Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women.

PubWeight™: 5.95‹?› | Rank: Top 1%

🔗 View Article (PMC 2585540)

Published in Am J Med on August 01, 2007

Authors

Aruna D Pradhan1, Nader Rifai, Julie E Buring, Paul M Ridker

Author Affiliations

1: Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass, USA. apradhan@partners.org

Associated clinical trials:

GMVs in Primary Care: An RCT of Group-Based Versus Individual Appointments to Reduce HbA1c in Older People (GAP) | NCT02002143

Articles citing this

Diagnosis and classification of diabetes mellitus. Diabetes Care (2010) 28.34

Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med (2010) 13.25

Diagnosis and classification of diabetes mellitus. Diabetes Care (2011) 9.37

Diagnosis and classification of diabetes mellitus. Diabetes Care (2012) 9.03

Diagnosis and classification of diabetes mellitus. Diabetes Care (2013) 6.83

Elevated A1C in adults without a history of diabetes in the U.S. Diabetes Care (2009) 2.49

A1C level and future risk of diabetes: a systematic review. Diabetes Care (2010) 2.35

HbA1c measured in stored erythrocytes and mortality rate among middle-aged and older women. Diabetologia (2007) 2.03

Utility of hemoglobin A(1c) for diagnosing prediabetes and diabetes in obese children and adolescents. Diabetes Care (2011) 1.86

The epidemic of pre-diabetes: the medicine and the politics. BMJ (2014) 1.78

Changes in BMI, duration of overweight and obesity, and glucose metabolism: 45 years of follow-up of a birth cohort. Diabetes Care (2011) 1.71

Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study. PLoS Genet (2008) 1.67

Hemoglobin A1c as a screen for previously undiagnosed prediabetes and diabetes in an acute-care setting. Diabetes Care (2011) 1.60

Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant (2011) 1.58

A1C between 5.7 and 6.4% as a marker for identifying pre-diabetes, insulin sensitivity and secretion, and cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetes Care (2010) 1.41

Postchallenge glucose, A1C, and fasting glucose as predictors of type 2 diabetes and cardiovascular disease: a 10-year prospective cohort study. Diabetes Care (2010) 1.35

The prediabetic period: review of clinical aspects. Diabetes Metab J (2011) 1.34

Low hemoglobin A1c and risk of all-cause mortality among US adults without diabetes. Circ Cardiovasc Qual Outcomes (2010) 1.33

Associations of diet with albuminuria and kidney function decline. Clin J Am Soc Nephrol (2010) 1.22

Ability among adolescents for the metabolic syndrome to predict elevations in factors associated with type 2 diabetes and cardiovascular disease: data from the national health and nutrition examination survey 1999-2006. Metab Syndr Relat Disord (2010) 1.10

Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in women. Clin J Am Soc Nephrol (2010) 1.04

Predictors of development of diabetes in patients with chronic heart failure in the Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM) program. Diabetes Care (2009) 0.98

Higher glycated hemoglobin level is associated with increased risk for ischemic stroke in non-diabetic korean male adults. Diabetes Metab J (2011) 0.97

Lipid and inflammatory biomarkers and kidney function decline in type 2 diabetes. Diabetologia (2009) 0.97

Impact of HbA1c Criterion on the Detection of Subjects with Increased Risk for Diabetes among Health Check-Up Recipients in Korea. Diabetes Metab J (2012) 0.96

Glycosylated hemoglobin and the risk of death and cardiovascular mortality in the elderly. Nutr Metab Cardiovasc Dis (2009) 0.92

High-normal HbA1c is a strong predictor of type 2 diabetes in the general population. Diabetes Care (2011) 0.91

Hemoglobin A1c as a predictor of incident diabetes. Diabetes Care (2011) 0.91

Type 2 diabetes mellitus and risk of incident atrial fibrillation in women. J Am Coll Cardiol (2012) 0.91

Estimation of the contribution of biomarkers of different metabolic pathways to risk of type 2 diabetes. Eur J Epidemiol (2010) 0.91

Glycated hemoglobin and risk of hypertension in the atherosclerosis risk in communities study. Diabetes Care (2012) 0.91

Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study. Cardiovasc Diabetol (2015) 0.88

Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience. Diabetes Metab Syndr Obes (2014) 0.87

HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population: NIPPON DATA90. Diabetes Care (2013) 0.87

Hemoglobin a1c is associated with increased risk of incident coronary heart disease among apparently healthy, nondiabetic men and women. J Am Heart Assoc (2013) 0.87

Genetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes care. Curr Diab Rep (2011) 0.86

