Published in BMC Genet on July 02, 2007
Genetic foundations of human intelligence. Hum Genet (2009) 2.71
The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38
The vitamin nicotinamide: translating nutrition into clinical care. Molecules (2009) 1.36
A "FOXO" in sight: targeting Foxo proteins from conception to cancer. Med Res Rev (2009) 1.31
Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders. Oxid Med Cell Longev (2010) 1.21
Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol (2008) 1.13
Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study. J Pain (2013) 1.08
Whole genome association scan for genetic polymorphisms influencing information processing speed. Biol Psychol (2010) 1.07
Erythropoietin and oxidative stress. Curr Neurovasc Res (2008) 1.07
Oxidative stress: Biomarkers and novel therapeutic pathways. Exp Gerontol (2010) 1.04
Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways. Curr Neurovasc Res (2008) 1.03
Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother (2008) 1.02
Raves and risks for erythropoietin. Cytokine Growth Factor Rev (2008) 0.99
New strategies for Alzheimer's disease and cognitive impairment. Oxid Med Cell Longev (2010) 0.98
Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology. ScientificWorldJournal (2009) 0.90
FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis. Curr Neurovasc Res (2009) 0.90
Genetic and environmental links between cognitive and physical functions in old age. J Gerontol B Psychol Sci Soc Sci (2009) 0.85
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. Exp Gerontol (2014) 0.85
eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease. PLoS One (2010) 0.83
Therapeutic promise and principles: metabotropic glutamate receptors. Oxid Med Cell Longev (2010) 0.82
Flight restriction prevents associative learning deficits but not changes in brain protein-adduct formation during honeybee ageing. J Exp Biol (2011) 0.77
The genetic basis of quality of life in healthy Swedish women: a candidate gene approach. PLoS One (2015) 0.77
Locus heterogeneity disease genes encode proteins with high interconnectivity in the human protein interaction network. Front Genet (2014) 0.76
Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging (2008) 0.75
Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa). Mol Biol Evol (2016) 0.75
Polymorphism of Nitric Oxide Synthase 1 Affects the Clinical Phenotypes of Ischemic Stroke in Korean Population. Ann Rehabil Med (2016) 0.75
"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res (1975) 301.74
Aging: a theory based on free radical and radiation chemistry. J Gerontol (1956) 20.39
Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics (2003) 17.92
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet (2005) 16.79
Mitochondria, oxidants, and aging. Cell (2005) 16.11
Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet (2005) 14.88
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature (1996) 7.04
DNA repair, genome stability, and aging. Cell (2005) 5.52
Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46
Oxidative stress and neurodegeneration: where are we now? J Neurochem (2006) 5.44
Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiol Aging (2005) 4.88
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A (1996) 4.20
The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947. J Pers Soc Psychol (2004) 4.09
Mitochondria take center stage in aging and neurodegeneration. Ann Neurol (2005) 3.83
Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet (2005) 3.76
VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet (2004) 3.60
What needs to be explained to account for age-related effects on multiple cognitive variables? Psychol Aging (2003) 3.47
An utter refutation of the "fundamental theorem of the HapMap". Eur J Hum Genet (2006) 3.41
Ageing and neuronal vulnerability. Nat Rev Neurosci (2006) 3.36
Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol (2005) 2.44
Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology (2005) 2.33
Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J Biol Chem (1998) 2.28
Genetics of intelligence. Eur J Hum Genet (2006) 2.23
Cognitive change and the APOE epsilon 4 allele. Nature (2002) 2.01
The portability of tagSNPs across populations: a worldwide survey. Genome Res (2006) 1.99
Deciphering the genetic basis of Alzheimer's disease. Annu Rev Genomics Hum Genet (2002) 1.96
The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc Natl Acad Sci U S A (2001) 1.72
Genetic and environmental contributions to general cognitive ability through the first 16 years of life. Dev Psychol (2004) 1.68
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science (1988) 1.51
Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease. J Neurochem (2005) 1.48
An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. PLoS Genet (2006) 1.47
The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills. Mol Psychiatry (2006) 1.46
Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms. Mol Psychiatry (2005) 1.46
A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels. Free Radic Biol Med (2001) 1.43
