The regulation of skin pigmentation.

Physiological factors that regulate skin pigmentation. Biofactors (2009) 1.93

What are melanocytes really doing all day long...? Exp Dermatol (2009) 1.65

Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Res (2009) 1.63

The "domestication syndrome" in mammals: a unified explanation based on neural crest cell behavior and genetics. Genetics (2014) 1.28

Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB. J Invest Dermatol (2010) 1.27

Signaling pathways in melanosome biogenesis and pathology. Int J Biochem Cell Biol (2010) 1.27

The hunt for natural skin whitening agents. Int J Mol Sci (2009) 1.21

Not just black and white: pigment pattern development and evolution in vertebrates. Semin Cell Dev Biol (2008) 1.10

Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT. Mol Endocrinol (2010) 1.06

LC/MS-based quantitative proteomic analysis of paraffin-embedded archival melanomas reveals potential proteomic biomarkers associated with metastasis. PLoS One (2009) 1.05

Protein signatures for survival and recurrence in metastatic melanoma. J Proteomics (2011) 1.02

Keratin 9 is required for the structural integrity and terminal differentiation of the palmoplantar epidermis. J Invest Dermatol (2013) 1.01

The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin. J Cell Sci (2010) 1.00

Wnt signaling in skin organogenesis. Organogenesis (2008) 1.00

Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity. PLoS One (2010) 0.99

Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation. PLoS One (2015) 0.99

Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration. Int J Mol Sci (2009) 0.98

Evidence that stress to the epidermal barrier influenced the development of pigmentation in humans. Pigment Cell Melanoma Res (2009) 0.96

Suppression of melanin production by expression of HSP70. J Biol Chem (2010) 0.96

Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions. J Biomed Opt (2015) 0.94

Identification of quinolines that inhibit melanogenesis by altering tyrosinase family trafficking. Mol Pharmacol (2008) 0.93

Conditional immortalization establishes a repertoire of mouse melanocyte progenitors with distinct melanogenic differentiation potential. J Invest Dermatol (2012) 0.92

Barrier requirements as the evolutionary "driver" of epidermal pigmentation in humans. Am J Hum Biol (2010) 0.89

Melanin: the biophysiology of oral melanocytes and physiological oral pigmentation. Head Face Med (2014) 0.88

Modifying skin pigmentation - approaches through intrinsic biochemistry and exogenous agents. Drug Discov Today Dis Mech (2008) 0.88

Signaling Pathways in Melanogenesis. Int J Mol Sci (2016) 0.87

Long-lasting molecular changes in human skin after repetitive in situ UV irradiation. J Invest Dermatol (2008) 0.87

"Trooping the color": restoring the original donor skin color by addition of melanocytes to bioengineered skin analogs. Pediatr Surg Int (2012) 0.85

Exosomes released by keratinocytes modulate melanocyte pigmentation. Nat Commun (2015) 0.85

Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression. J Biol Chem (2012) 0.85

Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1). J Investig Dermatol Symp Proc (2009) 0.85

Mechanisms for reaching the differentiated state: Insights from neural crest-derived melanocytes. Semin Cell Dev Biol (2008) 0.84

Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations in melanoma phenotype. PLoS One (2014) 0.84

Melanocytes--a novel tool to study mitochondrial dysfunction in Duchenne muscular dystrophy. J Cell Physiol (2013) 0.82

[6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway. Acta Pharmacol Sin (2012) 0.82

Short- and long-term effects of UV radiation on the pigmentation of human skin. J Investig Dermatol Symp Proc (2009) 0.81

MicroRNA 340 is involved in UVB-induced dendrite formation through the regulation of RhoA expression in melanocytes. Mol Cell Biol (2014) 0.81

Tissue engineering of skin: human tonsil-derived mesenchymal cells can function as dermal fibroblasts. Pediatr Surg Int (2014) 0.81

Effect of xanthohumol on melanogenesis in B16 melanoma cells. Exp Mol Med (2008) 0.81

The Dual Antimelanogenic and Antioxidant Activities of the Essential Oil Extracted from the Leaves of Acorus macrospadiceus (Yamamoto) F. N. Wei et Y. K. Li. Evid Based Complement Alternat Med (2012) 0.80

Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates. Cancer Immunol Res (2014) 0.80

The Genetics of Deafness in Domestic Animals. Front Vet Sci (2015) 0.80

Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin. Biomol Ther (Seoul) (2013) 0.80

Wnt5a inhibits the proliferation and melanogenesis of melanocytes. Int J Med Sci (2013) 0.79

Melanosomal dynamics assessed with a live-cell fluorescent melanosomal marker. PLoS One (2012) 0.79

Wnt10b promotes differentiation of mouse hair follicle melanocytes. Int J Med Sci (2013) 0.79

Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes. Sci Rep (2016) 0.79

TPC2 controls pigmentation by regulating melanosome pH and size. Proc Natl Acad Sci U S A (2016) 0.78

Conditioned Media from Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Inhibits Melanogenesis by Promoting Proteasomal Degradation of MITF. PLoS One (2015) 0.78

Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis. Sci Transl Med (2016) 0.78

Critical review of Ayurvedic Varṇya herbs and their tyrosinase inhibition effect. Anc Sci Life (2015) 0.77

Visible light is a better co-inducer of apoptosis for curcumin-treated human melanoma cells than UVA. PLoS One (2013) 0.77

Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of MITF via the intracellular cAMP and p38/JNK signalling pathways. Exp Dermatol (2015) 0.77

A Novel Role of Serotonin Receptor 2B Agonist as an Anti-Melanogenesis Agent. Int J Mol Sci (2016) 0.77

Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells. Biomol Ther (Seoul) (2014) 0.76

Identification and functional characterization of natural human melanocortin 1 receptor mutant alleles in Pakistani population. Pigment Cell Melanoma Res (2015) 0.76

A molecular systems approach to modelling human skin pigmentation: identifying underlying pathways and critical components. BMC Res Notes (2015) 0.76

KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model. Korean J Physiol Pharmacol (2014) 0.76

Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model. PLoS One (2016) 0.75

Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model. Life Sci Space Res (Amst) (2015) 0.75

The impact of skin colour on human photobiological responses. Pigment Cell Melanoma Res (2016) 0.75

Vitis amurensis Ruprecht root inhibited α-melanocyte stimulating hormone-induced melanogenesis in B16F10 cells. Nutr Res Pract (2014) 0.75

Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration. Sci Rep (2017) 0.75

[Biogenesis of melanosomes - the chessboard of pigmentation]. Med Sci (Paris) (2011) 0.75

Molecular and histological characterization of age spots. Exp Dermatol (2017) 0.75

Metastatic malignant melanoma with peritoneal seeding in a young woman: A case report. Obstet Gynecol Sci (2014) 0.75

Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions. Biomed Opt Express (2017) 0.75

The integrated analysis of RNA-seq and microRNA-seq depicts miRNA-mRNA networks involved in Japanese flounder (Paralichthys olivaceus) albinism. PLoS One (2017) 0.75

Soyasaponin Ag inhibits α‑MSH‑induced melanogenesis in B16F10 melanoma cells via the downregulation of TRP‑2. Int J Mol Med (2017) 0.75

Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J (2007) 2.62

The protective role of melanin against UV damage in human skin. Photochem Photobiol (2008) 2.45

Physiological factors that regulate skin pigmentation. Biofactors (2009) 1.93

UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin. FASEB J (2003) 1.88

The effects of dickkopf 1 on gene expression and Wnt signaling by melanocytes: mechanisms underlying its suppression of melanocyte function and proliferation. J Invest Dermatol (2006) 1.72

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res (2006) 1.63

Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation. J Invest Dermatol (2005) 1.60

Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J Cell Biol (2004) 1.56

Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB J (2006) 1.55

The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers. J Biol Chem (2006) 1.46

Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4. J Cell Sci (2003) 1.45

Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes. J Invest Dermatol (2012) 1.43

Regulation of human skin pigmentation and responses to ultraviolet radiation. Pigment Cell Res (2007) 1.41

Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res (2009) 1.38

Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase. J Invest Dermatol (2007) 1.37

MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. J Biol Chem (2005) 1.36

SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentation. Proc Natl Acad Sci U S A (2007) 1.32

