Published in Science on July 06, 2007
Interactions between the microbiota and the immune system. Science (2012) 10.45
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 7.45
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A (2008) 5.78
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell (2012) 4.98
NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev (2008) 4.61
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 4.41
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37
Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol (2010) 4.07
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med (2009) 4.03
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer (2013) 4.02
Role of the microbiota in immunity and inflammation. Cell (2014) 3.43
Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol (2012) 3.21
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A (2008) 3.19
The microbiome and cancer. Nat Rev Cancer (2013) 2.86
Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol (2010) 2.85
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One (2009) 2.79
Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci U S A (2012) 2.61
Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol (2010) 2.58
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med (2010) 2.57
The gut microbiome modulates colon tumorigenesis. MBio (2013) 2.45
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci U S A (2010) 2.33
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Oncogene (2008) 2.31
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A (2011) 2.12
ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med (2010) 2.09
ATF3 transcription factor and its emerging roles in immunity and cancer. J Mol Med (Berl) (2009) 2.08
Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest (2010) 2.02
Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology (2010) 2.01
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. Cancer Microenviron (2010) 1.96
Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell (2009) 1.95
Polarized immune responses differentially regulate cancer development. Immunol Rev (2008) 1.95
Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation. J Clin Invest (2010) 1.88
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med (2012) 1.82
Toll-like receptors in inflammatory bowel diseases: a decade later. Inflamm Bowel Dis (2010) 1.79
Toll-like receptor signaling in cell proliferation and survival. Cytokine (2009) 1.79
The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res (2008) 1.78
Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.73
ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med (2013) 1.70
Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling? Cell Div (2010) 1.70
Microbiota, disease, and back to health: a metastable journey. Sci Transl Med (2012) 1.70
Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology (2008) 1.70
Role of Toll-like receptors in gastrointestinal malignancies. Oncogene (2008) 1.69
Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia (2009) 1.66
Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest (2012) 1.66
Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol (2012) 1.61
Toll-like receptor signaling pathways--therapeutic opportunities. Mediators Inflamm (2010) 1.58
The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol (2011) 1.56
High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br J Cancer (2010) 1.56
Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death. Genes Dev (2010) 1.51
Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88. Proc Natl Acad Sci U S A (2010) 1.47
Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med (2016) 1.42
An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. J Exp Med (2010) 1.42
Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1. J Biol Chem (2008) 1.41
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.40
Cytokines, inflammation and colon cancer. Curr Cancer Drug Targets (2011) 1.38
TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. EMBO J (2010) 1.37
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol (2009) 1.35
Regulation of innate and adaptive immunity by the commensal microbiota. Curr Opin Immunol (2011) 1.34
Dual roles for immunity in gastrointestinal cancers. J Clin Oncol (2010) 1.31
Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res (2009) 1.29
Inflammasomes in intestinal inflammation and cancer. Gastroenterology (2011) 1.28
Toll-like receptors, wound healing, and carcinogenesis. J Mol Med (Berl) (2008) 1.27
Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One (2010) 1.26
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages. J Clin Invest (2011) 1.25
Vaccination strategies to promote mucosal antibody responses. Immunity (2010) 1.24
The Yin and Yang of Toll-like receptors in cancer. Oncogene (2013) 1.23
Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res (2010) 1.21
The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. J Gastroenterol (2012) 1.20
Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol (2011) 1.18
The struggle within: microbial influences on colorectal cancer. Inflamm Bowel Dis (2011) 1.15
Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms. J Exp Med (2009) 1.15
Pathogen recognition receptors, cancer and inflammation in the gut. Curr Opin Pharmacol (2009) 1.14
Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness. Br J Cancer (2008) 1.13
The NF-κB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1β. Cancer Microenviron (2009) 1.13
Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate. Br J Cancer (2008) 1.13
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Nat Med (2015) 1.11
TLR4 activates the β-catenin pathway to cause intestinal neoplasia. PLoS One (2013) 1.10
TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomes. Am J Pathol (2010) 1.09
Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology. World J Gastrointest Pathophysiol (2012) 1.09
Intestinal inflammation and colorectal cancer: a double-edged sword? World J Gastroenterol (2011) 1.09
NF-κB and cancer: a paradigm of Yin-Yang. Am J Cancer Res (2010) 1.08
