Published in Nat Methods on July 22, 2007
Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med (2011) 3.95
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annu Rev Biochem (2009) 2.80
Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog (2010) 2.63
Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors. J Biol Chem (2010) 2.57
Prion detection by an amyloid seeding assay. Proc Natl Acad Sci U S A (2007) 2.34
Crossing the species barrier by PrP(Sc) replication in vitro generates unique infectious prions. Cell (2008) 2.09
Accelerated high fidelity prion amplification within and across prion species barriers. PLoS Pathog (2008) 1.89
De novo generation of infectious prions in vitro produces a new disease phenotype. PLoS Pathog (2009) 1.83
Prion disease blood test using immunoprecipitation and improved quaking-induced conversion. MBio (2011) 1.82
Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions. Proc Natl Acad Sci U S A (2012) 1.77
Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains. PLoS Pathog (2015) 1.74
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? Front Physiol (2012) 1.65
Prion diseases and their biochemical mechanisms. Biochemistry (2009) 1.65
Genesis of mammalian prions: from non-infectious amyloid fibrils to a transmissible prion disease. PLoS Pathog (2011) 1.53
Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein. Protein Eng Des Sel (2009) 1.49
Mechanisms of prion protein assembly into amyloid. Proc Natl Acad Sci U S A (2008) 1.43
Detection of protease-resistant cervid prion protein in water from a CWD-endemic area. Prion (2009) 1.42
Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion. J Gen Virol (2011) 1.40
The Distribution of Prion Protein Allotypes Differs Between Sporadic and Iatrogenic Creutzfeldt-Jakob Disease Patients. PLoS Pathog (2016) 1.40
Prion hypothesis: the end of the controversy? Trends Biochem Sci (2010) 1.40
Parallel in-register intermolecular β-sheet architectures for prion-seeded prion protein (PrP) amyloids. J Biol Chem (2014) 1.27
Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. J Biol Chem (2009) 1.27
In vitro detection of prionemia in TSE-infected cervids and hamsters. PLoS One (2013) 1.17
Real-time quaking-induced conversion: a highly sensitive assay for prion detection. Prion (2011) 1.08
Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C). PLoS Pathog (2012) 1.07
Prions in the environment: occurrence, fate and mitigation. Prion (2008) 1.07
High CJD infectivity remains after prion protein is destroyed. J Cell Biochem (2011) 1.06
Prion protein misfolding and disease. Curr Opin Struct Biol (2009) 1.06
Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP. PLoS Pathog (2010) 1.06
Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL. J Clin Immunol (2012) 1.04
The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro. FEBS Lett (2009) 1.04
Recent advances in prion chemotherapeutics. Infect Disord Drug Targets (2009) 1.03
Prion protein amyloid formation under native-like conditions involves refolding of the C-terminal alpha-helical domain. J Biol Chem (2008) 1.02
Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins. J Virol (2012) 1.01
The polybasic N-terminal region of the prion protein controls the physical properties of both the cellular and fibrillar forms of PrP. J Mol Biol (2008) 1.01
Switching in amyloid structure within individual fibrils: implication for strain adaptation, species barrier and strain classification. FEBS Lett (2009) 1.00
Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion. J Gen Virol (2014) 0.99
Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations. J Clin Microbiol (2012) 0.99
Detection of prion protein particles in blood plasma of scrapie infected sheep. PLoS One (2012) 0.96
Quantitative recovery of scrapie agent with minimal protein from highly infectious cultures. Viral Immunol (2008) 0.96
Variety of antiprion compounds discovered through an in silico screen based on cellular-form prion protein structure: Correlation between antiprion activity and binding affinity. Antimicrob Agents Chemother (2008) 0.95
Charge neutralization of the central lysine cluster in prion protein (PrP) promotes PrP(Sc)-like folding of recombinant PrP amyloids. J Biol Chem (2014) 0.94
Low density subcellular fractions enhance disease-specific prion protein misfolding. J Biol Chem (2010) 0.94
A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues. Biochemistry (2011) 0.94
Redox control of prion and disease pathogenesis. Antioxid Redox Signal (2010) 0.93
Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. PLoS One (2015) 0.93
Report of the Working Group 'Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)': Statement on the Development and Implementation of Test Systems Suitable for the Screening of Blood Donors for vCJD - Dated September 17, 2008. Transfus Med Hemother (2009) 0.92
Sensitivity of protein misfolding cyclic amplification versus immunohistochemistry in ante-mortem detection of chronic wasting disease. J Gen Virol (2012) 0.91
In vitro amplification of misfolded prion protein using lysate of cultured cells. PLoS One (2011) 0.91
Relationships between clinicopathological features and cerebrospinal fluid biomarkers in Japanese patients with genetic prion diseases. PLoS One (2013) 0.90
Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity. PLoS One (2013) 0.90
Olfactory system involvement in natural scrapie disease. J Virol (2009) 0.90
Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification. MBio (2013) 0.89
Generation of prions in vitro and the protein-only hypothesis. Prion (2010) 0.88
Aggregation and amyloid fibril formation induced by chemical dimerization of recombinant prion protein in physiological-like conditions. J Biol Chem (2009) 0.86
Conformational properties of prion strains can be transmitted to recombinant prion protein fibrils in real-time quaking-induced conversion. J Virol (2014) 0.86
Detection of chronic wasting disease in the lymph nodes of free-ranging cervids by real-time quaking-induced conversion. J Clin Microbiol (2014) 0.85
A 2cM genome-wide scan of European Holstein cattle affected by classical BSE. BMC Genet (2010) 0.85
The identification of disease-induced biomarkers in the urine of BSE infected cattle. Proteome Sci (2008) 0.85
Shaking alone induces de novo conversion of recombinant prion proteins to β-sheet rich oligomers and fibrils. PLoS One (2014) 0.85
Introducing a rigid loop structure from deer into mouse prion protein increases its propensity for misfolding in vitro. PLoS One (2013) 0.85
Glycosylphosphatidylinositol anchor-dependent stimulation pathway required for generation of baculovirus-derived recombinant scrapie prion protein. J Virol (2011) 0.85
Cyclic amplification of prion protein misfolding. Methods Mol Biol (2012) 0.84
The role of the prion protein membrane anchor in prion infection. Prion (2009) 0.84
Presence and seeding activity of pathological prion protein (PrP(TSE)) in skeletal muscles of white-tailed deer infected with chronic wasting disease. PLoS One (2011) 0.83
Chemical and biophysical insights into the propagation of prion strains. HFSP J (2008) 0.83
Lipopolysaccharide induced conversion of recombinant prion protein. Prion (2014) 0.83
Superparamagnetic nanoparticle capture of prions for amplification. J Virol (2011) 0.82
Recombinant human prion protein inhibits prion propagation in vitro. Sci Rep (2013) 0.82
Genome-wide scan identifies loci associated with classical BSE occurrence. PLoS One (2011) 0.82
Prion propagation in vitro: are we there yet? Int J Med Sci (2008) 0.82
Dissociation of recombinant prion protein fibrils into short protofilaments: implications for the endocytic pathway and involvement of the N-terminal domain. Biochemistry (2012) 0.81
Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded form. PLoS One (2012) 0.81
The diversity and relationship of prion protein self-replicating states. Virus Res (2014) 0.80
Exploring prion protein biology in flies: genetics and beyond. Prion (2010) 0.80
Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process. Protein Sci (2011) 0.80
Phosphorylation of prion protein at serine 43 induces prion protein conformational change. J Neurosci (2009) 0.80
Diagnostic and Prognostic Value of Human Prion Detection in Cerebrospinal Fluid. Ann Neurol (2016) 0.80
Exploring physical and chemical factors influencing the properties of recombinant prion protein and the real-time quaking-induced conversion (RT-QuIC) assay. PLoS One (2014) 0.79
Detection and Quantification of CWD Prions in Fixed Paraffin Embedded Tissues by Real-Time Quaking-Induced Conversion. Sci Rep (2016) 0.78
Factors affecting the accuracy of urine-based biomarkers of BSE. Proteome Sci (2011) 0.78
A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion. Sci Rep (2016) 0.78
Treatment of Prion Disease with Heterologous Prion Proteins. PLoS One (2015) 0.78
Molecular interactions between prions as seeds and recombinant prion proteins as substrates resemble the biological interspecies barrier in vitro. PLoS One (2010) 0.78
