Published in Bioorg Med Chem on June 10, 2007
Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn (2010) 0.85
Synthesis and antioxidant evaluation of 4-(furan-2-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate esters. Res Pharm Sci (2012) 0.85
A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening. Molecules (2013) 0.84
Antimicrobial evaluation of some novel derivatives of 3,4-dihydropyrimidine-2(1H)-one. Res Pharm Sci (2012) 0.78
Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate shiga toxin and serum amyloid p component ternary complex formation. Toxins (Basel) (2011) 0.77
Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study. Org Med Chem Lett (2012) 0.77
Synthesis and molecular modeling of six novel monastrol analogues: evaluation of cytotoxicity and kinesin inhibitory activity against HeLa cell line. Daru (2013) 0.75
Methyl 6-methoxy-carbonyl-methyl-2-oxo-4-phenyl-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2008) 0.75
Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5. Biochemistry (2004) 2.95
S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression. J Biol Chem (2006) 2.09
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Mol Cancer Ther (2004) 1.98
Kinesins and cancer. Nat Rev Cancer (2012) 1.84
Automated analysis of vapor diffusion crystallization drops with an X-ray beam. Structure (2004) 1.53
Interaction of the mitotic inhibitor monastrol with human kinesin Eg5. Biochemistry (2003) 1.51
Motor-dependent microtubule disassembly driven by tubulin tyrosination. J Cell Biol (2009) 1.49
Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching. J Neurosci (2010) 1.40
The structure of the kinesin-1 motor-tail complex reveals the mechanism of autoinhibition. Science (2011) 1.39
Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Mol Cell Biol (2012) 1.22
Extracellular identification of a processed type II ComR/ComS pheromone of Streptococcus mutans. J Bacteriol (2012) 1.21
A global approach combining proteome analysis and phenotypic screening with RNA interference yields novel apoptosis regulators. Mol Cell Proteomics (2004) 1.21
Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training. Am J Physiol Endocrinol Metab (2011) 1.21
Distinct dynamics of Aurora B and Survivin during mitosis. Cell Cycle (2004) 1.16
Isobaric protein and peptide quantification: perspectives and issues. Expert Rev Proteomics (2010) 1.07
A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell (2004) 1.07
MiR-133b targets antiapoptotic genes and enhances death receptor-induced apoptosis. PLoS One (2012) 1.06
The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes. PLoS One (2010) 1.05
Crystal structure of the motor domain of the human kinetochore protein CENP-E. J Mol Biol (2004) 1.04
Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5. J Med Chem (2008) 1.04
Validating divergent ORF annotation of the Mycobacterium leprae genome through a full translation data set and peptide identification by tandem mass spectrometry. Proteomics (2009) 1.04
An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex. Biochem J (2009) 1.04
Proteogenomic analysis of polymorphisms and gene annotation divergences in prokaryotes using a clustered mass spectrometry-friendly database. Mol Cell Proteomics (2010) 1.02
Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J (2012) 1.01
Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa. PLoS Pathog (2012) 1.00
Using a label-free proteomics method to identify differentially abundant proteins in closely related hypo- and hypervirulent clinical Mycobacterium tuberculosis Beijing isolates. Mol Cell Proteomics (2010) 1.00
CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells. Blood (2011) 1.00
Rapid determination of amino acid incorporation by stable isotope labeling with amino acids in cell culture (SILAC). Rapid Commun Mass Spectrom (2007) 0.98
Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B. Mol Biol Cell (2009) 0.97
Docetaxel-resistant prostate cancer cells remain sensitive to S-trityl-L-cysteine-mediated Eg5 inhibition. Mol Cancer Ther (2010) 0.97
Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents. J Mol Biol (2006) 0.96
Analysis of the spindle-assembly checkpoint in HeLa cells. Methods Mol Biol (2004) 0.95
Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5. Rapid Commun Mass Spectrom (2006) 0.93
Proteome analysis of tunicamycin-induced ER stress. Electrophoresis (2012) 0.93
Expansion of multipotent stem cells from the adult human brain. PLoS One (2013) 0.93
Comprehensive quantitative proteome analysis of 20S proteasome subtypes from rat liver by isotope coded affinity tag and 2-D gel-based approaches. Proteomics (2006) 0.93
Distinctive mass losses of tryptic peptides generated by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight. Rapid Commun Mass Spectrom (2006) 0.92
