembly of Ire1. Nature (2008) 3.87
Bypassing a kinase activity with an ATP-competitive drug. Science (2003) 3.71
Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature (2002) 3.68
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science (2011) 3.19
Gene recruitment of the activated INO1 locus to the nuclear membrane. PLoS Biol (2004) 3.09
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
Eisosomes mark static sites of endocytosis. Nature (2006) 2.95
Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature (2008) 2.94
Substrate twinning activates the signal recognition particle and its receptor. Nature (2004) 2.91
Bioinformatics Training Network (BTN): a community resource for bioinformatics trainers. Brief Bioinform (2011) 2.79
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biol (2009) 2.35
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PLoS Biol (2010) 2.35
Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One (2009) 2.30
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc Natl Acad Sci U S A (2010) 2.23
Does surgical experience have an effect on the success of retinal detachment surgery? Retina (2012) 2.22
ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy (2007) 2.21
Targeting proteins to membranes: structure of the signal recognition particle. Curr Opin Struct Biol (2005) 2.18
Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol (2013) 2.02
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91
Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife (2013) 1.85
The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A (2011) 1.75
Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. PLoS Biol (2004) 1.73
Mechanism of association and reciprocal activation of two GTPases. PLoS Biol (2004) 1.72
A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol (2009) 1.54
ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife (2013) 1.52
Pkh-kinases control eisosome assembly and organization. EMBO J (2007) 1.52
Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J Cell Biol (2011) 1.50
Structural basis of FFAT motif-mediated ER targeting. Structure (2005) 1.49
Co-translational protein targeting by the signal recognition particle. FEBS Lett (2005) 1.47
Signal sequences activate the catalytic switch of SRP RNA. Science (2009) 1.44
A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol (2010) 1.44
ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology. J Cell Sci (2010) 1.43
Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol (2010) 1.37
Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation. J Cell Biol (2007) 1.32
IRE1-independent gain control of the unfolded protein response. PLoS Biol (2004) 1.31
Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol (2012) 1.31
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. Proc Natl Acad Sci U S A (2004) 1.30
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife (2012) 1.29
Fundus near infrared fluorescence correlates with fundus near infrared reflectance. Invest Ophthalmol Vis Sci (2006) 1.29
Induced nucleotide specificity in a GTPase. Proc Natl Acad Sci U S A (2003) 1.29
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease. Genome Biol (2004) 1.28
Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. J Biol Chem (2013) 1.25
A CHOP-regulated microRNA controls rhodopsin expression. J Cell Biol (2011) 1.22
Implantation and explantation of a wireless epiretinal retina implant device: observations during the EPIRET3 prospective clinical trial. Invest Ophthalmol Vis Sci (2009) 1.21
BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response. EMBO J (2011) 1.21
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol (2002) 1.21
Macular translocation with 360 degrees retinotomy for exudative age-related macular degeneration. Arch Ophthalmol (2002) 1.18
The unfolded protein response during prostate cancer development. Cancer Metastasis Rev (2009) 1.18
The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating. Mol Biol Cell (2006) 1.17
SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol (2008) 1.16
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol (2011) 1.14
Structural and functional basis for RNA cleavage by Ire1. BMC Biol (2011) 1.12
Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. J Oncol (2011) 1.11
Accuracy of intraocular lens power calculation using partial coherence interferometry in patients with high myopia. Ophthalmic Physiol Opt (2012) 1.08
Pil1 controls eisosome biogenesis. Mol Biol Cell (2008) 1.08
Visual resolution with retinal implants estimated from recordings in cat visual cortex. Vision Res (2006) 1.07
A method and technical equipment for an acute human trial to evaluate retinal implant technology. J Neural Eng (2005) 1.04
Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines. J Cell Biol (2008) 1.00
Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. Proc Natl Acad Sci U S A (2010) 0.99
Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment study (SPR Study): predictive factors for functional outcome. Study report no. 6. Graefes Arch Clin Exp Ophthalmol (2011) 0.97
Visual outcome of patients with macular edema after pars plana vitrectomy and indocyanine green-assisted peeling of the internal limiting membrane. Graefes Arch Clin Exp Ophthalmol (2004) 0.97
Novel organotypic culture model of adult mammalian neurosensory retina in co-culture with retinal pigment epithelium. J Neurosci Methods (2008) 0.97
Seg1 controls eisosome assembly and shape. J Cell Biol (2012) 0.95
The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating. J Cell Biol (2007) 0.95
Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment study (SPR study): Risk assessment of anatomical outcome. SPR study report no. 7. Acta Ophthalmol (2012) 0.94
Early hyperbaric oxygen treatment for nonarteritic central retinal artery obstruction. Am J Ophthalmol (2011) 0.93
Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc Natl Acad Sci U S A (2007) 0.92
Effects of bevacizumab (Avastin) on retinal cells in organotypic culture. Invest Ophthalmol Vis Sci (2008) 0.91
Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. PLoS One (2008) 0.91
X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. PLoS One (2007) 0.90
Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT. Graefes Arch Clin Exp Ophthalmol (2015) 0.90
Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum. J Biol Chem (2009) 0.90
Retinal pigment epithelium tears after intravitreal bevacizumab in pigment epithelium detachment. Am J Ophthalmol (2007) 0.89
Molecular crosstalk between the nucleotide specificity determinant of the SRP GTPase and the SRP receptor. Biochemistry (2005) 0.89
Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proc Natl Acad Sci U S A (2012) 0.89
Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells. Invest Ophthalmol Vis Sci (2012) 0.88
The cost-effectiveness of the Argus II retinal prosthesis in Retinitis Pigmentosa patients. BMC Ophthalmol (2014) 0.87
The in vitro and in vivo behaviour of retinal pigment epithelial cells cultured on ultrathin collagen membranes. Biomaterials (2008) 0.86
Angiographic findings following tack fixation of a wireless epiretinal retina implant device in blind RP patients. Graefes Arch Clin Exp Ophthalmol (2011) 0.86
TMBHMM: a frequency profile based HMM for predicting the topology of transmembrane beta barrel proteins and the exposure status of transmembrane residues. Biochim Biophys Acta (2011) 0.86
Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane. PLoS One (2008) 0.86
Long-term follow-up of macular translocation with 360 degrees retinotomy for exudative age-related macular degeneration. Arch Ophthalmol (2007) 0.84
Acute electrical stimulation of the human retina with an epiretinal electrode array. Acta Ophthalmol (2011) 0.84
Ocular aberrations in barn owl eyes. Vision Res (2007) 0.84
Selective photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea. Invest Ophthalmol Vis Sci (2014) 0.84
A case of siderosis bulbi without a radiologically detectable foreign body. Can J Ophthalmol (2013) 0.83
Development of surgical techniques for implantation of a wireless intraocular epiretinal retina implant in Göttingen minipigs. Graefes Arch Clin Exp Ophthalmol (2011) 0.82
Iris pigment epithelial translocation in the treatment of exudative macular degeneration: a 3-year follow-up. Arch Ophthalmol (2006) 0.82
Signal quality of biometry in silicone oil-filled eyes using partial coherence laser interferometry. J Cataract Refract Surg (2005) 0.82