Published in Biochemistry on July 13, 2007
Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats. Proc Natl Acad Sci U S A (2009) 1.64
Dynamics of the extracellular gate and ion-substrate coupling in the glutamate transporter. Biophys J (2008) 1.46
Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. IUBMB Life (2008) 1.30
Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101. J Biol Chem (2010) 1.25
Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter. Biophys J (2010) 1.25
Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter. Proc Natl Acad Sci U S A (2009) 1.09
New views of glutamate transporter structure and function: advances and challenges. Neuropharmacology (2010) 1.01
Induced fit substrate binding to an archeal glutamate transporter homologue. Proc Natl Acad Sci U S A (2013) 0.87
The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5. Biophys J (2011) 0.87
Mechanism of transport modulation by an extracellular loop in an archaeal excitatory amino acid transporter (EAAT) homolog. J Biol Chem (2013) 0.87
Hetero-oligomerization of neuronal glutamate transporters. J Biol Chem (2010) 0.85
Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2. J Gen Physiol (2013) 0.84
SLC1 glutamate transporters. Pflugers Arch (2013) 0.83
Molecular dynamics simulations elucidate the mechanism of proton transport in the glutamate transporter EAAT3. Biophys J (2014) 0.81
Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter. J Biol Chem (2012) 0.80
Capturing Functional Motions of Membrane Channels and Transporters with Molecular Dynamics Simulation. J Comput Theor Nanosci (2010) 0.79
Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1. J Biol Chem (2016) 0.76
Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B. Biochemistry (2012) 0.75
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature (2005) 12.56
Structure and mechanism of the lactose permease of Escherichia coli. Science (2003) 10.57
Simple allosteric model for membrane pumps. Nature (1966) 7.78
Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature (2004) 6.02
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature (2007) 4.14
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature (1995) 4.14
DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol (1998) 2.93
Kinetics of a human glutamate transporter. Neuron (1995) 2.87
Transporters buffer synaptically released glutamate on a submillisecond time scale. J Neurosci (1997) 2.74
Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel. J Neurosci (1998) 2.48
Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters. J Neurosci (2002) 2.04
Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters. J Neurosci Methods (2001) 2.02
Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds. Proc Natl Acad Sci U S A (2000) 1.99
Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1. J Gen Physiol (2001) 1.97
Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter. J Biol Chem (2000) 1.90
Anion currents and predicted glutamate flux through a neuronal glutamate transporter. J Neurosci (1998) 1.89
Binding order of substrates to the sodium and potassium ion coupled L-glutamic acid transporter from rat brain. Biochemistry (1982) 1.88
Voltage gating of Shaker K+ channels. The effect of temperature on ionic and gating currents. J Gen Physiol (1998) 1.66
Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2. J Neurosci (2000) 1.65
Fluorometric measurements of conformational changes in glutamate transporters. Proc Natl Acad Sci U S A (2004) 1.61
Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression. Neuron (2001) 1.50
Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1. J Biol Chem (2006) 1.49
The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate. J Biol Chem (2000) 1.46
Fast removal of synaptic glutamate by postsynaptic transporters. Neuron (2000) 1.44
Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1. J Biol Chem (2002) 1.30
Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1. J Biol Chem (2006) 1.26
The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse? J Neurochem (2006) 1.23
The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism. J Gen Physiol (2005) 1.20
Conformational changes monitored on the glutamate transporter GLT-1 indicate the existence of two neurotransmitter-bound states. J Biol Chem (1995) 1.15
The anion conductance of the glutamate transporter EAAC1 depends on the direction of glutamate transport. FEBS Lett (2001) 1.12
Investigation of the alpha(1)-glycine receptor channel-opening kinetics in the submillisecond time domain. Biophys J (1999) 1.10
Temperature dependence of ATP release from "caged" ATP. Acta Biochim Biophys Acad Sci Hung (1984) 1.06
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. J Mol Biol (2006) 1.04
Glutamate transporters contribute to the time course of synaptic transmission in cerebellar granule cells. J Neurosci (1999) 1.01
Temperature effects on the presteady-state and transport-associated currents of GABA cotransporter rGAT1. FEBS Lett (2002) 0.98
Roles of glutamate transporters in shaping excitatory synaptic currents in cerebellar Purkinje cells. Eur J Neurosci (2004) 0.95
The conserved histidine 295 does not contribute to proton cotransport by the glutamate transporter EAAC1. Biochemistry (2005) 0.94
Postsynaptic response kinetics are controlled by a glutamate transporter at cone photoreceptors. J Neurophysiol (1998) 0.91
Thermodynamics of active-site ligand binding to Escherichia coli glutamine synthetase. Biochemistry (1987) 0.81
Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other. Biochemistry (2005) 1.81
FTIP1 is an essential regulator required for florigen transport. PLoS Biol (2012) 1.61
Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1. J Biol Chem (2006) 1.49
Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. IUBMB Life (2008) 1.30
Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101. J Biol Chem (2010) 1.25
Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury. J Immunol (2014) 1.24
The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism. J Gen Physiol (2005) 1.20
Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function. J Neurosci (2008) 1.17
Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1. J Gen Physiol (2007) 1.11
Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis. Glia (2004) 1.09
Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1. Proc Natl Acad Sci U S A (2007) 1.06
MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation. Stroke (2013) 1.04
Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma. Radiother Oncol (2013) 1.00
Global identification of DELLA target genes during Arabidopsis flower development. Plant Physiol (2008) 0.99
Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor. J Neurosci Methods (2005) 0.99
The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. Biophys J (2007) 0.95
Rapid substrate-induced charge movements of the GABA transporter GAT1. Biophys J (2005) 0.94
Diversity of the skin microbiota of fishes: evidence for host species specificity. FEMS Microbiol Ecol (2013) 0.94
Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) Ligands with Novel Serine Analogs. Mol Pharmacol (2011) 0.94
The conserved histidine 295 does not contribute to proton cotransport by the glutamate transporter EAAC1. Biochemistry (2005) 0.94
A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2). J Biol Chem (2009) 0.92
Disruption of interdomain interactions in the glutamate binding pocket affects differentially agonist affinity and efficacy of N-methyl-D-aspartate receptor activation. J Biol Chem (2006) 0.92
Clinical observations on the association between diagnosis of lung cancer and serum tumor markers in combination. Asian Pac J Cancer Prev (2013) 0.92
Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1. ACS Chem Neurosci (2012) 0.90
Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1. Biochemistry (2008) 0.89
The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5. Biophys J (2011) 0.87
Hetero-oligomerization of neuronal glutamate transporters. J Biol Chem (2010) 0.85
Development of web-based geocoding applications for the population-based Birth Defects Surveillance System in New York state. J Registry Manag (2010) 0.85
Highly conserved asparagine 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2. J Biol Chem (2008) 0.85
Molecular dynamics simulation links conformation of a pore-flanking region to hyperekplexia-related dysfunction of the inhibitory glycine receptor. Chem Biol (2004) 0.84
A conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transporters. J Biol Chem (2011) 0.84
Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2. J Gen Physiol (2013) 0.84
Variation of blood T lymphocyte subgroups in patients with non- small cell lung cancer. Asian Pac J Cancer Prev (2013) 0.81
Safety and effectiveness of cryosurgery on advanced pancreatic cancer: a systematic review. Pancreas (2012) 0.81
Toward the development of new photolabile protecting groups that can rapidly release bioactive compounds upon photolysis with visible light. J Org Chem (2003) 0.81
The C-terminal domain of the neutral amino acid transporter SNAT2 regulates transport activity through voltage-dependent processes. Biochem J (2011) 0.80
Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury. FEBS J (2014) 0.79
Pre-steady-state currents in neutral amino acid transporters induced by photolysis of a new caged alanine derivative. Biochemistry (2007) 0.79
RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma. Tumour Biol (2013) 0.78
Molecular cloning, characterisation and tissue-specific expression of human LAG3, a member of the novel Lag1 protein family. DNA Seq (2003) 0.77
Overexpression of YKL-40 predicts plaque instability in carotid atherosclerosis with CagA-positive Helicobacter pylori infection. PLoS One (2013) 0.77
Down-regulation of EphB4 phosphorylation is necessary for esophageal squamous cell carcinoma tumorigenecity. Tumour Biol (2014) 0.76
Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B. Biochemistry (2012) 0.75
Enzymatic conversion from pyridoxal to pyridoxine caused by microorganisms within tobacco phyllosphere. Plant Physiol Biochem (2014) 0.75
[Biogeochemical processes of the major ions and dissolved inorganic carbon in the Guijiang River]. Huan Jing Ke Xue (2014) 0.75
A survey on readiness and needs regarding the transition from ICD-9-CM to ICD-10-CM. J Registry Manag (2013) 0.75
Survival of Fish-Pathogenic Strains of Aeromonas hydrophila under Starvation. J Aquat Anim Health (2014) 0.75
Implementing a web-based case reporting and communication system among hospitals reporting to the birth defects registry in New York State. J Public Health Manag Pract (2008) 0.75
Development of a web-based integrated birth defects surveillance system in New York State. J Public Health Manag Pract (2008) 0.75
[Study of the expression membrane protein LASS2]. Sheng Wu Gong Cheng Xue Bao (2003) 0.75
[Advances in studies on transported flux and properties of riverine organic carbon]. Ying Yong Sheng Tai Xue Bao (2003) 0.75