IsobariQ: software for isobaric quantitative proteomics using IPTL, iTRAQ, and TMT. J Proteome Res (2010) 0.90
Isobaric peptide termini labeling for MS/MS-based quantitative proteomics. J Proteome Res (2009) 0.90
SMC5 and MMS21 are required for chromosome cohesion and mitotic progression. Cell Cycle (2009) 0.90
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. J Med Chem (2010) 0.90
Development of a direct assay for measuring intracellular AZT triphosphate in humans peripheral blood mononuclear cells. Anal Chem (2002) 0.90
Quantitative proteome analysis of cisplatin-induced apoptotic Jurkat T cells by stable isotope labeling with amino acids in cell culture, SDS-PAGE, and LC-MALDI-TOF/TOF MS. Electrophoresis (2007) 0.89
Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Nucleic Acids Res (2013) 0.89
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration. J Biol Chem (2007) 0.88
Lung deposition and toxicological responses evoked by multi-walled carbon nanotubes dispersed in a synthetic lung surfactant in the mouse. Arch Toxicol (2011) 0.88
Structural insights into human Kif7, a kinesin involved in Hedgehog signalling. Acta Crystallogr D Biol Crystallogr (2012) 0.88
ApoptoProteomics, an integrated database for analysis of proteomics data obtained from apoptotic cells. Mol Cell Proteomics (2011) 0.87
Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl (2010) 0.87
Sorafenib-induced mitochondrial complex I inactivation and cell death in human neuroblastoma cells. J Proteome Res (2012) 0.87
Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178). FEBS Lett (2002) 0.86
Shotgun mass mapping of Lactobacillus species and subspecies from caries related isolates by MALDI-MS. Proteomics (2009) 0.86
Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. Int J Biochem Cell Biol (2004) 0.86
Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5. Proteomics (2008) 0.86
Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome. FEMS Microbiol Lett (2005) 0.86
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism. J Med Chem (2013) 0.85
Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines. Biochem Pharmacol (2009) 0.85
Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives. Eur J Med Chem (2012) 0.85
Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding. Acta Crystallogr D Biol Crystallogr (2013) 0.85
Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function. Proc Natl Acad Sci U S A (2013) 0.85
Structural variations in protein superfamilies: actin and tubulin. Mol Biotechnol (2009) 0.85
Structural insights into a unique inhibitor binding pocket in kinesin spindle protein. J Am Chem Soc (2013) 0.85
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem (2013) 0.84
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5. J Med Chem (2011) 0.84
Cloning and biochemical characterization of APIT, a new l-amino acid oxidase from Aplysia punctata. Toxicon (2005) 0.83
The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins. Biochemistry (2006) 0.83
Elucidating the functionality of kinesins: an overview of small molecule inhibitors. Semin Cell Dev Biol (2011) 0.83
The structure of human neuronal Rab6B in the active and inactive form. Acta Crystallogr D Biol Crystallogr (2006) 0.83
The proteome of the human parotid gland secretion in elderly with and without root caries. Acta Odontol Scand (2009) 0.82
"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5. J Biol Chem (2013) 0.82
Isobaric peptide termini labeling utilizing site-specific N-terminal succinylation. Anal Chem (2011) 0.82
Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity. J Med Chem (2012) 0.82
Analysis of detergent-insoluble and whole cell lysate fractions of resting neutrophils using high-resolution mass spectrometry. J Proteome Res (2010) 0.82
Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine. Eur J Med Chem (2012) 0.81
Decimal place slope, a fast and precise method for quantifying 13C incorporation levels for detecting the metabolic activity of microbial species. Mol Cell Proteomics (2010) 0.81
Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells. Proteomics (2010) 0.81
An approach for triplex-isobaric peptide termini labeling (triplex-IPTL). Anal Chem (2013) 0.81
Temporal proteome profiling of taxol-induced mitotic arrest and apoptosis. Electrophoresis (2010) 0.81
Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies. J Med Chem (2009) 0.80
Synthesis of a coumarin-based europium complex for bioanalyte labeling. Bioorg Med Chem Lett (2007) 0.80
Nucleic acid transfer with hemifluorinated polycationic lipids. Biomaterials (2010) 0.80
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones. PLoS One (2011) 0.80
Synthesis of enzymatically and chemically non-hydrolyzable analogues of dinucleoside triphosphates Ap(3)A and Gp(3)G. J Org Chem (2002) 0.80
Screening for inhibitors of microtubule-associated motor proteins. Methods Mol Med (2007) 0.79