HbA₁c versus oral glucose tolerance test as a method to diagnose diabetes mellitus in vascular surgery patients. Cardiovasc Diabetol (2013) 0.84

Hemoglobin A1c, fasting glucose, and cardiovascular risk in a population with high prevalence of diabetes: the strong heart study. Diabetes Care (2011) 0.82

Glycated hemoglobin level is significantly associated with the severity of coronary artery disease in non-diabetic adults. Lipids Health Dis (2014) 0.80

HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies. BMC Med (2016) 0.80

The relationship between glycated hemoglobin and complexity of coronary artery lesions among older patients with diabetes mellitus. PLoS One (2014) 0.79

Diabetes prevention: global health policy and perspectives from the ground. Diabetes Manag (Lond) (2015) 0.78

Change in HbA1c over 3 years does not improve the prediction of cardiovascular disease over and above HbA1c measured at a single time point. Diabetologia (2013) 0.77

Glycated hemoglobin and incident type 2 diabetes in singaporean chinese adults: the Singapore Chinese health study. PLoS One (2015) 0.76

Whole-Body MR Imaging Including Angiography: Predicting Recurrent Events in Diabetics. Eur Radiol (2015) 0.76

Cardiovascular disease: the other face of diabetes. CPT Pharmacometrics Syst Pharmacol (2013) 0.76

Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients. Biomark Insights (2016) 0.76

Diagnosis and management of diabetes and the relationship of dglucose to kidney function. Curr Diabetes Rev (2015) 0.75

Incidence of type 2 diabetes in pre-diabetic Japanese individuals categorized by HbA1c levels: a historical cohort study. PLoS One (2015) 0.75

Association of high normal HbA1c and TSH levels with the risk of CHD: a 10-year cohort study and SVM analysis. Sci Rep (2017) 0.75

Response: higher glycated hemoglobin level is associated with increased risk for ischemic stroke in non-diabetic korean male adults (diabetes metab j 2011;35:551-7). Diabetes Metab J (2012) 0.75

Value of serum 1,5-anhydroglucitol measurements in childhood obesity in the continuum of diabetes. Ann Pediatr Endocrinol Metab (2015) 0.75

Group Medical Visits (GMVs) in primary care: an RCT of group-based versus individual appointments to reduce HbA1c in older people. BMJ Open (2015) 0.75

High HbA1c is associated with higher risk of ischaemic stroke in Pakistani population without diabetes. Stroke Vasc Neurol (2016) 0.75

The Association of Serum 25-Hydroxyvitamin D Concentrations and Elevated Glycated Hemoglobin Values: A Longitudinal Study of Non-Diabetic Participants of a Preventive Health Program. Nutrients (2017) 0.75

Articles cited by this

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care (1997) 49.11

A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med (2005) 17.32

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA (2001) 15.85

Standards of medical care in diabetes--2006. Diabetes Care (2006) 9.56

The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care (1999) 9.16

Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med (2004) 8.36

Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus. N Engl J Med (1976) 7.02

Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk). BMJ (2001) 5.55

Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population. Diabetes Care (2000) 4.63

Diagnosis and classification of diabetes mellitus. Diabetes Care (2005) 4.47

Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diabetes Care (2002) 3.96

High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study. Diabetes Care (1998) 3.94

Relationship between fasting plasma glucose and glycosylated hemoglobin: potential for false-positive diagnoses of type 2 diabetes using new diagnostic criteria. JAMA (1999) 3.90

A clinical approach for the diagnosis of diabetes mellitus: an analysis using glycosylated hemoglobin levels. Meta-analysis Research Group on the Diagnosis of Diabetes Using Glycated Hemoglobin Levels. JAMA (1996) 3.66

Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study. Diabetologia (1999) 3.60

Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA (2004) 3.31

Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall study. Br Med J (Clin Res Ed) (1983) 3.28

Kinetics of HbA1c, glycated albumin, and fructosamine and analysis of their weight functions against preceding plasma glucose level. Diabetes Care (1995) 3.06

Glycated hemoglobin standardization--National Glycohemoglobin Standardization Program (NGSP) perspective. Clin Chem Lab Med (2003) 2.45

Tracking of glycated hemoglobin in the original cohort of the Framingham Heart Study. J Clin Epidemiol (1996) 2.03

Diagnostic strategies to detect glucose intolerance in a multiethnic population. Diabetes Care (2003) 1.93

Lilly Lecture 1993. Glycation and diabetic complications. Diabetes (1994) 1.92

GHb is a better predictor of cardiovascular disease than fasting or postchallenge plasma glucose in women without diabetes. The Rancho Bernardo Study. Diabetes Care (1996) 1.90

Hemoglobin A1c level and future cardiovascular events among women. Arch Intern Med (2004) 1.76