Influence of Mabs on PrP(Sc) formation using in vitro and cell-free systems. PLoS One (2012) 0.78
Peripherally administrated prions reach the brain at sub-infectious quantities in experimental hamsters. FEBS Lett (2014) 0.78
Using small molecule reagents to selectively modify epitopes based on their conformation. Prion (2012) 0.77
Y145Stop is sufficient to induce de novo generation prions using protein misfolding cyclic amplification. Prion (2012) 0.77
Urine proteins identified by two-dimensional differential gel electrophoresis facilitate the differential diagnoses of scrapie. PLoS One (2013) 0.77
Structural conservation of prion strain specificities in recombinant prion protein fibrils in real-time quaking-induced conversion. Prion (2015) 0.77
Prion biology: the quest for the test. Nat Methods (2007) 0.77
Identification of misfolded proteins in body fluids for the diagnosis of prion diseases. Int J Cell Biol (2013) 0.76
Non-reducing alkaline solubilization and rapid on-column refolding of recombinant prion protein. Prep Biochem Biotechnol (2012) 0.76
In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate. Prion (2014) 0.75
The prion protein preference of sporadic Creutzfeldt-Jakob disease subtypes. J Biol Chem (2012) 0.75
Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits. Sci Rep (2015) 0.75
Genomic Characteristics of Genetic Creutzfeldt-Jakob Disease Patients with V180I Mutation and Associations with Other Neurodegenerative Disorders. PLoS One (2016) 0.75
Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity. Sci Adv (2016) 0.75
Prions: Beyond a Single Protein. Clin Microbiol Rev (2016) 0.75
Role of polysaccharide and lipid in lipopolysaccharide induced prion protein conversion. Prion (2016) 0.75
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis (2006) 8.17
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med (2007) 7.75
Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science (2005) 5.52
The most infectious prion protein particles. Nature (2005) 5.37
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol (2005) 5.18
A test for Creutzfeldt-Jakob disease using nasal brushings. N Engl J Med (2014) 3.58
Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog (2010) 2.63
Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors. J Biol Chem (2010) 2.57
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat Methods (2008) 2.56
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease. Ann Neurol (2012) 2.18
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J (2002) 2.16
Staphylococcus aureus aconitase inactivation unexpectedly inhibits post-exponential-phase growth and enhances stationary-phase survival. Infect Immun (2002) 2.10
New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. J Virol (2003) 2.09
Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (2003) 1.99
Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nat Struct Mol Biol (2011) 1.90
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. J Neurosci (2005) 1.85
Prion disease blood test using immunoprecipitation and improved quaking-induced conversion. MBio (2011) 1.82
A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease. PLoS Pathog (2006) 1.66
Rabbits are not resistant to prion infection. Proc Natl Acad Sci U S A (2012) 1.63
Rapid neutrophil destruction following phagocytosis of Staphylococcus aureus. J Innate Immun (2010) 1.62
Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity. J Neurosci (2007) 1.61
Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein. Protein Eng Des Sel (2009) 1.49
Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages. Infect Immun (2010) 1.49
Biomedicine. A view from the top--prion diseases from 10,000 feet. Science (2003) 1.48
Immunohistochemical localization of aspartoacylase in the rat central nervous system. J Comp Neurol (2004) 1.47
Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains. J Virol (2007) 1.46
Characterization of the Bhanja serogroup viruses (Bunyaviridae): a novel species of the genus Phlebovirus and its relationship with other emerging tick-borne phleboviruses. J Virol (2013) 1.43
Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells. Proc Natl Acad Sci U S A (2002) 1.42
Dectin-1 promotes fungicidal activity of human neutrophils. Eur J Immunol (2007) 1.41
Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion. J Gen Virol (2011) 1.40
Multiple amino acid residues within the rabbit prion protein inhibit formation of its abnormal isoform. J Virol (2003) 1.35
