Published in Nat Genet on June 01, 2007
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Unlocking the secrets of the genome. Nature (2009) 11.80
Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Cell (2010) 9.50
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet (2008) 5.50
Systems genetics of complex traits in Drosophila melanogaster. Nat Genet (2009) 5.41
FlyMine: an integrated database for Drosophila and Anopheles genomics. Genome Biol (2007) 5.23
Identification of SLEEPLESS, a sleep-promoting factor. Science (2008) 4.56
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37
A protein complex network of Drosophila melanogaster. Cell (2011) 3.31
Gene expression divergence recapitulates the developmental hourglass model. Nature (2010) 3.20
Insect seminal fluid proteins: identification and function. Annu Rev Entomol (2011) 3.20
Comparative functional analysis of the Caenorhabditis elegans and Drosophila melanogaster proteomes. PLoS Biol (2009) 3.09
The sexually antagonistic genes of Drosophila melanogaster. PLoS Biol (2010) 2.99
Demasculinization of X chromosomes in the Drosophila genus. Nature (2007) 2.85
RNA sequencing reveals two major classes of gene expression levels in metazoan cells. Mol Syst Biol (2011) 2.77
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The transcriptional diversity of 25 Drosophila cell lines. Genome Res (2010) 2.47
Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat Genet (2012) 2.43
A portrait of copy-number polymorphism in Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 2.24
The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Cell Metab (2009) 2.23
A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nat Biotechnol (2015) 2.21
Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes. PLoS Genet (2009) 2.13
Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila. Genetics (2007) 2.10
Proteomics reveals novel Drosophila seminal fluid proteins transferred at mating. PLoS Biol (2008) 2.09
Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation. Nature (2014) 2.04
Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell (2011) 2.02
Global patterns of tissue-specific alternative polyadenylation in Drosophila. Cell Rep (2012) 1.99
Using translational enhancers to increase transgene expression in Drosophila. Proc Natl Acad Sci U S A (2012) 1.98
Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PLoS One (2008) 1.95
A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae. BMC Genomics (2011) 1.88
Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis. Proc Natl Acad Sci U S A (2011) 1.87
Identification and validation of housekeeping genes in brains of the desert locust Schistocerca gregaria under different developmental conditions. BMC Mol Biol (2009) 1.84
A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Curr Biol (2008) 1.75
Stability and dynamics of polycomb target sites in Drosophila development. PLoS Genet (2008) 1.72
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MEF2 is an in vivo immune-metabolic switch. Cell (2013) 1.71
Modulated modularity clustering as an exploratory tool for functional genomic inference. PLoS Genet (2009) 1.71
The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming. Genome Res (2011) 1.70
Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: potential tools for control of female feeding and reproduction. Insect Biochem Mol Biol (2007) 1.69
General gene movement off the X chromosome in the Drosophila genus. Genome Res (2009) 1.68
Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep (2014) 1.66
Gut-associated microbes of Drosophila melanogaster. Gut Microbes (2012) 1.66
Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Cell Res (2010) 1.64
Characterization of Drosophila melanogaster cytochrome P450 genes. Proc Natl Acad Sci U S A (2009) 1.62
A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages. Nat Commun (2014) 1.60
The SILAC fly allows for accurate protein quantification in vivo. Mol Cell Proteomics (2010) 1.60
Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Nat Genet (2009) 1.59
A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. EMBO J (2011) 1.58
Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. Mol Biol Cell (2008) 1.58
Effects of X-linkage and sex-biased gene expression on the rate of adaptive protein evolution in Drosophila. Mol Biol Evol (2008) 1.54
Age-dependent chromosomal distribution of male-biased genes in Drosophila. Genome Res (2010) 1.54
Battle and ballet: molecular interactions between the sexes in Drosophila. J Hered (2009) 1.53
The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster. PLoS Genet (2015) 1.51
Robust RT-qPCR data normalization: validation and selection of internal reference genes during post-experimental data analysis. PLoS One (2011) 1.50
A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila. Mol Cell (2013) 1.49
Concern Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances. BMC Genomics (2011) 1.49
Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol (2014) 1.48
Global analysis of trans-splicing in Drosophila. Proc Natl Acad Sci U S A (2010) 1.47
Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. PLoS Biol (2011) 1.46
Buffering of segmental and chromosomal aneuploidies in Drosophila melanogaster. PLoS Genet (2009) 1.43
Physiological and stem cell compartmentalization within the Drosophila midgut. Elife (2013) 1.43
A magnetic protein biocompass. Nat Mater (2015) 1.42
Towards the elements of successful insect RNAi. J Insect Physiol (2013) 1.42
Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF. PLoS Genet (2016) 1.40
Disentangling the relationship between sex-biased gene expression and X-linkage. Genome Res (2012) 1.40
Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster. Proc Natl Acad Sci U S A (2011) 1.40
Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Mol Cell Biol (2009) 1.40
Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan. Cell Metab (2017) 1.40
Mutations in AtPS1 (Arabidopsis thaliana parallel spindle 1) lead to the production of diploid pollen grains. PLoS Genet (2008) 1.39
The B-type lamin is required for somatic repression of testis-specific gene clusters. Proc Natl Acad Sci U S A (2009) 1.37
FlyAtlas: database of gene expression in the tissues of Drosophila melanogaster. Nucleic Acids Res (2012) 1.37
Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. Genome Biol (2009) 1.36
The genetic makeup of the Drosophila piRNA pathway. Mol Cell (2013) 1.35
Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila. PLoS Biol (2008) 1.33
A complex suite of forces drives gene traffic from Drosophila X chromosomes. Genome Biol Evol (2009) 1.32
Towards a more nuanced understanding of the relationship between sex-biased gene expression and rates of protein-coding sequence evolution. Mol Biol Evol (2011) 1.32
Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. J Cell Biol (2008) 1.32
Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome. BMC Biol (2011) 1.31
Genomic variation and its impact on gene expression in Drosophila melanogaster. PLoS Genet (2012) 1.31
Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. PLoS One (2012) 1.30
Towards a semen proteome of the dengue vector mosquito: protein identification and potential functions. PLoS Negl Trop Dis (2011) 1.29
Distinct mechanisms of transcriptional pausing orchestrated by GAGA factor and M1BP, a novel transcription factor. EMBO J (2013) 1.27
Phenotypic plasticity of the Drosophila transcriptome. PLoS Genet (2012) 1.26
Mutations in NSUN2 cause autosomal-recessive intellectual disability. Am J Hum Genet (2012) 1.24
Factors that regulate insulin producing cells and their output in Drosophila. Front Physiol (2013) 1.23
insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron (2011) 1.23
Origin and spread of de novo genes in Drosophila melanogaster populations. Science (2014) 1.22
Genome-scale analysis of positionally relocated genes. Genome Res (2007) 1.21
Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. Autophagy (2012) 1.21
The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. J Neurosci (2009) 1.21
Network-level molecular evolutionary analysis of the insulin/TOR signal transduction pathway across 12 Drosophila genomes. Genome Res (2009) 1.20
straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol (2008) 1.20
Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging (Albany NY) (2009) 1.19
Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. BMC Genomics (2010) 1.19
A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. PLoS One (2008) 1.19
FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal. Cell Rep (2012) 1.19
A versatile method for cell-specific profiling of translated mRNAs in Drosophila. PLoS One (2012) 1.19
The fat body transcriptomes of the yellow fever mosquito Aedes aegypti, pre- and post- blood meal. PLoS One (2011) 1.18
Plasticity of the chemoreceptor repertoire in Drosophila melanogaster. PLoS Genet (2009) 1.18
Rab3-GAP controls the progression of synaptic homeostasis at a late stage of vesicle release. Neuron (2011) 1.18
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33
Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet (2008) 9.17
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
Changes in diabetes-related complications in the United States, 1990-2010. N Engl J Med (2014) 8.73
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Self-monitoring in weight loss: a systematic review of the literature. J Am Diet Assoc (2011) 5.12
AlleleSeq: analysis of allele-specific expression and binding in a network framework. Mol Syst Biol (2011) 4.71
The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science (2009) 4.63
Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol (2004) 3.95
Glycolytic enzymes can modulate cellular life span. Cancer Res (2005) 3.78
Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell (2003) 3.75
Large-gap quantum spin Hall insulators in tin films. Phys Rev Lett (2013) 3.60
Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice. Nat Genet (2010) 3.56
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res (2005) 3.56
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res (2012) 3.48
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection. N Engl J Med (2015) 3.13
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
HIV/STD risk behaviors and perceptions among rural-to-urban migrants in China. AIDS Educ Prev (2004) 3.04
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metab (2008) 2.84
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes (2007) 2.83
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst (2012) 2.79
Rapid cardiotonic effects of lipid emulsion infusion*. Crit Care Med (2013) 2.76
BGI-RIS: an integrated information resource and comparative analysis workbench for rice genomics. Nucleic Acids Res (2004) 2.69
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov (2012) 2.68
Trends in physical activity, sedentary behavior, diet, and BMI among US adolescents, 2001-2009. Pediatrics (2013) 2.66
Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Science (2006) 2.62
A developmental approach to complex PTSD: childhood and adult cumulative trauma as predictors of symptom complexity. J Trauma Stress (2009) 2.59
PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature (2011) 2.53
The effect of passengers and risk-taking friends on risky driving and crashes/near crashes among novice teenagers. J Adolesc Health (2011) 2.53
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron (2003) 2.51
Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov (2013) 2.49
Physics. Learning and scientific reasoning. Science (2009) 2.49
PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell (2008) 2.49