The reproducibility and usefulness of the oral glucose tolerance test in screening for diabetes and other cardiovascular risk factors. Ann Clin Biochem (1998) 1.63

Combined use of fasting plasma glucose and HbA1c predicts the progression to diabetes in Chinese subjects. Diabetes Care (2000) 1.62

Glycated haemoglobin predicts progression to diabetes mellitus in Pima Indians with impaired glucose tolerance. Diabetologia (1994) 1.45

Do atherosclerosis and type 2 diabetes share a common inflammatory basis? Eur Heart J (2002) 1.45

Reproducibility of hemoglobin AIc and sensitivity to various degrees of glucose intolerance. Ann Intern Med (1979) 1.25

Effectiveness of glycosylated hemoglobin, fasting plasma glucose, and a single post load plasma glucose level in population screening for glucose intolerance. Am J Epidemiol (1984) 1.15

Sex differences in fasting glycemia as a risk factor for ischemic heart disease death. Am J Epidemiol (1991) 1.14

Reproducibility of HbA1c in a healthy adult population: the Telecom Study. Diabetes Care (1999) 1.12

Reproducibility and comparative analysis of repeated intravenous and oral glucose tolerance tests. Diabetes (1978) 1.12

Fasting blood glucose and risk of coronary heart disease, stroke, and all-cause mortality: a 17-year follow-up study of men born in 1913. Diabet Med (1986) 1.07

High glycosylated hemoglobin levels increase the risk of progression to diabetes mellitus in subjects with glucose intolerance. Diabetes Res Clin Pract (1996) 1.04

A two-step strategy for identification of high-risk subjects for a clinical trial of prevention of NIDDM. Diabetes Care (1996) 0.97

Asymptomatic hyperglycaemia and major ischaemic heart disease events in Britain. J Epidemiol Community Health (1994) 0.97

Variability of capillary plasma glucose in healthy individuals in repeated 75 g oral glucose tolerance tests. Ann Clin Biochem (1988) 0.86

Articles by these authors

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation (2003) 23.97

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Inflammation and atherosclerosis. Circulation (2002) 20.77

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med (2005) 17.32

Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med (2002) 16.23

Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60

Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA (2007) 15.32

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 12.09

Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA (2007) 9.68

C-reactive protein levels and outcomes after statin therapy. N Engl J Med (2005) 9.47

Progress and challenges in translating the biology of atherosclerosis. Nature (2011) 9.41

Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 9.03

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation (2003) 8.61

Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures. Ann Intern Med (2009) 7.62

Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ (2007) 7.54

Plasma adiponectin levels and risk of myocardial infarction in men. JAMA (2004) 7.46

C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation (2008) 7.33

Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med (2002) 7.32

C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation (2003) 6.99

Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79

C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39

Migraine and risk of cardiovascular disease in women. JAMA (2006) 6.16

Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16

Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol (2009) 6.11

Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol (2004) 6.08

Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med (2009) 6.00

Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98

Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA (2008) 5.92

Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med (2004) 5.86

C-reactive protein and the risk of developing hypertension. JAMA (2003) 5.75

Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA (2005) 5.74

The effect of including C-reactive protein in cardiovascular risk prediction models for women. Ann Intern Med (2006) 5.69

New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48

Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol (2008) 5.28

Physical activity and weight gain prevention. JAMA (2010) 5.27

Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 5.25

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14

Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 5.13

Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ (2009) 4.98

C-reactive protein and the risk of incident colorectal cancer. JAMA (2004) 4.94

Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94

Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med (2004) 4.92

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89

Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78

Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillation. JAMA (2011) 4.73

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet (2009) 4.71

Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes (2004) 4.67

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63

Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation (2004) 4.58

Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA (2012) 4.49

Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA (2004) 4.47

Association between a literature-based genetic risk score and cardiovascular events in women. JAMA (2010) 4.46

A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med (2009) 4.46

Prevalence of dry eye syndrome among US women. Am J Ophthalmol (2003) 4.46

Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women. Clin Chem (2007) 4.45

Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 4.40

Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials. Circulation (2010) 4.37

Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet (2008) 4.31

Inflammation as a cardiovascular risk factor. Circulation (2004) 4.26

Association between C-reactive protein and age-related macular degeneration. JAMA (2004) 4.16

Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA (2004) 4.04

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation (2003) 3.94

Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women. Circulation (2009) 3.93

Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov (2005) 3.92

Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91

Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men. Circulation (2005) 3.85

Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81

Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71

Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA (2004) 3.69

Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68

Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. Am J Hum Genet (2008) 3.61

Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr (2004) 3.61

Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr (2005) 3.55

The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med (2004) 3.50