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res. J Virol (2006) 1.35
Susceptibilities of nonhuman primates to chronic wasting disease. Emerg Infect Dis (2009) 1.33
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). PLoS Pathog (2009) 1.30
Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages. J Infect Dis (2002) 1.28
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. Biochemistry (2011) 1.27
Prion diseases--close to effective therapy? Nat Rev Drug Discov (2004) 1.27
Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. J Biol Chem (2009) 1.27
Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. J Infect Dis (2004) 1.25
Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PLoS One (2012) 1.25
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis. J Bacteriol (2007) 1.23
Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge. Virology (2008) 1.21
Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro. J Biol Chem (2004) 1.21
Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils. Neurobiol Aging (2008) 1.18
Molecular basis of scrapie strain glycoform variation. J Biol Chem (2002) 1.16
Prion shedding from olfactory neurons into nasal secretions. PLoS Pathog (2010) 1.15
Prion strain-dependent differences in conversion of mutant prion proteins in cell culture. J Virol (2006) 1.14
The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein. J Biol Chem (2003) 1.14
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J Virol (2006) 1.14
Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor. J Clin Invest (2005) 1.13
Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform. J Biol Chem (2003) 1.12
New generation QuIC assays for prion seeding activity. Prion (2012) 1.12
A three-dimensional comparison of tick-borne flavivirus infection in mammalian and tick cell lines. PLoS One (2012) 1.11
Structural insights into the interaction between prion protein and nucleic acid. Biochemistry (2006) 1.10
Rapid antemortem detection of CWD prions in deer saliva. PLoS One (2013) 1.10
Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent. Virology (2008) 1.10
Yersinia pestis subverts the dermal neutrophil response in a mouse model of bubonic plague. MBio (2013) 1.09
Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides. Antimicrob Agents Chemother (2006) 1.08
Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins. Mol Biol Cell (2008) 1.08
A solid-phase assay for identification of modulators of prion protein interactions. Anal Biochem (2003) 1.07
Cells expressing anchorless prion protein are resistant to scrapie infection. J Virol (2009) 1.07
Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death. Immunity (2013) 1.07
Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation. Protein Sci (2006) 1.07
Prion protein misfolding and disease. Curr Opin Struct Biol (2009) 1.06
Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps. J Immunol (2013) 1.05
Inhibition of chlamydiae by primary alcohols correlates with the strain-specific complement of plasticity zone phospholipase D genes. Infect Immun (2006) 1.04
Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models. Biochemistry (2006) 1.04
Prions and the potential transmissibility of protein misfolding diseases. Annu Rev Microbiol (2013) 1.04
Recent advances in prion chemotherapeutics. Infect Disord Drug Targets (2009) 1.03
A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae. Protein Sci (2003) 1.02
Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapie. Neurosci Lett (2005) 1.02
Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro. J Biol Chem (2004) 1.01
Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins. J Virol (2012) 1.01
Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase. Proc Natl Acad Sci U S A (2003) 1.01
A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrob Agents Chemother (2006) 0.99
Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations. J Clin Microbiol (2012) 0.99
Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations. Proteomics (2010) 0.99
DNA aptamers that bind to PrP(C) and not PrP(Sc) show sequence and structure specificity. Exp Biol Med (Maywood) (2006) 0.98
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1. J Neurosci (2008) 0.96
Role of cyclophilin A from brains of prion-infected mice in stimulation of cytokine release by microglia and astroglia in vitro. J Biol Chem (2011) 0.95
Hemin interactions and alterations of the subcellular localization of prion protein. J Biol Chem (2007) 0.94