Published in Nat Med on July 01, 2007
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med (2009) 4.58
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med (2012) 3.34
Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med (2009) 2.51
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc Natl Acad Sci U S A (2012) 2.38
Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB. Nat Med (2014) 2.30
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. Nat Commun (2014) 2.08
Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov (2012) 1.91
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis. Nat Med (2014) 1.90
Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. J Clin Invest (2012) 1.77
Control of bone formation by the serpentine receptor Frizzled-9. J Cell Biol (2011) 1.77
Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med (2009) 1.72
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J Clin Invest (2010) 1.71
Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest (2013) 1.70
Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci U S A (2012) 1.68
Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab (2014) 1.65
Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling. Cell Stem Cell (2010) 1.60
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proc Natl Acad Sci U S A (2013) 1.54
PTH expands short-term murine hemopoietic stem cells through T cells. Blood (2012) 1.53
The harmonies played by TGF-β in stem cell biology. Cell Stem Cell (2012) 1.47
Engineering bone tissue from human embryonic stem cells. Proc Natl Acad Sci U S A (2012) 1.47
Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nat Med (2016) 1.43
Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell (2008) 1.38
TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling. Nat Cell Biol (2010) 1.33
Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand. Proc Natl Acad Sci U S A (2010) 1.33
T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab (2009) 1.32
Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci (2009) 1.31
ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proc Natl Acad Sci U S A (2010) 1.26
Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice. Proc Natl Acad Sci U S A (2013) 1.26
Promising bone-related therapeutic targets for rheumatoid arthritis. Nat Rev Rheumatol (2009) 1.25
Bone metastasis: pathogenesis and therapeutic implications. Clin Exp Metastasis (2007) 1.23
The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation. PLoS One (2010) 1.22
The immune system and bone. Arch Biochem Biophys (2010) 1.19
Role of decorin in the antimyeloma effects of osteoblasts. Blood (2008) 1.19
Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling. J Bone Miner Res (2009) 1.19
Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia. Proc Natl Acad Sci U S A (2013) 1.17
Eph receptors and ephrin signaling pathways: a role in bone homeostasis. Int J Med Sci (2008) 1.17
Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. J Clin Invest (2009) 1.15
Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation. Mol Cell Biol (2009) 1.12
Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab (2013) 1.09
Mapping the growth hormone--Stat5b--IGF-I transcriptional circuit. Trends Endocrinol Metab (2012) 1.07
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection. J Clin Invest (2011) 1.05
Calcium signaling in osteoclasts. Biochim Biophys Acta (2010) 1.05
Mechanical stretching for tissue engineering: two-dimensional and three-dimensional constructs. Tissue Eng Part B Rev (2012) 1.04
T cells: critical bone regulators in health and disease. Bone (2010) 1.04
Effect of aging on cellular mechanotransduction. Ageing Res Rev (2009) 1.04
RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor. Structure (2012) 1.04
Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis. Proc Natl Acad Sci U S A (2012) 1.04
Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. PLoS One (2010) 1.03
Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells. Biomaterials (2012) 1.03
Cyclic tensile stretch modulates osteogenic differentiation of adipose-derived stem cells via the BMP-2 pathway. Arch Med Sci (2010) 1.00
Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2. PLoS One (2010) 1.00
The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts. J Biol Chem (2014) 0.99
The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look. Open Rheumatol J (2012) 0.99
Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts. World J Stem Cells (2013) 0.98
MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest (2011) 0.97
Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms. World J Diabetes (2011) 0.97
Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1. FASEB J (2011) 0.96
Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts. J Bone Miner Res (2012) 0.96
Minireview: The link between fat and bone: does mass beget mass? Endocrinology (2012) 0.95
Parathyroid hormone regulates the distribution and osteoclastogenic potential of hematopoietic progenitors in the bone marrow. J Bone Miner Res (2011) 0.95
Bone status in a mouse model of genetic hemochromatosis. Osteoporos Int (2010) 0.95
Targeting osteoclast-osteoblast communication. Nat Med (2011) 0.95
Serum response factor regulates bone formation via IGF-1 and Runx2 signals. J Bone Miner Res (2012) 0.95
Regulation of bone turnover by sex steroids in men. J Bone Miner Res (2008) 0.95
Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling. J Spinal Cord Med (2013) 0.95
Bone density and brain atrophy in early Alzheimer's disease. J Alzheimers Dis (2009) 0.93
Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers. J Clin Endocrinol Metab (2012) 0.93
Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. J Bone Miner Res (2009) 0.92
Is Alzheimer's disease a systemic disease? Biochim Biophys Acta (2014) 0.92
Reduced limbic and hypothalamic volumes correlate with bone density in early Alzheimer's disease. J Alzheimers Dis (2010) 0.91
The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates. J Bone Miner Res (2011) 0.91
Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking. Mol Cell Biol (2015) 0.91
Determination of the differentiation capacities of murines' primary mononucleated cells and MC3T3-E1 cells. Cancer Cell Int (2010) 0.90
Function of matrix IGF-1 in coupling bone resorption and formation. J Mol Med (Berl) (2013) 0.90
Effects of Inositol 1,4,5-triphosphate on Osteoclast Differentiation in RANKL-induced Osteoclastogenesis. Korean J Physiol Pharmacol (2012) 0.89
The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. J Exp Med (2013) 0.89
Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development. Mol Cell Biol (2011) 0.89
Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Cell Metab (2011) 0.89
Leptin-dependent co-regulation of bone and energy metabolism. Aging (Albany NY) (2009) 0.89
The sclerostin-independent bone anabolic activity of intermittent PTH treatment is mediated by T-cell-produced Wnt10b. J Bone Miner Res (2014) 0.88
Integrin αv in the mechanical response of osteoblast lineage cells. Biochem Biophys Res Commun (2014) 0.87
IGF-1 Signaling is Essential for Differentiation of Mesenchymal Stem Cells for Peak Bone Mass. Bone Res (2013) 0.87
Factors and mechanisms involved in the coupling from bone resorption to formation: how osteoclasts talk to osteoblasts. J Bone Metab (2014) 0.86
Translational medicine: Double protection for weakened bones. Nature (2012) 0.86
Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass. J Clin Invest (2014) 0.86
Nuclear receptors in bone physiology and diseases. Physiol Rev (2013) 0.86
Mediators of inflammation-induced bone damage in arthritis and their control by herbal products. Evid Based Complement Alternat Med (2013) 0.85
Vitamin C prevents hypogonadal bone loss. PLoS One (2012) 0.85
Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function. J Cell Mol Med (2011) 0.85
Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption. Mol Cell Biol (2011) 0.85
Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation. Cell Calcium (2012) 0.85
Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases. J Mol Med (Berl) (2009) 0.85
Calcium gluconate supplementation is effective to balance calcium homeostasis in patients with gastrectomy. Osteoporos Int (2014) 0.84
Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult mice progeny with and without swimming exercise. Arthritis Res Ther (2012) 0.84
Molecular biology of bone remodelling. Clin Cases Miner Bone Metab (2008) 0.84
PTH battles TGF-beta in bone. Nat Cell Biol (2010) 0.84
Effects of anti-tumor necrosis factor α agents on bone. Curr Opin Rheumatol (2012) 0.84
Stomaching calcium for bone health. Nat Med (2009) 0.84
The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures. J Biol Chem (2013) 0.84