Published in Hum Mol Genet on June 20, 2007
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. ASN Neuro (2009) 2.85
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J Biol Chem (2008) 2.77
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell (2014) 2.63
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc Natl Acad Sci U S A (2008) 2.36
A Drosophila model for LRRK2-linked parkinsonism. Proc Natl Acad Sci U S A (2008) 2.12
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci (2008) 1.86
LRRK2 is involved in the IFN-gamma response and host response to pathogens. J Immunol (2010) 1.85
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet (2011) 1.68
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites. Biochem Biophys Res Commun (2009) 1.67
GTPase activity plays a key role in the pathobiology of LRRK2. PLoS Genet (2010) 1.63
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J (2008) 1.62
Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease. Biochim Biophys Acta (2008) 1.55
Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation. Biochemistry (2010) 1.47
Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities. J Mol Biol (2011) 1.42
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. Neurology (2008) 1.39
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS One (2010) 1.39
Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease. J Neurosci Res (2009) 1.38
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. PLoS One (2012) 1.09
LRRK2 and neuroinflammation: partners in crime in Parkinson's disease? J Neuroinflammation (2014) 1.05
Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2. J Biol Chem (2010) 1.02
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc Natl Acad Sci U S A (2012) 0.99
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One (2010) 0.98
Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5. Exp Neurobiol (2010) 0.98
LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease. Mov Disord (2010) 0.96
Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications. Neurotherapeutics (2014) 0.94
Combined kinase inhibition modulates parkin inactivation. Hum Mol Genet (2008) 0.92
Models for LRRK2-Linked Parkinsonism. Parkinsons Dis (2011) 0.91
Update on the functional biology of Lrrk2. Future Neurol (2008) 0.89
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis. Exp Neurol (2014) 0.88
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Exp Mol Med (2013) 0.88
Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy? Neurobiol Dis (2010) 0.88
Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design. Future Med Chem (2012) 0.86
The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition. J Neurochem (2010) 0.86
The role of the LRRK2 gene in Parkinsonism. Mol Neurodegener (2014) 0.85
Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC. J Biol Chem (2011) 0.84
Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes. Fly (Austin) (2014) 0.81
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports (2015) 0.79
Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S. Biochemistry (2013) 0.79
Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration. Biochim Biophys Acta (2014) 0.79
Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease. Neurotherapeutics (2013) 0.76
LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Nat Commun (2016) 0.76
GST P1, a novel downstream regulator of LRRK2, G2019S-induced neuronal cell death. Front Biosci (Elite Ed) (2012) 0.76
Decoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation. J Parkinsons Dis (2016) 0.75
Protein Kinases and Parkinson's Disease. Int J Mol Sci (2016) 0.75
Role and mechanism of action of leucine-rich repeat kinase 1 in bone. Bone Res (2017) 0.75
Synthesis and In Vitro and In Vivo Evaluation of [(3)H]LRRK2-IN-1 as a Novel Radioligand for LRRK2. Mol Imaging Biol (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron (2004) 13.99
Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet (2002) 2.65
Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP. Neurobiol Aging (2008) 1.76
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet (2011) 1.68
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. J Immunol (2003) 1.39
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. Hum Mol Genet (2006) 1.29
Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia. Neurobiol Aging (2013) 1.12
The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. Trends Biochem Sci (2002) 1.11
Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation. Neurobiol Aging (2010) 1.05
Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells. J Biol Chem (2002) 1.05
Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. Cell Adh Migr (2012) 1.02
LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain. Eur J Neurosci (2006) 1.02
Transmembrane-domain determinants for SNARE-mediated membrane fusion. J Cell Sci (2010) 1.02
Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings. Biol Psychiatry (2007) 1.01
Analysis of the C9orf72 gene in patients with amyotrophic lateral sclerosis in Spain and different populations worldwide. Hum Mutat (2012) 0.99
Vesicle pools and synapsins: new insights into old enigmas. Brain Cell Biol (2007) 0.97
Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis. J Cell Sci (2002) 0.97
Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. Brain Res (2009) 0.97
Homocysteine and cognitive impairment in Parkinson's disease: a biochemical, neuroimaging, and genetic study. Mov Disord (2009) 0.94
Parkinson's disease due to the R1441G mutation in Dardarin: a founder effect in the Basques. Mov Disord (2006) 0.93
Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations. Psychiatr Genet (2006) 0.93
Combined kinase inhibition modulates parkin inactivation. Hum Mol Genet (2008) 0.92
Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. Am J Med Genet B Neuropsychiatr Genet (2010) 0.91
Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis. PLoS One (2013) 0.87
A delayed response enhancement during hippocampal presynaptic plasticity in mice. J Physiol (2007) 0.86
Phylogenetic and in silico structural analysis of the Parkinson disease-related kinase PINK1. Hum Mutat (2011) 0.86
A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion. Mol Biol Cell (2008) 0.83
LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy. Autophagy (2012) 0.83
A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling. Biochem Soc Trans (2012) 0.82
Parkinson's disease genetics: a complex disease comes to the clinic. Lancet Neurol (2006) 0.81
A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease. Parkinsons Dis (2012) 0.80
ABCA1 polymorphisms and Alzheimer's disease. Neurosci Lett (2007) 0.79
Benign hereditary chorea: clinical features and long-term follow-up in a Spanish family. Parkinsonism Relat Disord (2012) 0.77
Genetic screening for two LRRK2 mutations in French patients with idiopathic Parkinson's disease. Genet Test (2006) 0.76
Structural and functional in silico analysis of LRRK2 missense substitutions. Mol Biol Rep (2014) 0.76
Sexy Regulation of SNARE-Mediated Membrane Fusion by Local Lipid Metabolism. Front Synaptic Neurosci (2010) 0.75
Hydroxytyrosol increases norepinephrine transporter function in pheochromocytoma cells. Nucl Med Biol (2008) 0.75
[Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain]. Rev Neurol (2010) 0.75