Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness.

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Published in Shock on October 01, 2007

Authors

Jessica A Clark1, Craig M Coopersmith

Author Affiliations

1: Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

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Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest (1992) 47.46

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Host-bacterial mutualism in the human intestine. Science (2005) 26.39

Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med (2006) 24.38

The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67

American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med (1992) 20.79

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell (2005) 15.46

Commensal host-bacterial relationships in the gut. Science (2001) 14.82

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol (2001) 11.07

Management of sepsis. N Engl J Med (2006) 9.01

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science (2004) 8.68

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat (1974) 8.05

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med (1999) 7.24

Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol (2003) 6.17

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol (2003) 5.87

A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science (2000) 5.78

Honor thy symbionts. Proc Natl Acad Sci U S A (2003) 5.72

Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest (2007) 5.55

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Immunity, inflammation, and allergy in the gut. Science (2005) 4.82

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J Cell Sci (1994) 4.38

Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol (1995) 4.37

Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol (2003) 4.00

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Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am J Clin Nutr (2001) 2.70

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology (2002) 2.66

Multiple-organ-failure syndrome. Arch Surg (1986) 2.52

Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. J Trauma (1991) 2.34

Post-injury multiple organ failure: the role of the gut. Shock (2001) 2.31

Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med (2006) 2.27

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Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells. Gastroenterology (2000) 2.07

The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiota. Cell Microbiol (2001) 2.04

Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Gut (2003) 2.00

Mucins in the gastrointestinal tract in health and disease. Front Biosci (2001) 1.99

IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding. J Immunol (1993) 1.98

Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin (2005) 1.95

Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review. Front Biosci (2006) 1.92

Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability. Gastroenterology (1997) 1.86

Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med (2003) 1.83

Cytokine-induced intestinal epithelial hyperpermeability: role of nitric oxide. Crit Care Med (1999) 1.81

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc Natl Acad Sci U S A (2003) 1.71

Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock (1997) 1.71

Altered gut flora and environment in patients with severe SIRS. J Trauma (2006) 1.67

Antigen processing and presentation by intestinal epithelial cells - polarity and complexity. Immunol Today (2000) 1.65

Gut ischemia-reperfusion affects gut mucosal immunity: a possible mechanism for infectious complications after severe surgical insults. Crit Care Med (2006) 1.63

Murine enterocytes can present soluble antigen to specific class II-restricted CD4+ T cells. Eur J Immunol (1989) 1.63

The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol (2004) 1.61

Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut (1998) 1.61

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LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells. Cell Immunol (2003) 1.38

Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion. Gastroenterology (1997) 1.35

Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined. Crit Care Med (2003) 1.30

Over-expression of Bcl-2 provides protection in septic mice by a trans effect. J Immunol (2003) 1.29

The Sirens' song. Nature (2001) 1.29

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The gut: a cytokine-generating organ in systemic inflammation? Shock (1995) 1.25

A prospective randomised trial of probiotics in critically ill patients. Clin Nutr (2005) 1.25

Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers. Am J Physiol (1995) 1.25

Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. Am J Physiol Gastrointest Liver Physiol (2004) 1.25

Bcl-2 inhibits ischemia-reperfusion-induced apoptosis in the intestinal epithelium of transgenic mice. Am J Physiol (1999) 1.25

Interferon gamma induces translocation of commensal Escherichia coli across gut epithelial cells via a lipid raft-mediated process. Gastroenterology (2005) 1.23

Structure of the intestinal flora responsible for development of the gut immune system in a rodent model. Microbes Infect (2000) 1.23

Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells. Gastroenterology (2003) 1.22

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Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement. J Biol Chem (2000) 1.19

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Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. Gastroenterology (2002) 1.17

Bacterial modulation of mucosal innate immunity. Mol Immunol (2005) 1.13

The role of the sympathetic nervous system in intestinal inflammation. Gut (2006) 1.10

Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro. Am J Physiol Gastrointest Liver Physiol (2003) 1.10

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Factors larger than 100 kd in post-hemorrhagic shock mesenteric lymph are toxic for endothelial cells. Surgery (2001) 1.09

Cutaneous burn increases apoptosis in the gut epithelium of mice. J Am Coll Surg (1999) 1.08