Role of free radicals in aging and disease. Ann N Y Acad Sci (1992) 1.34
Validity of tagging SNPs across populations for association studies. Eur J Hum Genet (2006) 1.24
Factor analysis of four measures of prefrontal lobe functioning. Arch Clin Neuropsychol (1998) 1.20
Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. Brain Res Brain Res Rev (2005) 1.19
Cognitive decline is associated with systemic oxidative stress: the EVA study. Etude du Vieillissement Artériel. J Am Geriatr Soc (2000) 1.18
Cerebral white matter abnormalities and lifetime cognitive change: a 67-year follow-up of the Scottish Mental Survey of 1932. Psychol Aging (2003) 1.18
A functional genetic variation of the 5-HT2a receptor affects human memory. Nat Neurosci (2003) 1.16
Biomarkers, health, lifestyle, and demographic variables as correlates of reaction time performance in early, middle, and late adulthood. Q J Exp Psychol A (2005) 1.16
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Hum Mol Genet (2004) 1.13
Searching for genetic influences on normal cognitive ageing. Trends Cogn Sci (2004) 1.12
Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition. Mol Psychiatry (2003) 1.11
Recent advances in amyotrophic lateral sclerosis. Curr Opin Neurol (2000) 1.09
Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Mol Psychiatry (2003) 1.08
Childhood IQ, smoking, and cognitive change from age 11 to 64 years. Addict Behav (2005) 1.02
Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease. Neurobiol Aging (2004) 1.00
Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide. Ann N Y Acad Sci (1996) 0.98
Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates. Neuron (1990) 0.98
Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats. Neurobiol Aging (2005) 0.93
Androgen receptor CAG repeat polymorphism is associated with cognitive function in older men. Biol Psychiatry (2003) 0.92
Genetic influences on oxidative stress and their association with normal cognitive ageing. Neurosci Lett (2005) 0.91
Longitudinal change in memory performance associated with HTR2A polymorphism. Neurobiol Aging (2006) 0.89
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease. Neurosci Lett (1999) 0.89
Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing. Neurosci Lett (2005) 0.88
Age at natural menopause and cognition. Maturitas (2004) 0.84
Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE). Neurosci Lett (2003) 0.84
Interleukin-1B polymorphism is associated with age at onset of Alzheimer's disease. Neurobiol Aging (2003) 0.83
5-HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease. Int J Geriatr Psychiatry (2004) 0.81
Poorer cognitive performance in humans with mild cognitive impairment carrying the T variant of the Glu/Asp NOS3 polymorphism. Neurosci Lett (2004) 0.80
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75
Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med (2007) 6.47
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet (2008) 5.93
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Runs of homozygosity in European populations. Am J Hum Genet (2008) 5.34
Mutations in SOX2 cause anophthalmia. Nat Genet (2003) 5.03
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947. J Pers Soc Psychol (2004) 4.09
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr (2007) 3.33
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nat Genet (2012) 3.19
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Intelligence in youth and all-cause-mortality: systematic review with meta-analysis. Int J Epidemiol (2010) 3.08
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat (2005) 3.02
Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: a systematic review and analysis. Lancet (2013) 3.02
Cognition and diabetes: a lifespan perspective. Lancet Neurol (2008) 2.96
Premorbid (early life) IQ and later mortality risk: systematic review. Ann Epidemiol (2006) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Cohort profile: the Lothian Birth Cohorts of 1921 and 1936. Int J Epidemiol (2011) 2.78
Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation (2010) 2.78
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
Intelligence in childhood and chronic widespread pain in middle age: the National Child Development Survey. Pain (2012) 2.71
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
Childhood IQ, social class, deprivation, and their relationships with mortality and morbidity risk in later life: prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies. Psychosom Med (2003) 2.69
Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis. Hum Mol Genet (2008) 2.66
Genetic contributions to stability and change in intelligence from childhood to old age. Nature (2012) 2.63
Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies. BMJ (2012) 2.56
Age and sex differences in reaction time in adulthood: results from the United Kingdom Health and Lifestyle Survey. Psychol Aging (2006) 2.55
Effect of breast feeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis. BMJ (2006) 2.51
Retinal image analysis: concepts, applications and potential. Prog Retin Eye Res (2005) 2.49