Published in J Immunol on July 15, 2007
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med (2011) 4.71
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity (2008) 3.56
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J Exp Med (2008) 1.86
During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J Exp Med (2008) 1.66
The transcriptional landscape of αβ T cell differentiation. Nat Immunol (2013) 1.61
Murine thymic selection quantified using a unique method to capture deleted T cells. Proc Natl Acad Sci U S A (2013) 1.52
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. Nat Immunol (2013) 1.42
T-cell tolerance: central and peripheral. Cold Spring Harb Perspect Biol (2012) 1.28
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. J Exp Med (2013) 1.26
Genetic control of programmed cell death during animal development. Annu Rev Genet (2009) 1.24
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A (2014) 1.03
Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens. Proc Natl Acad Sci U S A (2012) 1.03
Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2). Proc Natl Acad Sci U S A (2010) 1.00
Central tolerance: what have we learned from mice? Semin Immunopathol (2008) 0.97
A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway. PLoS One (2010) 0.97
Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc Natl Acad Sci U S A (2012) 0.96
Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis. Eur J Immunol (2010) 0.94
Diacylglycerol kinase ζ limits the generation of natural regulatory T cells. Sci Signal (2013) 0.86
Examination of thymic positive and negative selection by flow cytometry. J Vis Exp (2012) 0.85
PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion. Immunity (2016) 0.84
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. Elife (2014) 0.82
Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. J Exp Med (2013) 0.82
The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. EMBO J (2011) 0.82
Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X. J Exp Med (2014) 0.81
Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation. Immunol Cell Biol (2014) 0.81
Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8. PLoS One (2014) 0.77
Avidity-dependent programming of autoreactive T cells in T1D. PLoS One (2014) 0.76
T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells. Front Immunol (2016) 0.75
Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ. J Immunol (2016) 0.75
Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes. Cell Death Differ (2016) 0.75
Thymic progenitors of TCRαβ(+) CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development. J Exp Med (2017) 0.75
Positive and negative selection of T cells. Annu Rev Immunol (2002) 8.32
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med (2011) 4.71
Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature (2006) 4.51
Identification of a novel population of Langerin+ dendritic cells. J Exp Med (2007) 4.13
KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity (2009) 2.90
Thymic emigration revisited. J Exp Med (2007) 2.60
T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol (2010) 2.49
Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat Immunol (2013) 2.33
Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students. J Infect Dis (2012) 2.33
Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat Immunol (2013) 2.23
Progress and problems in understanding and managing primary Epstein-Barr virus infections. Clin Microbiol Rev (2011) 2.22
Selection of self-reactive T cells in the thymus. Annu Rev Immunol (2011) 1.98
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J Exp Med (2008) 1.86
The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med (2005) 1.85
Sweet 'n' sour: the impact of differential glycosylation on T cell responses. Nat Immunol (2002) 1.65
Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ. Sci Signal (2013) 1.63
A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc Natl Acad Sci U S A (2005) 1.60
Alternative memory in the CD8 T cell lineage. Trends Immunol (2011) 1.60
Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state. Immunity (2004) 1.58
Langerin expressing cells promote skin immune responses under defined conditions. J Immunol (2008) 1.54
Murine thymic selection quantified using a unique method to capture deleted T cells. Proc Natl Acad Sci U S A (2013) 1.52
Acute ablation of Langerhans cells enhances skin immune responses. J Immunol (2010) 1.47
Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. PLoS Biol (2005) 1.47
Rare, structurally homologous self-peptides promote thymocyte positive selection. Immunity (2002) 1.41
The fourth way? Harnessing aggressive tendencies in the thymus. J Immunol (2004) 1.31
Thymic emigration: when and how T cells leave home. J Immunol (2008) 1.31
T-cell tolerance: central and peripheral. Cold Spring Harb Perspect Biol (2012) 1.28
Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans. J Exp Med (2012) 1.20
Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells. J Immunol (2010) 1.19
The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J Immunol (2004) 1.15
Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens. J Immunol (2009) 1.12
A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter. J Immunol (2002) 1.12
Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression. Proc Natl Acad Sci U S A (2010) 1.12
Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire. Proc Natl Acad Sci U S A (2009) 1.09
Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. J Immunol (2014) 1.08
Virtual memory CD8 T cells display unique functional properties. Proc Natl Acad Sci U S A (2013) 1.04
Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells. J Immunol (2010) 1.02
T-cell receptor affinity in thymic development. Immunology (2012) 0.99
Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection. Proc Natl Acad Sci U S A (2013) 0.98
Antigen receptor selection by editing or downregulation of V(D)J recombination. Curr Opin Immunol (2003) 0.97
Central tolerance: what have we learned from mice? Semin Immunopathol (2008) 0.97
Krüppel-like factors in lymphocyte biology. J Immunol (2012) 0.97
CD53, a thymocyte selection marker whose induction requires a lower affinity TCR-MHC interaction than CD69, but is up-regulated with slower kinetics. Int Immunol (2002) 0.96
Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation. J Immunol (2003) 0.95
Conditioning of Langerhans cells induced by a primary CD8 T cell response to self-antigen in vivo. J Immunol (2006) 0.91
Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5. J Immunol (2010) 0.91
Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol (2009) 0.91
Central tolerance to self-antigen expressed by cortical epithelial cells. J Immunol (2004) 0.89
Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc Natl Acad Sci U S A (2012) 0.88
Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. Proc Natl Acad Sci U S A (2012) 0.85
Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond. Eur J Immunol (2009) 0.83
T-cell migration: Kruppeled T cells move again. Immunol Cell Biol (2008) 0.81
Immunodeficiency: when T cells are stuck at home. Nat Immunol (2008) 0.80
The central tolerance response to male antigen in normal mice is deletion and not receptor editing. J Immunol (2003) 0.78
Death diverted, but to what? Nat Immunol (2012) 0.77
Pillars article: T cell receptor antagonist peptides induce positive selection. Cell. 1994. 76: 17-27. J Immunol (2012) 0.77
T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction. JCI Insight (2017) 0.75
Corrigendum: Spontaneous partial loss of the OT-I transgene. Nat Immunol (2017) 0.75