A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One (2007) 2.47
Microarrays: retracing steps. Nat Med (2007) 2.39
The spectrum of SCN1A-related infantile epileptic encephalopathies. Brain (2007) 2.30
Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A (2004) 2.28
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A (2004) 2.25
Crash and risky driving involvement among novice adolescent drivers and their parents. Am J Public Health (2011) 2.25
Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis. Proc Natl Acad Sci U S A (2012) 2.22
The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J Neurosci (2010) 2.20
Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res (2006) 2.14
Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer. Clin Cancer Res (2013) 2.09
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. Int J Urol (2011) 2.07
Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain. J Neurosci (2012) 2.06
Applications of beta-mixture models in bioinformatics. Bioinformatics (2005) 2.04
Concordance of sustained virological response 4, 12, and 24 weeks post-treatment with sofosbuvir-containing regimens for hepatitis C virus. Hepatology (2014) 2.04
A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron (2005) 2.03
Pregnancy, contraceptive use, and HIV acquisition in HPTN 039: relevance for HIV prevention trials among African women. J Acquir Immune Defic Syndr (2010) 2.01
A comprehensive approach to the analysis of matrix-assisted laser desorption/ionization-time of flight proteomics spectra from serum samples. Proteomics (2003) 2.01
Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration. J Cell Biol (2009) 1.98
A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. J Biol Chem (2008) 1.98
How many human genes can be defined as housekeeping with current expression data? BMC Genomics (2008) 1.97
SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science (2012) 1.89
Structure acquisition of the T1 domain of Kv1.3 during biogenesis. Neuron (2004) 1.89
Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms. J Clin Invest (2008) 1.87
Regulation of endothelial nitric oxide synthase by small RNA. Proc Natl Acad Sci U S A (2005) 1.85
MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling. J Exp Med (2010) 1.84
i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res (2010) 1.83
Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives. Chem Pharm Bull (Tokyo) (2008) 1.83
The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest (2005) 1.82
MethyCancer: the database of human DNA methylation and cancer. Nucleic Acids Res (2007) 1.81
Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. J Immunol (2009) 1.81
A brain-to-brain interface for real-time sharing of sensorimotor information. Sci Rep (2013) 1.80
Bacterial vaginosis and vaginal yeast, but not vaginal cleansing, increase HIV-1 acquisition in African women. J Acquir Immune Defic Syndr (2008) 1.80
Fitness of anopheline mosquitoes expressing transgenes that inhibit Plasmodium development. Genetics (2004) 1.79
Secular changes in the age-specific prevalence of diabetes among U.S. adults: 1988-2010. Diabetes Care (2013) 1.79
Use of a multifaceted approach to analyze HIV incidence in a cohort study of women in the United States: HIV Prevention Trials Network 064 Study. J Infect Dis (2012) 1.78
Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab (2007) 1.77
Control of phyllotaxy by the cytokinin-inducible response regulator homologue ABPHYL1. Nature (2004) 1.77
Rural-to-urban migrants and the HIV epidemic in China. AIDS Behav (2006) 1.75
Obtaining reliable information from minute amounts of RNA using cDNA microarrays. BMC Genomics (2002) 1.75
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes (2002) 1.74
Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci U S A (2013) 1.74
Chaperonins facilitate KNOTTED1 cell-to-cell trafficking and stem cell function. Science (2011) 1.73
Brominated flame retardants in children's toys: concentration, composition, and children's exposure and risk assessment. Environ Sci Technol (2009) 1.71
ReAS: Recovery of ancestral sequences for transposable elements from the unassembled reads of a whole genome shotgun. PLoS Comput Biol (2005) 1.71
Edge-based scoring and searching method for identifying condition-responsive protein-protein interaction sub-network. Bioinformatics (2007) 1.69
Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells. Clin Cancer Res (2012) 1.68
Compressed sensing based cone-beam computed tomography reconstruction with a first-order method. Med Phys (2010) 1.68
Noise suppression in scatter correction for cone-beam CT. Med Phys (2009) 1.66
An automatic patient-specific seizure onset detection method in intracranial EEG based on incremental nonlinear dimensionality reduction. Comput Biol Med (2010) 1.65
SalK/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive Streptococcus suis serotype 2. PLoS One (2008) 1.64
HIV acquisition among women from selected areas of the United States: a cohort study. Ann Intern Med (2013) 1.59
Interleukin 17-producing gamma delta T cells increased in patients with active pulmonary tuberculosis. Cell Mol Immunol (2008) 1.58
Clinical significance of EML4-ALK fusion gene and association with EGFR and KRAS gene mutations in 208 Chinese patients with non-small cell lung cancer. PLoS One (2013) 1.57
Parent, family, and neighborhood effects on the development of child substance use and other psychopathology from preschool to the start of adulthood. J Stud Alcohol Drugs (2009) 1.55
MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells. Gynecol Oncol (2010) 1.55
Scatter correction for cone-beam CT in radiation therapy. Med Phys (2009) 1.55
Early childhood family intervention and long-term obesity prevention among high-risk minority youth. Pediatrics (2012) 1.55