Gastrointestinal malignancy and the microbiome. Gastroenterology (2014) 1.07
Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat Res (2010) 1.06
Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer. Gastroenterology (2011) 1.05
Role of bacteria in oncogenesis. Clin Microbiol Rev (2010) 1.05
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Proc Natl Acad Sci U S A (2012) 1.04
Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice. Gastroenterology (2010) 1.04
The Role of Inflammation in the Pathogenesis of Colorectal Cancer. Curr Colorectal Cancer Rep (2009) 1.04
Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. J Clin Invest (2013) 1.03
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations. Mol Cancer (2010) 1.03
Problems with using the normal distribution--and ways to improve quality and efficiency of data analysis. PLoS One (2011) 1.02
Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res (2013) 1.02
The dual role of inflammation in colon carcinogenesis. Int J Mol Sci (2012) 1.01
Cancer. Sex, cytokines, and cancer. Science (2007) 1.01
Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury. Cancer Res (2013) 1.00
Activated macrophages in the tumour microenvironment-dancing to the tune of TLR and NF-kappaB. J Pathol (2009) 1.00
Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response. Cell Microbiol (2012) 1.00
Genetic reconstitution of tumorigenesis in primary intestinal cells. Proc Natl Acad Sci U S A (2013) 1.00
The role of pattern recognition receptors in intestinal inflammation. Mucosal Immunol (2013) 1.00
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
Innate immune recognition. Annu Rev Immunol (2001) 26.65
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61
Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59
Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49
Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34
Type I interferons in host defense. Immunity (2006) 7.32
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79
A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78
Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57
Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
Toll-like receptor signaling pathways. Science (2003) 5.86
Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30
Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98
Pattern recognition receptors and control of adaptive immunity. Immunol Rev (2009) 3.91
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12
On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11
Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90
Toll-dependent control mechanisms of CD4 T cell activation. Immunity (2004) 2.88
Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65
Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A (2002) 2.43
Toll-like receptors: linking innate and adaptive immunity. Microbes Infect (2004) 2.38
Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol (2005) 2.30
Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22
Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11
Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09
Allergic host defences. Nature (2012) 1.99
Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88
Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88
Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80
Toll-like receptors and acquired immunity. Semin Immunol (2004) 1.79
Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62
Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62
Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity (2011) 1.57
Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis (2007) 1.56
Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52
The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 1.48
Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44
Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40
Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38
Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36
Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35
Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol (2003) 1.34
Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33
Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31
Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog (2008) 1.27
Evolution of inflammatory diseases. Curr Biol (2012) 1.27
Impact of CD1d deficiency on metabolism. PLoS One (2011) 1.21
Learning tolerance while fighting ignorance. Cell (2009) 1.20
Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20
A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14
Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10
Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10
Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10
Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08
Innate sensors of microbial infection. J Clin Immunol (2005) 1.05
Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05
The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01
Two modes of ligand recognition by TLRs. Cell (2007) 0.99
Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A (2013) 0.97
Role of ITAM signaling module in signal integration. Curr Opin Immunol (2012) 0.94
Antifungal defense turns 17. Nat Immunol (2007) 0.93
Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90
Not so fast: adaptive suppression of innate immunity. Nat Med (2007) 0.89
Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol (2011) 0.89
A new shield for a cytokine storm. Cell (2011) 0.88
graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol (2004) 0.85
Skin antibiotics get in the loop. Nat Med (2002) 0.84
The origins of tumor-promoting inflammation. Cancer Cell (2013) 0.84
Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A (2013) 0.82
Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxid Redox Signal (2014) 0.82
A plague on host defense. J Exp Med (2002) 0.81
T helper 17 cells get the NOD. Immunity (2007) 0.78
Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest (2007) 0.78
Training the next generation of biomedical investigators in glycosciences. J Clin Invest (2016) 0.76
Honor thy Go(na)ds. Immunol Cell Biol (2013) 0.75
Germs gone wild. Nat Med (2012) 0.75