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J Proteome Res (2003) 1.31

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci U S A (2004) 1.31

Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/beta-catenin signaling in keratinocytes. FASEB J (2007) 1.29

Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. J Clin Invest (2009) 1.28

Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. J Biol Chem (2003) 1.27

Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB. J Invest Dermatol (2010) 1.27

The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase. Pigment Cell Res (2002) 1.23

Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes. J Cell Sci (2006) 1.20

Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation. J Cell Sci (2002) 1.19

UVA tanning is involved in the increased incidence of skin cancers in fair-skinned young women. Pigment Cell Melanoma Res (2009) 1.19

MC1R and the response of melanocytes to ultraviolet radiation. Mutat Res (2005) 1.18

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proc Natl Acad Sci U S A (2006) 1.18

Stimulation of melanoblast pigmentation by 8-methoxypsoralen:the involvement of microphthalmia-associated transcription factor, the protein kinase a signal pathway, and proteasome-mediated degradation. J Invest Dermatol (2002) 1.17

Update on the regulation of mammalian melanocyte function and skin pigmentation. Expert Rev Dermatol (2011) 1.15

Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Pigment Cell Res (2005) 1.12

Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein. FASEB J (2010) 1.12

Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV irradiation. Exp Dermatol (2008) 1.08

Regulation of eumelanin/pheomelanin synthesis and visible pigmentation in melanocytes by ligands of the melanocortin 1 receptor. Pigment Cell Melanoma Res (2008) 1.07

Tyrosinase: a developmentally specific major determinant of peripheral dopamine. FASEB J (2003) 1.06

Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes. Int J Mass Spectrom (2007) 1.04

Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi. J Cell Physiol (2009) 1.03

Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. J Biol Chem (2007) 1.03

Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function. J Biol Chem (2004) 1.01

Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r. Proc Natl Acad Sci U S A (2009) 1.00

The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin. J Cell Sci (2010) 1.00

Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment. J Biol Chem (2004) 1.00

The inhibitory effect of androgen and sex-hormone-binding globulin on the intracellular cAMP level and tyrosinase activity of normal human melanocytes. Pigment Cell Res (2003) 0.98

Evidence for the ectopic synthesis of melanin in human adipose tissue. FASEB J (2008) 0.98

Melanocytes and their diseases. Cold Spring Harb Perspect Med (2014) 0.97

Direct interaction of tyrosinase with Tyrp1 to form heterodimeric complexes in vivo. J Cell Sci (2007) 0.97

Pigmentation effects of solar-simulated radiation as compared with UVA and UVB radiation. Pigment Cell Melanoma Res (2008) 0.97

The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding. FASEB J (2009) 0.97

Mesenchymal-epithelial interactions in the skin: aiming for site-specific tissue regeneration. J Dermatol Sci (2005) 0.97

The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin. Pigment Cell Melanoma Res (2010) 0.97

Involvement of dynein and spectrin with early melanosome transport and melanosomal protein trafficking. J Invest Dermatol (2007) 0.96

Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer. Arch Dermatol Res (2008) 0.95

Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway. Biochem J (2006) 0.94

The Seiji memorial lecture: the melanosome: an ideal model to study cellular differentiation. Pigment Cell Res (2003) 0.93

Regulation of melanocortin 1 receptor expression at the mRNA and protein levels by its natural agonist and antagonist. FASEB J (2003) 0.93

AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma. Proc Natl Acad Sci U S A (2011) 0.92

Forskolin protects keratinocytes from UVB-induced apoptosis and increases DNA repair independent of its effects on melanogenesis. J Invest Dermatol (2008) 0.91

A melanocyte-keratinocyte coculture model to assess regulators of pigmentation in vitro. Anal Biochem (2002) 0.90

NUAK2: an emerging acral melanoma oncogene. Oncotarget (2011) 0.90

Down-regulation of melanogenesis by phospholipase D2 through ubiquitin proteasome-mediated degradation of tyrosinase. J Biol Chem (2004) 0.90

Reconstituted 3-dimensional human skin of various ethnic origins as an in vitro model for studies of pigmentation. Anal Biochem (2003) 0.89