Development of intestinal M cells. Immunol Rev (2005) 1.08

The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol (2006) 1.08

Gut microbes out of control in HIV infection. Nat Med (2006) 1.04

Tight junctions and cell-cell interactions. Methods Mol Biol (2006) 1.04

Microbial-gut interactions in health and disease. Mucosal immune responses. Best Pract Res Clin Gastroenterol (2004) 1.02

Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis. Am J Physiol Regul Integr Comp Physiol (2006) 1.01

The influence of intestinal ischemia and reperfusion on bidirectional intestinal barrier permeability, cellular membrane integrity, proteinase inhibitors, and cell death in rats. Shock (1998) 0.95

The lipid fraction of post-hemorrhagic shock mesenteric lymph (PHSML) inhibits neutrophil apoptosis and enhances cytotoxic potential. Shock (2000) 0.95

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Inhibition of IKKβ in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality. Crit Care Med (2013) 0.85

A new safety event reporting system improves physician reporting in the surgical intensive care unit. J Am Coll Surg (2006) 0.84

Anti-apoptotic peptides protect against radiation-induced cell death. Biochem Biophys Res Commun (2007) 0.84

Epithelial cells. Crit Care Med (2005) 0.83

Microfluidic amperometric sensor for analysis of nitric oxide in whole blood. Anal Chem (2013) 0.83

Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis. Shock (2008) 0.83

Role of intestinal epithelial apoptosis in survival. Curr Opin Crit Care (2003) 0.83

Mechanisms of Intestinal Barrier Dysfunction in Sepsis. Shock (2016) 0.83

Adoptive transfer of dying cells causes bystander-induced apoptosis. Biochem Biophys Res Commun (2006) 0.82

Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury. PLoS One (2013) 0.82

Iron dysregulation combined with aging prevents sepsis-induced apoptosis. J Surg Res (2005) 0.82

ICU director data: using data to assess value, inform local change, and relate to the external world. Chest (2015) 0.81

Pharmacoepidemiology of QT-interval prolonging drug administration in critically ill patients. Pharmacoepidemiol Drug Saf (2008) 0.81

Using Incentives to Improve Resource Utilization: A Quasi-Experimental Evaluation of an ICU Quality Improvement Program. Crit Care Med (2016) 0.80

Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial. Surg Infect (Larchmt) (2007) 0.79

Clinical and billing review of extracorporeal membrane oxygenation. Chest (2015) 0.78

Differential regulation of tissue thiol-disulfide redox status in a murine model of peritonitis. J Inflamm (Lond) (2012) 0.77

Patient-care time allocation by nurse practitioners and physician assistants in the intensive care unit. Crit Care (2012) 0.77

Sequence makes a difference: paradoxical effects of stress in vivo. Shock (2004) 0.77

Organ failure avoidance and mitigation strategies in surgery. Surg Clin North Am (2012) 0.76

Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion. Shock (2016) 0.76

Abdominal compartment syndrome in a patient resulting from pneumothorax. Intensive Care Med (2003) 0.76

The turn team: a novel strategy for reducing pressure ulcers in the surgical intensive care unit. J Am Coll Surg (2013) 0.76

Erythropoietin in sepsis: a new use for a familiar drug? Crit Care Med (2009) 0.76

Sleeping to survive?: The impact of volatile anesthetics on mortality in sepsis. Anesthesiology (2013) 0.76

Just the right amount of JNK: How nuclear factor-kappaB and downstream mediators prevent burn-induced intestinal injury. Crit Care Med (2007) 0.75

Levosimendan and gut mucosal blood flow--not all inotropes are created equal. Crit Care Med (2005) 0.75

Pathophysiology of the Gut and the Microbiome in the Host Response. Pediatr Crit Care Med (2017) 0.75

Prevalence and cost of full-time research fellowships during general surgery residency. Ann Surg (2009) 0.75

Mitochondrial membrane dysfunction in endotoxemia: the difference between what's in and what's out. Crit Care Med (2004) 0.75

New insights into the gut as the driver of critical illness and organ failure. Curr Opin Crit Care (2017) 0.75

Central venous catheter insertion in septic patients admitted from the emergency department: it is all in the timing*. Crit Care Med (2014) 0.75