Published in Mol Microbiol on July 03, 2007
CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes. Infect Immun (2009) 1.62
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Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS). BMC Genomics (2011) 1.19
Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR. Mol Microbiol (2009) 1.13
PerR confers phagocytic killing resistance and allows pharyngeal colonization by group A Streptococcus. PLoS Pathog (2008) 1.10
A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. PLoS Pathog (2010) 1.10
Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. PLoS Pathog (2011) 1.07
Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus. PLoS Pathog (2011) 1.05
CsrRS regulates group B Streptococcus virulence gene expression in response to environmental pH: a new perspective on vaccine development. J Bacteriol (2009) 1.01
Environmental acidification drives S. pyogenes pilus expression and microcolony formation on epithelial cells in a FCT-dependent manner. PLoS One (2010) 0.95
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Peroxide stimulon and role of PerR in group A Streptococcus. J Bacteriol (2011) 0.94
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Bacterial Mg2+ homeostasis, transport, and virulence. Annu Rev Genet (2013) 0.91
The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus. PLoS Pathog (2013) 0.88
Regulation of prokaryotic gene expression by eukaryotic-like enzymes. Curr Opin Microbiol (2012) 0.87
Deletion of a cation transporter promotes lysis in Streptococcus pneumoniae. Infect Immun (2011) 0.87
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Inhibition of dendritic cell maturation by group A Streptococcus. J Infect Dis (2009) 0.87
TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus. Infect Immun (2008) 0.86
Thermoregulation of capsule production by Streptococcus pyogenes. PLoS One (2012) 0.85
Clindamycin-induced CovS-mediated regulation of the production of virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes. Antimicrob Agents Chemother (2009) 0.84
Characterization of transcription within sdr region of Staphylococcus aureus. Antonie Van Leeuwenhoek (2010) 0.83
Vitamin D and the human antimicrobial peptide LL-37 enhance group a streptococcus resistance to killing by human cells. MBio (2012) 0.83
Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus. Infect Immun (2015) 0.82
PepO, a CovRS-controlled endopeptidase, disrupts Streptococcus pyogenes quorum sensing. Mol Microbiol (2015) 0.82
Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease. BMC Res Notes (2013) 0.80
The human antimicrobial peptide LL-37 binds directly to CsrS, a sensor histidine kinase of group A Streptococcus, to activate expression of virulence factors. J Biol Chem (2014) 0.79
Metal-mediated modulation of streptococcal cysteine protease activity and its biological implications. Infect Immun (2014) 0.79
PolA1, a putative DNA polymerase I, is coexpressed with PerR and contributes to peroxide stress defenses of group A Streptococcus. J Bacteriol (2012) 0.79
CovR alleviates transcriptional silencing by a nucleoid-associated histone-like protein in Streptococcus mutans. J Bacteriol (2012) 0.77
The two-component system GrvRS (EtaRS) regulates ace expression in Enterococcus faecalis OG1RF. Infect Immun (2014) 0.76
Streptococcus pyogenes Endopeptidase O Contributes to Evasion from Complement-mediated Bacteriolysis via Binding to Human Complement Factor C1q. J Biol Chem (2017) 0.75
Use of a Phosphorylation Site Mutant to Identify Distinct Modes of Gene Repression by the Control of Virulence Regulator (CovR) in Streptococcus pyogenes. J Bacteriol (2017) 0.75
RocA is an accessory protein to the virulence-regulating CovR/S two-component system in the group A Streptococcus. Infect Immun (2017) 0.75
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Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A (2003) 4.56
Pili in gram-positive pathogens. Nat Rev Microbiol (2006) 4.21
Genome analysis reveals pili in Group B Streptococcus. Science (2005) 3.85
Identification of a universal Group B streptococcus vaccine by multiple genome screen. Science (2005) 3.83
Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens. Proc Natl Acad Sci U S A (2005) 3.59
Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome. Nat Biotechnol (2006) 3.03
Rational design of a meningococcal antigen inducing broad protective immunity. Sci Transl Med (2011) 2.59
Structural and genetic diversity of group B streptococcus capsular polysaccharides. Infect Immun (2005) 2.51
Identification of novel genomic islands coding for antigenic pilus-like structures in Streptococcus agalactiae. Mol Microbiol (2006) 2.31
Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B. Proc Natl Acad Sci U S A (2003) 2.17
Group B Streptococcus: global incidence and vaccine development. Nat Rev Microbiol (2006) 2.16
Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formation. Mol Microbiol (2007) 2.01
Genomic approach for analysis of surface proteins in Chlamydia pneumoniae. Infect Immun (2002) 1.94
The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol (2006) 1.94
The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J Exp Med (2003) 1.87
The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun (2005) 1.86
Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat Biotechnol (2002) 1.83
Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes. Microbiology (2006) 1.75
NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci. Mol Microbiol (2002) 1.67
Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Blood (2006) 1.65
The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+. Proc Natl Acad Sci U S A (2003) 1.65
Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigm. J Infect Dis (2009) 1.64
Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. Pediatr Res (2006) 1.59
A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response. Infect Immun (2008) 1.54
Sortase A utilizes an ancillary protein anchor for efficient cell wall anchoring of pili in Streptococcus agalactiae. Infect Immun (2008) 1.51
Regulation of virulence by a two-component system in group B streptococcus. J Bacteriol (2005) 1.46
Induction of group A Streptococcus virulence by a human antimicrobial peptide. Proc Natl Acad Sci U S A (2008) 1.45
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88. Proc Natl Acad Sci U S A (2011) 1.44
Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles. Proteomics (2006) 1.39
T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. Proc Natl Acad Sci U S A (2003) 1.37
Cytolysin-dependent evasion of lysosomal killing. Proc Natl Acad Sci U S A (2005) 1.35
Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci. Infect Immun (2003) 1.34
Vaccinology in the genome era. J Clin Invest (2009) 1.31
Proteomics characterization of outer membrane vesicles from the extraintestinal pathogenic Escherichia coli DeltatolR IHE3034 mutant. Mol Cell Proteomics (2007) 1.30
Inferring reasons for the failure of Staphylococcus aureus vaccines in clinical trials. Front Cell Infect Microbiol (2012) 1.29
Approach to discover T- and B-cell antigens of intracellular pathogens applied to the design of Chlamydia trachomatis vaccines. Proc Natl Acad Sci U S A (2011) 1.27
Characterization of a novel Neisseria meningitidis Fur and iron-regulated operon required for protection from oxidative stress: utility of DNA microarray in the assignment of the biological role of hypothetical genes. Mol Microbiol (2004) 1.24
Burden and economic cost of group A streptococcal pharyngitis. Pediatrics (2008) 1.23
Structural vaccinology starts to deliver. Nat Rev Microbiol (2012) 1.22
Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity. J Bacteriol (2008) 1.21
Role of NADase in virulence in experimental invasive group A streptococcal infection. Infect Immun (2005) 1.20
Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease. J Infect Dis (2006) 1.19
Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefield T serotypes. J Infect Dis (2008) 1.18
Enhancement of streptolysin O activity and intrinsic cytotoxic effects of the group A streptococcal toxin, NAD-glycohydrolase. J Biol Chem (2006) 1.18
BibA: a novel immunogenic bacterial adhesin contributing to group B Streptococcus survival in human blood. Mol Microbiol (2007) 1.18
Role of FNR and FNR-regulated, sugar fermentation genes in Neisseria meningitidis infection. Mol Microbiol (2006) 1.17
Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. Biol Chem (2002) 1.17
Protein array profiling of tic patient sera reveals a broad range and enhanced immune response against Group A Streptococcus antigens. PLoS One (2009) 1.17
Effect of Neisseria meningitidis fur mutations on global control of gene transcription. J Bacteriol (2006) 1.16
Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing. PLoS Pathog (2013) 1.16
Molecular mimicry between Helicobacter pylori antigens and H+, K+ --adenosine triphosphatase in human gastric autoimmunity. J Exp Med (2003) 1.14
Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case. Mol Cell Proteomics (2012) 1.13
Surfome analysis as a fast track to vaccine discovery: identification of a novel protective antigen for Group B Streptococcus hypervirulent strain COH1. Mol Cell Proteomics (2009) 1.13
PerR confers phagocytic killing resistance and allows pharyngeal colonization by group A Streptococcus. PLoS Pathog (2008) 1.10
Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections. Proc Natl Acad Sci U S A (2011) 1.09
Extracellular group A Streptococcus induces keratinocyte apoptosis by dysregulating calcium signalling. Cell Microbiol (2005) 1.09
Pilus backbone contributes to group B Streptococcus paracellular translocation through epithelial cells. J Infect Dis (2008) 1.06
Specific involvement of pilus type 2a in biofilm formation in group B Streptococcus. PLoS One (2010) 1.06
Immune subversion by Helicobacter pylori. Trends Immunol (2005) 1.06
Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus. PLoS Pathog (2011) 1.05
GNA33 from Neisseria meningitidis serogroup B encodes a membrane-bound lytic transglycosylase (MltA). Eur J Biochem (2002) 1.05
Capsular gene typing of Streptococcus agalactiae compared to serotyping by latex agglutination. J Clin Microbiol (2012) 1.04
Capturing host-pathogen interactions by protein microarrays: identification of novel streptococcal proteins binding to human fibronectin, fibrinogen, and C4BP. FASEB J (2009) 1.04
EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts. J Mol Med (Berl) (2012) 1.04
Distribution of surface plastic debris in the eastern Pacific Ocean from an 11-year data set. Environ Sci Technol (2014) 1.03
Scavenger receptor gp340 aggregates group A streptococci by binding pili. Mol Microbiol (2008) 1.03
Identification of new potential vaccine candidates against Chlamydia pneumoniae by multiple screenings. Vaccine (2005) 1.02