In vitro migration of melanoblasts requires matrix metalloproteinase-2: implications to vitiligo therapy by photochemotherapy. Pigment Cell Res (2002) 0.88

Modifying skin pigmentation - approaches through intrinsic biochemistry and exogenous agents. Drug Discov Today Dis Mech (2008) 0.88

Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes. FASEB J (2001) 0.87

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease. J Neurochem (2005) 0.87

Long-lasting molecular changes in human skin after repetitive in situ UV irradiation. J Invest Dermatol (2008) 0.87

Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein. Biochem J (2005) 0.87

Different approaches for assaying melanosome transfer. Pigment Cell Res (2005) 0.86

Long-lasting pigmentation of human skin, a new look at an overlooked response to UV. Pigment Cell Melanoma Res (2009) 0.86

Influence of melanosome dynamics on melanoma drug sensitivity. J Natl Cancer Inst (2009) 0.86

Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clin Cosmet Investig Dermatol (2010) 0.86

Immunohistochemistry and in situ hybridization in the study of human skin melanocytes. Exp Dermatol (2007) 0.86

Role of the ubiquitin proteasome system in regulating skin pigmentation. Int J Mol Sci (2009) 0.85

Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms. FASEB J (2006) 0.85

Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1). J Investig Dermatol Symp Proc (2009) 0.85

Regulating melanosome transfer: who's driving the bus? Pigment Cell Res (2007) 0.85

Epidermal gene expression and ethnic pigmentation variations among individuals of Asian, European and African ancestry. Exp Dermatol (2014) 0.84

Pmel17: controversial indeed but critical to melanocyte function. Pigment Cell Res (2006) 0.84

UV exposure modulates hemidesmosome plasticity, contributing to long-term pigmentation in human skin. J Pathol (2015) 0.84

Regulatory elements of the melanocortin 1 receptor. Peptides (2005) 0.84

Photobiologic role of melanin distribution in the epidermis. J Photochem Photobiol B (2006) 0.82

Short- and long-term effects of UV radiation on the pigmentation of human skin. J Investig Dermatol Symp Proc (2009) 0.81

The effects of topically applied glycolic acid and salicylic acid on ultraviolet radiation-induced erythema, DNA damage and sunburn cell formation in human skin. J Dermatol Sci (2009) 0.81

Photobiological implications of melanin photoprotection after UVB-induced tanning of human skin but not UVA-induced tanning. Pigment Cell Melanoma Res (2015) 0.81

Characterization of the bioactive motif of neuregulin-1, a fibroblast-derived paracrine factor that regulates the constitutive color and the function of melanocytes in human skin. Pigment Cell Melanoma Res (2012) 0.79

Standardization of in vitro macrophotography for assessment of cutaneous responses. Photochem Photobiol (2009) 0.79

The efficacy of photodynamic therapy in actinic cheilitis of the lower lip: a prospective study of 15 patients. Dermatol Surg (2007) 0.78

Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules. Chest (2015) 0.78

Immortalization of mouse melanocytes carrying mutations in various pigmentation genes. Anal Biochem (2004) 0.78

The expanding role and presence of neuromelanins in the human brain - why gray matter is gray. Pigment Cell Melanoma Res (2008) 0.78

NADPH:quinone oxidoreductase-1 as a new regulatory enzyme that increases melanin synthesis. J Invest Dermatol (2010) 0.78

Synergistic effect of interleukin-2 and a vaccine of irradiated melanoma cells transfected to secrete staphylococcal enterotoxin A. Clin Exp Metastasis (2002) 0.77

Essential role of the molecular chaperone gp96 in regulating melanogenesis. Pigment Cell Melanoma Res (2013) 0.77

Isolation of melanosomes. Curr Protoc Cell Biol (2005) 0.76

Co-culture of mouse epidermal cells for studies of pigmentation. Pigment Cell Res (2003) 0.76

The Roles of ADAMs Family Proteinases in Skin Diseases. Enzyme Res (2011) 0.75

Non-invasive diffuse reflectance measurements of cutaneous melanin content can predict human sensitivity to ultraviolet radiation. Exp Dermatol (2013) 0.75